Publications of Frédéric FRIPPIAT
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See detailMeropenem: continuous or extended infusion?
FRIPPIAT, Frédéric ULiege; Vercheval, Christelle ULiege; Layios, Nathalie ULiege

in Critical care (London, England) (2020), 24(1), 192

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See detailTemocillin susceptibility testing with Vitek2® system and E-test® Are these methods reliable to determine temocillin MIC ?
DESCY, Julie ULiege; VISEE, Clotilde; FRIPPIAT, Frédéric ULiege et al

Poster (2018, April 21)

Background: The use of temocillin (TEM) is increasing in serious infections caused by Enterobacteriaceae, including extended-spectrum β-lactamase (ESBL), as an alternative to carbapenems. Accuracy of in ... [more ▼]

Background: The use of temocillin (TEM) is increasing in serious infections caused by Enterobacteriaceae, including extended-spectrum β-lactamase (ESBL), as an alternative to carbapenems. Accuracy of in vitro minimal inhibitory concentration (MIC) values is of high importance in an era of antibiotic stewardship based on PK/PD. We performed a method comparison between Vitek2®, E-test® and the standard method, broth microdilution (BMD), in order to evaluate which method is reliable to determine TEM MIC. Materials/methods: One hundred Enterobacteriaceae were collected from respiratory samples isolated from ICU patients. MIC of temocillin was determined in parallel by 3 methods: Vitek2® (Biomérieux), E-test® (Biomérieux) and BMD, the latter following CLSI recommendations. Susceptibility to temocillin was determined according to breakpoints provided by BSAC (British Society for Antimicrobial Chemotherapy) - S: MIC ≤ 8 mg/L; R: MIC > 8 mg/L.- in order to evaluate categorical agreement (CA), essential agreement (EA), very major errors (VME) and major errors (ME), as defined in Cumitech 31A. Results: Isolates (N=100) included: Klebsiella pneumoniae (34%), Escherichia coli (23%), Serratia sp. (18%), others (25 %). Thirty-five strains were ESBL-producers; 13% were carbapenemase-producers. 41/100 (41%) isolates were resistant to TEM according to BMD. EA of 96 % was calculated for E-test® and 95% for Vitek2® versus BMD, while CA was of 82% (E-test®) and 84% (Vitek2®). Both VME (12.2% for E-test®; 24.4% for Vitek2®) and ME (22.0% for E-test®; 10.2% for Vitek2®) exceeded the 3% threshold. As a part of errors can be explained by BSAC breakpoints (no “intermediate” category), VME and ME with MIC > ± 1 twofold dilution were calculated, for E-test® (VME:0%; ME: 6.8%) and for Vitek2® (VME: 7.3%; ME: 3.4%). Overestimation of TEM resistance (E-test®) or TEM susceptibility (Vitek2®) was observed. Conclusions: Compared to BMD, E-test® seems to be more reliable than Vitek2® to predict MIC of TEM. Contrary to E-test®, even when taking the adapted definition of VME and ME with MIC > ± 1 twofold dilution, VME rate for Vitek2® is still unacceptable. When the use of TEM is considered by the clinician, we would recommend to control systematically TEM MIC by E-test®, or, even better, by BMD. [less ▲]

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See detailPrise en charge multidisciplinaire d'une volumineuse hydatidose hepatique.
HALLEUX, Danaé ULiege; Juriens, I.; Delwaide, Jean ULiege et al

in Revue Médicale de Liège (2018), 73(2), 65-71

Cystic echinococcosis or hydatidosis, is a zoonosis caused by larval stages of Echinococcus granulosus that can be encountered in Belgium in patients originating from endemic countries. The liver is the ... [more ▼]

Cystic echinococcosis or hydatidosis, is a zoonosis caused by larval stages of Echinococcus granulosus that can be encountered in Belgium in patients originating from endemic countries. The liver is the most commonly affected organ. In this paper, the authors describe the multidisciplinary management of this pathology based on the clinical case of a patient suffering from a 28 cm cystic echinococcosis treated by combination of albendazole and liver resection. Several treatment options are described in the literature although there is currently no clear consensus on the management of this condition. [less ▲]

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See detailUne urgence bien souvent meconnue.
MARCHETTA, Stella ULiege; DULGHERU, Raluca Elena ULiege; Oury, Cécile ULiege et al

in Revue Médicale de Liège (2018), 73(5-6), 283-289

Infective endocarditis is a rare disease that can lead to some diagnostic wandering because of its often nonspecific and polymorphic clinical manifestations. This latency is at the origin of severe ... [more ▼]

Infective endocarditis is a rare disease that can lead to some diagnostic wandering because of its often nonspecific and polymorphic clinical manifestations. This latency is at the origin of severe cardiac and extra-cardiac complications, yet highly fatal. The clinician should always bear in mind the differential diagnosis of a patient with fever of undetermined origin, with risk factors for valve infection such as foreign material, and history recent invasive procedures (including dental procedures) or recent hospitalization. The current medical tools make it possible to highlight the infection and its complications in a fast and complete manner, so as not to delay the patient's management, particularly with the introduction of urgent empirical antibiotherapy. [less ▲]

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See detailEpithelial lining fluid penetration of temocillin administered by continuous infusion in critically ill patients with nosocomial pneumonia
VISEE, Clotilde ULiege; LAYIOS, Nathalie ULiege; MISTRETTA, Virginie ULiege et al

Conference (2017, April 23)

The administration of 6g per day of temocillin by continuous infusion in critically patients with severe nosocomial pneumonia allows a penetration ratio, measured by the ELF/plasma ratio of AUCs, of 0.14 ... [more ▼]

The administration of 6g per day of temocillin by continuous infusion in critically patients with severe nosocomial pneumonia allows a penetration ratio, measured by the ELF/plasma ratio of AUCs, of 0.14 and 0.57 and a mean (± SE) ELF concentration , in mg/L, of 9.8 ± 1.3 and 9.8 ± 1.6 for total and free drug, respectively. Standard error of AUCs should be calculated by the Bootstrap method and Monte Carlo simulations should be performed for subsequent PK/PD analysis. [less ▲]

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See detailAre Vitek2 system and E-test relevant and reliable for determining susceptibility to temocillin?
VISEE, Clotilde ULiege; FRIPPIAT, Frédéric ULiege; DESCY, Julie ULiege et al

Poster (2017, April 22)

Compared to BMD, Vitek2® seems to overestimate sensitivity and underestimate resistance, while E-test® seems to overestimate resistance, pleading for the use of BMD when evaluating susceptibility to ... [more ▼]

Compared to BMD, Vitek2® seems to overestimate sensitivity and underestimate resistance, while E-test® seems to overestimate resistance, pleading for the use of BMD when evaluating susceptibility to temocillin. However, this study, which is currently enrolling more patients, will include more isolates in order to meet FDA criteria set out in Cumitech 31A for validation of method comparison [less ▲]

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See detailEndocardite à aggregatibacter aphrophilus sur prothèses valvulaires
Deleixhe, Benjamin ULiege; FRIPPIAT, Frédéric ULiege; Léonard, Philippe ULiege et al

in Revue Médicale de Liège (2017), 72(12), 522-528

We present the case of an acute endocarditis of mitral and aortic prosthetic heart valves caused by Aggregatibacter aphrophilus (Haemophilus aphrophilus-paraphrophilus). This third report in the ... [more ▼]

We present the case of an acute endocarditis of mitral and aortic prosthetic heart valves caused by Aggregatibacter aphrophilus (Haemophilus aphrophilus-paraphrophilus). This third report in the literature emphasizes the diagnostic work-up and the role of positron emission tomography combined with computed tomography in this setting. The specificities of endocarditis due to the HACEK group (Haemophilus spp., Aggregatibacter, Cardiobacterium hominis, Eikenella corrodens and Kingella spp.) and the specific microbiological data and therapeutic options pertinent to this germ are discussed. [less ▲]

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See detailFATAL ALVEOLAR ECHINOCOCCOSIS OF THE LUMBAR SPINE
KEUTGENS, Aurore ULiege; SIMONI, Paolo ULiege; DETREMBLEUR, Nancy ULiege et al

in Journal of Clinical Microbiology (2013), 51(2), 688-91

For the last ten years, the southern part of Belgium has been recognized as a low-risk endemic area for alveolar echinococcosis. This infection, caused by Echinococcus multilocularis, usually induces a ... [more ▼]

For the last ten years, the southern part of Belgium has been recognized as a low-risk endemic area for alveolar echinococcosis. This infection, caused by Echinococcus multilocularis, usually induces a severe liver condition, and can sometimes spread to other organs. However, alveolar echinococcosis involving bones has been described only very rarely. Here, a fatal case of spondylodiscitis due to E. multilocularis contracted in southern Belgium is reported. [less ▲]

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See detailMétastase septique dorsale secondaire d’un abcès rétropharyngé responsable d’une tétraparésie
Kaux, Jean-François ULiege; LENELLE, Jacques ULiege; FRIPPIAT, Frédéric ULiege et al

in Revue Neurologique (2011), 167(8-9), 638-640

Introduction: Peri-tonsillar abscess remains one of the most frequent serous complications of oropharyngeal or dental infections. It can evolve to parapharyngeal and/or retropharyngeal spaces. It can be ... [more ▼]

Introduction: Peri-tonsillar abscess remains one of the most frequent serous complications of oropharyngeal or dental infections. It can evolve to parapharyngeal and/or retropharyngeal spaces. It can be life-threatning and, more rarely, neurological complications are described. Observations: We report the case of a 56 year old woman who developed within few days a progressive tetraparesia due to cervical medullary compression. This compression was consecutive to an epidurite which was a complication of a retropharyngeal abscess. The only surgical act was a cervicotomy to drain the abscess and identify the pathological germ. A targeted antibiotherapy was quickly begun. The recovery was obtained rather quickly and the neurological evolution was good. After one year, the cervical spine presents a post-infectious deformation without sign of root or spinal-cord compression. Conclusion: A cervical tetraparesia induced by spondylodiscitis and epiduritis following a retropharyngeal abscess with Staphylococcus aureus is a rare complication. Adequate diagnosis, as fast as possible, is mandatory in order to carry out an adapted antibiotherapy in the hopes of a complete recovery. The place of surgery on the spine remains to be specified. [less ▲]

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See detailSyphilis treatment in the human immunodeficiency virus-infected patient: follow the guidelines.
FRIPPIAT, Frédéric ULiege; Moutschen, Michel ULiege

in Clinical Infectious Diseases (2011), 53(8), 845

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See detailA pauci-symptomatic case of documented Hantavirus (Puumala) infection in a patient under anti-TNF treatment.
Moutschen, Pierre; Bourhaba, Maryam ULiege; FRIPPIAT, Frédéric ULiege et al

in Journal of Clinical Virology (2011), 50(3), 247-8

We describe the case of an 18-yr-old male under anti-TNF treatment for Crohn's disease for more than 8 months. He developed fever and biological inflammatory syndrome without absolutely no accompanying ... [more ▼]

We describe the case of an 18-yr-old male under anti-TNF treatment for Crohn's disease for more than 8 months. He developed fever and biological inflammatory syndrome without absolutely no accompanying sign or symptom or paraclinical abnormality despite extensive work-up performed in the context of his immunocompromised state. Symptoms disappeared after 10 days and a diagnosis of Puumala infection was made retrospectively on a serological basis. The case illustrates that anti-TNF treatment does not worsen the course of Puumala infection and could even be associated with a milder clinical picture. [less ▲]

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See detailQu’avons-nous appris de la pandémie de grippe de 2009 ?
Vanmeerbeek, Marc ULiege; Burette, Philippe ULiege; Giet, Didier ULiege et al

Scientific conference (2010, November 16)

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See detailAutoimmune angioneurotic edema in a patient with Helicobacter pylori infection.
Mukeba, Didier; Chandrikakumari, Kavitha; Giot, Jean-Baptiste ULiege et al

in Helicobacter (2009), 14(1), 9-11

Association of acquired autoimmune angioneurotic edema with other diseases is increasing. However, the precise mechanism by which antibodies to C1-esterase inhibitor (C1-INH) are produced, is not ... [more ▼]

Association of acquired autoimmune angioneurotic edema with other diseases is increasing. However, the precise mechanism by which antibodies to C1-esterase inhibitor (C1-INH) are produced, is not elucidated. We describe a patient with IgA antibodies against C1-INH without other autoimmune markers. Our patient had gastritis and Helicobacter pylori infection, proven by biopsy. This case suggests that H. pylori infection can act as triggering factor for acquired autoimmune angioneurotic edema. [less ▲]

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See detailA Patient with Hiv Infection, Cough, Asthenia, and Fever
Mayasi, N.; Chandrikakumari, Kavitha; Mukeba, D. et al

in Clinical Infectious Diseases (2007), 45(5), 662-3559-600

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See detailWhen the book is wrong
Leclercq, Philippe ULiege; Betz, Romain ULiege; Lambermont, Bernard ULiege et al

in Lancet (2007), 9559

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See detailAvancees therapeutiques en pathologie infectieuse au cours de la derniere decennie
GIOT, Jean-Baptiste ULiege; Mukeba Tshialala, D.; Mayasi Ngongo, N. et al

in Revue Médicale de Liège (2007), 62(5-6, May-Jun), 377-83

This review focuses on new antibiotics, particularly for gram-positive infections, new antiretroviral drugs, new treatment of fungal infections and indications of miltefosine in the treatment of ... [more ▼]

This review focuses on new antibiotics, particularly for gram-positive infections, new antiretroviral drugs, new treatment of fungal infections and indications of miltefosine in the treatment of leishmaniasis. [less ▲]

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See detailDisseminated Penicillium marneffei infection contrated in China
Hayette, Marie-Pierre ULiege; Mukeba Tschialala, Didier; Meex, Cécile ULiege et al

Poster (2007)

Penicillium marneffei infection is a rare fungal disease that cause significant disease in immunosuppressed patients. The geographical distribution of this dimorphic fungus is restricted to Asia ... [more ▼]

Penicillium marneffei infection is a rare fungal disease that cause significant disease in immunosuppressed patients. The geographical distribution of this dimorphic fungus is restricted to Asia, Southeast and Far East, where the disease is considered as an indicator of acquired immunodeficiency syndrome (AIDS). Case report. A 42-year old Congolese woman living in Lubumbashi was admitted at the university hospital of Liège for exploration of a general status impairment. She experienced for three months spiking fever, weight loss, productive cough with bloody expectorations and progressive dyspnoea. She reported also to have non-bloody mild diarrhoea with abdominal pain. The HIV antibody status was positive with a low CD4 T lymphocytes count (28/µl). Pulmonary infiltrates were visualized on chest radiography and the computed tomography revealed the presence of a severe pneumopathy characterised by bilateral micronodular lesions. Mediastinal polyadenopathies associated with hepato- and splenomegaly were also highlighted. Bronchoscopy was performed and bronchial aspirations revealed the presence of numerous leucocytes with the presence of intracellular Gram positive organisms suggestive of yeasts. Ziehl, Giemsa and Gomori-Grocott staining were also performed. Ziehl staining was negative. The morphological aspect given by Giemsa staining excluded infection and the PCR specific for T. gondii B1 gene was negative. However, Gomori-Grocott staining revealed the presence of intracellular oval, elongated, sausage-shaped cells with a single transverse septum (3 to 5 µm). Penicillium marneffei was isolated from blood culture and respiratory samples. Intraveinous amphotericin B treatment was administrated during 15 days followed by itraconazole oral administration (200 mg/j). The antimycotic treatment improved the patient condition and despite other clinical troubles she was prematurely discharged because of financial problems. Conclusion. Opportunistic agents involved in HIV-infected patients differ in Africa and Asia and it is important to be able to make a rapid diagnosis with the aid of an experienced laboratory. [less ▲]

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See detailDownregulation of CD94/NKG2A inhibitory receptors on CD8+ T cells in HIV infection is more pronounced in subjects with detected viral load than in their aviraemic counterparts.
Zeddou, Mustapha ULiege; Rahmouni, Souad ULiege; Vandamme, Arnaud ULiege et al

in Retrovirology (2007), 4

The CD94/NKG2A heterodimer is a natural killer receptor (NKR), which inhibits cell-mediated cytotoxicity upon interaction with MHC class I gene products. It is expressed by NK cells and by a small ... [more ▼]

The CD94/NKG2A heterodimer is a natural killer receptor (NKR), which inhibits cell-mediated cytotoxicity upon interaction with MHC class I gene products. It is expressed by NK cells and by a small fraction of activated CD8+ T lymphocytes. Abnormal upregulation of the CD94/NKG2A inhibitory NKR on cytotoxic T cells (CTLs) could be responsible for a failure of immunosurveillance in cancer or HIV infection. In this study, CD94/NKG2A receptor expression on CD8+ T lymphocytes and NK cells was assessed in 46 HIV-1-infected patients (24 viraemic, 22 aviraemic) and 10 healthy volunteers. The percentage of CD8+ T lymphocytes expressing the CD94/NKG2A inhibitory heterodimer was very significantly decreased in HIV-1-infected patients in comparison with non-infected controls. Within the HIV infected patients, the proportion of CD8+ T lymphocytes and NK cells expressing CD94/NKG2A was higher in subjects with undetectable viral loads in comparison with their viraemic counterparts. No significant difference was detected in the proportion of CD8+ T lymphocytes expressing the activatory CD94/NKG2C heterodimer between the HIV-1 infected patients and the healthy donors, nor between the vireamic and avireamic HIV-1 infected patients. In conclusion, chronic stimulation with HIV antigens in viraemic patients leads to a decreased rather than increased CD94/NKG2A expression on CD8+ T lymphocytes and NK cells. [less ▲]

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