Publications of Jean-Baptiste GIOT
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See detailCoronavirus et COVID-19 : le point sur une pandémie galopante.
Davenne, Eric ULiege; GIOT, Jean-Baptiste ULiege; HUYNEN, Pascale ULiege

in Revue Médicale de Liège (2020), 75

La communauté internationale fait actuellement face à une pandémie de syndrome respiratoire aigu due à un nouveau coronavirus, le SARS-CoV-2. Ce syndrome a été nommé COVID-19 pour COronaVIrus Disease 2019 ... [more ▼]

La communauté internationale fait actuellement face à une pandémie de syndrome respiratoire aigu due à un nouveau coronavirus, le SARS-CoV-2. Ce syndrome a été nommé COVID-19 pour COronaVIrus Disease 2019 par l’Organisation Mondiale de la Santé. Le point de départ de l’épidémie est la ville de Wuhan (Chine), où le virus aurait été transmis de l’animal à l’homme préalablement à la transmission inter-humaine. Il s’agit de la 3ème épidé-mie causée par un coronavirus après celles du syndrome respiratoire aigu sévère (SARS) en 2003 et du syndrome respiratoire du Moyen-Orient (MERS) débutée en 2012. Le COVID-19 s’est rapidement propagé en Chine et se répand actuellement à travers le monde entier. L’infection touche surtout les patients de plus de 40 ans et la mortalité est accrue en présence de comorbidités. Les enfants sont, quant à eux, pauci- ou asymptomatiques. Le diagnostic repose, le plus souvent, sur la détection du génome viral au niveau du nasopharynx par des méthodes de biologie moléculaire. En l’absence de molécules anti-virales spéci-fiques, le traitement reste, à l’heure actuelle, principalement symptomatique. Force est de constater que la pandémie de COVID-19 est plus difficile à contrôler que ce que les premières données ne laissaient présager. L’élément clé face au SARS-CoV-2 est de limiter sa transmission. Les mesures de prévention reposent, principalement, sur l’application de mesures d’hygiène des mains adéquates et la désinfection de l’environnement, ainsi que sur des mesures de distance sociale visant à limiter les contacts dans la population et à protéger les populations à risque. [less ▲]

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See detailHepatic alveolar echinococcosis.
DETRY, Olivier ULiege; MEURISSE, Nicolas ULiege; Delwaide, Jean ULiege et al

in Acta Chirurgica Belgica (2018), 118(3), 200-201

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See detailAlveolar echinococcosis in southern Belgium: retrospective experience of a tertiary center.
Cambier, Audrey ULiege; LEONARD, Philippe ULiege; Losson, Bertrand ULiege et al

in European Journal of Clinical Microbiology and Infectious Diseases (2018), 37(6), 1195-1196

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See detailPrise en charge multidisciplinaire de l'echinococcose alveolaire : le groupe Echino-Liege.
Cambier, Audrey; GIOT, Jean-Baptiste ULiege; LEONARD, Philippe ULiege et al

in Revue Médicale de Liège (2018), 73(3), 135-142

Alveolar echinococcosis is a zoonotic disease due to the tapeworm Echinococcus multilocularis. The definitive host is the red fox. Until recently, Belgium was considered a country at very low risk for ... [more ▼]

Alveolar echinococcosis is a zoonotic disease due to the tapeworm Echinococcus multilocularis. The definitive host is the red fox. Until recently, Belgium was considered a country at very low risk for alveolar echinococcosis. However, recent studies carried out in southern Belgium have revealed, through post-mortem examination, high prevalences (up to 62 %) in foxes. Cats and dogs can act as definitive hosts. Human are accidentally infected by ingestion of food contaminated by the feces. After a long incubation period, invasive hepatic lesions may appear, as well as extra-hepatic lesions. The disease may be fatal. The diagnosis is based on imaging techniques, serology and nucleic acid detection in tissues. Early diagnosis may allow surgical removal of the lesion associated with at least 2 years of albendazole postoperative treatment. In case of contraindication to surgery, a long term treatment with albendazole is necessary. Liver transplantation is sometimes necessary. This article presents the epidemiologic, clinical, diagnostic and therapeutics features of this zoonotic disease. [less ▲]

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See detailL’Echinococcose alvéolaire, une zoonose émergente en Wallonie. Une approche « one health » par le groupe ECHINO-LIEGE
Cambier, Audrey ULiege; DETRY, Olivier ULiege; Lempereur, Laetitia ULiege et al

in Veterinaria: Bulletin d'Information de l'Union Syndicale Vétérinaire Belge (2018)

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See detailAlveolar echinococcosis is now endemic in southern Belgium
Cambier, A; Leonard, Philippe ULiege; Losson, Bertrand ULiege et al

in Acta Gastro-Enterologica Belgica (2018, January), 81(1), 31

Introduction: Until now, Belgium has been considered as a low-risk country for alveolar echinococcosis (AE). However it was recently demonstrated by necropsy series that up to 51% of the red foxes (Vulpes ... [more ▼]

Introduction: Until now, Belgium has been considered as a low-risk country for alveolar echinococcosis (AE). However it was recently demonstrated by necropsy series that up to 51% of the red foxes (Vulpes vulpes) may be infected by E. multilocaris in some parts of Southern Belgium. The first local Belgian human AE cases were described in the early 2000's. Aim: The aim of this study was to report the experience of a tertiary university hospital of Southern Belgium with AE management. Methods: The authors retrospectively collected data from the parasitology laboratory (serologies), the hospital pharmacy in charge of supplying albendazole, and by searching through patient’s files with medico-economic information service of a tertiary university hospital. The medical files were retrospectively reviewed. Results: Twenty-one cases (66% male) of local AE have been recorded from 1999 to 2016. All patients were Belgian citizens with more than 30 years of life in Southern Belgium (Liege province: 10 cases (47.4%), Luxembourg province: 8 cases (36.8%), Namur Province: 3 cases (15.8 %)). Mean age of diagnosis was 66 years (ranges: (35-85y). Eighteen patients had hepatic involvement: 14 underwent surgical resection and 5 had unresectable liver lesions and underwent albendazole palliative therapy until death. During the same period, the faculty of veterinary medicine observed an increased rate of lethal hepatic AE in dogs, another indication of high AE incidence. Conclusions: AE appears to be spreading in Belgium and has actually an uneven geographical distribution with endemicity in areas of Southern and Eastern Belgium. However, it is probable that local AE cases will be diagnosed in the whole country, considering that there is no reason that infected foxes remain in Southern Belgium and also the fact that some people from Northern Belgium might spend long period in Southern Belgium, with or without their dogs. The liver is the most frequently involved organ and the only cure can be achieved by complete R0 resection of all AE lesions. In reaction to this experience, the authors created a multidisciplinary group for AE diagnosis and management, including hepatologists, infectiologists, microbiologists, pathologists, radiologists, nuclear medicine specialists, surgeons and veterinarians. The authorities should be aware of this medical issue and should facilitate the access to Albendazole for AE patients. A complete national survey should be encouraged, and BASL might have an important role in this study. [less ▲]

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See detailA case of giant cell arteritis associated with culture-proven Coxiella burnetii aortitis
de Worm, S.; GIOT, Jean-Baptiste ULiege; Courtoy, C. et al

in International Journal of Infectious Diseases (2018), 69

A case of proven Coxiella burnetii aortitis, possibly associated with giant cell arteritis (GCA), is reported. A 72-year-old man, who is a hunter, presented with weight loss, fever, jaw claudication, and ... [more ▼]

A case of proven Coxiella burnetii aortitis, possibly associated with giant cell arteritis (GCA), is reported. A 72-year-old man, who is a hunter, presented with weight loss, fever, jaw claudication, and hardened temporal arteries associated with a persistent inflammatory syndrome and arteritis of the whole aorta, including the brachiocephalic arteries, as seen on 18F-fluorodeoxyglucose positron emission tomography/computed tomography. The diagnosis of GCA was retained, and treatment with prednisolone was started. Given the aneurysm of the abdominal aorta, the patient underwent replacement of the abdominal aorta with an allograft. Histology showed intense chronic arteritis attributed to atherosclerosis with dissection. However, Coxiella burnetii infection was confirmed by serology and then by culture and molecular biology on the surgical specimen. A combination of hydroxychloroquine and doxycycline was added to tapered prednisolone and the outcome was favourable. © 2018 The Author(s) [less ▲]

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See detailRecurrence of visceral and muco-cutaneous leishmaniasis in a patient under immunosuppressive therapy
DARCIS, Gilles ULiege; Van der Auwera, Gert; GIOT, Jean-Baptiste ULiege et al

in BMC Infectious Diseases (2017), 17

Background: Leishmaniasis is a protozoan disease caused by parasites of the genus Leishmania, transmitted to humans by sandflies. The diagnosis of leishmaniasis is often challenging as it mimics many ... [more ▼]

Background: Leishmaniasis is a protozoan disease caused by parasites of the genus Leishmania, transmitted to humans by sandflies. The diagnosis of leishmaniasis is often challenging as it mimics many other infectious or alignant diseases. The disease can present in three ways: cutaneous, mucocutaneous, or visceral leishmaniasis, which rarely occur together or consecutively. Case presentation: The patient was a 52 years old immunosuppressed Belgian woman with a long history of severe rheumatoid arthritis. She underwent bone marrow biopsy to explore thrombocytopenia. Diagnosis of visceral leishmaniasis was made by identification of Leishman Donovan (LD) bodies in macrophages. Treatment with liposomal amphotericin B was successful. She later developed cutaneous leishmaniasis treated with amphotericin B lipid complex. She next presented with relapsing cutaneous lesions followed by rapidly progressing lymphadenopathies. Biopsy confirmed the diagnosis of leishmaniasis. Treatments by miltefosine, amphotericin B, N-methyl-glucamine antimoniate were subsequently initiated. She later presented a recurrent bone marrow involvement treated with intramuscular paromomycin and miltefosine. She died two years later from leukemia. At the time of death, she presented with a mucosal destruction of the nose. A Leishmania-specific PCR (Polymerase Chain Reaction) identified L. infantum as etiological agent. Conclusions: Clinicians should be aware of the potential concomitant or sequential involvement of multiple anatomic localizations of Leishmania in immunosuppressed patients. [less ▲]

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See detailAbcès cérébraux à nocardia farcinica dans le cadre d'une infection systémique
DELVENNE, Eléonore ULiege; Farnir, Florent ULiege; GUIOT, Julien ULiege et al

in Revue Médicale de Liège (2017), 72(7-8), 340-343

The prevalence of Nocardia infections is increasing because of both improved detection laboratory techniques and a higher number of immunosuppressed patients. We report the case of a patient with brain ... [more ▼]

The prevalence of Nocardia infections is increasing because of both improved detection laboratory techniques and a higher number of immunosuppressed patients. We report the case of a patient with brain abcesses resulting from Nocardia farcinica cerebral dissemination associated with lung infection, endocarditis and ocular lesions for which we suspected a similar origin. This case gives the opportunity to discuss the main issues of these infections and the current therapeutic guidelines. [less ▲]

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See detailPrise en charge de la neutropénie fébrile chez le patient cancéreux
FRERES, Pierre ULiege; GONNE, Elodie ULiege; COLLIGNON, Joëlle ULiege et al

in Revue Médicale de Liège (2015), 70(4), 195-200

Les cancers sont de plus en plus fréquents et leurs traitements de plus en plus agressifs. En conséquence, médecins généralistes, urgentistes, hématologues et oncologues se trouvent régulièrement ... [more ▼]

Les cancers sont de plus en plus fréquents et leurs traitements de plus en plus agressifs. En conséquence, médecins généralistes, urgentistes, hématologues et oncologues se trouvent régulièrement confrontés à un effet secondaire sévère des traitements cytotoxiques, le neutropénie fébrile (NF). La NF est une complication gravissime de la chimiothérapie, car elle peut être rapidement mortelle et provoque un arrêt temporaire, voire définitif, des traitements. Dans cet article, nous résumons les dernières recommandations quant à la prise en charge thérapeutique des patients présentant une NF sous traitements anti-cancéreux. [less ▲]

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See detailFATAL ALVEOLAR ECHINOCOCCOSIS OF THE LUMBAR SPINE
KEUTGENS, Aurore ULiege; SIMONI, Paolo ULiege; DETREMBLEUR, Nancy ULiege et al

in Journal of Clinical Microbiology (2013), 51(2), 688-91

For the last ten years, the southern part of Belgium has been recognized as a low-risk endemic area for alveolar echinococcosis. This infection, caused by Echinococcus multilocularis, usually induces a ... [more ▼]

For the last ten years, the southern part of Belgium has been recognized as a low-risk endemic area for alveolar echinococcosis. This infection, caused by Echinococcus multilocularis, usually induces a severe liver condition, and can sometimes spread to other organs. However, alveolar echinococcosis involving bones has been described only very rarely. Here, a fatal case of spondylodiscitis due to E. multilocularis contracted in southern Belgium is reported. [less ▲]

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See detailL'image du mois. Agenesie de l'artere pulmonaire droite associee a une hypoplasie du poumon droit.
FRUSCH, Nicolas ULiege; DUYSINX, Bernard ULiege; BLEUS, Nicolas ULiege et al

in Revue Médicale de Liège (2012), 67(1), 4

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See detailA pauci-symptomatic case of documented Hantavirus (Puumala) infection in a patient under anti-TNF treatment.
Moutschen, Pierre; Bourhaba, Maryam ULiege; FRIPPIAT, Frédéric ULiege et al

in Journal of Clinical Virology (2011), 50(3), 247-8

We describe the case of an 18-yr-old male under anti-TNF treatment for Crohn's disease for more than 8 months. He developed fever and biological inflammatory syndrome without absolutely no accompanying ... [more ▼]

We describe the case of an 18-yr-old male under anti-TNF treatment for Crohn's disease for more than 8 months. He developed fever and biological inflammatory syndrome without absolutely no accompanying sign or symptom or paraclinical abnormality despite extensive work-up performed in the context of his immunocompromised state. Symptoms disappeared after 10 days and a diagnosis of Puumala infection was made retrospectively on a serological basis. The case illustrates that anti-TNF treatment does not worsen the course of Puumala infection and could even be associated with a milder clinical picture. [less ▲]

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See detailAutoimmune angioneurotic edema in a patient with Helicobacter pylori infection.
Mukeba, Didier; Chandrikakumari, Kavitha; Giot, Jean-Baptiste ULiege et al

in Helicobacter (2009), 14(1), 9-11

Association of acquired autoimmune angioneurotic edema with other diseases is increasing. However, the precise mechanism by which antibodies to C1-esterase inhibitor (C1-INH) are produced, is not ... [more ▼]

Association of acquired autoimmune angioneurotic edema with other diseases is increasing. However, the precise mechanism by which antibodies to C1-esterase inhibitor (C1-INH) are produced, is not elucidated. We describe a patient with IgA antibodies against C1-INH without other autoimmune markers. Our patient had gastritis and Helicobacter pylori infection, proven by biopsy. This case suggests that H. pylori infection can act as triggering factor for acquired autoimmune angioneurotic edema. [less ▲]

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See detailA Patient with Hiv Infection, Cough, Asthenia, and Fever
Mayasi, N.; Chandrikakumari, Kavitha; Mukeba, D. et al

in Clinical Infectious Diseases (2007), 45(5), 662-3559-600

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See detailAvancees therapeutiques en pathologie infectieuse au cours de la derniere decennie
GIOT, Jean-Baptiste ULiege; Mukeba Tshialala, D.; Mayasi Ngongo, N. et al

in Revue Médicale de Liège (2007), 62(5-6, May-Jun), 377-83

This review focuses on new antibiotics, particularly for gram-positive infections, new antiretroviral drugs, new treatment of fungal infections and indications of miltefosine in the treatment of ... [more ▼]

This review focuses on new antibiotics, particularly for gram-positive infections, new antiretroviral drugs, new treatment of fungal infections and indications of miltefosine in the treatment of leishmaniasis. [less ▲]

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See detailNouvelles approches dans la prise en charge de l'infection a VIH.
Chandrika, K.; Dellot, Patricia ULiege; Frippiat, Frédéric ULiege et al

in Revue Médicale de Liège (2007), 62 Spec No

HIV infection remains a major problem of public health in Belgium as well as globally. The number of new diagnosies of HIV infection in Belgium remains between two and three daily. Given the dramatic ... [more ▼]

HIV infection remains a major problem of public health in Belgium as well as globally. The number of new diagnosies of HIV infection in Belgium remains between two and three daily. Given the dramatic effect of antiretroviral therapy on the mortality due to HIV infection, the number of patients is constantly increasing. The different problems related to HIV care are also changing. Aging of the patients and chronic exposure to antiretroviral medications have induced new complications. We will present in this brief article several new experimental and clinical approaches in which our centre has participated during the last two years. [less ▲]

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See detailL'Hantavirose fait encore parler d'elle
Bourhaba, Maryam ULiege; GIOT, Jean-Baptiste ULiege; Tshialala, D. M. et al

in Revue Médicale de Liège (2006), 61(5-6, May-Jun), 322-8

We propose a review of history, aetiology, physiopathology, clinical features, treatment and prevention of nephropathia epidemica (NE) which represents the only form of Hantavirus infection in Belgium.

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See detailAnomalies du metabolisme osseux chez les patients infectes par le HIV et traites par tritherapie
GIOT, Jean-Baptiste ULiege; Franchimont, N.; Moutschen, Michel ULiege

in Revue Médicale de Liège (2003), 58(3), 155-63

For several years already, a growing number of studies reports modifications in the bone metabolism among HIV-infected patients. Some of these studies, published even before the use of HAART, involved the ... [more ▼]

For several years already, a growing number of studies reports modifications in the bone metabolism among HIV-infected patients. Some of these studies, published even before the use of HAART, involved the infection itself. With the experience already available as concerns HAART, antiretroviral treatments (ART) seem however to be called into question. Data are divergent yet. Some studies tend to invalidate the collected data about the harmful role of HAART and prove the absence of effect or even the beneficial action of ART on bone. Moreover, the three important classes of ART are implied, even if the proteases inhibitors are most commonly charged. Pathogenic mechanism remain hypothetical. While the impact on morbidity seems to be weak for the time being, long-term repercussions are still unknown, in particular when children are concerned. In such conditions, it appears difficult to set up coherent politics of screening, prevention and treatment. Nevertheless beyond the divergences, the multifactorial character of alteration of HIV-infected patient's bone metabolism seems to be undeniable. The identification of the different parameters should in the future clarify the situation and enable the publishing of exact criteria of screening, prevention and treatment. [less ▲]

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