Publications of Patricia FORGET
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See detailCoincidental Central Precocious Puberty and Wilms Tumor in a 5-Year-Old Girl.
Kasongo, Laura ULiege; FORGET, Patricia ULiege; Nicolescu, Corina Ramona ULiege

in Case reports in pediatrics (2019), 2019

Wilms tumor is the most frequent pediatric renal malignancy, and its usual presentation is an abdominal mass or hematuria. Unusual presentations have also been reported, such as paraneoplastic syndromes ... [more ▼]

Wilms tumor is the most frequent pediatric renal malignancy, and its usual presentation is an abdominal mass or hematuria. Unusual presentations have also been reported, such as paraneoplastic syndromes (acquired von Willebrand disease, sudden death due to pulmonary embolism, and Cushing syndrome). These conditions can precede, occur concomitantly, or present in a later phase of tumor development. Precocious puberty, as paraneoplastic endocrine syndrome, has already been described in children with malignant tumors (brain, gonadal, adrenal tumors, and hepatoblastoma). However, little is known about central precocious puberty, as paraneoplastic manifestation of nephroblastoma or secondary to its specific chemotherapy. Here, we report a case of Wilms tumor and simultaneous precocious puberty in a 5-year-old girl. The initial diagnosis was premature telarche, but the clinical and biological pubertal progression changed our diagnosis to idiopathic central precocious puberty. Chemotherapy and nephrectomy were well tolerated, and we began treatment with a gonadotropin-releasing hormone agonist which showed favorable outcomes over the short term. We highlight the need for early diagnosis and work-up in all patients of precocious puberty, in order to institute timely management. [less ▲]

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See detailEpidémiologie des cancers de l'enfant, une étude monocentrique (1985-2016)
Jankowski, M.; Dresse, Marie-Françoise ULiege; FORGET, Patricia ULiege et al

in Revue Medicale de Liege (2019), 74(3), 146-151

Cancer is the second leading cause of death among children aged 5 to 14, after accidents. We conducted a study on the epidemiology of childhood cancer in the university pediatric oncology department of ... [more ▼]

Cancer is the second leading cause of death among children aged 5 to 14, after accidents. We conducted a study on the epidemiology of childhood cancer in the university pediatric oncology department of the CHU-CHR in Liège, Belgium. We studied a cohort of 662 patients between the ages of 0 and 17 whose malignancy diagnosis was made between 1985 and 2016. The analyzes were performed retrospectively using medical files. The number of new cases, the proportion of different cancers, sex ratio, age at diagnosis and survival at 5 and 10 years were the epidemiological factors studied.We have been able to show an increase in the number of new diagnoses per year. More than 40 % of childhood cancers occur before the age of five. The most common neoplasias are leukemias, tumors of the central nervous system and lymphomas. This distribution is influenced by age. All malignant tumours combined, we observed a slightly larger proportion of affected boys than girls. Overall survival at 5 years reaches 80.2 %. However, it varies according to the type of tumour from 59.3 % for malignant soft tissue tumors up to 100 % for hepatoblastomas. © 2019 Revue Medicale de Liege. All Rights Reserved. [less ▲]

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See detailMethotrexate-induced Acute Myelopathy in a Teenager With High-risk Acute Lymphoblastic Leukemia
Geurten, Claire ULiege; FORGET, Patricia ULiege; LEROY, Patricia ULiege et al

in Journal of Pediatric Hematology/Oncology (2018)

Acute lymphoblastic leukemia (ALL) is one of the most frequent malignancies in childhood whose long-term survival has increased up to 80% thanks to modern therapy enhancements. Nevertheless, methotrexate ... [more ▼]

Acute lymphoblastic leukemia (ALL) is one of the most frequent malignancies in childhood whose long-term survival has increased up to 80% thanks to modern therapy enhancements. Nevertheless, methotrexate (MTX) remains a mainstay of ALL therapy, but also represents one of the major causes of neurotoxicity in patients with ALL. MTX-induced toxicity occurs in about 9% of patients treated for ALL. It usually affects deep white matter region leading to leukoencephalopathy, which has varying clinical manifestations ranging from acute neurological disturbances to seizures or chronic permanent encephalopathy. Here we describe a 13-year-old girl affected with ALL who developed lower limbs hypesthesia and static ataxia due to transverse myelopathy after intrathecal administration of MTX therapy. A high-dose corticotherapy combined to vitamin supplementation and rehabilitation was tested. Neurological evolution was characterized by slow and partial recovery. [less ▲]

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See detailAtteintes osseuses des leucemies lymphoblastiques aigues pediatriques : experience monocentrique et revue de la litterature.
Pécheux, Lucie ULiege; FORGET, Patricia ULiege; Geurten, Claire ULiege et al

in Revue Médicale de Liège (2018), 73(11), 575-582

Bone pain associated with bone marrow infiltration is often present at diagnosis of pediatric acute lymphoblastic leukemia (ALL). It sometimes signs the presence of pathological fracture, lytic lesions ... [more ▼]

Bone pain associated with bone marrow infiltration is often present at diagnosis of pediatric acute lymphoblastic leukemia (ALL). It sometimes signs the presence of pathological fracture, lytic lesions, arthritis, or osteitis associated to ALL that can delay the diagnosis. During treatment, bone complications (pain, osteopenia, fracture, avascular necrosis, ...) are also reported. In order to describe bone involvement (BI) of pediatric LLA, we reviewed the records of 104 patients followed in our unit. The overall incidence of BI was 67 %. At diagnosis, 50 % of patients had BI and in 19 %, the diagnosis of ALL was delayed. During and after treatment, respectively 28 % and 37 % of patients presented bone complications (pain, fractures, avascular necrosis, osteopenia). Patients with BI had a lower leukocytosis inferior to 10x109/l (p = 0.005) and an ALL of average risk (p = 0.019). 38 % of patients with BI during treatment were over 10 years old and 55 % were girls (vs. 21 % and 38 % in the entire cohort, respectively). Osteoporosis was more severe at diagnosis than during treatment, suggesting the presence of constitutional promoting factors. In our cohort, the majority of BI was resolved at the end of treatment with no long-term sequelae. [less ▲]

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See detailMetronomic treatments in Pediatric Neuro-Oncology, a new therapeutic alternative?
Fohn, Anaïs ULiege; Hoyoux, Claire ULiege; DRESSE, Marie-Françoise ULiege et al

in Tijdschrift van de Belgische Kinderarts (2017, March), 19(1), 88

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See detailPurpura thrombocytopénique idiopathique...idiopathique, vraiment?
LONGTON, Julie ULiege; DRESSE, Marie-Françoise ULiege; Florkin, Benoît et al

in Tijdschrift van de Belgische Kinderarts (2016), 18(1), 112

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See detailPosterior Reversible Encephalopathy Syndrome in Pediatric Leukemia
Carichon, Tifenn ULiege; Piette, Caroline ULiege; Florkin, Benoît et al

in Tijdschrift van de Belgische Kinderarts (2015), 17(1), 48

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See detailUNE TUMEUR RARE DE LA FACE CHEZ UN NOURRISSON DE 6 MOIS
Fontaine, C; DEMEZ, Pierre ULiege; FORGET, Patricia ULiege et al

in Tijdschrift van de Belgische Kinderarts (2015), 17(1), 46

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See detailLE CANCER DU TRES JEUNE ENFANT : EPIDEMIOLOGIE LIEGEOISE
Fontaine, C; RIGO, Vincent ULiege; FORGET, Patricia ULiege et al

in Tijdschrift van de Belgische Kinderarts (2015), 17(1), 47

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See detailTumeurs rhabdoïdes néonatales : à propos de deux cas.
Carichon, T; FORGET, Patricia ULiege; Piette, Caroline ULiege et al

in Tijdschrift van de Belgische Kinderarts (2015), 17(1),

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See detailLE CAS CLINIQUE DU MOIS. Présentation clinique atypique d’un neuroblastome chez un nourrisson
Dauphin, G; COSTA DE ARAUJO, Pedro ULiege; FORGET, Patricia ULiege et al

in Revue Médicale de Liège (2013)

A babygirl, aged six weeks, was hospitalized for rectal prolapse and isolated constipation. The investigation revealed a neuroblastoma (NB) inducing a medullar compression responsible for the sphincter ... [more ▼]

A babygirl, aged six weeks, was hospitalized for rectal prolapse and isolated constipation. The investigation revealed a neuroblastoma (NB) inducing a medullar compression responsible for the sphincter disorders. NB is second among pediatric solid tumors, but is the most frequent cancer among infants. Its diagnosis is difficult because of its rarity and the variety of its symptoms. A new staging, based on imaging, has recently been proposed by the International Neuroblastoma Risk Group. With the exception of its localized, easily resectable forms, NB is best treated by chemotherapy. [less ▲]

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See detailParavertebral Burkitt’s Lymphoma in a Child: An Unusual Presentation
Hoyoux, Claire ULiege; FORGET, Patricia ULiege; Piette, Caroline ULiege et al

in Case Reports in Medicine (2012), Article ID 891714, 4 pages

Paravertebral malignant tumors constitute 4.8% of cancer cases in pediatric oncology and are mostly composed of neuroblastoma (46.4%) and soft tissue sarcomas (35.7%). We describe the case of a Caucasian ... [more ▼]

Paravertebral malignant tumors constitute 4.8% of cancer cases in pediatric oncology and are mostly composed of neuroblastoma (46.4%) and soft tissue sarcomas (35.7%). We describe the case of a Caucasian 6-year-old boy who was admitted for middle back pain radiated to limbs and progressively increasing weakness of the legs, suggesting a spinal cord disease. The exploration revealed two paravertebral masses extending through the neural foraminae into the epidural space. The association with elevated serum neuron specific enolase suggested at first the diagnosis of neuroblastoma, but the pathological examination revealed a Burkitt’s lymphoma. This is a rare location of sporadic Burkitt’s lymphoma with neurologic syndrome as first symptoms. [less ▲]

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See detailA Case of Osteosarcoma in a Patient With Pycnodysostosis
Cortisse, Natasha; FORGET, Patricia ULiege; DRESSE, Marie-Françoise ULiege et al

in American Journal of Pediatric Hematology/Oncology (2012), 34

Pycnodysostosis is a rare sclerosing bone dystrophy. The main clinical features are short stature and oral and maxillofacial abnormalities such as a large head, a small and underdeveloped face with ... [more ▼]

Pycnodysostosis is a rare sclerosing bone dystrophy. The main clinical features are short stature and oral and maxillofacial abnormalities such as a large head, a small and underdeveloped face with prominent nose and eyes, irregular dentition, small hands and feet with dystrophic nails, and trunk deformities such as scoliosis. The differential diagnosis is established with other skeletal dysplasias such as osteopetrosis, cleidocranial dysplasia, and idiopathic acroosteolysis. Since its first description in 1962 by Maroteaux and Lamy, about 100 cases have been published, some of these with uncommon features. We describe the case of a 22-year-old European man with pycnodysostosis who developed a chondroblastic osteosarcoma of the right femur. No case of bone cancer in this sclerosing bone disease had been described so far. [less ▲]

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See detailCord blood transplantation in a child with Pearson's disease.
Hoyoux, Claire; Dresse, Marie-Françoise ULiege; Robinet, Sébastien ULiege et al

in Pediatric Blood and Cancer (2008), 51(4), 566

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See detailManagement of diffuse glioma in children: a retrospective study of 27 cases and review of literature.
Piette, Caroline ULiege; Deprez, Manuel ULiege; Born, Jacques et al

in Acta Neurologica Belgica (2008), 108(2), 35-43

Gliomas are the most common CNS tumours in children and present either as circumscribed tumours or diffusely infiltrative neoplasms. Diffuse gliomas develop both in the cerebral hemispheres and the ... [more ▼]

Gliomas are the most common CNS tumours in children and present either as circumscribed tumours or diffusely infiltrative neoplasms. Diffuse gliomas develop both in the cerebral hemispheres and the brainstem and have a poor prognosis. Guidelines for the therapy of these tumours are still debated. In this study, we reviewed the clinical features of 27 consecutive patients with diffuse gliomas admitted to the Department of Paediatrics of CHR Citadelle, University of Liege, between 1985 and 2005. We review their clinical presentation, diagnosis, treatment and outcome with reference to the published literature. [less ▲]

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See detailPrise en charge du médulloblastome de l'enfant
Fransolet, Anne-Catherine; Born, Jacques Daniel; Misson, Jean-Paul ULiege et al

in Revue Médicale de Liège (2007), 62(4), 200-4

We present the experience of the Citadelle Hospital (Liege, B) in the diagnosis, treatment and follow-up of medulloblastoma in children. A retrospective study of 10 cases of medulloblastoma was performed ... [more ▼]

We present the experience of the Citadelle Hospital (Liege, B) in the diagnosis, treatment and follow-up of medulloblastoma in children. A retrospective study of 10 cases of medulloblastoma was performed. Five years after diagnosis, the event-free survival was 77%. [less ▲]

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See detailSecondary cancers in childhood
FORGET, Patricia ULiege; DRESSE, Marie-Françoise ULiege; Schmitz, V et al

in Revue Médicale de Liège (2006), 61(2), 76-80

Improved survival of pediatric cancer patients will lead to an increase of late sequellae such as secondary malignant neoplasms (SMN). Specific pediatric factors predisposing to these SMN are as follows ... [more ▼]

Improved survival of pediatric cancer patients will lead to an increase of late sequellae such as secondary malignant neoplasms (SMN). Specific pediatric factors predisposing to these SMN are as follows: long expecting duration of life, high cellular proliferative potential, toxicity of often combined cancer therapies (radio- and chemotherapies) and more frequent genetic predisposition to cancer. Better understanding of these factors could improve patients management and could lead to the development of less toxic future therapies with the hope to decrease the risk of SMN. [less ▲]

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See detailAcute lymphoblastic leukemia in children
Panizzotto, S; DRESSE, Marie-Françoise ULiege; Schmitz, V et al

in Revue Médicale de Liège (2005), 60(1), 23-29

We report our experience over the last seventeen years (1985-2002) of the treatment of acute lymphoblastic leukemia (ALL) in children at the University of Liege Pediatric Department of Hematogy-Oncology ... [more ▼]

We report our experience over the last seventeen years (1985-2002) of the treatment of acute lymphoblastic leukemia (ALL) in children at the University of Liege Pediatric Department of Hematogy-Oncology (CHU-Sart Tilman and CHR-Citadelle). Seventy seven children are enrolled in our study; the mean follow-up is 6,7 years. The 5 years over all survival and the disease free survival for the entire group are respectively 83 % and 79 %. Prognostic factors shown in our study are sex, high white blood cells counts at diagnosis and immunophenotypes [less ▲]

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See detailEtude rétrospective des lymphomes de l'enfant. A propos de 27 cas traités dans une méme institution
KEMPENEERS, Céline ULiege; FORGET, Patricia ULiege; DRESSE, Marie-Françoise ULiege et al

in Revue Médicale de Liège (2005), 60(11), 855-862

Childhood lymphomas represent a heterogeneous group of disorders that are quite different from adult lymphomas. Over the past three decades, empirical chemotherapeutic management has transformed survival ... [more ▼]

Childhood lymphomas represent a heterogeneous group of disorders that are quite different from adult lymphomas. Over the past three decades, empirical chemotherapeutic management has transformed survival figures, and more recently greater understanding of the biology is offering hope for improved management of resistant disease. We present here the experience of a single institution in the management of 27 childhood lymphomas; epidemiological and clinical characteristics are described as well as survival rates. The median follow up of the patients is 4 years 7 months. The five-year overall survival for the entire group is more than 95 %; the 5-year disease free survival is 91,6 % for Hodgkin's lymphomas, 92,8% for non Hodgkin's lymphomas and 100% for Burkitt diseases. Two relapses have occurred and all of them appeared within the 18 months of the diagnosis. No toxic death has been reported. [less ▲]

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See detailLes neuroblastomes de l'enfant. A propos de 23 cas.
Piette, Catherine ULiege; Dresse, Marie-Françoise ULiege; Forget, Patricia ULiege et al

in Revue Médicale de Liège (2005), 60(3), 173-80

In this retrospective study, we analyse epidemiology, clinical symptoms and therapeutic results in a group of 23 children with neuroblastoma. Half of them were less than 2 years of age; in 19 of 23, the ... [more ▼]

In this retrospective study, we analyse epidemiology, clinical symptoms and therapeutic results in a group of 23 children with neuroblastoma. Half of them were less than 2 years of age; in 19 of 23, the primitive tumour was abdominal; 35% of them were initially metastatic. The overall survival was 83% at 5 years and the event free survival, 75% at 5 years. Pronostic factors are age, extension of the disease at diagnosis, biologic parameters and genetic study of the neuroblast cells (amplification of N-myc oncogen). Our study shows the deleterious effect of bone lesions. [less ▲]

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