Publications of Hernan Gonzalo VALDES SOCIN
Bookmark and Share    
See detailDommage Corporel: Endocrinologie
VALDES SOCIN, Hernan Gonzalo ULiege

Learning material (2022)

L’évaluation médico-légale d’un dommage corporel uniquement constitué par un déficit endocrinien est une éventualité rare. En effet, on note des problèmes difficiles d’imputabilité, compte tenu de ... [more ▼]

L’évaluation médico-légale d’un dommage corporel uniquement constitué par un déficit endocrinien est une éventualité rare. En effet, on note des problèmes difficiles d’imputabilité, compte tenu de l’existence possible, préalablement au fait incriminé, de déficits biologiques ignorés dont ce fait a précipité l’évolution. Ce cours est un complément d'endocrinologie en relation avec la réparation du dommage corporel, adressé aux futurs médecins expert . Nous abordons des sujets associés aux problèmes hypophysaires (hyper-hypo pituitarisme), thyroidiens (hyper-hypothyroidie-goitre et pathologie nodulaire) et surrénaliens (insuffisance surrénale iatrogène). La problématique de l'hypopituitarisme après un traumatisme cranien (accidents de roulage, accidents de voiture) est abordé en détail, suivant notre expérience clinique et les données plus récentes de la littérature. [less ▲]

Detailed reference viewed: 32 (1 ULiège)
Full Text
See detailAlterations in SLC4A2, SLC26A7 and SLC26A9 DriveAcid–Base Imbalance in Gastric Neuroendocrine Tumors and Uncover a Novel Mechanism for a Co-Occurring Polyautoimmune Scenario
Calvete, Oriol; Reyes, José; VALDES SOCIN, Hernan Gonzalo ULiege et al

in Cells (2021), 10

bstract:Autoimmune polyendocrine syndrome (APS) is assumed to involve an immune systemmalfunction and entails several autoimmune diseases co-occurring in different tissues of the samepatient; however ... [more ▼]

bstract:Autoimmune polyendocrine syndrome (APS) is assumed to involve an immune systemmalfunction and entails several autoimmune diseases co-occurring in different tissues of the samepatient; however, they are orphans of its accurate diagnosis, as its genetic basis and pathogenicmechanism are not understood. Our previous studies uncovered alterations in the ATPase H+/K+Transporting Subunit Alpha (ATP4A) proton pump that triggered an internal cell acid–base imbal-ance, offering an autoimmune scenario for atrophic gastritis and gastric neuroendocrine tumors withsecondary autoimmune pathologies. Here, we propose the genetic exploration of APS involvinggastric disease to understand the underlying pathogenic mechanism of the polyautoimmune scenario.The whole exome sequencing (WES) study of five autoimmune thyrogastric families uncovered differ-ent pathogenic variants in SLC4A2, SLC26A7 and SLC26A9, which cotransport together with ATP4A.Exploratoryin vitrostudies suggested that the uncovered genes were involved in a pathogenicmechanism based on the alteration of the acid–base balance. Thus, we built a custom gene panelwith 12 genes based on the suggested mechanism to evaluate a new series of 69 APS patients. In total,64 filtered putatively damaging variants in the 12 genes of the panel were found in 54.17% of thestudied patients and none of the healthy controls. Our studies reveal a constellation of solute carriersthat co-express in the tissues affected with different autoimmune diseases, proposing a unique geneticorigin for co-occurring pathologies. These results settle a new-fangled genetics-based mechanismfor polyautoimmunity that explains not only gastric disease, but also thyrogastric pathology and disease co-occurrence in APS that are different from clinical incidental findings. This opens a newwindow leading to the prediction and diagnosis of co-occurring autoimmune diseases and clinicalmanagement of patients. [less ▲]

Detailed reference viewed: 39 (6 ULiège)
Full Text
See detailInsuffisance Surrénalienne: mythe ou réalité ?
VALDES SOCIN, Hernan Gonzalo ULiege

Scientific conference (2021, December 04)

While studying three patient cases who died with idiopathic anemia Dr. Thomas Addison discovered at autopsy some alterations in the adrenal glands. He made a paper, which he communicated to the South ... [more ▼]

While studying three patient cases who died with idiopathic anemia Dr. Thomas Addison discovered at autopsy some alterations in the adrenal glands. He made a paper, which he communicated to the South London Medical Society on 15 March 1849: "On anemia: disease of the suprarenal capsules." He also noted that these patients are not pale but tanned: he then described the term "suprarenal melasma". Later, in 1855, he compiled eleven similar cases in a 39-page monograph: "On The Constitutional And Local Effects Of Disease Of The Supra-Renal Capsules" (1). The name of Addison's disease is given to the disease corresponding to a lack of hormone production by the adrenal glands. In 1896, William Osler showed that patients with Addison's disease could be treated by giving them fresh extracts of adrenal glands from animals (2). In this presentation addressed to general practitioners, we recall, the pathophysiology of central and peripheral adrenal insufficiency. We then describe the management of adrenal insufficiency. We end our presentation with the follow-up and prevention in patients with chronic adrenal insufficiency (3). Références Valdes Socin H. La Saga du cortisol (en préparation) 2021. Osler W. On six cases of Addison’s disease with the report of a case greatly benefited by the use of the suprarenal cortical extract. Int Med Magazine. 1896 Valdes Socin H. Insuffisance Surrénalienne: mythe ou réalité ? Hotel Tangla, Bruxelles 4.12.2021 [less ▲]

Detailed reference viewed: 37 (5 ULiège)
Full Text
See detailArt and Endocrinology
VALDES SOCIN, Hernan Gonzalo ULiege

Conference (2021, December)

Art and Endocrinology Dr H Valdes-Socin. Assistant Professsor of Physiopathology. University of Liège. Belgium Medicine requires scientific knowledge, but this probably is not enough to practice good ... [more ▼]

Art and Endocrinology Dr H Valdes-Socin. Assistant Professsor of Physiopathology. University of Liège. Belgium Medicine requires scientific knowledge, but this probably is not enough to practice good medicine. Indeed, medical schools are rediscovering that teaching the arts to medical students may help them to increase their observational skills and become more empathetic “to heal the sick and relieve suffering”. Therefore, art can also enrich the practice of endocrinology. In this workshop of endocrinology dedicated to internal medicine students, we challenge the students to exercise their diagnostic and empathetic skills. Through the observation of some famous paintings and the study of life and illness of some astonishing artists, we aim to develop both their observation and diagnostic skills. The painting of Mona Lisa was started by Leonardo da Vinci around 1503. Taking a close look, a yellow lump can be spotted in her left eyelid and a lipoma or xanthoma on the dorsum of her right hand. Did Mona Lisa suffered from hypercholesterolemia? The sfumato technique, combined with Mona Lisa’s sophisticated simplicity, exemplifies Da Vinci’s mastery as an artist and a compulsory anatomist. Five hundred years later, enigmatic Mona Lisa still continues to inspire Endocrinology and Art (1). Leonel Edmundo Rivero (1911 - 1986) was a one of the most famous Argentinean tango singers of the second half of the 20th century. A deep bass-baritone voice was his trademark, whereas most tango singers used to be tenors. Don Edmundo Rivero had huge hands and feet. He also had other symptoms which are typical of acromegaly like marked prognatism, diastema and visible nasolabial folds and he received treatment for acromegaly (2). James Victor Scott (1925 – 2014) was a famous afroamerican singer that suffered from Kallmann syndrome (3). Jimmy Scott never went through puberty. Because the late stages of puberty are associated with deep changes in speaking and singing fundamental voice frequency (4), his voice did not change when he reached adolescence. Critics admired his way of singing and his resilience after a life of adversity. His extraordinary feminine voice was still there, penetrating and clear, sorrowful and fragile. “All I needed was the courage to be me,” he told to his biographer. “That courage took a lifetime to develop.” Notre-Dame at the Rose Hospital, from Lessines, in Belgium, has among its collections an astonishing and unique work of its kind. The painting, an oil on wood (103 cm x 73.5 cm) from the end of the 16th century, represents "the Lamentation around the remains of Christ". Unexpectedly, restoration discovered an androgynous Christ, occulted under a layer of paint in the upper torso. Indeed, the painting shows some additional female characteristics of Christ, such as breasts, as well as hip feminine curves (4). Why did the anonymous painter gave to Christ both male and female characteristics? We discuss some artistic hypothesis and differential diagnosis of gynecomastia. Henri Marie Raymond de Toulouse-Lautrec Monfa (1864-1901) was an extraordinary French painter and artist. He was the eldest son of the Count Alphonse and the Countess Adèle de Toulouse-Lautrec. Their consanguinity was likely to have contributed to their son’s congenital dwarfism. Artistic legacy from Henri includes 737 paintings, 275 aquarelles and 369 posters immortalizing Belle Époque in Paris. Dr Pierre Marie, from Pitié-Salpêtrière Hospital, fixed in him the features of the dwarf with achondroplasic features. An alternative explanation for his illness was osteogenesis imperfecta. More recently, this constellation of signs has been related to pycnodysostosis, sometimes known as Toulouse-Lautrec Syndrome (6), that we will discuss during this endocrinology workshop. References 1. Valdes-Socin H. Leonardo Da Vinci: inspiring endocrinology and art since 500 years. J Endocrinol Invest. 2020 Mar;43(3):397-398. doi: 10.1007/s40618-019-01117-3. 2. Valdes-Socin H, Finck C, Beckers A. La voix acromégale. Tempo Médical Janvier 2020. p48-50. 3. Valdes-Socin H, Finck C. La voix du syndrome de Kallmann: Little Jimmy Scott (1925-2014). Tempo Médical fev 2019 p18-19. 4. Valdes-Socin H, Vuidar M. The androgyny of Christ. J Endocrinol Invest. 2021 May;44(5):1125. doi: 10.1007/s40618-020-01413-3. 5. Valdes-Socin H, De Herder WW, Beckers A. ENDOCRINOLOGY AND ART. The acromegalic voice of Tango: Don Edmundo Rivero. J Endocrinol Invest . 2015 Sep;38(9):1023-4. 6. Valdes-Socin H. The syndrome of Toulouse-Lautrec. J Endocrinol Invest. 2021 Sep;44(9):2013-2014. [less ▲]

Detailed reference viewed: 38 (12 ULiège)
Full Text
See detailIt’s all in their eyes: a three-generation family with branchio-oculo-facial syndrome (BOFS) reveals a heterozygous novel mutation in TFAP2A gene.
VALDES SOCIN, Hernan Gonzalo ULiege; ANDRIS, Cécile ULiege; CROMMEN, Jessica ULiege et al

in Acta Clinica Belgica (2021, December), 2(76), 27-29

Introduction: Ocular defects are important semiological clues for the internist, leading sometimes to diagnose a familial disease. Branchio-oculo-facial syndrome is a rare congenital disorder ... [more ▼]

Introduction: Ocular defects are important semiological clues for the internist, leading sometimes to diagnose a familial disease. Branchio-oculo-facial syndrome is a rare congenital disorder characterized by ophtalmic malformations, branchial skin defects and craniofacial anomalies. Ocular features include coloboma of choroid and/or iris, microphtalmia, cataract, ptosis and strabismus. We herein describe a new three-generation family with BOFS. Patients The proband (A) was the 67 years-old grandfather. He presented with a left eye coloboma and microcornea. His only 39 years-old son (B) was diagnosed as a baby with a left coloboma and microphtalmia, right pre axial polydactilia. As an adult, B had a craniopharyngioma treated with surgery and radiotherapy. The 6 years-old grand daughter (C) had a left coloboma and microphtalmia and a right kidney hydrophrosis. The sister D of the proband presented a branchial fistula and a melanoma and his son (E) had a prolactinoma. Because of this intriguing phenotype, an inherited anomaly closest to BOFS was suspected in this non consanguineous family. Genetic Studies In 2011, BMP4 gene study was unremarkable. In 2018 none PAX2 (coloboma-kidney sundrome) nor PAX6 gene mutation were found, among a panel of different 35 genes. Then, a panel of ocular developmental genetic anomalies was done in this family. Finally, a large MAC-ASD genetic panel found only in A, B and C patients an heterozygous frameshift variant in exon 2/7 of the TFAP2 gene: c.38-56 dup, p.(Ala20ArgfsTer149). This is a likely pathogenic variant (type IV), causing a mutation stop codon in exon 2 in transcription factor AP2-alpha gene (TFAP2A). Discussion TFAP2A mutations have been related with BOFS, ectopic thymus and anophthalmia-microphthalmia syndrome. Reported BOFS associated malformation are diverse and heterogeneous, like in most dominant diseases. We report a novel TFAP2A mutation in a three-generational BOFS affected family. TFAP2A is a retinoic acid response gene to direct ocular morphogenesis. It is localized on the minus strand of chromosome 6. In addition, two antisense non-coding RNA molecules have been identified. TFAP2A also regulates gene expression during embryogenesis of the eye, ear, face, body wall, limbs, kidney and neural tube in humans as well as in Tfap2 knockout mice embryos. A, B and C presented with coloboma whereas B had also right pre axial polydactilia. We thought to also study B and D for a TFAP2A mutation, because there is a down-regulation of AP-2α in some tumors (like hepatic carcinoma), with has an impact on Wnt/β-catenin pathway (like in craniopharyngiomas), and there is abolition of TFAP2A expression in melanoma. Intriguingly, D did not have the familial TFAP2 mutation although she had a melanoma and branchial fistula. Moreover, the presence of two unrelated pituitary tumors in B and E remain unexplained. TFAP2A mosaicism could not been excluded. [less ▲]

Detailed reference viewed: 18 (1 ULiège)
Full Text
See detailL’épopée de la transfusion sanguine citratée
VALDES SOCIN, Hernan Gonzalo ULiege

in Vaisseaux, Coeur, Poumons (2021), 26(6), 6-10

Albert Hustin communicates a new method of transfusion using a glucose-citrated mixture in Brussels on April 6, 1914. Working independently, Luis Agote also used the citrate method in Buenos Aires on ... [more ▼]

Albert Hustin communicates a new method of transfusion using a glucose-citrated mixture in Brussels on April 6, 1914. Working independently, Luis Agote also used the citrate method in Buenos Aires on November 14, 1914, and Lewisohn made his announcement in New York on January 23, 1915. During the Great War, this new method of citrated transfusion was not introduced into the medical services of the British Army until the end of 1917, by Oswald Robertson. Today, and with the hindsight of time, we can measure the importance of this heroic research. They have enabled the preservation of blood donations and the development of blood banks around the world. The epic of citrated blood transfusion made delayed blood transfusions possible, saving millions of human lives. [less ▲]

Detailed reference viewed: 48 (13 ULiège)
Full Text
See detailHypertension et Glandes Surrénales
VALDES SOCIN, Hernan Gonzalo ULiege

Scientific conference (2021, October 07)

Exposé sur le diagnostic et exploration de l'hypertension dépendante des différentes pathologies tumorales surrénaliennes destiné aux assistants de Cardiologie

Detailed reference viewed: 26 (5 ULiège)
Full Text
See detailHypercalcémie aggravée par l’administration de vitamine D chez un patient adulte révélant une mutation hétérozygote composite CYP24A1 : réponse et traitement à long terme par rifampicine.
Parotte, Marie Christine; VALDES SOCIN, Hernan Gonzalo ULiege; CAVALIER, Etienne ULiege

in Annales d'Endocrinologie (2021, October 01), 82

Cas clinique : un patient de 61 ans est hospitalisé avec une perte de poids (10kg) et une insuffisance rénale aigue. Il prenait de la vitamine D 800 UI/j depuis quelques mois. A l’admission : Calcium : 4 ... [more ▼]

Cas clinique : un patient de 61 ans est hospitalisé avec une perte de poids (10kg) et une insuffisance rénale aigue. Il prenait de la vitamine D 800 UI/j depuis quelques mois. A l’admission : Calcium : 4.2 mmol/L (2.1-2.5), PTH : 5ng/ml, PTH-Rp <20 pg/ml, 25-hydroxy-vitD3(cholécalciférol) : 76 ng/ml (<60), PO4 : 1.1 mmol/L (0.8-1.45), ACE <25, normo calciurie, pas de lithiases rénales. On note une ostéoporose lombaire et une ostéopénie fémorale sévère. Le PET scan corps entier exclu une lésion néoplasique. Une fibrose pulmonaire interstitielle idiopathique est décelée. Des prélèvements ganglionnaires excluent une sarcoïdose. L’hydratation, la calcitonine, les corticoïdes et l’acide zoledronique ne normalisent pas la calcémie. La 1,25-dihydroxy-vitD3(calcitriol) : 161 ng/ml (29-82) et le FGF23 : 284 pg/ml (23-95) font suspecter un déficit fonctionnel de la CYP24A1, enzyme responsable de la dégradation du cholécalciférol et du calcitriol. Une analyse génétique par NSG confirme une mutation hétérozygote de CYP24A1 combinant : c.62del (p.Pro21ArFs 8) et c.428_430 del (p.Glu143del), mutations décrites de classe V. Depuis 1 an, l’administration de rifampicine 300 mgx2/J permet de normaliser le bilan phosphocalcique : calcium 2.6 mmol/L, PTH 15 ng/ml, 1-25 vitD 46 pg/ml. Conclusions : Les mutations inactivantes de CYP24A1 sont une cause rare d’hypercalcémie : elles contre indiquent la supplémentation en vitamine D et l’exposition solaire. La rifampicine, inducteur enzymatique stimulant la CYP3A4 et favorisant le catabolisme des métabolites de vitamine D, est un traitement efficace et bien toléré pour cette affection (Hawkes & al. J ClinEndocMetab 2017). [less ▲]

Detailed reference viewed: 26 (2 ULiège)
Full Text
See detailMale and female hypogonadotropic hypogonadism associated with two novel non sense heterozygous mutations of Klotho beta gene (KLB)
VALDES SOCIN, Hernan Gonzalo ULiege; LIBIOULLE, Cécile ULiege; PETIGNOT, Sandrine ULiege et al

Poster (2021, September 17)

Clinical Case 1: A 15-year-old boy, with congenital deafness of the right ear, without olfaction disorders, consults for pubertal and growth retardation (1.59m, 47kg). Bone age of 14 years, GH: 6.4 ng/ml ... [more ▼]

Clinical Case 1: A 15-year-old boy, with congenital deafness of the right ear, without olfaction disorders, consults for pubertal and growth retardation (1.59m, 47kg). Bone age of 14 years, GH: 6.4 ng/ml after ITT, LHRH-stimulateable gonadotropins, testosterone-total 99ng/dl (28-1110 ng/dl). Pituitary MRI is normal. His father and sister had late puberty around the age of 16. The patient treated with GH and Sustanon, reaches 1.77m and 79 kg. At the age of 16, suffering from MS, like his father. At 18 years, the gonadic balance is re-evaluated, normal (bilateral testicular volume: 14 ml). Clinical case 2: A 30 years old woman (1.62m, 61 kg) consults for secondary amenorrhea and infertility after clomiphene stimulation. She is normal weighted. After some left hypoesthesic symptomatology, a brain neuro inflammatory pathology was suspected on MRI (several frontal hyper intense T2 lesions) without a precise diagnosis. No pituitary lesions were identified. During follow up, a normal pregnancy was obtained. She delivered a 3.3 kg girl in 2019 . Genetic analysis: A panel of 61 genes of hypogonadotropic hypogonadism found in case 1 an heterozygous variant KLB c.3092T>A, p.(Leu1031*). This new variant (likely pathogenic, class IV), causes the appearance of a premature stop codon in exon 5 of the KLB gene. In case 2, a novel mutation c.2230_2231insGGTT, p.(Ala744Glyfs*45) was confirmed, causing a frame shift and stop codon (since codon Ala744).. Discussion: We describe two novel non sense KLB mutations and for the first time, a reproductive phenotype in a female affected patient. In our series of 54 consecutive patients with congenital hypogonadotropic hypogonadism sequenced with a panel of 61 candidate genes, KLB mutations represents 3.7% . This prevalence is in line with the 4% finding of Xu. et al(EMBO Mol Med 2017). In the series of XU et al, patients with missense KLB mutations had (n= 9/13) a metabolic syndrome too, unlike our patients, carrying a nonsense mutation. In mice, the loss of the klb gene leads to delayed puberty, impaired estrogenic cycle, subfertility. The association with multiple sclerosis/brain inflammatory lesions is intriguing, so other family members will be studied. [less ▲]

Detailed reference viewed: 48 (4 ULiège)
Full Text
See detailLes petites tailles à tavers la peinture
VALDES SOCIN, Hernan Gonzalo ULiege

Scientific conference (2021, July 03)

Detailed reference viewed: 25 (7 ULiège)
Full Text
See detailChirurgie bariatrique associée à chirurgie cervicale et risque d'hypocalcémie: cas cliniques et révision de la littérature
VALDES SOCIN, Hernan Gonzalo ULiege

Scientific conference (2021, June 11)

A few recent series and several clinical cases document an increased risk of hypocalcemia in patients undergoing bariatric surgery after thyroidectomy. This hypocalcemia can be "resistant" to conventional ... [more ▼]

A few recent series and several clinical cases document an increased risk of hypocalcemia in patients undergoing bariatric surgery after thyroidectomy. This hypocalcemia can be "resistant" to conventional treatments, especially in case of documented hypo parathyroidism. During this presentation, we will discuss some clinical cases in light of the data available in the literature. In such cases, the risks and benefits of a bariatric intervention require, beforehand, a collegial and multidisciplinary discussion [less ▲]

Detailed reference viewed: 25 (7 ULiège)
Full Text
See detailLes hypercalcémies
VALDES SOCIN, Hernan Gonzalo ULiege

Scientific conference (2021, May 06)

Detailed reference viewed: 24 (3 ULiège)
Full Text
See detailHenri de Toulouse-Lautrec : l’artiste et sa maladie
VALDES SOCIN, Hernan Gonzalo ULiege

in Pharma-Sphère (2021), 264

Henri de Toulouse-Lautrec is the painter, draughtsman and lithographer who, through his works, reproduced for posterity the nightlife and dance of the Belle Époque, in Paris. Of fragile health and ... [more ▼]

Henri de Toulouse-Lautrec is the painter, draughtsman and lithographer who, through his works, reproduced for posterity the nightlife and dance of the Belle Époque, in Paris. Of fragile health and suffering from dwarfism, which some authors attribute to pycnodisostosis, Henri de Toulouse-Lautrec will have an extraordinary destiny: a short but intense life, which we try to retrace here. [less ▲]

Detailed reference viewed: 89 (5 ULiège)
Full Text
See detailLa Saga du Système Rénine-Angiotensine-Aldostérone
VALDES SOCIN, Hernan Gonzalo ULiege

Scientific conference (2021, March 20)

Abstract The renin-angiotensin-aldosterone system (RAAS) is an elegant cascade of hormones and enzymes regulating blood pressure. Its essential components were identified between the end of the 19th ... [more ▼]

Abstract The renin-angiotensin-aldosterone system (RAAS) is an elegant cascade of hormones and enzymes regulating blood pressure. Its essential components were identified between the end of the 19th century and the year 2000 (discovery of the conversion enzyme of type 2 angiotensin). As in any legend, the saga of the RAAS is punctuated by success but also the defeats of many researchers. In this historical review, we take the reader on a journey back in time to recall some of the highlights inspiring the discoveries of the RAAS.The current COVID-19 pandemic and the particular tropism of SARS CoV2 for the angiotensin II conversion enzyme (ACE-2) have put the spotlight back on the puzzle of the angiotensin aldosterone renin system [less ▲]

Detailed reference viewed: 172 (11 ULiège)
Full Text
See detailHypopituitarisme post TBI chez le patient âgé
VALDES SOCIN, Hernan Gonzalo ULiege

Scientific conference (2021, March 16)

Brain injuries namely traumatic brain injuries (TBI) and subarachnoid haemorrhage (SAH) are relevant causes of acquired adult hypopituitarism, perhaps more prevalent than ever believed. TBI represent a ... [more ▼]

Brain injuries namely traumatic brain injuries (TBI) and subarachnoid haemorrhage (SAH) are relevant causes of acquired adult hypopituitarism, perhaps more prevalent than ever believed. TBI represent a major health problem with an annual incidence of 300 cases per 100.000. SAH affects six new cases per 1.000.000 habitants in USA. In Belgium we estimate nearly 30.000 new TBI cases and 600 SAH cases per year. In the English literature, TBI secondary hypopituitarism has been well documented in retrospective and prospective series In this review, we analyze recent data and discuss diagnostic and treatment features of secondary hypopituitarism due TBI and SAH. [less ▲]

Detailed reference viewed: 31 (3 ULiège)
Full Text
See detailHypercalcémie pour le Gériatre
VALDES SOCIN, Hernan Gonzalo ULiege

Scientific conference (2021, March 09)

Symptoms of hypercalcemia include fatigue, depression, confusion, anorexia, thirst, constipation, increased urination. It can cause electrocardiogram (ECG) mainly short QT interval, and ... [more ▼]

Symptoms of hypercalcemia include fatigue, depression, confusion, anorexia, thirst, constipation, increased urination. It can cause electrocardiogram (ECG) mainly short QT interval, and electroencephalogram (EEG) changes, leading to ECG and EEG arrhythmias. Thus, severe hypercalcemia is a medical emergency, because it can cause cardiac arrest and epilepsy. In aging patients, hypercalcemia may be a manifestation of primary hyperpaathyroidism, cancer, prolonged bed resting, vitamine D intoxication, etc. Confirmatory diagnosis of primary hyperparathyroidism can be established by the presence of elevated parathormone levels, neck ultrasound and parathyroid CT scan and scintigraphy. Parathyroid adenomas respond well to surgical treatment. Medical treatment includes cinacalcet, a calcium sensing receptor agonist, that reduces PTH adenoma secretion and hypercalcemia. Biphosphonates and other bone-protective drugs can also help to control hypercalcemia. [less ▲]

Detailed reference viewed: 43 (5 ULiège)
Full Text
See detailLA CÉCITÉ DE JORGE LUIS BORGES
VALDES SOCIN, Hernan Gonzalo ULiege; ANDRIS, Cécile ULiege

in Pharma-Sphère (2021), 262

One of the most important Spanish-language writers of the 20th century, Jorge Luis Borges, suffered from chronic, progressive, debilitating blindness and hereditary, the precise diagnosis of which is not ... [more ▼]

One of the most important Spanish-language writers of the 20th century, Jorge Luis Borges, suffered from chronic, progressive, debilitating blindness and hereditary, the precise diagnosis of which is not mentioned in his writings. It is admitted, however, that the progression of his blindness influenced his work, becoming one of the central themes of his literature. In this brief overview, we return to some singular relationships between his illness and the creative process of his works. [less ▲]

Detailed reference viewed: 51 (7 ULiège)
Full Text
See detailHypogonadisme Hypogonadotrope Congénital - Symposium Maladies Rares
VALDES SOCIN, Hernan Gonzalo ULiege

Scientific conference (2021, February 26)

Detailed reference viewed: 27 (5 ULiège)
Full Text
See detailPhysiopathology for Biomedical Sciences: Endocrinology
VALDES SOCIN, Hernan Gonzalo ULiege

Learning material (2020)

The endocrine system relies on different endocrine axis to assure homeostasis and the control of reproduction, growth and metabolism. Several internal secretory glands function as different endocrine axis ... [more ▼]

The endocrine system relies on different endocrine axis to assure homeostasis and the control of reproduction, growth and metabolism. Several internal secretory glands function as different endocrine axis: the pituitary, the pineal gland, the thymus gland, the thyroid, four parathyroid glands, two adrenals, two gonads, the endocrine pancreas, the gastrointestinal endocrine cells, the adipose tissue and their specific secretions known as hormones. Endocrine glands present with high vascularization in order to secrete the hormones into circulatory system. They also receive regulatory signals (negative and positive feedbacks) from hormones and other signals (glucose, electrolytes, etc…). Hormones are chemical messengers secreted by endocrine glands, acting in autocrine, paracrine, or endocrine manner. These molecules may derive from aminoacids (for instance thyroid hormones, serotonin or melatonin), peptides (like insulin or thyrotropin hormone), steroids (mineralocorticoids, glucocorticoids and sexual steroids) or eicosanoids (such as prostaglandins). Their cellular actions depend on the binding of transmembrane or intracellular receptors, to bring about the effects on metabolism. The physiology and pathology of the endocrine system are the result of increased or decreased production of various hormones: these constitute hyper or hypofunction endocrine syndromes. It must also be taken into account the mass and distant effects caused by gland tumors and, rarely, their metastasis. We will review in this course differents aspects of endocrine physiopathology. [less ▲]

Detailed reference viewed: 61 (4 ULiège)