Publications of Charlotte CASTRONOVO
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See detailUn nouveau traitement de l’alopécie androgéno-génétique : les injections dans le cuir chevelu de plasma riche en plaquettes (PRP) autologue
MOREAU, Thomas; CASTRONOVO, Charlotte ULiege; Kaux, Jean-François ULiege et al

in Revue Médicale de Liège (2021), 76(2), 117-121

Androgenic alopecia is a genetically determined and leads to a progressive hair loss of the vertex, affecting both men and women. It is related to an important psychological and social distress. Medical ... [more ▼]

Androgenic alopecia is a genetically determined and leads to a progressive hair loss of the vertex, affecting both men and women. It is related to an important psychological and social distress. Medical therapies include topical minoxidil, oral 5α-reductase inhibitors and oestroprogestative drugs with anti-androgen effects for women. The surgical option is autograft hair transplantation. Recently, phototherapy with low-level energy lasers became available. All these treatments may present adverse effects and their effectiveness is questionable. Subcutaneous injections of autologous platelet-rich plasma into the scalp represent an interesting alternative treatment for androgenetic alopecia, as monotherapy or as an adjuvant treatment. The methodology, the possible mechanisms of action and some initial clinical results of this treatment are presented. [less ▲]

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See detailProspective pilot evaluation of the efficacy and safety of topical ingenol mebutate gel for localized patch/plaque stage mycosis fungoides
CASTRONOVO, Charlotte ULiege; ARRESE ESTRADA, Jorge ULiege; Libon, Florence ULiege et al

in Open Dermatology Journal (2017), 11

Background: Mycosis Fungoides (MF) is the most frequent type of the primary cutaneous NK/T-cell lymphomas. Ingenol mebutate (IM) displays in vitro pro-apoptotic properties on neoplastic lymphocytes ... [more ▼]

Background: Mycosis Fungoides (MF) is the most frequent type of the primary cutaneous NK/T-cell lymphomas. Ingenol mebutate (IM) displays in vitro pro-apoptotic properties on neoplastic lymphocytes. Objectives: To evaluate the efficacy and safety of IM gel as topical treatment for MF. Materials and Methods: Ten male patients with longstanding classic type MF (n=9) and follicular MF (FMF; n=1), T2bN0M0B0, stage Ib, resistant to systemic methotrexate or acitretin therapies for at least 3 months, were included in this pilot study. In these patients, 11 target patch/plaque stage lesions with an area ≤ 25 cm2 were selected for IM therapy (0,05%, 2 weekly applications). The primary endpoint was the improvement of the CAILS scores. Biopsies were performed before and after treatment from 10 target lesions. Relapse rates were evaluated at 6 months. Results: The mean CAILS score of treated target lesions was reduced by 58.2%. The mean erythema, scaling and plaque elevation scores were improved by 73.6%, 93.9% and 97.9% (p<0.0001), respectively, while the lesion size remained unchanged (p=0.34). A complete or partial clearance of histological and immunohistochemical features was observed in 6/10 (60%) and 4/10 (40%) of the MF or FMF target lesions, respectively. Monoclonal TCR rearrangement was evidenced in 100% (7/7) of the patients and in 3/7 (43%) after treatment. The relapse rate at 6 months was 18%. All the patients experienced burning sensations, oozing and crusting. Conclusion: IM gel warrants further investigation and development as a potential topical treatment for localized patch/plaque stage MF and FMF. © 2017 Lebas et al. [less ▲]

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See detailLES ACTIVITES ANTI-CANCEREUSES DE LA VITAMINE D: les observations, les doutes et les certitudes.
Castronovo, Charlotte ULiege; Castronovo, Vincenzo ULiege; Nikkels, Arjen ULiege et al

in Revue Médicale de Liège (2015), 70(10), 495-500

The importance of vitamin D in bone and phosphocalcic status is well recognized by the scientific and medical communities; however, recently identified properties of this cholesterol derived molecule ... [more ▼]

The importance of vitamin D in bone and phosphocalcic status is well recognized by the scientific and medical communities; however, recently identified properties of this cholesterol derived molecule, such as immunomodulator and anticancer activities, are yet discussed. Actually, the debate is not so much about the new vitamin D properties, but rather about the optimal concentration required to reach these properties. The difficulty in determining the norms is rendered even more complex by the existence of a vitamin D receptor gene polymorphism. The body pool of this vitamin depends essentially on its endogenous synthesis, but also on its dietary intakes. Many epidemiological studies interested in Vitamin D serum level and cancer suggest a relation between low Vitamin D level and cancer risk, especially in breast and colon adenocarcinomas. In vitro, many studies showed, in different human and animal malignant cell lines, that this molecule exerts anticancer activities: it induces apoptosis and cell differentiation as well as it inhibits proliferation and angiogenesis. This review tries to update the current knowledge on vitamin D and, more particularly, the potential interest of this molecule in cancer prevention and management. [less ▲]

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See detailVitamin D receptor polymorphism and melanoma outcome
CASTRONOVO, Charlotte ULiege; DECKERS, Myriam ULiege; NIKKELS, Arjen ULiege et al

Poster (2014, January 27)

Vitamin D is a 9,10-secosteroid active under the form of 1,25-dihydroxyvitamin D. In vitro, this molecule shows anticancer potential since it regulates cell growth, differentiation and apoptosis which are ... [more ▼]

Vitamin D is a 9,10-secosteroid active under the form of 1,25-dihydroxyvitamin D. In vitro, this molecule shows anticancer potential since it regulates cell growth, differentiation and apoptosis which are cellular mechanisms central to the development and progression of cancer. Moreover, epidemiologic studies suggest an inverse assiociation between sun exposure, serum levels of vitamin D, its intake and the risk of developing/progression cancer. As vitamin D exerts its functions by blinding its receptor (VDR), it has been suggested that polymorphism of the VDR may affect interaction with its ligand and ultimately its biological activities. [less ▲]

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See detailLa place de l'échographie à haute fréquence dans la dermatologie aujourd'hui
CASTRONOVO, Charlotte ULiege; Boufflette, Nicolas ULiege; NIKKELS, Arjen ULiege

in Skin (2013), 16(N°5), 14-16

L'échographie cutanée est une technique d'imagerie cutanée non invasive avec plusieurs indications en dermatologie, qui est fondée sur la réflexion différentielle d'une onde ultrasonique en fonction des ... [more ▼]

L'échographie cutanée est une technique d'imagerie cutanée non invasive avec plusieurs indications en dermatologie, qui est fondée sur la réflexion différentielle d'une onde ultrasonique en fonction des structures sous-jacentes, incluant la kératine, le collagène et l'eau. Les différentes possibilités techniques et le rôle de la fréquence des sondes sont brièvement expliqués. L'échographie cutanée est rapide, sans douleurs, non invasive, reproductible et peut être répétée sans risque. Cette technique a une place dans l'évaluation préopératoire de l'épaisseur des lésions tumorales, telles que le mélanome et les carcinomes basocellulaires et spinocellulaires. Elle est également utilisée dans l'évaluation des maladies inflammatoires. [less ▲]

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See detailMyxofibrosarcoma
CASTRONOVO, Charlotte ULiege; ARRESE ESTRADA, Jorge ULiege; QUATRESOOZ, Pascale ULiege et al

in Rare Tumors (2013), 5(15), 60-61

Myxofibrosarcoma (MFS) is a variant of the group of malignant fibrous histiocytomas. It is one of the most aggressive types of soft tissue neoplasms. The clinical presentation is not pathognomonic and the ... [more ▼]

Myxofibrosarcoma (MFS) is a variant of the group of malignant fibrous histiocytomas. It is one of the most aggressive types of soft tissue neoplasms. The clinical presentation is not pathognomonic and the histological aspects are highly heterogenous, frequently delaying the diagnosis or leading to misdiagnosis. Complementary histochemical and immunohistochemical stainings are mandatory to achieve the diagnosis of MFS. A 78-year-old male patient is presented illustrating this diagnostic pitfall. Extensive surgery followed by radiotherapy is the first choice treatment. [less ▲]

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See detailMyxofibrosarcoma: a diagnostic pitfall.
CASTRONOVO, Charlotte ULiege; ARRESE ESTRADA, Jorge ULiege; Quatresooz, Pascale ULiege et al

in Rare Tumors (2013), 5(2), 60-1

Myxofibrosarcoma (MFS) is a variant of the group of malignant fibrous histiocytomas. It is one of the most aggressive types of soft tissue neoplasms. The clinical presentation is not pathognomonic and the ... [more ▼]

Myxofibrosarcoma (MFS) is a variant of the group of malignant fibrous histiocytomas. It is one of the most aggressive types of soft tissue neoplasms. The clinical presentation is not pathognomonic and the histological aspects are highly heterogenous, frequently delaying the diagnosis or leading to misdiagnosis. Complementary histochemical and immunohistochemical stainings are mandatory to achieve the diagnosis of MFS. A 78-year-old male patient is presented illustrating this diagnostic pitfall. Extensive surgery followed by radiotherapy is the first choice treatment. [less ▲]

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See detailChronic Herpes Zoster Duplex Bilateralis
CASTRONOVO, Charlotte ULiege; NIKKELS, Arjen ULiege

in Clinical Reports (2012)

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See detailChronic Herpes Zoster Duplex Bilateralis
CASTRONOVO, Charlotte ULiege; NIKKELS, Arjen ULiege

in Acta Dermato Venereologica (2012)

Although varicella zoster virus latency has been demonstrated in several sensory ganglia, herpes zoster usually effects only one single, either left or right, dermatome in half of the body. In ... [more ▼]

Although varicella zoster virus latency has been demonstrated in several sensory ganglia, herpes zoster usually effects only one single, either left or right, dermatome in half of the body. In immunocompromised patients, more than one contiguous unilateral dermatome may be involved. Bilateral non-contiguous herpes zoster, also termed herpes zoster duplex, is rarely reported. Chronic varicella zoster viurs skin infection is another rare entity encountered in HIV-infected and immunocompromised patients, often associated with aciclovir resistance. We describe here a patient with chronic lymphocytic leukaemia, who presented simultaneously non-contiguous bilateral and chronic herpes zoster lasting fore more than 2 months, with resistance to aciclovir. To our knowledge, this is the first report of chronic herpes zoster duplex bilateralis. Physicians should be aware of and recognize the atypical manifestations of varicella zoster virus. [less ▲]

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See detailViral infections of the pubis
CASTRONOVO, Charlotte ULiege; LEBAS, Eglantine ULiege; NIKKELS-TASSOUDJI, Nazli ULiege et al

in International Journal of STD and AIDS (2012)

There are no demographic data published on those with viral infections of the pubis (VIPs). We conducted a two-year prospective study to collect demographic information on patient with VIPs. Data were ... [more ▼]

There are no demographic data published on those with viral infections of the pubis (VIPs). We conducted a two-year prospective study to collect demographic information on patient with VIPs. Data were gathered on age, sex, diagnosis, low (<=10) or high (>10) lesion number, symptoms, how the patien discovered the lesions, localization, lesions beyond the pubis, risk factors, shaving habits, human papillomavirus vaccination status and treatment. In a total of 61 patients, molluscum contagiosum (MC) was indentified in 71 %, condylomata acuminata (CA) in 11 %, concomitant MC and CA infections in 11 % and herpes simplex virus (HSV) infection in 4.8 %. Shaving represented a risk factor for a high lesion number, but not for the extension beyond the pubis. MC, CA and HSV infections affecting the pubis are uncommon and often symptomatic. As they may represent a hidden source of infection we recommend thourough inspection of the pubis during routine skin examination. [less ▲]

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See detailHerpes zoster in patients treated with biologicals
FAILLA, Valérie ULiege; JACQUES, Jessica ULiege; CASTRONOVO, Charlotte ULiege et al

in Dermatology (2012)

Background : The incidence and severity of herpes zoster (HZ) appear increased in patients receiving tumor necrosis factor-alpha antagonists. Objective : To study the incidence and clinical features of HZ ... [more ▼]

Background : The incidence and severity of herpes zoster (HZ) appear increased in patients receiving tumor necrosis factor-alpha antagonists. Objective : To study the incidence and clinical features of HZ in 1,220 patients (4.206 patient-years) receiving either adalimumab, etanercept, infliximumab, rituximab or ustekinumab. Results: Twenty-two HZ cases were identified (1.26% of total cohort; adalimumab: 11/1,546 patient-years, incidence rate (IR) 7.1; etanercept: 4/789 patient-years, IR5.1; rituximab: 1/168 patient-years, IR 5.2; ustekinumab: 2/37 patient-years, IR53.5; infliximab: 4/1.666 patient-years, IR 2.4). The time to event varied widely (1.5-108 months). Extensive HZ was reported in 45 and 32% of the cases, respectively. Persistent postzoster neuralgia (PHN;>6months) was observed in 5/20 patients. Conclusions: The Hz incidence was 2.1-fold higher among patients over 60 years, compared with a reference population, although not statistically significant. Severe, multidermatomal HZ and persistent PHN were common. [less ▲]

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