Publications of Paul MASSION
Bookmark and Share    
Full Text
See detailNovel method of transpulmonary pressure measurement with an air‑flled esophageal catheter
MASSION, Paul ULiege; Berg, Julien ULiege; SAMALEA SUAREZ, Nicolas ULiege et al

in Intensive Care Medicine Experimental (2021)

Background: There is a strong rationale for proposing transpulmonary pressureguided protective ventilation in acute respiratory distress syndrome. The reference esophageal balloon catheter method requires ... [more ▼]

Background: There is a strong rationale for proposing transpulmonary pressureguided protective ventilation in acute respiratory distress syndrome. The reference esophageal balloon catheter method requires complex in vivo calibration, expertise and specifc material order. A simple, inexpensive, accurate and reproducible method of measuring esophageal pressure would greatly facilitate the measure of transpulmonary pressure to individualize protective ventilation in the intensive care unit. Results: We propose an air-flled esophageal catheter method without balloon, using a disposable catheter that allows reproducible esophageal pressure measurements. We use a 49-cm-long 10 Fr thin suction catheter, positioned in the lower-third of the esophagus and connected to an air-flled disposable blood pressure transducer bound to the monitor and pressurized by an air-flled infusion bag. Only simple calibration by zeroing the transducer to atmospheric pressure and unit conversion from mmHg to cmH2O are required. We compared our method with the reference balloon catheter both ex vivo, using pressure chambers, and in vivo, in 15 consecutive mechanically ventilated patients. Esophageal-to-airway pressure change ratios during the dynamic occlusion test were close to one (1.03±0.19 and 1.00±0.16 in the controlled and assisted modes, respectively), validating the proper esophageal positioning. The Bland– Altman analysis revealed no bias of our method compared with the reference and good precision for inspiratory, expiratory and delta esophageal pressure measurements in both the controlled (largest bias −0.5 cmH2O [95% confdence interval: −0.9; −0.1] cmH2O; largest limits of agreement −3.5 to 2.5 cmH2O) and assisted modes (largest bias −0.3 [−2.6; 2.0] cmH2O). We observed a good repeatability (intra-observer, intraclass correlation coefcient, ICC: 0.89 [0.79; 0.96]) and reproducibility (inter-observer ICC: 0.89 [0.76; 0.96]) of esophageal measurements. The direct comparison with pleural pressure in two patients and spectral analysis by Fourier transform confrmed the reliability of the air-flled catheter-derived esophageal pressure as an accurate surrogate of pleural pressure. A calculator for transpulmonary pressures is available online. Conclusions: We propose a simple, minimally invasive, inexpensive and reproducible method for esophageal pressure monitoring with an air-flled esophageal catheter without balloon. It holds the promise of widespread bedside use of transpulmonary pressure-guided protective ventilation in ICU patients. [less ▲]

Detailed reference viewed: 28 (1 ULiège)
Full Text
See detailLe don d’organes en 2020.
Detry, Olivier ULiege; MASSION, Paul ULiege; LEDOUX, Didier ULiege

in Revue medicale de Liege (2020), 75(5-6), 276-279

The success of solid organ transplantation induced an increased need for grafts and the necessary registration of transplant candidates on long waiting lists. Many patients die while waiting for ... [more ▼]

The success of solid organ transplantation induced an increased need for grafts and the necessary registration of transplant candidates on long waiting lists. Many patients die while waiting for transplantation, even in Belgium where the donation rates have been high these last years. In order to fight this lack of donor organs, the transplant centers widened donation criteria for brain dead donors, including older age and potential transmissible diseases. In addition, programs of donation after circulation death have been developed, first for kidneys, then for livers and recently for the hearts. Organ donation after euthanasia is also regularly performed in Belgium. All these policies lead to the fact that organ donation rates stay high in Belgium, and particularly in the Liege region, but efforts are still ahead if we aim to reduce waiting list mortalities. [less ▲]

Detailed reference viewed: 167 (14 ULiège)
Full Text
See detailCan hypnosis and virtual reality reduce anxiety, pain and fatigue among patients who undergo cardiac surgery: a randomised controlled trial
Rousseaux, Floriane ULiege; FAYMONVILLE, Marie-Elisabeth ULiege; NYSSEN, Anne-Sophie ULiege et al

in Trials (2020)

Different non-pharmacological techniques, including hypnosis and virtual reality (VR) are currently used as complementary tools in the treatment of anxiety, acute and chronic pain. A new technique called ... [more ▼]

Different non-pharmacological techniques, including hypnosis and virtual reality (VR) are currently used as complementary tools in the treatment of anxiety, acute and chronic pain. A new technique called 'virtual reality hypnosis' (VRH), which encompasses a combination of both tools, is regularly used although its benefits and underlying mechanisms remain unknown to this date. With the goal to improve our understanding of VRH combination effects, it is necessary to conduct randomized and controlled research trials in order to understand their clinical interest and potential benefits. [less ▲]

Detailed reference viewed: 152 (23 ULiège)
Full Text
See detailCan hypnosis be used in Intensive Care Units?
Rousseaux, Floriane ULiege; Bicego, Aminata Yasmina ULiege; MALENGREAUX, Christophe ULiege et al

in Médecine Intensive Réanimation (2020)

Detailed reference viewed: 118 (35 ULiège)
Full Text
See detailLa première vague de la COVID-19 aux Soins intensifs
MARCHETTA, Stella ULiege; LAMBERMONT, Bernard ULiege; MASSION, Paul ULiege et al

in Revue Médicale de Liège (2020)

In December 2019, in Wuhan, a new human infectious pathology was born, COVID-19, consisting above all in pneumoniae, induced by the coronavirus named SARS-CoV-2 because of the respiratory distress it ... [more ▼]

In December 2019, in Wuhan, a new human infectious pathology was born, COVID-19, consisting above all in pneumoniae, induced by the coronavirus named SARS-CoV-2 because of the respiratory distress it caused (SARS for severe acute respiratory syndrome, and CoV for Coronavirus). A real health and planetary crisis has appeared, much more substantial than that linked to SARS-CoV-1 in 2002-2004 and to MERS-CoV (Middle East Respiratory Syndrome Coronavirus) in 2012. In addition to respiratory damage that can be dramatic, this pathology is complicated by the frequency of cardiovascular, renal and coagulation diseases. Health care systems have had to adapt urgently, in the absence of hindsight from the patho- logy, and without effective therapeutic weapons. Through this review of the literature, we detail our local practices for the overall management of patients hospitalized in Intensive care. [less ▲]

Detailed reference viewed: 73 (11 ULiège)
Full Text
See detailLow incidence of thrombotic events in SARS-CoV-2 mechanically ventilated anticoagulated patients
Perot, Antoine ULiege; Misset, Benoît ULiege; MASSION, Paul ULiege et al

in Intensive Care Medicine Experimental (2020)

Detailed reference viewed: 47 (6 ULiège)
Full Text
See detailThe impact of non-pharmacological approaches on the patient’s comfort after a cardiac surgery: A randomized controlled trial.
Rousseaux, Floriane ULiege; Puttaert, Ninon ULiege; LEDOUX, Didier ULiege et al

Conference (2019, May 30)

Different non-pharmacological techniques including hypnosis, music, and virtual reality (VR) are being used as complementary tools in the treatment of pain. A new technique which encompasses a combination ... [more ▼]

Different non-pharmacological techniques including hypnosis, music, and virtual reality (VR) are being used as complementary tools in the treatment of pain. A new technique which encompasses a combination of hypnosis and VR, called "virtual reality hypnosis" (VRH), should soon be used on a regular basis in clinical settings. The aim of this study is to better understand the impact of hypnosis, music, VR and VRH, and to investigate their influence on the patient’s perception of pain, anxiety and tiredness after a cardiac surgery in intensive care unit [less ▲]

Detailed reference viewed: 244 (21 ULiège)
Full Text
See detailLe syndrome de detresse respiratoire aigue.
Parzibut, Gilles ULiege; CANIVET, Jean-Luc ULiege; GUIOT, Julien ULiege et al

in Revue medicale de Liege (2019), 74(10), 514-520

Since its first description in 1967, a lot of progress has been made in understanding the pathophysiology, diagnosis and management of acute respiratory distress syndrome (ARDS). This nosological entity ... [more ▼]

Since its first description in 1967, a lot of progress has been made in understanding the pathophysiology, diagnosis and management of acute respiratory distress syndrome (ARDS). This nosological entity is based on the appearance of a diffuse alveolar damage associating pulmonary epithelial barrier disruption with an alveolar filling, both responsible of profound hypoxemia and important morbi-mortality. Nowadays, ARDS remains a frequent syndrome, associated with various etiologies. Diagnosis is based on the occurrence of acute hypoxic respiratory failure not explained by cardiac insufficiency or volume overload, within 7 days after a recognized risk factor, and in the presence of bilateral pulmonary opacities not fully explained by effusions, atelectasis or nodules on the chest radiography. Survivors present an increased risk of developing cognitive decline, depression, post-traumatic stress, and typical ICU related side-effects such as polyneuropathy and sarcopenia. In this context and not withstanding significant recent progress in the field of mechanical ventilation and extra-corporeal respiratory assistance, early diagnosis remains essential to identify patients with ARDS in order to offer them the most appropriate therapy. [less ▲]

Detailed reference viewed: 145 (22 ULiège)
Full Text
See detailIncidence and risk factors for early renal dysfunction after liver transplantation.
WIESEN, Patricia ULiege; MASSION, Paul ULiege; JORIS, Jean ULiege et al

in World Journal of Transplantation (2016), 6(1), 220-232

AIM: To determine renal dysfunction post liver transplantation, its incidence and risk factors in patients from a Belgian University Hospital. METHODS: Orthotopic liver transplantations performed from ... [more ▼]

AIM: To determine renal dysfunction post liver transplantation, its incidence and risk factors in patients from a Belgian University Hospital. METHODS: Orthotopic liver transplantations performed from January 2006 until September 2012 were retrospectively reviewed (n = 187). Patients with no renal replacement therapy (RRT) before transplantation were classified into four groups according to their highest creatinine plasma level during the first postoperative week. The first group had a peak creatinine level below 12 mg/L, the second group between 12 and 20 mg/L, the third group between 20 and 35 mg/L, and the fourth above 35 mg/L. In addition, patients who needed RRT during the first week after transplantation were also classified into the fourth group. Perioperative parameters were recorded as risk factors, namely age, sex, body mass index (BMI), length of preoperative hospital stay, prior bacterial infection within one month, preoperative ascites, preoperative treatment with beta-blocker, angiotensin-converting enzyme inhibitor or non steroidal anti-inflammatory drugs, preoperative creatinine and bilirubin levels, donor status (cardiac death or brain death), postoperative lactate level, need for intraoperative vasopressive drugs, surgical revision, mechanical ventilation for more than 24 h, postoperative bilirubin and transaminase peak levels, postoperative hemoglobin level, amount of perioperative blood transfusions and type of immunosuppression. Univariate and multivariate analysis were performed using logistic ordinal regression method. Post hoc analysis of the hemostatic agent used was also done. RESULTS: There were 78 patients in group 1 (41.7%), 46 in group 2 (24.6%), 38 in group 3 (20.3%) and 25 in group 4 (13.4%). Twenty patients required RRT: 13 (7%) during the first week after transplantation. Using univariate analysis, the severity of renal dysfunction was correlated with presence of ascites and prior bacterial infection, preoperative bilirubin, urea and creatinine level, need for surgical revision, use of vasopressor, postoperative mechanical ventilation, postoperative bilirubin and urea, aspartate aminotransferase (ASAT), and hemoglobin levels and the need for transfusion. The multivariate analysis showed that BMI (OR = 1.1, P = 0.004), preoperative creatinine level (OR = 11.1, P < 0.0001), use of vasopressor (OR = 3.31, P = 0.0002), maximal postoperative bilirubin level (OR = 1.44, P = 0.044) and minimal postoperative hemoglobin level (OR = 0.059, P = 0.0005) were independent predictors of early post-liver transplantation renal dysfunction. Neither donor status nor ASAT levels had significant impact on early postoperative renal dysfunction in multivariate analysis. Absence of renal dysfunction (group 1) was also predicted by the intraoperative hemostatic agent used, independently of the extent of bleeding and of the preoperative creatinine level. CONCLUSION: More than half of receivers experienced some degree of early renal dysfunction after liver transplantation. Main predictors were preoperative renal dysfunction, postoperative anemia and vasopressor requirement. [less ▲]

Detailed reference viewed: 74 (16 ULiège)
Full Text
See detailIdentification of biomarkers of hemostatic, endothelial and immune function in sepsis
GOTHOT, André ULiege; GOSSET, Christian ULiege; FOGUENNE, Jacques ULiege et al

in Belgian Journal of Hematology (2013)

Detailed reference viewed: 35 (21 ULiège)
Full Text
See detailInsulin clearance during hyper-insulinemia euglycemia therapy
Penning, Sophie ULiege; MASSION, Paul ULiege; Pretty, Christopher ULiege et al

in Proceedings of the 11th Belgian Day on Biomedical Engineering (2012, December)

Detailed reference viewed: 39 (15 ULiège)
Full Text
See detailInsulin clearance during hyper-insulinemia euglycemia therapy
Penning, Sophie ULiege; MASSION, Paul ULiege; Pretty, Christopher ULiege et al

Poster (2012, December)

Detailed reference viewed: 39 (15 ULiège)
Full Text
See detailSecond pilot trials of the STAR-Liege protocol for tight glycemic control in critically ill patients
Penning, Sophie ULiege; Le Compte, Aaron J.; MASSION, Paul ULiege et al

in BioMedical Engineering OnLine (2012)

Detailed reference viewed: 57 (8 ULiège)
Full Text
See detailInsulin Kinetics during Hyper-Insulinemia Euglycemia Therapy (HIET)
Penning, Sophie ULiege; MASSION, Paul ULiege; Le Compte, Aaron J. et al

in Proceedings of the 8th IFAC Symposium on Biological and Medical Systems (2012, August)

Hyper-insulinemia euglycemia therapy (HIET) is a supra-physiological insulin dosing protocol used in acute cardiac failure to reduce dependency on inotropes to augment or generate cardiac output, and is ... [more ▼]

Hyper-insulinemia euglycemia therapy (HIET) is a supra-physiological insulin dosing protocol used in acute cardiac failure to reduce dependency on inotropes to augment or generate cardiac output, and is based on the inotropic effects of insulin at high doses up to 45-250x normal daily dose. Such high insulin doses are managed using intravenous glucose infusion to control glycemia and prevent hypoglycemia. However, both insulin dosing and glycemic control in these patients is managed ad-hoc. This research examines a selection of clinical data to determine the effect of high insulin dosing on renal clearance and insulin sensitivity, to assess the feasibility of using model-based methods to control and guide these protocols. The results show that the model and, in particular, the modeled renal clearance constant are adequate and capture measured data well, although not perfectly. Equally, insulin sensitivity over time is similar to broader critical care cohorts in level and variability, and these results are the first time they have been presented for this cohort. While more data is needed to confirm and further specify these results, it is clear that the model used is adequate for controlling HIET in a model-based framework. [less ▲]

Detailed reference viewed: 43 (7 ULiège)
Full Text
See detailInsulin Kinetics during Hyper-Insulinemia Euglycemia Therapy (HIET)
Penning, Sophie ULiege; MASSION, Paul ULiege; Le Compte, Aaron J. et al

Conference (2012, August)

Detailed reference viewed: 26 (4 ULiège)
Full Text
See detailDoes Tight Glycemic Control positively impact on patient mortality?
Penning, Sophie ULiege; Le Compte, Aaron J.; Signal, Matthew et al

Poster (2012, March 20)

Detailed reference viewed: 32 (6 ULiège)
Full Text
See detailDoes Tight Glycemic Control positively impact on patient mortality?
Penning, Sophie ULiege; Le Compte, Aaron J.; Signal, Matthew et al

in Critical Care (2012, March 20)

Detailed reference viewed: 28 (5 ULiège)