Publications of Frédérique DEPIERREUX
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See detailMultimodal Imaging In Parkinson’s Disease: Exploring Iron–, Neuromelanin-Sensitive MRI And FDOPA PET Relationships
DEPIERREUX, Frédérique ULiege

Doctoral thesis (2021)

This thesis explores the relationships between different imaging modalities (namely FDOPA PET, Neuromelanin-sensitive MRI, Iron-sensitive MRI) and how they could reflect the neuropathological processes ... [more ▼]

This thesis explores the relationships between different imaging modalities (namely FDOPA PET, Neuromelanin-sensitive MRI, Iron-sensitive MRI) and how they could reflect the neuropathological processes underlying Parkinson's disease. [less ▲]

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See detailParkinson’s disease multimodal imaging: F-DOPA PET, neuromelanin-sensitive and quantitative iron-sensitive MRI
DEPIERREUX, Frédérique ULiege; PARMENTIER, Eric ULiege; MACKELS, Laurane ULiege et al

in NPJ Parkinson's Disease (2021)

Parkinson’s disease is a neurodegenerative synucleinopathy characterized by the degeneration of neuromelanin-containing dopaminergic neurons and deposition of iron in the substantia nigra (SN). How ... [more ▼]

Parkinson’s disease is a neurodegenerative synucleinopathy characterized by the degeneration of neuromelanin-containing dopaminergic neurons and deposition of iron in the substantia nigra (SN). How regional neuromelanin (NM) loss and iron accumulation within specific areas of SN relates to nigro-striatal dysfunction needs to be clarified. We measured dopaminergic function in pre- and post-commissural putamen by [18F]DOPA PET in twenty-three Parkinson’s disease (PD) patients and 23 healthy control (HC) participants in whom NM content and iron load was assessed in medial and lateral SN, respectively by neuromelanin-sensitive and quantitative R2* MRI. Data analysis consisted of voxelwise regressions testing the group effect and its interaction with NM or iron signals. In PD patients, R2* was selectively increased in left lateral SN as compared to healthy participants, suggesting a local accumulation of iron in Parkinson’s disease. By contrast, NM signal differed between PD and HC, without specific regional specificity within SN. Dopaminergic function in posterior putamen decreased as R2* increased in lateral SN, indicating that dopaminergic function impairment progresses with iron accumulation in the SN. Dopaminergic function was also positively correlated with NM signal in lateral SN, indicating that dopaminergic function impairment progresses with depigmentation in the SN. A complex relationship was detected between R2* in the lateral SN and NM signal in the medial substantia nigra. In conclusion, multimodal imaging reveals regionally-specific relationships between iron accumulation and depigmentation within the SN of Parkinson’s disease and provides in vivo insights in its neuropathology. [less ▲]

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See detailBotulinum toxin treatment of focal dystonia in kernicterus-related movement disorders
Drion, Emilie ULiege; DEPIERREUX, Frédérique ULiege

Conference (2021, January)

Management of patients with movement disorders due to kernicterus mainly focuses on physical therapies. For the specific treatment of dystonia, trihexyphenidyl is usually not beneficial, but ... [more ▼]

Management of patients with movement disorders due to kernicterus mainly focuses on physical therapies. For the specific treatment of dystonia, trihexyphenidyl is usually not beneficial, but benzodiazepines may be used. Botulinum toxin has been proposed by some authors to relieve muscle tone. We report the case of a young boy, treated by botulinum toxin with success for upper limb dystonia. [less ▲]

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See detailSuccessful treatment of hand dystonia with botulinum toxin in a DYT12 patient
DEPIERREUX, Frédérique ULiege; PARMENTIER, Eric ULiege; HARDY, Pierre-Yves ULiege et al

in Toxicon (2021), 190S1(January 2021), 16

Dystonia 12 (DYT12) or rapid-onset dystonia-parkinsonism is a rare neurological disease with onset in childhood or early adulthood. The few published reports of ATP1A3-mutated patients who received ... [more ▼]

Dystonia 12 (DYT12) or rapid-onset dystonia-parkinsonism is a rare neurological disease with onset in childhood or early adulthood. The few published reports of ATP1A3-mutated patients who received pallidal surgery (deep brain stimulation or pallidotomy targeting the globus pallidus pars interna [GPi-DBS]) are disappointing as all implanted patients failed to improve. In this situation, botulinum toxin is one of the remaining options to treat focal dystonia. [less ▲]

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See detailRecurrent Ataxia and Dystonia with Anti-Neurochondrin Autoantibodies
BARREA, Christophe ULiege; DEPIERREUX, Frédérique ULiege

in Neuropediatrics (2021)

We report the case of a 7-years-old boy who developed severe recurrent episodes of ataxia. Following the persistence of intrathecal pleocytosis and oligoclonal bands, auto-immune workup was performed and ... [more ▼]

We report the case of a 7-years-old boy who developed severe recurrent episodes of ataxia. Following the persistence of intrathecal pleocytosis and oligoclonal bands, auto-immune workup was performed and anti-neurochondrin antibodies in the cerebro-spinal fluid were discovered. Other investigations returned normal, no oncologic accompaniments were found. Clinical examination identified cerebellar ataxia, cervical dystonia, choreic movements of the upper limbs, action tremor, opsoclonus, dysarthria and akathisis (Video 1). Cognitive affective cerebellar syndrome, including neuropsychological impairment associated with significant emotional lability, was also found. Initial corticosteroid therapy (intravenous methylprednisolone 30mg/kg for 3 days) resulted in significant improvement. However, following the third relapse, a long-term corticotherapy with monthly intravenous methylprednisolone 500mg/m² was initiated. After 8 months, in order to avoid side effects, this treatment was replaced by mycophenolic acid. No relapse was observed since then. The child currently keeps slightly ataxic gait as well as significant cognitive impairment. Autoimmune etiologies of movement disorders are increasingly recognized, even in children. Unexplained repeated episodes of ataxia of subacute onset may require a workup with comprehensive neural IgG screening, especially since immune therapies seem more effective than what is observed in adults. [less ▲]

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See detailMouvements anormaux pédiatriques (workshop)
DEPIERREUX, Frédérique ULiege

Scientific conference (2020, March 07)

This workshop has been dedicated to pediatric movement disorders and related topics: 1. Phenomenology of children movement disorders (Dr Depierreux) 2. Hypokinetic diseases in children (Pr Garraux) 3 ... [more ▼]

This workshop has been dedicated to pediatric movement disorders and related topics: 1. Phenomenology of children movement disorders (Dr Depierreux) 2. Hypokinetic diseases in children (Pr Garraux) 3. Hyperkinetic disease in children (Dr Depierreux) 4. Genetics (Dr Alkan) 5. GPi DBS in dystonia (Dr Parmentier) 6. Therapeutic approaches (medications and botulinum toxin) (Dr Depierreux) 7 Video analysis (Dr Depierreux) [less ▲]

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See detailCosmetic injection of botulinum toxin unmasking subclinical myasthenia gravis : a case report and literature review
Timmermans, Grégory ULiege; DEPIERREUX, Frédérique ULiege; WANG, François-Charles ULiege et al

in Case Reports in Neurology (2019), 11

Cosmetic or therapeutic use of botulinum toxin type A (BoNT-A) is usually safe but can rarely cause iatrogenic botulism. Iatrogenic botulism and myasthenia gravis (MG) share similar clinical features ... [more ▼]

Cosmetic or therapeutic use of botulinum toxin type A (BoNT-A) is usually safe but can rarely cause iatrogenic botulism. Iatrogenic botulism and myasthenia gravis (MG) share similar clinical features, because both BoNT-A and anti-acetylcholine receptor antibodies impair neuromuscular transmission. We report a patient who underwent cosmetic BoNT-A injection and later developed serious local and systemic adverse reactions. The peculiarity of this case is that a latent seropositive MG was eventually discovered, suggesting that both iatrogenic botulism and MG contributed to the clinical picture. This patient is one of the less than 10 reported cases worldwide in whom MG was unmasked by BoNT-A injection. He is the first to be assessed in detail by single-fiber electromyography (SFEMG). This case emphasises the risk associated with BoTN-A injection in patients with subclinical impairment of neuromuscular transmission and prompts the search for MG in case of exaggerated response. [less ▲]

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See detailNMOSD with anti-MOG antibodies following anti-TNFα therapy: A case report
LOMMERS, Emilie ULiege; DEPIERREUX, Frédérique ULiege; HANSEN, Isabelle ULiege et al

in Multiple Sclerosis and Related Disorders (2018), 26

Tumor necrosis factor α (TNFα) inhibitors are highly effective and a therapeutic choice for several inflammatory diseases. Their broad and long-term use is associated with a growing number of paradoxical ... [more ▼]

Tumor necrosis factor α (TNFα) inhibitors are highly effective and a therapeutic choice for several inflammatory diseases. Their broad and long-term use is associated with a growing number of paradoxical autoimmune events including demyelinating lesions of the central nervous system (CNS). We report and discuss a case of neuromyelitis optica spectrum disorder (NMOSD) with positive myelin oligodendrocyte glycoprotein antibodies (MOG-IgG1) following anti-TNFα therapy for a pustular psoriasis. [less ▲]

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See detailDegree of Centrality within the motor network for Parkinson’s Disease
Baquero Duarte, Katherine Andrea ULiege; Guldenmund, Pieter; Rouillard, Maud ULiege et al

Poster (2018, June)

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See detailUne petite histoire de la syphilis. La maladie a travers l'art et l'artiste.
Jedidi, H; Laverdeur, C; DEPIERREUX, Frédérique ULiege et al

in Revue Médicale de Liège (2018), 73(7-8), 363-369

Considering its strong symbolic connotations and its rich history, syphilis could be regarded as the perfect example of venerian disease. It could also be seen as a representative disease of the whole ... [more ▼]

Considering its strong symbolic connotations and its rich history, syphilis could be regarded as the perfect example of venerian disease. It could also be seen as a representative disease of the whole medical history and the evolution of both medical ways of thinking and curing. In this work we will briefly discuss the history of the syphilitic disease and try to show how this condition has affected the life and works of some of the most famous artists of the 19th century. Moreover, we shall try to evoke the complex relationship between art and pathology. [less ▲]

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See detailData set of healthy old people assessed for three walking conditions using accelerometric and opto-electronic methods
GILLAIN, Sophie ULiege; Boutaayamou, Mohamed ULiege; Dardenne, Nadia ULiege et al

in Aging Clinical and Experimental Research (2017), 29(6), 1201-1209

Background Gait patterns of healthy aging are needed to allow a comparison with pathological situations. However, little data is available. Objective To present gait pattern of healthy older specially ... [more ▼]

Background Gait patterns of healthy aging are needed to allow a comparison with pathological situations. However, little data is available. Objective To present gait pattern of healthy older specially selected to be “healthy walkers”. Method Fifty-seven older people benefited from a geriatric assessment including clinical and functional evaluations to include only those without gait disorders. Gait data were simultaneously recorded using a tri-axial accelerometer placed on the waist and four 3D position markers placed on the feet at the level of the heel and the toe. Volunteers walked at comfortable self-selected speed (CW), fast self-selected speed (FW), and finally in dual task walking condition (DTW). The extracted gait parameters were: gait speed, stride length, stride frequency, regularity and symmetry, swing, stance and double support time and ratio and minimum toe clearance. Gait speed and stride length were normalized to the right leg length. Results Fifty-seven older people with a mean age of 69.7 ± 4.2 years old (range from 65 to 82 years) were included. Data were analyzed according to the gender and according to the age (<70 or ≥70 years old). After normalization to leg length, the main significant differences were shown for stride length and minimum toe clearance in CW, FW and in DTW that were shorter in women. The regularity in FW was significantly lower among older volunteers. Conclusions This work provides a data set considering 14 gait parameters obtained from 57 healthy old people strictly selected and assessed for three walking conditions and shows that GS, SL and MTC have to be related to the gender. The age-related impact on gait performances appears reduced in this cohort. [less ▲]

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See detailLa pollution lumineuse, entre écologie et santé
JEDIDI, Haroun ULiege; DEPIERREUX, Frédérique ULiege; JEDIDI, Zayd ULiege et al

in Revue Médicale de Liège (2015), 70(11), 557-562

Light pollution is defined as the abnormal and disturbing presence of light and its adverse consequences on flora, faunae, ecosystems and its suspected or proven effects on human health. Light pollution ... [more ▼]

Light pollution is defined as the abnormal and disturbing presence of light and its adverse consequences on flora, faunae, ecosystems and its suspected or proven effects on human health. Light pollution is a quite recent and increasing phenomenon within our society and it leads to a major environmental damage, obviously near wildlife, but also on human health (cancers, obesity, fatigue, depression...). The solutions to this problem are however simple, efficient and de facto inexpensive and involving a substantial energy saving. [less ▲]

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See detailLa Narcolepsie-Cataplexie aujourd'hui
DEPIERREUX, Frédérique ULiege; FANIELLE, Julien ULiege; Lecomte, Marianne ULiege et al

in Revue Médicale de Liège (2014), 69(2), 72-81

Diagnostic criteria and pathophysiology of narcolepsy- <br />cataplexy have evolved considerably over the last 10 years. <br />The main cause, already mentioned in a previous paper, in the <br />Revue ... [more ▼]

Diagnostic criteria and pathophysiology of narcolepsy- <br />cataplexy have evolved considerably over the last 10 years. <br />The main cause, already mentioned in a previous paper, in the <br />Revue Médicale de Liège, in 2002, is based, in human beings, <br />on a destruction of specific cells located in the lateral and <br />posterior part of the hypothalamus (the perifornical nuclei, <br />containing some 70,000 neurons), producing peptides which <br />stimulate the central nervous system; they are called hypocretins <br />or orexins. The role of autoimmunity in their disappearance <br />becomes more evident. The treatment is simplified but <br />remains symptomatic. It is mainly based on Sodium Oxybate <br />or Gamma-Hydroxybutyrate, syrup, prescribed for the night. <br />The authors report on their own experience in this regard and <br />on future therapeutics more targeted towards the cause of the <br />disease. [less ▲]

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See detailLes troubles du contrôle des impulsions associés au traitement dopaminergique substitutif antiparkinsonien
DEPIERREUX, Frédérique ULiege; CREMERS, Julien ULiege; SKAWINIAK, Eva ULiege et al

in Revue Médicale de Liège (2013), 68(mai-juin), 221-225

Summary : In some patients, impulse control behaviours can be triggered by dopaminergic replacement therapy, particularly dopamine agonist drugs: hobbyism, punding (stereotyped behaviours), compulsive ... [more ▼]

Summary : In some patients, impulse control behaviours can be triggered by dopaminergic replacement therapy, particularly dopamine agonist drugs: hobbyism, punding (stereotyped behaviours), compulsive buying, binge eating disorder, pathological gamgling, hypersexuality, hedonistic homeostatic dysregulation syndrome ... The pathogenesis of these behaviours is not well understood, but likely involves aberrant changes in the dopaminergic pathways that mediate motivation i.e., a dopaminergic “overdose” in meso-cortico-limbic circuits. An early diagnosis is difficult, but mandatory to prevent the occurrence of devastating familial, marital, professional, socio-economic, medical and medico-legal consequences. Their management is not yet well standardized. Patients and caregivers should be warned about impulse control behaviours before starting dopamine agonists and monitoring for such behaviours while on therapy is requested. [less ▲]

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See detailMaladie de Creutzfeldt-Jakob sporadique: à propos d'un cas
DEPIERREUX, Frédérique ULiege

Master's dissertation (2012)

Description d'un cas clinique de maladie de Creutzfeldt-Jakob sporadique et discussion de son diagnostic différentiel (dont les encéphalites limbiques).

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