Publications of Marjolein DE CUYPERE
Bookmark and Share    
Full Text
See detailCorrelation between hematological parameters and outcome in patients with locally advanced cervical cancer treated by concomitant chemoradiotherapy.
Gennigens, Christine ULiege; DE CUYPERE, Marjolein ULiege; SEIDEL, Laurence ULiege et al

in Cancer Medicine (2020)

BACKGROUND: Hemoglobin (Hb), white blood cell (WBC), and polymorphonuclear neutrophil (PMN) blood counts may be correlated with outcomes in patients with locally advanced cervical cancer. METHODS: Hb, WBC ... [more ▼]

BACKGROUND: Hemoglobin (Hb), white blood cell (WBC), and polymorphonuclear neutrophil (PMN) blood counts may be correlated with outcomes in patients with locally advanced cervical cancer. METHODS: Hb, WBC, and PMN counts were measured at diagnosis and during concomitant cisplatin-based chemoradiotherapy (CCRT) in a retrospective sample of 103 patients between 2010 and 2017. Red blood cell (RBC) transfusions were also recorded. The associations between hematological variables and patient overall survival (OS) and recurrence-free survival (RFS) were assessed by Cox regression models. RESULTS: The 3-year OS and RFS rates were 81.4% and 76.8%, respectively. In addition to tumor size and smoking, OS and RFS were found to be significantly associated with changes in WBC and PMN counts from the first to the last cisplatin cycle. Hb count throughout the treatment and RBC transfusions were not predictive of outcome. CONCLUSIONS: This study found no association between Hb count or RBC transfusions and outcome. The daily practice of maintaining the Hb count above 12 g/dL during CCRT should be weighed against the potential risks of transfusions. Drops in WBC and PMN counts during treatment positively impacted OS and RFS and could, therefore, serve as biomarkers during CCRT to adapt the follow-up and consider the need for adjuvant systemic treatments. [less ▲]

Detailed reference viewed: 22 (4 ULiège)
Full Text
See detailTumor total lesion glycolysis and number of positive pelvic lymph nodes on pretreatment positron emission tomography/computed tomography (PET/CT) predict survival in patients with locally advanced cervical cancer.
DE CUYPERE, Marjolein ULiege; Lovinfosse, Pierre; Gennigens, Christine ULiege et al

in International journal of gynecological cancer : official journal of the International Gynecological Cancer Society (2020), 0

OBJECTIVE: The aim of this study was to investigate the prognostic value of metabolic parameters obtained at pretreatment [(18)F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography ... [more ▼]

OBJECTIVE: The aim of this study was to investigate the prognostic value of metabolic parameters obtained at pretreatment [(18)F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography ([(18)F]FDG PET/CT) in patients with locally advanced cervical cancer. We hypothesize that these metabolic parameters could optimize the treatment decision and thus favor the outcome of patients suffering locally advanced cervical cancer. METHODS: Patients with locally advanced cervical cancer underwent pretreatment PET/CT. Standard uptake values (maximum, mean, peak), metabolic tumor volume, and total lesion glycolysis were measured in the tumor and in the hypermetabolic pelvic lymph nodes. The relationship between clinical, pathological, and PET/CT metabolic parameters with recurrence-free survival and overall survival was assessed by Cox regression analysis. RESULTS: 115 patients with a median age of 52 years (range 23-77) presented with locally advanced cervical cancer. After a mean follow-up of 33.0 months after initiation of therapy, 26 patients (22.6%) recurred of which 17 patients had distant metastasis; 18 (15.7%) patients died. Recurrence-free survival at 2 and 5 years was 79.2% and 72.2%, respectively. The total lesion glycolysis of the tumor and the delay between diagnosis and treatment were significantly associated with recurrence-free survival in the multivariate analysis (HR 1.00, p=0.004, and HR 2.04, p=0.02, respectively). Only the total lesion glycolysis of the tumor ≥373.54 (HR 2.49, 95% CI 1.15 to 5.38; p=0.02) remained significant after log rank testing. Overall survival at 2 and 5 years was 91.7% and 68.8%, respectively. The number of PET-positive pelvic lymph nodes was the only independent prognostic factor for overall survival in the multivariate analysis (HR 1.43, 95% CI 1.13 to 1.81; p=0.003). CONCLUSION: Tumor total lesion glycolysis and the number of positive pelvic lymph nodes on pretreatment PET/CT appear to be independent prognostic factors for recurrence and survival in patients with locally advanced cervical cancer. This may help to select patients who may benefit from therapeutic optimization and closer surveillance. [less ▲]

Detailed reference viewed: 20 (3 ULiège)
See detailFDG PET radiomics to predict disease free survival in Cervical Cancer
Da Silva Ferreira, Marta ULiege; LOVINFOSSE, Pierre ULiege; DE CUYPERE, Marjolein ULiege et al

Scientific conference (2019, November 29)

Detailed reference viewed: 21 (3 ULiège)
Full Text
See detailAdded value of para-aortic surgical staging compared to (18)F-FDG PET/CT on the external beam radiation field for patients with locally advanced cervical cancer: An ONCO-GF study.
DE CUYPERE, Marjolein ULiege; LOVINFOSSE, Pierre ULiege; GOFFIN, Frédéric ULiege et al

in European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology (2019)

OBJECTIVE: Extended field chemoradiation is recommended for patients with locally advanced cervical cancer (LACC) and para-aortic lymph node (PALN) metastases. The radiation planning may be based on PET ... [more ▼]

OBJECTIVE: Extended field chemoradiation is recommended for patients with locally advanced cervical cancer (LACC) and para-aortic lymph node (PALN) metastases. The radiation planning may be based on PET/CT while others recommend to rely on surgical staging. We report the rate of patients for whom the radiation field defined on PET/CT was modified by the histological PALN status. METHODS: Between March 2010 and December 2016, 168 consecutive patients with LACC underwent a pre-therapeutic PET/CT and PALN dissection. The data were reviewed retrospectively. The diagnostic performance of the PET/CT for definition of PALN status was calculated. We determined the percentage of patients for whom PALN dissection altered the external beam radiotherapy (EBRT) field defined on the PET/CT basis. RESULTS: Of 151 patients with negative PALNs on PET/CT, 26 had histological PALN metastases. Of 17 patients with positive PALNs on PET/CT, 9 were negative on histology of which 7 were located in the common iliac region. Sensitivity, specificity, positive and negative predictive value of PET/CT were 23.5, 93.3, 47.1 and 82.8% respectively. In total, 35 out of 168 patients underwent EBRT - field adaptation (pelvic vs extended field). The rate of radiation field modification (27,7%) was particularly high in the subgroup of patients with metastatic pelvic lymph nodes (PLNs) on PET/CT. CONCLUSION: Para-aortic surgical staging contributes significantly to individualize the radiation treatment of patients with LACC, particularly for those with positive PLNs at PET/CT. Indication of surgical staging deserves particular attention when the PET/CT suggests positive LNs in the common iliac region. [less ▲]

Detailed reference viewed: 31 (10 ULiège)
Full Text
See detailA specific immune and lymphatic profile characterizes the pre-metastatic state of the sentinel lymph node in patients with early cervical cancer
Balsat, Cédric ULiege; Blacher, Silvia ULiege; Herfs, Michael ULiege et al

in Oncoimmunology (2017), 6(2), 1265718

The lymph node (LN) pre-metastatic niche is faintly characterized in lymphophilic human neoplasia, although LN metastasis is considered as the strongest prognostic marker of patient survival. Due to its ... [more ▼]

The lymph node (LN) pre-metastatic niche is faintly characterized in lymphophilic human neoplasia, although LN metastasis is considered as the strongest prognostic marker of patient survival. Due to its specific dissemination through a complex bilateral pelvic lymphatic system, early cervical cancer is a relevant candidate for investigating the early nodal metastatic process. In the present study, we analyzed in-depth both the lymphatic vasculature and the immune climate of pre-metastatic sentinel LN (SLN), in 48 cases of FIGO stage IB1 cervical neoplasms. An original digital image analysis methodology was used to objectively determine whole slide densities and spatial distributions of immunostained structures. We observed a marked increase in lymphatic vessel density (LVD) and a specific capsular and subcapsular distribution in pre-metastatic SLN when compared with non-sentinel counterparts. Such features persisted in the presence of nodal metastatic colonization. The inflammatory profile attested by CD8+, Foxp3, CD20 and PD-1expression was also significantly increased in pre-metastatic SLN. Remarkably, the densities of CD20+ B cells and PD-1 expressing germinal centers were positively correlated with LVD. All together, these data strongly support the existence of a pre-metastatic dialog between the primary tumor and the first nodal relay. Both lymphatic and immune responses contribute to the elaboration of a specific pre-metastatic microenvironment in human SLN. Moreover, this work provides evidence that, in the context of early cervical cancer, a pre-metastatic lymphangiogenesis occurs within the SLN (pre-metastatic niche) and is associated with a specific humoral immune response. [less ▲]

Detailed reference viewed: 138 (47 ULiège)
See detailLaparoscopy and endometrial cancer
KRIDELKA, Frédéric ULiege; GOFFIN, Frédéric ULiege; Leblanc, Eric et al

in Minimally Invasive surgery (2015)

Detailed reference viewed: 137 (24 ULiège)
Full Text
See detailFaut-il opérer un cancer du col utérin après radiochimiothérapie initiale?
Ferron, G.; DE CUYPERE, Marjolein ULiege; Querleu, D. et al

Conference (2013, December 19)

Detailed reference viewed: 101 (12 ULiège)
Full Text
See detailChimio-hyperthermie intrapéritonéale (CHIP) et cancer de l'ovaire: où en sommes-nous?
Ferron, G.; Luyckx, M.; DE CUYPERE, Marjolein ULiege et al

in Louvain Medical (2013), 132

Detailed reference viewed: 72 (6 ULiège)
Full Text
See detailUtilisation de la voie laparoscopie extra-péritonéale pour la réalisation des lymphadénectomies aortiques chez des patientes obèses
Ferron, G.; Martinez, A.; DE CUYPERE, Marjolein ULiege et al

in e-mémoires de l'Académie Nationale de Chirurgie (2013), 12(3), 013

Detailed reference viewed: 37 (5 ULiège)
Full Text
See detailFertility-preserving surgical procedures, techniques
Martinez, Alejandra; Poilblanc, Mathieu; Ferron, Gwenael et al

in Best Practice and Research. Clinical Obstetrics and Gynaecology (2012), 26

As a result of the trend toward late childbearing, fertility preser- vation has become a major issue in young women with gynaeco- logical cancer. Fertility-sparing treatments have been successfully ... [more ▼]

As a result of the trend toward late childbearing, fertility preser- vation has become a major issue in young women with gynaeco- logical cancer. Fertility-sparing treatments have been successfully attempted in selected cases of cervical, endometrial and ovarian cancer, and gynaecologists should be familiar with fertility- preserving options in women with gynaecological malignancies. Options to preserve fertility include shielding to reduce radiation damage, fertility preservation when undergoing cytotoxic treat- ments, cryopreservation, assisted reproduction techniques, and fertility-sparing surgical procedures. Radical vaginal trachelectomy with laparoscopic lymphadenectomy is an oncologically safe, fertility-preserving procedure. It has been accepted worldwide as a surgical treatment of small early stage cervical cancers. Selected cases of early stage ovarian cancer can be treated by unilateral salpingo-ophorectomy and surgical staging. Hysteroscopic resec- tion and progesterone treatment are used in young women who have endometrial cancer to maintain fertility and avoid surgical menopause. Appropriate patient selection, and careful oncologic, psychologic, reproductive and obstetric counselling, is mandatory. [less ▲]

Detailed reference viewed: 141 (5 ULiège)