Publications of France LAMBERT
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See detailPractical considerations for reducing mortality rates in alloxan-induced diabetic rabbits
BACEVIC, Miljana ULiege; Rompen, Eric ULiege; RADERMECKER, Régis ULiege et al

in Heliyon (2020)

Chemically-induced diabetic animal models have been employed in many areas of diabetes mellitus (DM) research, but managing post-induction animal survival rates remains one of the main downsides. The aim ... [more ▼]

Chemically-induced diabetic animal models have been employed in many areas of diabetes mellitus (DM) research, but managing post-induction animal survival rates remains one of the main downsides. The aim of the present study was to propose a reliable approach to animal management and monitoring after DM induction in a rabbit model in order to reduce animal mortality rates. DM was induced by injecting alloxan in 12 New Zealand White rabbits. A preventive subcutaneous glucose administration to counteract a potentially lethal hypoglycemic phase following alloxan injection was performed on individual bases. Blood glucose level (BGL) was checked hourly for the first 36 hours, then every 2 hours until the hyperglycemic state was confirmed. All 12 rabbits survived a 48-hour post-induction phase. The critical hypoglycemic phase’s start points and duration differed significantly among the rabbits, lasting from 6.7 to 37 hours (19.75 ± 8.44). The rabbits entered the final hyperglycemic phase 18 hours at the earliest and 42 hours at the latest after induction (26.63 ± 7.07). The average daily BGLs throughout the study period ranged from 268 to 512 (413.73 ± 76.69). Eleven rabbits survived until the end of the experiment. The variability of rabbits’ responses to alloxan injection emphasizes the importance of monitoring rabbit behavior and thoroughly checking BGLs, followed by a preventive glucose administration based on rabbits’ individual needs for up to 36 hours after alloxan injection. The proposed approach seems to reduce animal mortality. [less ▲]

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See detailDeveloping a predictive empirical model to optimize biomaterials characteristics for intra-oral bone regeneration
Sadeghian Dehkord, Ehsan ULiege; Kerckhofs, Greet; Lambert, France ULiege et al

Scientific conference (2018, September 11)

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See detailImpact of biomaterial physical characteristics on bone regeneration: Comparison of three hydroxyapatites
LAMBERT, France ULiege; Bacevic, Miljana ULiege; Schupbach, P et al

Poster (2015, June 03)

Bone regeneration biomaterials with identical chemical compositions are frequently considered by clinicians as similar. However, the clinical performance of regenerative biomaterial may be influenced by ... [more ▼]

Bone regeneration biomaterials with identical chemical compositions are frequently considered by clinicians as similar. However, the clinical performance of regenerative biomaterial may be influenced by other parameters such as topographical properties. [less ▲]

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See detailPrimary prevention of peri-implantitis: Managing peri-implant mucositis
Jepsen, Søren; Berglundh, Tord; Genco, Robert et al

in Journal of Clinical Periodontology (2015), 42(S16), 152157

Abstract AIMS: Over the past decades, the placement of dental implants has become a routine procedure in the oral rehabilitation of fully and partially edentulous patients. However, the number of patients ... [more ▼]

Abstract AIMS: Over the past decades, the placement of dental implants has become a routine procedure in the oral rehabilitation of fully and partially edentulous patients. However, the number of patients/implants affected by peri-implant diseases is increasing. As there are--in contrast to periodontitis--at present no established and predictable concepts for the treatment of peri-implantitis, primary prevention is of key importance. The management of peri-implant mucositis is considered as a preventive measure for the onset of peri-implantitis. Therefore, the remit of this working group was to assess the prevalence of peri-implant diseases, as well as risks for peri-implant mucositis and to evaluate measures for the management of peri-implant mucositis. METHODS: Discussions were informed by four systematic reviews on the current epidemiology of peri-implant diseases, on potential risks contributing to the development of peri-implant mucositis, and on the effect of patient and of professionally administered measures to manage peri-implant mucositis. This consensus report is based on the outcomes of these systematic reviews and on the expert opinion of the participants. RESULTS: Key findings included: (i) meta-analysis estimated a weighted mean prevalence for peri-implant mucositis of 43% (CI: 32-54%) and for peri-implantitis of 22% (CI: 14-30%); (ii) bleeding on probing is considered as key clinical measure to distinguish between peri-implant health and disease; (iii) lack of regular supportive therapy in patients with peri-implant mucositis was associated with increased risk for onset of peri-implantitis; (iv) whereas plaque accumulation has been established as aetiological factor, smoking was identified as modifiable patient-related and excess cement as local risk indicator for the development of peri-implant mucositis; (v) patient-administered mechanical plaque control (with manual or powered toothbrushes) has been shown to be an effective preventive measure; (vi) professional intervention comprising oral hygiene instructions and mechanical debridement revealed a reduction in clinical signs of inflammation; (vii) adjunctive measures (antiseptics, local and systemic antibiotics, air-abrasive devices) were not found to improve the efficacy of professionally administered plaque removal in reducing clinical signs of inflammation. CONCLUSIONS: Consensus was reached on recommendations for patients with dental implants and oral health care professionals with regard to the efficacy of measures to manage peri-implant mucositis. It was particularly emphasized that implant placement and prosthetic reconstructions need to allow proper personal cleaning, diagnosis by probing and professional plaque removal. [less ▲]

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See detailThe effect of collagenated space filling materials in sinus bone augmentation: a study in rabbits
LAMBERT, France ULiege; Léonard, Angélique ULiege; Drion, Pierre ULiege et al

in Clinical Oral Implants Research (2013), 24(5),

Aim: The inclusion of biomaterial particles used for alveolar bone regeneration in a carrier or in binding agents such as collagen gel or fibers is of interest as a means to help with surgical handling ... [more ▼]

Aim: The inclusion of biomaterial particles used for alveolar bone regeneration in a carrier or in binding agents such as collagen gel or fibers is of interest as a means to help with surgical handling. However, the possible influence of collagen on bone tissue response to biomaterials is poorly studied. The objective of the present study was to investigate, in a sub-sinus bone augmentation model in rabbits, the effect of collagen at different stages of the osteogenesis process. Histologic, histomorphometric and volumetric analyses were performed. Materials and methods: Rabbits underwent a double sinus lift procedure using bovine hydroxyapatite (BHA), collagenated bovine hydroxyapatite (BHAColl), and prehydrated and collagenated porcine hydroxyapatite (PHAColl). Animals were sacrificed at 1 week, 5 weeks or 6 months. Samples were subjected to X-ray micro-tomography and histology. Qualitative analysis was performed on the non-decalcified sections and quantitative histomorphometric analyses were conducted using scanning electron microscopy (SEM). Volume variations of bone augmentations were calculated at different time points. Results: The three biomaterials allowed an optimal bone formation and were able to equally withstand sinusal reexpansion. A comparable percentage of new bone, as well as 3D volume stability, was found between the groups at each time point. However, the PHAColl resorption rate was significantly higher than the rates in other groups (P = 0.0003), with only 3.6% of the particles remaining at 6 months. At 1 week, both collagenated groups displayed the presence of inflammatory cells although BHA did not show any sign of inflammation. At 5 weeks and 6 months, the inflammatory process had disappeared completely in the BHAColl groups, whereas some inflammatory-like cells could still be observed around the remaining particles of PHAColl. Conclusions and clinical implications: Within the limitations of this study in rabbits, the findings showed the presence of inflammatory-like cells at the early stage of bone regeneration when collagenated xenogenic biomaterials were used compared to xenogenic granules alone. Nevertheless, similar bone formation occurred and comparable 3D volumes were found at 6 months in the different groups. [less ▲]

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See detailPrise en charge pluridisciplinaire d'une parodontite juvénile: Traitement Paro-Ortho-Prothétique
LAMBERT, France ULiege; ROMPEN, Eric ULiege

in Le point (2010), 218(Janvier -Février), 27-30

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See detailAugmentation osseuse sous-sinusienne : actualisation du concept du sinus lift.
Lambert, France ULiege; Lecloux, Geoffrey ULiege; Rompen, Eric ULiege

in Revue d'Odonto-Stomatologie (2008), 37(1), 3-17

L’élévation du plancher sinusal est une technique permettant de placer des implants d’une longueur suffisante au niveau du maxillaire postérieur. Depuis qu’elle a été initialement décrite dans les années ... [more ▼]

L’élévation du plancher sinusal est une technique permettant de placer des implants d’une longueur suffisante au niveau du maxillaire postérieur. Depuis qu’elle a été initialement décrite dans les années 80, cette technique a beaucoup évolué. A l’heure actuelle, on peut considérer cette approche comme prédictible, simple et réalisable au fauteuil sous anesthésie locale. Cet article vise d’abord à expliciter clairement le phénomène biologique du « sinus-lift », ensuite, de décrire le protocole chirurgical que nous appliquons à l’Université de Liège (Belgique) et de le confronter avec la littérature scientifique existante. [less ▲]

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