Publications of Julien FANIELLE
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See detailImpact of a shift in treatment funding on a multidisciplinary sleep clinic: a cohort study.
VERMEIRE, Pierre ULiege; Fanielle, Julien ULiege; Gilon, Yves ULiege et al

in Acta Neurologica Belgica (2020)

Multidisciplinary Sleep Clinics for sleep apnea have long existed, bringing together neurologists, sleep specialists, dentists, orthodontists and surgeons. In Belgium, a shift in funding for obstructive ... [more ▼]

Multidisciplinary Sleep Clinics for sleep apnea have long existed, bringing together neurologists, sleep specialists, dentists, orthodontists and surgeons. In Belgium, a shift in funding for obstructive sleep apnea treatment was implemented from January 1st, 2017. Funding was allowed for moderate to severe obstructive sleep apnea and the rules shifted for treatments delivery and monitoring by authorised medical opinion. We aimed to assess whether a shift in treatment funding was associated with a change in the multidisciplinary sleep practice. Sample consisted of all patients discussed in the sleep multidisciplinary team meetings of the University Hospital of Liege from January 2016 to December 2018. Interrupted times series, Mann-Whitney U tests and descriptive statistics were produced. There were no differences in patients age, male sex preponderance, body mass index, clinical presentation and level of obstruction. Baseline obstructive sleep apnea severity was significantly lower (mean apnea-hypopnea index and mean oxygen desaturation index lowered with p = 0.0189 and p = 0.0466, respectively) after the funding rules changed. Oral appliance and ENT surgery were more often offered after the shift in funding. The key changes of the new funding rules for obstructive sleep apnea were reflected in the patient selection and management by sleep multidisciplinary team meeting. Funding terms could influence the care we give, not only in treatment options, but also in patients selection. [less ▲]

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See detailImpact of the European Union directive on driving licences on a Multidisciplinary Sleep Clinic: a Cohort Study
POIRRIER, Anne-Lise ULiege; VERMEIRE, Pierre ULiege; BRUWIER, Annick ULiege et al

Poster (2019, June 29)

Introduction: The threat of Obstructive Sleep Apnea (OSA) for motor vehicle accident has led to a revision of annex III of the European Union directive on driving licences that was implemented in all ... [more ▼]

Introduction: The threat of Obstructive Sleep Apnea (OSA) for motor vehicle accident has led to a revision of annex III of the European Union directive on driving licences that was implemented in all member states from December 31, 2015. In Belgium, it was followed by a shift in funding for OSA from January 1, 2017. Funding was allowed for moderate to severe OSA and the rules shifted for treatments delivery and monitoring by authorised medical opinion. Multidisciplinary Sleep Clinics have long existed, bringing together sleep specialists, dentists, orthodontists and surgeons. We aimed to assess whether a shift in treatment funding was associated with a change in the multidisciplinary sleep practice. Material and Methods: Sample consisted of all patients discussed in the sleep multidisciplinary team meetings of the University Hospital of Liege from January 2016 to December 2018. Interrupted times series, Mann-Whitney U tests and descriptive statistics were produced. Results: There were no differences in patients age, male sex preponderance, body mass index, clinical presentation and level of obstruction. Baseline OSA severity was significantly lower (mean apnea-hypopnea index and mean oxygen desaturation index lowered respectively with p = 0.0189 and p = 0.0466) after the funding rules changed. Oral appliance and ENT surgery were more often offered after the shift in funding. Conclusion: Sleep multidisciplinary team meeting changed patient selection and management after the implementation of the new funding rules for OSA. The shift in funding often resulted in treatment options change, reaching more people and offering more options. [less ▲]

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See detailValidation des mouvements de la mandibule pour mesurer le sommeil par comparaison directe à la polysomnographie et à l’actimetrie
Chakar, Bassam; Senny, Frédéric ULiege; POIRRIER, Anne-Lise ULiege et al

in Médecine du Sommeil (2019, March), 16(1), 57

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See detailImpact of a Shift in Treatment Funding on a Multidisciplinary Sleep Clinic: a Cohort Study
VERMEIRE, Pierre ULiege; FANIELLE, Julien ULiege; BRUWIER, Annick ULiege et al

in B-ENT (2019)

Introduction and Aim: A shift in Obstructive Sleep Apnea (OSA) funding was implemented in Belgium on January 1, 2017. Funding was allowed for moderate to severe OSA and the rules shifted for treatments ... [more ▼]

Introduction and Aim: A shift in Obstructive Sleep Apnea (OSA) funding was implemented in Belgium on January 1, 2017. Funding was allowed for moderate to severe OSA and the rules shifted for treatments delivery and monitoring by authorised medical opinion. Multidisciplinary Sleep Clinics have long existed, bringing together sleep specialists, dentists, orthodontists and surgeons. We aimed to assess whether a shift in treatment funding was associated with a change in the multidisciplinary sleep practice. Material and Methods: Sample consisted of all patients discussed in the sleep multidisciplinary team meetings of the University Hospital of Liege from January 2016 to December 2018. Interrupted times series, Mann-Whitney U tests and descriptive statistics were produced. Results: There were no differences in patients age, male sex preponderance, body mass index, clinical presentation and level of obstruction. Baseline OSA severity was significantly lower (mean apnea-hypopnea index and mean oxygen desaturation index lowered respectively with p = 0.0189 and p = 0.0466) after the funding rules changed. Oral appliance and ENT surgery were more often offered after the shift in funding. Conclusion: Sleep multidisciplinary team meeting changed patient selection and management after the implementation of the new funding rules for OSA. The shift in funding often resulted in treatment options change, reaching more people and offering more options. [less ▲]

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See detailValidation of midsagittal jaw movements to measure sleep in healthy adults by comparison with actigraphy and polysomnography.
Chakar, Bassam ULiege; Senny, Frédéric ULiege; Poirrier, Anne-Lise ULiege et al

in Sleep Science (2017), 10(3), 122-127

OBJECTIVE: In a device based on midsagittal jaw movements analysis, we assessed a sleep-wake automatic detector as an objective method to measure sleep in healthy adults by comparison with wrist ... [more ▼]

OBJECTIVE: In a device based on midsagittal jaw movements analysis, we assessed a sleep-wake automatic detector as an objective method to measure sleep in healthy adults by comparison with wrist actigraphy against polysomnography (PSG). METHODS: Simultaneous and synchronized in-lab PSG, wrist actigraphy and jaw movements were carried out in 38 healthy participants. Epoch by epoch analysis was realized to assess the ability to sleep-wake distinction. Sleep parameters as measured by the three devices were compared. This included three regularly reported parameters: total sleep time, sleep onset latency, and wake after sleep onset. Also, two supplementary parameters, wake during sleep period and latency time, were added to measure quiet wakefulness state. RESULTS: The jaw movements showed sensitivity level equal to actigraphy 96% and higher specificity level (64% and 48% respectively). The level of agreement between the two devices was high (87%). The analysis of their disagreement by discrepant resolution analysis used PSG as resolver revealed that jaw movements was right (58.9%) more often than actigraphy (41%). In sleep parameters comparison, the coefficient correlation of jaw movements was higher than actigraphy in all parameters. Moreover, its ability to distinct sleep-wake state allowed for a more effective estimation of the parameters that measured the quiet wakefulness state. CONCLUSIONS: Midsagittal jaw movements analysis is a reliable method to measure sleep. In healthy adults, this device proved to be superior to actigraphy in terms of estimation of all sleep parameters and distinction of sleep-wake status. [less ▲]

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See detailBrain Mapping in Sleep Medicine
FANIELLE, Julien ULiege; Maquet, Pierre ULiege

Book published by Academic Press (2015)

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See detailLa Narcolepsie-Cataplexie aujourd'hui
DEPIERREUX, Frédérique ULiege; FANIELLE, Julien ULiege; Lecomte, Marianne ULiege et al

in Revue Médicale de Liège (2014), 69(2), 72-81

Diagnostic criteria and pathophysiology of narcolepsy- <br />cataplexy have evolved considerably over the last 10 years. <br />The main cause, already mentioned in a previous paper, in the <br />Revue ... [more ▼]

Diagnostic criteria and pathophysiology of narcolepsy- <br />cataplexy have evolved considerably over the last 10 years. <br />The main cause, already mentioned in a previous paper, in the <br />Revue Médicale de Liège, in 2002, is based, in human beings, <br />on a destruction of specific cells located in the lateral and <br />posterior part of the hypothalamus (the perifornical nuclei, <br />containing some 70,000 neurons), producing peptides which <br />stimulate the central nervous system; they are called hypocretins <br />or orexins. The role of autoimmunity in their disappearance <br />becomes more evident. The treatment is simplified but <br />remains symptomatic. It is mainly based on Sodium Oxybate <br />or Gamma-Hydroxybutyrate, syrup, prescribed for the night. <br />The authors report on their own experience in this regard and <br />on future therapeutics more targeted towards the cause of the <br />disease. [less ▲]

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See detailUpper airway imaging in sleep-disordered breathing.
POIRRIER, Anne-Lise ULiege; Fanielle, Julien ULiege; Bruwier, Annick ULiege et al

in Acta Neurologica Belgica (2014)

Our understanding of sleep-disordered breathing has evolved considerably over the past three decades, and clinical techniques of evaluation have progressed tremendously. Myriad imaging techniques are now ... [more ▼]

Our understanding of sleep-disordered breathing has evolved considerably over the past three decades, and clinical techniques of evaluation have progressed tremendously. Myriad imaging techniques are now available for the physician to approach the dynamic features resulting in turbulent airflow, upper airway narrowing or collapse at different levels. Controversy exists in the choice of investigations, probably because the best evaluation should be a combination of different techniques. Physical, radiographic, endoscopic and acoustic evaluations could be integrated to understand the degree and the levels of airway reduction and/or obstruction in a given patient. This review focuses on cost-effective and easily implemented techniques in daily practice, allowing quality assessment of the dynamic anatomy of sleep-disordered breathing: cephalometry, (sleep-)endoscopy and acoustic reflectometry of the upper airway. [less ▲]

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See detailInvolvement of placental growth factor in Wallerian degeneration
Chaballe, Linda ULiege; Close, Pierre ULiege; SEMPELS, Maxime ULiege et al

in Glia (2011), 59(3), 379-396

Wallerian degeneration (WD) is an inflammatory process of nerve degeneration, which occurs more rapidly in the peripheral nervous system compared with the central nervous system, resulting, respectively ... [more ▼]

Wallerian degeneration (WD) is an inflammatory process of nerve degeneration, which occurs more rapidly in the peripheral nervous system compared with the central nervous system, resulting, respectively in successful and aborted axon regeneration. In the peripheral nervous system, Schwann cells (SCs) and macrophages, under the control of a network of cytokines and chemokines, represent the main cell types involved in this process. Within this network, the role of placental growth factor (PlGF) remains totally unknown. However, properties like monocyte activation/attraction, ability to increase expression of pro-inflammatory molecules, as well as neuroprotective effects, make it a candidate likely implicated in this process. Also, nothing is described about the expression and localization of this molecule in the peripheral nervous system. To address these original questions, we decided to study PlGF expression under physiological and degenerative conditions and to explore its role in WD, using a model of sciatic nerve transection in wild-type and Pgf(-/-) mice. Our data show dynamic changes of PlGF expression, from periaxonal in normal nerve to SCs 24h postinjury, in parallel with a p65/NF-κB recruitment on Pgf promoter. After injury, SC proliferation is reduced by 30% in absence of PlGF. Macrophage invasion is significantly delayed in Pgf(-/-) mice compared with wild-type mice, which results in worse functional recovery. MCP-1 and proMMP-9 exhibit a 3-fold reduction of their relative expressions in Pgf(-/-) injured nerves, as demonstrated by cytokine array. In conclusion, this work originally describes PlGF as a novel member of the cytokine network of WD. [less ▲]

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See detailInvolvement of Placental growth factor in Wallerian degeneration
Chaballe, Linda ULiege; Close, Pierre ULiege; Sempels, Maxime ULiege et al

Poster (2010, September)

Detailed reference viewed: 69 (13 ULiège)