Publications of Selma BEN MUSTAPHA
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See detailEtude pilote : évaluation de l'impact de l'utilisation de l'imagerie médicale comme outil d'éducation thérapeutique du patient en radiothérapie
Kirkove, Delphine ULiege; BARTHELEMY, Nicole ULiege; COUCKE, Philippe ULiege et al

Conference (2021, May 28)

Introduction Le cancer du poumon constitue un problème de Santé Publique du fait de sa fréquence et sa mortalité élevée. Habituellement traité par radiothérapie, combinée ou non avec de la chimiothérapie ... [more ▼]

Introduction Le cancer du poumon constitue un problème de Santé Publique du fait de sa fréquence et sa mortalité élevée. Habituellement traité par radiothérapie, combinée ou non avec de la chimiothérapie, le patient peut présenter des effets secondaires et un retentissement psycho-affectif important. Même s’il reçoit de l’information, l’utilisation des images médicales personnelles en éducation thérapeutique est peu étudiée. Cette communication présente l’évaluation de l’intervention selon Kirkpatrick. L’objectif principal concerne l’impact en terme d’anxiété et de dépression. Les objectifs secondaires concernent les autres niveaux : la satisfaction, le sentiment d’implication, les connaissances rapportées, la perception de se sentir préparé et l’adhésion thérapeutique. Méthode Une étude expérimentale de type « essai contrôlé randomisé » a été menée de façon mono-centrique afin de suivre des patients adultes, porteurs d’une pathologie cancéreuse traitée par radiothérapie thoracique, sur quatre périodes de temps. Le recrutement des patients s’est déroulé entre novembre 2019 et mars 2020. Le groupe contrôle a reçu oralement les informations données usuellement par le radiothérapeute. En plus de celles-ci, le groupe expérimental a bénéficié d’une intervention consistant en la visualisation de ses propres images de CT-Scanner combinées à la dosimétrie, via le programme informatique « Stone of Orthanc », accompagnée d’explications personnalisées du radiothérapeute selon un scénario standardisé. Le critère de jugement principal a été évalué par le questionnaire validé HADS « Hospital Anxiety And Depression Scale », complété par une échelle visuelle analogique de l’anxiété aux différents temps. Les critères secondaires ont été évalués via différents questionnaires créés spécifiquement pour cette étude. Résultats L’échantillon était composé d’un total de 45 patients. La crise du COVID-19 a prématurément interrompu la collecte des données. Au final, seules les données de quinze patients ont pu être utilisées. Bien que non-significatif, le groupe expérimental a montré un gain de connaissance plus important (47.5%) entre le T1 et le T3 que le groupe contrôle (35%) (p = 0.345), ainsi qu’une diminution plus importante des scores liés à l’anxiété (p = 0.577). Les résultats de l’EVA indiquent une tendance commune : le niveau d’anxiété augmente au T2 pour diminuer au T3 avec un niveau plus bas dans le groupe expérimental (0.65) que dans le groupe contrôle (1.00). Un paramètre présente une différence significative entre le T1 et le T3 : le score de dépression (p = 0.043) avec une diminution plus importante dans le groupe expérimental (-9.52%) que dans le groupe contrôle (aucune différence). Les résultats des autres paramètres sont restés similaires dans les deux groupes. Discussion Cette étude indique des résultats prometteurs pour l’utilisation de l’imagerie médicale au service de l’éducation thérapeutique du patient, notamment par l’individualisation des contenus. Les travaux futurs s’attacheront à confirmer ces constats sur une plus grande population. [less ▲]

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See detailLa radiothérapie palliative, c’est aussi notre rayon !
Lamande, Maréva ULiege; Lallemand, François ULiege; BEN MUSTAPHA, Selma ULiege et al

in Revue Médicale de Liège (2021), 76(5-6), 375-379

Radiotherapy (RT), both with a curative and a palliative intent, is one of the cornerstones of oncological treatments. A variety of symptoms linked to cancer can be relieved with RT (such as pain ... [more ▼]

Radiotherapy (RT), both with a curative and a palliative intent, is one of the cornerstones of oncological treatments. A variety of symptoms linked to cancer can be relieved with RT (such as pain, bleeding, compression exerted by a tumour lesion…). Very often, palliative RT is proposed when other medical treatments (painkillers, morphine…) are no longer efficient, or the patient does not tolerate them anymore. Palliative RT is an integral part of the global supportive oncological care. Indeed, patients’ wishes and prognosis are taken into account in each and every step of the treatment pathway. Every treatment deserves an individualized approach and benefits from the best available techniques. [less ▲]

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See detailIncidence, risk factors, and CT characteristics of radiation recall pneumonitis induced by immune checkpoint inhibitor in lung cancer.
COUSIN, François ULiege; DESIR, Colin ULiege; BEN MUSTAPHA, Selma ULiege et al

in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology (2021), 157

BACKGROUND AND PURPOSE: Radiation recall pneumonitis (RRP) is a delayed radiation-induced lung toxicity triggered by systemic agents, typically anticancer drugs. Immune checkpoint inhibitors (ICIs) have ... [more ▼]

BACKGROUND AND PURPOSE: Radiation recall pneumonitis (RRP) is a delayed radiation-induced lung toxicity triggered by systemic agents, typically anticancer drugs. Immune checkpoint inhibitors (ICIs) have recently been identified as potential causal agents of RRP but its real incidence and potential risk factors remain unknown. MATERIALS AND METHODS: Medical records and CTs of patients treated with programmed death 1 (PD-1) or programmed death ligand 1 (PD-L1) inhibitors for advanced lung cancer between 2014 and 2019 at our tertiary center, and who had a previous history of lung irradiation were retrospectively analyzed. We identified RRP as lung CT modifications occurring in the irradiation field >6 months after conventionally fractionated radiotherapy completion and >1 year after stereotactic body radiation therapy. Clinical and dosimetric data were analyzed to identify potential risk factors for RRP. RESULTS: Among 348 patients treated with ICIs, data from 80 eligible patients were analyzed (median age, 69 years [interquartile range, 11]; 45 men). Fifteen patients (18.8%) presented with RRP. Median time between end of radiotherapy and RRP was 450 days (range, 231-1859). No risk factor was significantly associated with RRP. ICI-related pneumonitis was associated with RRP in 33.3% of cases (p = 0.0021), developing either concomitantly or after RRP. Incidence of grade ≥ 3 pneumonitis in the RRP population was 13.3 %. CONCLUSION: We demonstrated a high incidence of RRP (18.8%) in our population of previously irradiated patients treated with ICIs for lung cancer. We identified no risk factors for RRP, but an association was noted between RRP and ICI-related pneumonitis. [less ▲]

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See detailImpact of the COVID-19 Pandemic on Patients and Staff in Radiation Oncology Departments in Belgium: A National Survey
Vaandering, Aude; Ben Mustapha, Selma ULiege; Lambrecht, Marten et al

in Frontiers in Oncology (2020)

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See detailThe status of radiation oncology (RO) teaching to medical students in Europe
BEN MUSTAPHA, Selma ULiege; Meijnders, paul; COUCKE, Philippe ULiege et al

in Clinical and Translational Radiation Oncology (2019)

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See detailThe Influence of Treatment Position (Prone vs. Supine) on Clip Displacement, Seroma, Tumor Bed and Partial Breast Target Volumes: Comparative Study
Lakosi, Ferenc; GULYBAN, Akos ULiege; BEN MUSTAPHA, Selma ULiege et al

in Pathology Oncology Research (2016), 22(3), 493-500

To analyse the displacement of surgical clips in prone (Pr) position and assess the consequences on target volumes and integral dose of partial breast irradiation (PBI). 30 post-lumpectomy breast cancer ... [more ▼]

To analyse the displacement of surgical clips in prone (Pr) position and assess the consequences on target volumes and integral dose of partial breast irradiation (PBI). 30 post-lumpectomy breast cancer patients underwent CT imaging in supine (Su) and Pr. Clip displacements were measured by the distances from the clips to a common fix bony reference point. On each dataset, the tumour bed (TB = clips ± seroma), clinical target volume (CTV = TB + 1.5 cm) and planning target volumes (PTV = CTV + 1 cm) for PBI were determined and the volume pairs were compared. Furthermore estimation of integral dose ratio (IDR) within the breast from tangential treatment was performed as the ratio of the irradiated breast volume and the volume encompassing all clips. Clips close to the chest wall (CW) in Su showed significantly less displacement in Pr. The mean volumes of seroma, CTV and PTV were significantly higher in Pr than in Su. The PTV volume difference (Pr-Su) was significantly higher in patients with presence of seroma, deep clips and TB location in the superior-internal-quadrant (SIQ) and at the junction of superior quadrants (jSQ). In a multivariate analysis two factors remained significant: seroma and TB localization in SIQ-jSQ. The IDR was significantly larger in Su than in Pr (7.6 vs. 4.1 p < 0.01). Clip displacements varied considerably with respect to their relative position to the CW. In selected patients Pr position potentially leads to a significant increase in target volumes of PBI. Tangential beam arrangement for PBI should be avoided, not only in Su but in Pr as well in case of clip-based target volume definition. [less ▲]

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See detailFeasibility evaluation of prone breast irradiation with the Sagittilt© system including residual-intrafractional error assessment
Lakosi, Ferenc; GULYBAN, Akos ULiege; BEN MUSTAPHA, Selma ULiege et al

in Cancer Radiotherapie (2016), 3429

Purpose:Feasibility evaluation of the Sagittilt© prone breast board system (Orfit Industries, Wijnegem, Belgium) for radiotherapy focusing on patient and staff satisfaction, treatment time, treatment ... [more ▼]

Purpose:Feasibility evaluation of the Sagittilt© prone breast board system (Orfit Industries, Wijnegem, Belgium) for radiotherapy focusing on patient and staff satisfaction, treatment time, treatment reproducibility with the assessment of residual-intrafractional errors. Material and methods: Thirty-six patients underwent whole-breast irradiation in prone position. Seventeen received a sequential boost (breast: 42.56 Gy in 16 fractions, boost: 10 Gy in five fractions), while 19 patients received a concomitant boost protocol (breast/boost: 45.57/55.86 Gy in 21 fractions). Treatment verification included a daily online cone-beam CT (CBCT). In order to assess the residual and residual-intrafractional errors post-treatment CBCTs were performed systematically at the first five treatment sessions. Treatment time, patient comfort, staff satisfaction were also evaluated. Results: The pretreatment CBCT resulted in a population systematic error of 4.5/3.9/3.3 mm in lateral/longitudinal/vertical directions, while the random error was 5.4/3.8/2.8 mm. Without correction these would correspond to a clinical to planning target volume margin of 15.0/12.3/10.3 mm. The population systematic and random residual-intrafractional errors were 1.5/0.9/1.7 mm and 1.7/1.9/1.6 mm. Patient and staffs’ satisfaction were considered good and average. The mean treatment session time was 21 minutes (range: 13–40 min). Conclusion: The Sagittilt© system seems to be feasible for breast irradiation and well-tolerated by patients, acceptable to radiographers and reasonable in terms of treatment times. Set-up accuracy was comparable with other prone systems; residual errors need further investigations. [less ▲]

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See detailBone mass of the calvarium
SIMONI, Paolo ULiege; STULKO, Jennifer ULiege; BEN MUSTAPHA, Selma ULiege et al

in Skeletal Radiology (2013), 42

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