Publications of Martine DEVOS
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See detailExercise and Education Program After Breast Cancer: Benefits on Quality of Life and Symptoms at 3, 6, 12, and 24 Months' Follow-up
LECLERC, Anne-France ULiege; Slomian, Justine ULiege; JERUSALEM, Guy ULiege et al

in Clinical Breast Cancer (2018), 18(5), 1189-1204

BACKGROUND: Various clinical trials show benefits of physical training offered during and / or after breast cancer treatments. However, given the variety of side effects that may be encountered, physical ... [more ▼]

BACKGROUND: Various clinical trials show benefits of physical training offered during and / or after breast cancer treatments. However, given the variety of side effects that may be encountered, physical training could be combined with psychological, relational and social guidance. This kind of multidisciplinary program, just like their long-term effects, have been little studied so far. Therefore, the objective of our study is to determine the benefits at 3, 6, 12 and 24 months of a three-month exercise and education program among women after breast cancer treatment. MATERIALS AND METHODS: Two hundred and nine outpatients who have been treated for a primary breast carcinoma were divided into a control group (n=106) and an experimental group (n=103) which has benefited from a three-month rehabilitation program including physical training and psycho-educational sessions. The assessments, performed before the program and at 3, 6, 12 and 24 months after inclusion, included validated questionnaires on quality of life and symptoms. RESULTS: The analyses show an improvement in quality of life and symptoms following the exercise and education program within the experimental group and a maintenance of these improvements during the two years of follow-up. These improvements are significantly superior to those presented in the control group, demonstrating the programs benefits. CONCLUSIONS: This trial identifies the benefits of a well detailed three-month exercise and education program over a follow-up of 24 months among women after breast cancer treatment. [less ▲]

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See detailMultidisciplinary rehabilitation program after breast cancer: benefits on physical function, anthropometry and quality of life.
Leclerc, Anne-France ULiege; Foidart-Dessalle, Marguerite ULiege; Tomasella, Marco ULiege et al

in European Journal of Physical and Rehabilitation Medicine (2017), 53(5), 633-642

BACKGROUND: Different clinical trials show beneficial effects of physical training offered during and / or after breast cancer treatment. However, given the variety of side effects that may be encountered ... [more ▼]

BACKGROUND: Different clinical trials show beneficial effects of physical training offered during and / or after breast cancer treatment. However, given the variety of side effects that may be encountered, physical training could be combined with psychological, relational and social guidance. This kind of multidisciplinary program has been little studied so far. AIM: To determine the benefits of a three-month multidisciplinary rehabilitation program among women after breast cancer treatment. DESIGN: Controlled no-randomized trial. SETTING: University for outcomes, University Hospital Center for interventions. POPULATION: Two hundred and nine outpatients who have been treated for a primary breast carcinoma. METHODS: Patients were divided into a control group (n=106) and an experimental group (n=103) which has benefited from a rehabilitation program of three months including physical training and psycho-educational sessions. The assessments, performed before and after the program, included functional assessments ("Sit and Reach Test", maximal incremental exercise test and "Six-Minute Walk Test"), body composition measurements (body mass index (BMI) and body fat percentage) and a questionnaire (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30). RESULTS: After three months, flexibility, walking distance and all parameters measured during the maximal incremental exercise, except maximal heart rate, were significantly improved in the experimental group. The body fat percentage was significantly decreased and a significant improvement was observed for perceived health status (quality of life), functional role, emotional state, physical, cognitive and social functions and for most symptoms. In the control group, most of these improvements didn't appear and a significant increase in BMI and body fat percentage was observed. CONCLUSIONS: This trial identifies the benefits of a well detailed multidisciplinary rehabilitation program, including physical re-conditioning and psycho-educational sessions, with important improvements in functional capacity, body composition and the majority of functions and symptoms among women after breast cancer treatment. CLINICAL REHABILITATION IMPACT: Through its results, this study could contribute to the development of hospital quality standards for oncologic rehabilitation. Physiotherapists can efficiently propose this kind of multidisciplinary rehabilitation program. [less ▲]

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See detailFactors associated with self-perceived burden to the primary caregiver in older patients with hematologic malignancies: an exploratory study
Libert, Y; Borghgraef, C; BEGUIN, Yves ULiege et al

in Psycho-oncology (2017), 26

Objective: Although cancer patients frequently experience self-perceived burden to others, this perception has not been enough studied. The aim of this study was to investigate the prevalence of ... [more ▼]

Objective: Although cancer patients frequently experience self-perceived burden to others, this perception has not been enough studied. The aim of this study was to investigate the prevalence of selfperceived burden to the primary caregiver (SPB-PC) and associated factors in an older patient population with hematologic malignancies at the time of chemotherapy initiation. Methods: In total, 166 consecutive patients with hematologic malignancies aged ≥65 years were recruited at the time of chemotherapy initiation. Patients’ SPB-PC was assessed using a 100-mm visual analogue scale (VAS). Characteristics potentially associated with SPB-PC, including sociodemographic and medical characteristics, physical functioning status (Karnofsky performance score, activities of daily living (ADL)/instrumental ADL), symptoms (fatigue, pain, nausea, quality of life), psychological distress (Hospital Anxiety and Depression Scale (HADS)), perceived cognitive function (Functional Assessment of Cancer Therapy Cognitive (FACT-Cog) Scale), and patients’/primary caregivers’ personal relationship characteristics (family tie, support), were assessed. Results: Thirty-five percent of patients reported moderate to severe SPB-PC (VAS ≥ 50 mm). Patients’ SPB-PC was associated with lower Karnofsky performance (β = 0.135, p = 0.058) and ADL (β = 0.148, p = 0.037) scores, and higher HADS (β = 0.283, p<0.001) and FACT-Cog perceived cognitive impairments subscale (β = 0.211, p = 0.004) scores. The proportion of explained variance was 23.5%. Conclusions: Health care professionals should be aware that about one third of older cancer patients experience moderate to severe SPB-PC at the time of chemotherapy initiation. They should adapt their support of patients who report such a feeling. [less ▲]

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See detailCognitive compensatory processes of older, clinically fit patients with hematologic malignancies undergoing chemotherapy: A longitudinal cohort study
Libert, Y.; Borghgraef, C.; Beguin, Yves ULiege et al

in Psycho-oncology (2017), 26(12), 2086-2093

Objective: Despite the well-known negative impacts of cancer and anticancer therapies on cognitive performance, little is known about the cognitive compensatory processes of older patients with cancer ... [more ▼]

Objective: Despite the well-known negative impacts of cancer and anticancer therapies on cognitive performance, little is known about the cognitive compensatory processes of older patients with cancer. This study was designed to investigate the cognitive compensatory processes of older, clinically fit patients with hematologic malignancies undergoing chemotherapy. Methods: We assessed 89 consecutive patients (age ≥ 65 y) without severe cognitive impairment and 89 age-, sex-, and education level-matched healthy controls. Cognitive compensatory processes were investigated by (1) comparing cognitive performance of patients and healthy controls in novel (first exposure to cognitive tasks) and non-novel (second exposure to the same cognitive tasks) contexts, and (2) assessing psychological factors that may facilitate or inhibit cognitive performance, such as motivation, psychological distress, and perceived cognitive performance. We assessed cognitive performance with the Trail-Making, Digit Span and FCSR-IR tests, psychological distress with the Hospital Anxiety and Depression Scale, and perceived cognitive performance with the FACT-Cog questionnaire. Results: In novel and non-novel contexts, average cognitive performances of healthy controls were higher than those of patients and were associated with motivation. Cognitive performance of patients was not associated with investigated psychological factors in the novel context but was associated with motivation and psychological distress in the non-novel context. Conclusions: Older, clinically fit patients with hematologic malignancies undergoing chemotherapy demonstrated lower cognitive compensatory processes compared to healthy controls. Reducing distress and increasing motivation may improve cognitive compensatory processes of patients in non-novel contexts. Copyright © 2017 John Wiley & Sons, Ltd. [less ▲]

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See detailMultidisciplinary management of breast cancer
Leclerc, Anne-France ULiege; JERUSALEM, Guy ULiege; DEVOS, Martine ULiege et al

in Archives of Public Health (2016), 74

Breast cancer, with an increasing incidence, is the most frequently diagnosed cancer in women worldwide. The treatments proposed, generally a combination of surgery, radiotherapy, chemotherapy, endocrine ... [more ▼]

Breast cancer, with an increasing incidence, is the most frequently diagnosed cancer in women worldwide. The treatments proposed, generally a combination of surgery, radiotherapy, chemotherapy, endocrine therapy and / or targeted therapy, are constantly improving, allowing a reduction in the mortality rate, but they are still causing many side effects, not only early but also late, which leads us to consider the post-cancer period as a chronic condition. Side effects, reviewed in this commentary, may affect physical functions, psychological status, social situation, body composition, well-being and quality of life of the patient. In view of the extent of these areas in which side effects of breast cancer and of its treatments can be found, the supportive care offered at the end of treatment need to be multidisciplinary. Different supportive care interventions may be proposed to the patients such as psychological and behavioral interventions, complementary therapies, diet interventions, physical activity/rehabilitation or also physiotherapy interventions for example, all having shown some beneficial effects in the literature. The benefits of these supportive care interventions are thereby already established and they are described in this article, but others studies will be needed to clearly define indications and most optimal modalities of application to reduce side effects and improve quality of life of patients. [less ▲]

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See detailInfluence d'un programme de revalidation multidisciplinaire post-cancer du sein sur la fonction physique
Leclerc, Anne-France ULiege; Foidart-Dessalle, Marguerite ULiege; BURY, Thierry ULiege et al

in 9ème Congrès commun SFMES - SFTS : Abstract book (2016, September 22)

Objectif : Le cancer du sein ainsi que ses traitements sont à l'origine de nombreux effets secondaires indésirables, notamment sur la fonction physique. Cette étude a pour objectif de déterminer les ... [more ▼]

Objectif : Le cancer du sein ainsi que ses traitements sont à l'origine de nombreux effets secondaires indésirables, notamment sur la fonction physique. Cette étude a pour objectif de déterminer les bénéfices éventuels d’un programme de revalidation multidisciplinaire sur la santé physique des femmes ayant été traitées pour un cancer du sein et d'évaluer l'influence de certaines caractéristiques individuelles initiales sur la réponse du groupe expérimental au programme de revalidation. Matériel et méthodes : L'étude constitue un essai clinique contrôlé non-randomisé évaluant une population totale de 209 patientes, recrutées sur base du volontariat et réparties en deux groupes, soit un groupe contrôle (n = 106) et un groupe expérimental (n = 103). Ce dernier a bénéficié d’une revalidation de trois mois comprenant un entraînement physique supervisé à raison de trois séances par semaine et diverses sessions psycho-éducatives. Pour l'ensemble des participantes, des évaluations constituées d'une part de mesures physiques et fonctionnelles et d'autre part de mesures de composition corporelle ont été programmées à 0 et 3 mois. Celles-ci ont inclus un test de souplesse ("Sit and Reach"), un test d'effort maximal sur bicyclette ergométrique avec suivi cardio-respiratoire, un test de marche de six minutes et la mesure de l'indice de masse corporelle et du pourcentage de graisse corporelle. Afin d'affiner l'analyse, trois groupes ont également été constitués au sein du groupe expérimental à partir des caractéristiques individuelles de thérapie adjuvante (présence de chimiothérapie ou non), de chirurgie (mastectomie ou tumorectomie) et de délai de fin de traitement (délai ≤ 4 mois ou ≥ 8 mois). Résultats : Initialement, toutes les patientes présentent un état de déconditionnement physique, non influencé par le délai de fin de traitement ou par le type de chirurgie, mais bien influencé par la présence d'une chimiothérapie puisque la VO2max apparaît significativement plus faible dans ce cas. Au terme des trois mois, la souplesse (p < 0,0001), la consommation maximale d'oxygène (p < 0,0001), la puissance maximale aérobie (p < 0,0001) et la distance de marche en six minutes (p < 0,0001) s’améliorent significativement au sein du groupe expérimental. Au sein du groupe contrôle, aucune amélioration n'est constatée, excepté pour la distance de marche (p = 0,0031). Par ailleurs, une augmentation significative de l'indice de masse corporelle (p = 0,034) et du pourcentage de graisse corporelle (p = 0,034) est observée au sein du groupe contrôle alors que ce paramètre diminue significativement au sein du groupe expérimental (p = 0,037). Enfin, toutes les patientes du groupe expérimental présentent un même profil de progression quelles que soient leurs caractéristiques individuelles initiales. Conclusion : Cette étude démontre ainsi les effets bénéfiques, tant sur le plan physique que de la composition corporelle, d’une prise en charge multidisciplinaire chez des femmes ayant été traitées pour le cancer du sein. [less ▲]

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See detailEtude pilote auprès de patientes atteintes d'un cancer du sein: Apport des méthodes alternatives.
Bragard, Isabelle ULiege; Etienne, Anne-Marie ULiege; Faymonville, Marie-Elisabeth ULiege et al

in Etienne, Anne-Marie; Bragard, Isabelle (Eds.) Evolutions Sociales, Innovations et Politiques: nouvelles questions et nouveaux enjeux pour la psychologie de la santé. (2016)

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See detailPsychological benefits of a multidisciplinary rehabilitation program after breast cancer
Leclerc, Anne-France ULiege; FOIDART-DESSALLE, Marguerite ULiege; Bury, Thierry ULiege et al

in European Cancer Congress : Abstract book (2015, September 27)

Background : Breast cancer is the most frequent cancer in women, affecting 8 women out of 100. With early detection and improved treatments, the number of deaths linked to this disease has declined ... [more ▼]

Background : Breast cancer is the most frequent cancer in women, affecting 8 women out of 100. With early detection and improved treatments, the number of deaths linked to this disease has declined. However, the disease and its treatments are at the origin of many undesirable side effects such as fatigue, anxiety, weight gain and sleep disorders. The objective of this study is to determine the psychological benefits of a multidisciplinary rehabilitation program among women treated for breast cancer (on average six months after the end of the adjuvant radiotherapy or chimiotherapy). Material and methods : 122 patients were included into a control group (n = 61) and a treated group (n = 61). All participants were submitted to evaluations before the beginning of the trial and after three months. These evaluations included different questionnaires exploring the quality of life, anxiety, depression and various functions and other symptoms related to cancer (EORTC QLQ-C30, EQ-5D, STAI, HADS) and functional assessments. The control group has received no intervention unlike the treated group that received a three-month rehabilitation including supervised physical training (90 min) with three times a week and various psycho-educational sessions (120 min) once a week. Results : After three months, the health status (quality of life) (p < 0,0001), the functional role (p = 0,031), emotional state (p < 0,0001) and physical (p = 0,0045), cognitive (p = 0,0027) and social functions (p = 0,0018) improve significantly in the treated group. This observation also applies to symptoms of fatigue (p < 0,0001), insomnia (p < 0,0001), pain (p = 0,002), dyspnea (p = 0,009), loss of appetite (p = 0,04), anxiety (p < 0,0001) and depression (p < 0,0001) as well as physical parameters obtained through functional assessments. In the control group, these improvements do not appear. Conclusions : This study shows the feasibility and psychological benefits of such a multidisciplinary oncological rehabilitation program in women after their treatments for breast cancer. Additional studies are needed to know the optimal time of beginning (during treatments or after them) and the optimal management time for this support. [less ▲]

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See detailPhysical benefits of a multidisciplinary rehabilitation program after breast cancer
Leclerc, Anne-France ULiege; FOIDART-DESSALLE, Marguerite ULiege; Bury, Thierry ULiege et al

Poster (2015, September 26)

Background : Breast cancer is the most frequent cancer in women, affecting 8 women out of 100. With early detection and improved treatments, the number of deaths linked to this disease has declined ... [more ▼]

Background : Breast cancer is the most frequent cancer in women, affecting 8 women out of 100. With early detection and improved treatments, the number of deaths linked to this disease has declined. However, the disease and its treatments are at the origin of many undesirable side effects such as fatigue, anxiety, weight gain and decreased physical fitness. The objective of this study is to determine the physical benefits of a multidisciplinary rehabilitation program among women treated for breast cancer (on average six months after the end of the adjuvant radiotherapy or chimiotherapy). Material and methods : 122 patients were included into a control group (n = 61) and a treated group (n = 61). All participants were submitted to evaluations before the beginning of the trial and after three months. These evaluations included functional assessments (a maximal incremental exercise protocol on a cycle ergometer, flexibility by Sit and Reach Test and walking distance by Six-Minute Walk Test), anthropometric and body composition measurements (Body Mass Index and body fat percentage) and different questionnaires on quality of life, anxiety and other symptoms related to cancer. The control group has received no intervention unlike the treated group that received a three-month rehabilitation including supervised physical training (90 min) with three times a week and various psycho-educational sessions (120 min) once a week. Results : After three months, maximal oxygen consumption (p < 0,0001), maximal aerobic power (p < 0,0001), peak of ventilation (p < 0,0001) and time to exhaustion (p = 0,0055) during the maximal incremental exercise protocol improve significantly in the treated group. This observation also applies to flexibility (p < 0,0001), walking distance in six minutes (p < 0,0001) and different physical and psychological parameters obtained through questionnaires. In the control group, these improvements do not appear and a significant increase in body mass index (p = 0,032) and body fat percentage (p = 0,034) is observed while these data remain constant in the treated group. Conclusions : This study shows the feasibility and physical benefits of such a multidisciplinary oncological rehabilitation program in women after their treatments for breast cancer. Additional studies are needed to know the optimal time of beginning (during treatments or after them) and the optimal management time for this support. [less ▲]

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See detailOncologie et revalidation physique
Leclerc, Anne-France ULiege; Foidart-Dessalle, Marguerite ULiege; COUCKE, Philippe ULiege et al

in Abstract Book du Colloque "Femmes et Santé" (Université d'Hiver) (2015, January 26)

Le cancer constitue une maladie fréquente en Belgique puisqu'un homme sur trois et une femme sur quatre sont confrontés à la maladie avant l'âge de septante-cinq ans (Fondation Registre du Cancer, 2008 ... [more ▼]

Le cancer constitue une maladie fréquente en Belgique puisqu'un homme sur trois et une femme sur quatre sont confrontés à la maladie avant l'âge de septante-cinq ans (Fondation Registre du Cancer, 2008). La détection précoce et l'amélioration des traitements du cancer, généralement une combinaison de chirurgie, radiothérapie, chimiothérapie, hormonothérapie et thérapie ciblée, ont permis une augmentation du taux de survie. Cependant, ces traitements peuvent être à l'origine de nombreux effets secondaires, non seulement précoces, mais également tardifs, réduisant la qualité de vie. De nombreux programmes de réhabilitation après cancer sont basés sur la psychothérapie et le support social uniquement, or ceux-ci n'agissent généralement pas sur les problèmes physiques encourus par les patients tels que la fatigue, la prise de poids et la diminution des capacités fonctionnelles. C'est pourquoi nous émettons l'hypothèse qu'une revalidation physique, associée à des séances psycho-éducatives et constituant ainsi une prise en charge multidisciplinaire, permettrait d'améliorer d'autant plus la qualité de vie et le bien-être tant physique que psychologique des patients ayant été traités pour un cancer. [less ▲]

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See detailProgramme de revalidation multidisciplinaire post-cancer du sein : analyse des bénéfices éventuels sur la fonction physique et la qualité de vie
LECLERC, Anne-France ULiege; FOIDART-DESSALLE, Marguerite ULiege; COUCKE, Philippe ULiege et al

in AFPSA - 8e congrès francophone, Psychologie de la Santé - Evolutions sociales, innovations & politiques - Résumé des communications (2014, December 16)

Introduction : Le cancer du sein ainsi que ses traitements sont à l'origine de nombreux effets secondaires indésirables. L'objectif de l'étude est de déterminer les bénéfices éventuels, tant sur le plan ... [more ▼]

Introduction : Le cancer du sein ainsi que ses traitements sont à l'origine de nombreux effets secondaires indésirables. L'objectif de l'étude est de déterminer les bénéfices éventuels, tant sur le plan physique que psychologique, d’un programme de revalidation multidisciplinaire chez des femmes ayant été traitées pour un cancer du sein. Méthodologie : 122 patientes ont été recrutées, 61 faisant partie du groupe contrôle et 61 du groupe traité. Celui-ci a bénéficié d’une revalidation de trois mois comprenant un entraînement physique supervisé et diverses sessions psycho-éducatives. Les évaluations, effectuées avant et après la prise en charge, ont inclus des mesures anthropométriques et de composition corporelle, une évaluation des capacités fonctionnelles et différents questionnaires. Résultats : Au terme des trois mois, l’état de santé (qualité de vie), le rôle fonctionnel, l’état émotionnel et les fonctions physiques, cognitives et sociales s’améliorent significativement au sein du groupe traité. Cette observation s’applique également aux symptômes de fatigue, d'insomnie, de douleur, de dyspnée, de perte d'appétit, d’anxiété et de dépression ainsi qu'aux paramètres physiques obtenus par l'intermédiaire des évaluations fonctionnelles. Au sein du groupe contrôle, ces améliorations n’apparaissent pas et une augmentation significative de l'indice de masse corporelle et du pourcentage de graisse corporelle est observée. Conclusion : Cette étude préliminaire montre ainsi la faisabilité et les effets bénéfiques d’une prise en charge multidisciplinaire chez des femmes au terme de leurs traitements pour le cancer du sein. [less ▲]

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See detailProgramme de revalidation multidisciplinaire post-cancer du sein : analyse des bénéfices éventuels sur la fonction physique et la qualité de vie
LECLERC, Anne-France ULiege; FOIDART-DESSALLE, Marguerite ULiege; COUCKE, Philippe ULiege et al

in 29ème Congrès de la Sofmer et 19ème Congrès européen de Médecine Physique et de Réadaptation : Abstract book (2014, May 26)

Objective: To determine the potential benefits, both physically and psychologically, of a multidisciplinary rehabilitation program among women treated for breast cancer. Materials and Methods: Thirty ... [more ▼]

Objective: To determine the potential benefits, both physically and psychologically, of a multidisciplinary rehabilitation program among women treated for breast cancer. Materials and Methods: Thirty patients were recruited, sixteen in the control group and fourteen in the treated group. This group has benefited from a rehabilitation of three months including a supervised training and various psycho-educational sessions. The assessments, performed before and after the programme, included anthropometric and body composition measurements, a functional assessment and various questionnaires. Results: After three months, the health state (quality of life), emotional state, physical, cognitive and social functions and the symptoms of insomnia and anxiety significantly improve in the treated group. This observation also applies to the flexibility, maximal aerobic power / body weight, time to exhaustion during the physical effort test and walking distance in six minutes. In the control group, these improvements do not appear. Discussion: This preliminary study demonstrates the feasibility and benefits of a multidisciplinary approach in women after their treatments for breast cancer. [less ▲]

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See detailEtude longitudinale des besoins psychosociaux de personnes atteintes de cancer : Hiérarchisation et résolution de problème
Wagener, Aurélie ULiege; Jonius, Bénédicte; DEVOS, Martine ULiege et al

in Christophe, Véronique; Ducro, Claire; Antoine, Pascale (Eds.) Psychologie de la santé : Individu, famille et société (2014)

INTRODUCTION. L’existence et l’importance des besoins psychosociaux vécus par les conjoints de personnes atteintes de cancer ont été mises en évidence à plusieurs reprises. Afin de diminuer ces besoins ... [more ▼]

INTRODUCTION. L’existence et l’importance des besoins psychosociaux vécus par les conjoints de personnes atteintes de cancer ont été mises en évidence à plusieurs reprises. Afin de diminuer ces besoins, notre recherche-action teste l’efficacité de la combinaison de deux méthodes d’action : la hiérarchisation des besoins puis la résolution de problème ajustée à ces besoins. MÉTHODOLOGIE. Notre étude, longitudinale, randomisée, comporte trois temps d’évaluations séparés de trois semaines (T0, T1 et T2) et deux groupes (expérimental et contrôle). Au T0, les deux groupes réalisent la hiérarchisation des besoins. Entre T0 et T1, le groupe expérimental bénéficie de la résolution de problème. Entre T1 et T2, le groupe contrôle reçoit, à son tour, cette méthode. Les questionnaires administrés aux différents temps d’évaluation sont : données sociodémographiques, Hospital Anxiety and Depression Scale (HADS), Psychosocial Needs Inventory (PNI), questionnaire relatif au sentiment d’autoefficacité (GSES). HYPOTHESES. Entre T0 et T1, une amélioration générale des scores est attendue dans les deux groupes : celle-ci devrait s’avérer plus importante dans le groupe expérimental, ayant réalisé la résolution de problème. Entre T1 et T2, les scores du groupe contrôle, ayant alors pratiqué cette méthode, devraient s’améliorer et rejoindre ceux obtenus par le groupe expérimental au T1.RÉSULTATS. Trente-sept personnes ont accepté de participer : groupe expérimental (N=19, hommes=12, femmes=7) et groupe contrôle (N=18, hommes=11, femmes=7). Les groupes expérimental et contrôle présentent respectivement une moyenne d’âge de 59 et de 58 ans. Au T0, les scores moyens sur la HADS sont de 11,95 pour le groupe expérimental et de 13,94 pour le groupe contrôle ; le nombre moyen de besoins psychosociaux sur le PNI est de 29 dans les deux groupes ; les moyennes sur la GSES sont de 33,53 pour le groupe expérimental et de 32,33 pour le groupe contrôle. La récolte des données se poursuit et nous réaliserons des analyses de type ANOVA à mesures répétées afin d’évaluer les changements en fonction du temps (T0, T1 et T2) et du groupe (expérimental vs contrôle). [less ▲]

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See detailEtude longitudinale des besoins psychosociaux des conjoints de personnes atteintes d'un cancer : hiérarchisation et résolution de problème
Wagener, Aurélie ULiege; Jonius, Bénédicte; DEVOS, Martine ULiege et al

Poster (2012, December 18)

The existence and importance of psychosocial needs experienced by spouses of cancer patients have been demonstrated repeatedly. In order to reduce these needs, our study assesses the efficacy of the ... [more ▼]

The existence and importance of psychosocial needs experienced by spouses of cancer patients have been demonstrated repeatedly. In order to reduce these needs, our study assesses the efficacy of the combination of two psychotherapeutic methods: psychosocial needs' organisation into a hierarchy and problem solving. Our longitudinal and randomized study comprises three assessment times, separated from three weeks, (T0, T1 and T2) and two groups (experimental and control). At T0, both groups realize the hierarchy of needs. Between T0 and T1, only the experimental group practices problem solving. Then, between T1 and T2, the control group practices this method too. Questionnaires administered at each assessment time are: sociodemographic questionnaire, Hospital Anxiety and Depression Scale (HADS), Psychosocial Needs Inventory (PNI), self-efficacy questionnaire (GSES). Between T0 and T1, a general improvement in scores is expected in both groups: it is expected to be higher in the experimental group who completed the problem solving. Between T1 and T2, scores in the control group should improve to join those obtained by theexperimental group at T1. Thirty-seven people participated: experimental group (N=19, male=12, female=7) and control group (N=18, male=11, female=7). The results confirm our initial hypotheses and emphasize the importance of taking care of cancer patients' spouses. [less ▲]

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See detailMaintenance of Remission Among Patients With Crohn's Disease on Antimetabolite Therapy After Infliximab Therapy Is Stopped.
Louis, Edouard ULiege; Mary, J. Y.; Vernier-Massouille, G. et al

in Gastroenterology (2012), 142(1), 63-70531

BACKGROUND & AIMS: It is important to determine whether infliximab therapy can be safely interrupted in patients with Crohn's disease who have undergone a period of prolonged remission. We assessed the ... [more ▼]

BACKGROUND & AIMS: It is important to determine whether infliximab therapy can be safely interrupted in patients with Crohn's disease who have undergone a period of prolonged remission. We assessed the risk of relapse after infliximab therapy was discontinued in patients on combined maintenance therapy with antimetabolites and identified factors associated with relapse. METHODS: We performed a prospective study of 115 patients with Crohn's disease who were treated for at least 1 year with scheduled infliximab and an antimetabolite and had been in corticosteroid-free remission for at least 6 months. Infliximab was stopped, and patients were followed up for at least 1 year. We associated demographic, clinical, and biologic factors with time to relapse using a Cox model. RESULTS: After a median follow-up period of 28 months, 52 of the 115 patients experienced a relapse; the 1-year relapse rate was 43.9% +/- 5.0%. Based on multivariable analysis, risk factors for relapse included male sex, the absence of surgical resection, leukocyte counts >6.0 x 10(9)/L, and levels of hemoglobin </=145 g/L, C-reactive protein >/=5.0 mg/L, and fecal calprotectin >/=300 mug/g. Patients with no more than 2 of these risk factors (approximately 29% of the study population) had a 15% risk of relapse within 1 year. Re-treatment with infliximab was effective and well tolerated in 88% of patients who experienced a relapse. CONCLUSIONS: Approximately 50% of patients with Crohn's disease who were treated for at least 1 year with infliximab and an antimetabolite agent experienced a relapse within 1 year after discontinuation of infliximab. However, patients with a low risk of relapse can be identified using a combination of clinical and biologic markers. [less ▲]

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See detailMeta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
Anderson, Carl A; Boucher, Gabrielle; Lees, Charlie W et al

in Nature Genetics (2011), 43(3), 246-52

Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association ... [more ▼]

Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P < 5 x 10(-8)), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared association signals between Crohn's disease and ulcerative colitis. [less ▲]

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See detailEvidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis.
Laukens, Debby; Georges, Michel ULiege; Libioulle, Cécile ULiege et al

in PLoS ONE (2010), 5(11), 13795

BACKGROUND: A multicenter genome-wide association scan for Crohn's Disease (CD) has recently reported 40 CD susceptibility loci, including 29 novel ones (19 significant and 10 putative). To gain insight ... [more ▼]

BACKGROUND: A multicenter genome-wide association scan for Crohn's Disease (CD) has recently reported 40 CD susceptibility loci, including 29 novel ones (19 significant and 10 putative). To gain insight into the genetic overlap between CD and ankylosing spondylitis (AS), these markers were tested for association in AS patients. PRINCIPAL FINDINGS: Two previously established associations, namely with the MHC and IL23R loci, were confirmed. In addition, rs2872507, which maps to a locus associated with asthma and influences the expression of the ORMDL3 gene in lymphoblastoid cells, showed a significant association with AS (p = 0.03). In gut biopsies of AS and CD patients, ORMDL3 expression was not significantly different from controls and no correlation was found with the rs2872507 genotype (Spearman's rho: -0.067). The distribution of p-values for the remaining 36 SNPs was significantly skewed towards low p-values unless the top 5 ranked SNPs (ORMDL3, NKX2-3, PTPN2, ICOSLG and MST1) were excluded from the analysis. CONCLUSIONS: Association analysis using risk variants for CD led to the identification of a new risk variant associated with AS (ORMDL3), underscoring a role for ER stress in AS. In addition, two known and five potentially relevant associations were detected, contributing to common susceptibility of CD and AS. [less ▲]

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