Publications of Pedro COSTA DE ARAUJO
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See detailContact allergy to benzalkonium chloride in patients using a steroid nasal spray: A report of 3 cases
Lechien, Jr; COSTA DE ARAUJO, Pedro ULiege; De Marrez, LG et al

in Ear, Nose, and Throat Journal (2018), E20-E22

Benzalkonium chloride (BAC) is a bactericidal preservative excipient commonly found in steroid nasal sprays used to treat allergic rhinitis and nasal polyposis. In rare cases, BAC can be responsible for ... [more ▼]

Benzalkonium chloride (BAC) is a bactericidal preservative excipient commonly found in steroid nasal sprays used to treat allergic rhinitis and nasal polyposis. In rare cases, BAC can be responsible for type I and type IV hypersensitivity reactions that can manifest as rhinorrhea, which a clinician might misinterpret as a lack of response to nasal spray therapy rather than a complication of it. We report 3 cases of type IV hypersensitivity reactions in patients who were being treated with mometasone nasal spray. We describe the epidemiology, clinical features, diagnosis, and treatment of these reactions. [less ▲]

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See detailVoice outcomes of laryngopharyngeal reflux treatment: a systematic review of 1483 patients
Lechien, J. R.; Finck, Camille ULiege; COSTA DE ARAUJO, Pedro ULiege et al

in European Archives of Oto-Rhino-Laryngology (2017), 274(1), 1-23

The aim of this study is to explore voice quality modifications in laryngopharyngeal reflux (LPR) disease and to understand better the pathophysiological mechanisms underlying the development of ... [more ▼]

The aim of this study is to explore voice quality modifications in laryngopharyngeal reflux (LPR) disease and to understand better the pathophysiological mechanisms underlying the development of communicative disability. Biological Abstracts, BioMed Central, Cochrane database, PubMed and Scopus were assessed for subject headings using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) recommendations. Relevant studies published between January 1990 and December 2015 describing the evaluation of voice quality in LPR disease were retrieved. Issues of clinical relevance, such as LPR diagnosis method, treatment efficacy and outcomes, were evaluated for each study. We determined the grade of recommendation for each publication according to the Oxford Centre for Evidence-Based Medicine evidence levels. The search identified 145 publications, of which 25 studies met the inclusion criteria for a total of 1483 LPR patients. Data were extracted by 2 independent physicians who identified 16 trials with a IIb evidence level, 7 trials with a IIa evidence level and 2 RCTs with a Ib evidence level where 4 patient-based instruments and 5 clinician-based instruments were used. The main voice assessment outcomes reported were hoarseness assessments by physicians or patients, followed by acoustic parameters; 15 and 14 articles, respectively, demonstrated significant improvements in subjective and objective voice assessments after treatment. The methodology used to measure acoustic parameters (i.e. sustained vowel duration, the sample portion choice for measurement, etc.) varied from one study to another. The majority of studies indicated that voice quality assessments (especially acoustic parameters) remain an interesting outcome to measure the effectiveness of treatment, but further studies using standardised and transparent methodology to measure acoustic parameters are necessary to confirm the place of each tool in the LPR disease evaluation. [less ▲]

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See detailLichen nitidus on the dorsal tongue.
COSTA DE ARAUJO, Pedro ULiege; Lechien, JR

in Ear, Nose, and Throat Journal (2016)

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See detailChronic maxillary rhinosinusitis of dental origin: a systematic review of 674 patient cases.
Lechien, JR; Filleul, O; COSTA DE ARAUJO, Pedro ULiege et al

in International Journal of Otolaryngology (2014)

Abstract OBJECTIVES: The aim of this systematic review is to study the causes of odontogenic chronic maxillary rhinosinusitis (CMRS), the average age of the patients, the distribution by sex, and the ... [more ▼]

Abstract OBJECTIVES: The aim of this systematic review is to study the causes of odontogenic chronic maxillary rhinosinusitis (CMRS), the average age of the patients, the distribution by sex, and the teeth involved. MATERIALS AND METHODS: We performed an EMBASE-, Cochrane-, and PubMed-based review of all of the described cases of odontogenic CMRS from January 1980 to January 2013. Issues of clinical relevance, such as the primary aetiology and the teeth involved, were evaluated for each case. RESULTS: From the 190 identified publications, 23 were selected for a total of 674 patients following inclusion criteria. According to these data, the main cause of odontogenic CMRS is iatrogenic, accounting for 65.7% of the cases. Apical periodontal pathologies (apical granulomas, odontogenic cysts, and apical periodontitis) follow them and account for 25.1% of the cases. The most commonly involved teeth are the first and second molars. CONCLUSION: Odontogenic CMRS is a common disease that must be suspected whenever a patient undergoing dental treatment presents unilateral maxillary chronic rhinosinusitis. [less ▲]

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See detailLi-Fraumeni syndrome: multiple distinct brain tumours in two brothers.
Lechien, JR; Brotchi, Jacques; Van Maldergem, L et al

in Neuro-Chirurgie (2014)

Li-Fraumeni syndrome is a rare autosomal dominant cancer-prone condition characterized by the occurrence of a large set of different types of cancer in a patient and their family. A germline disease ... [more ▼]

Li-Fraumeni syndrome is a rare autosomal dominant cancer-prone condition characterized by the occurrence of a large set of different types of cancer in a patient and their family. A germline disease-causing mutation of the gene encoding the p53 protein is associated with the syndrome. We report on a family in which segregation of a TP53 mutation in two generations was associated with two brain tumours, a leiomyosarcoma and a thyroid carcinoma in four male patients. The main patient presented with seizures revealing several primary brain tumours. We review recent views on its molecular basis and discuss management of the condition as well as a review of the literature. [less ▲]

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See detailRetroauricular abscess from first bilateral branchial cleft sinus.
COSTA DE ARAUJO, Pedro ULiege; HSIEH, JW; KUNTZLER, S et al

in BMJ Case Reports (2013)

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See detailLE CAS CLINIQUE DU MOIS. Présentation clinique atypique d’un neuroblastome chez un nourrisson
Dauphin, G; COSTA DE ARAUJO, Pedro ULiege; FORGET, Patricia ULiege et al

in Revue Médicale de Liège (2013)

A babygirl, aged six weeks, was hospitalized for rectal prolapse and isolated constipation. The investigation revealed a neuroblastoma (NB) inducing a medullar compression responsible for the sphincter ... [more ▼]

A babygirl, aged six weeks, was hospitalized for rectal prolapse and isolated constipation. The investigation revealed a neuroblastoma (NB) inducing a medullar compression responsible for the sphincter disorders. NB is second among pediatric solid tumors, but is the most frequent cancer among infants. Its diagnosis is difficult because of its rarity and the variety of its symptoms. A new staging, based on imaging, has recently been proposed by the International Neuroblastoma Risk Group. With the exception of its localized, easily resectable forms, NB is best treated by chemotherapy. [less ▲]

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See detailHerpes zoster mandibularis.
Hsieh, J. W.; COSTA DE ARAUJO, Pedro ULiege; Lechien, JR et al

in BMJ Case Reports (2013)

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See detailHerpes zoster mandibularis.
Hsieh, Julien Wen; Costa de Araujo, Pedro ULiege; Lechien, Jerome et al

in BMJ Case Reports (2013), 2013

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See detailObjective tinnitus from middle ear myoclonus.
Costa de Araujo, Pedro ULiege; Savage, Julian

in Archives of Otolaryngology - Head and Neck Surgery (2012), 138(4), 421

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See detailTraitement par fleurs de Bach: Pensée magique ou médecine factuelle? Revue de la littérature
Lechien, JR; COSTA DE ARAUJO, Pedro ULiege; Linkowski, P

in Revue Médicale de Bruxelles (2012)

In 1930, Dr Edward Bach developed flower essences known as Bach flowers. Today, over 70 years later, they are becoming more and more popular and are used by many practitioners, despite a total lack of ... [more ▼]

In 1930, Dr Edward Bach developed flower essences known as Bach flowers. Today, over 70 years later, they are becoming more and more popular and are used by many practitioners, despite a total lack of scientific support for their use. A review of the literature on the controversial use of this alternative treatment is discussed. [less ▲]

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See detailPresbyastasie et application de la réhabilitation vestibulaire en gériatrie
Costa de Araujo, Pedro ULiege; DEMANEZ, Laurent CH P ULiege; Lechien, Jerôme et al

in Revue Médicale de Liège (2011), 66(3), 130-4

Balance disorders can have a major functional impact among the elderly. The main risk is falling. Three elements are implicated in the loss of balance: vision, proprioception and the vestibular system ... [more ▼]

Balance disorders can have a major functional impact among the elderly. The main risk is falling. Three elements are implicated in the loss of balance: vision, proprioception and the vestibular system. This article will discuss mainly vestibular damage and its implications. The assessment of balance disorders, particularly in geriatric patients, is based on validated scales composed of several items. These provide scores and are based on the results of chronometric measurements. They can be useful for the application of Vestibular Rehabilitation (VR ), a technique improving the adaptation and autonomy of these patients. Vestibular rehabilitation is therefore part of an overall support, the goal of therapy being to improve daily life and to reduce the risk of falls. [less ▲]

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See detailComment j'explore une masse cervicale chez l'enfant
Costa de Araujo, Pedro ULiege; Battisti, Oreste ULiege

in Revue Médicale de Liège (2010), 65

The discovery of a cervical mass in a child suggests several possible diagnoses ranging from benign conditions to more severe pathologies, even cancer. Parents often worry and consult a physician when ... [more ▼]

The discovery of a cervical mass in a child suggests several possible diagnoses ranging from benign conditions to more severe pathologies, even cancer. Parents often worry and consult a physician when such a mass fails to regress after a few weeks. Palpation of small and solid lymph nodes is commonplace and generally trivial in children. A detailed clinical history and a careful examination often allow a distinction to be made between a benign and a serious condition. Additional tests are needed in case of doubt or in the prospect of reaching an precise aetiological diagnosis. These exams should be selected according to a decision algorithm. The investigation remains delicate. When the physician is convinced of the benign nature of the lymphadenopathy, there is no real need to identify the aetiology with the greatest precision, especially in acute cases with bilateral nodes that are commonly benign and spontaneously resolve. [less ▲]

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