Publications of France LAMBERT
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See detailOne tooth-One time (1T1T), immediate loading of posterior single implants with the final crown: Two-year results of a case series.
LAMBERT, France ULiege; Eldafrawy, Maher ULiege; BEKAERT, Sandrine ULiege et al

in International Journal of Oral Implantology: Implantologist (in press)

AIMS: The aim of this study was to evaluate the two-year outcomes of the One Tooth-One Time (1T1T) completely digital workflow, allowing the immediate loading of a single implant in the posterior region ... [more ▼]

AIMS: The aim of this study was to evaluate the two-year outcomes of the One Tooth-One Time (1T1T) completely digital workflow, allowing the immediate loading of a single implant in the posterior region with a final CAD-CAM crown made of a polymer-infiltrated ceramic network (PICN). MATERIALS AND METHODS: A series of 10 implants were placed, and an intra-oral scan was taken after the surgery. A final screw-retained PICN crown was manufactured chair-side and placed the same day in full occlusion. Marginal peri-implant bone changes and soft-tissue health were evaluated, as well as restoration performance using World Dental Federation criteria and Pink and White Esthetic Scores. Patient-related outcome measures (PROMs) and time consumption data were collected. RESULTS: After two years, the implant survival rate was 100%. The debonding of one crown from its Titanium Base led to a 90% prosthodontic survival rate and the remaining crowns were all considered successful. The mean marginal peri-implant bone changes yielded 0.87 (SD: 0.96) and 0.55 (SD: 0.53) mm after one and two years, respectively. Mild or no inflammation of peri-implant soft tissue was observed in most implants. The overall treatment time reached 175 min and PROMs displayed high patient satisfaction. CONCLUSIONS: This study constitutes the first report considering immediate loading of a single implant in the posterior region with a final crown in occlusion. In this case-series, the two-year outcomes of the 1T1T protocol seem rather promising and fulfil patient expectations. However, those preliminary results need to be confirmed by randomized control trials and patient selection is probably a key factor in this procedure success. [less ▲]

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See detailClinical and Radiographic Assessment of Circular Versus Triangular cross-section neck Implants in the Posterior Maxilla: A 1-year Randomized Controlled Trial
LI MANNI, Lou ULiege; LECLOUX, Geoffrey ULiege; Rompen, Eric ULiege et al

in Clinical Oral Implants Research (in press)

Objectives: Implants with a triangular neck were recently introduced to limit peri-implant bone loss. The primary objective of this randomized controlled trial was to compare peri-implant bone changes of ... [more ▼]

Objectives: Implants with a triangular neck were recently introduced to limit peri-implant bone loss. The primary objective of this randomized controlled trial was to compare peri-implant bone changes of circular versus triangular cross-section neck implants 1-year after loading. The secondary objectives were to assess buccal hard tissue thickness changes, Pink Esthetic Score (PES) and patient satisfaction. Material and methods: Thirty four patients requiring replacement of the single, intercalated missing tooth of healed site for at least 4 months in the posterior maxilla were randomized into 2 groups according to the type of implant. Immediately after surgery and 1 year after final restoration, a cone beam CT (CBCT) was performed to assess proximal bone remodeling and buccal bone thickness. Peri-implant soft tissue health, PES and patient-reported outcome measures (PROMs) were recorded. Results: No implant loss occurred within the follow-up period. The mean ± SD peri-implant proximal bone loss 1-year after loading was 0.22 ± 0.30 mm for triangular and 0.42 ± 0.67 mm for circular implants necks (p=0.25). Peri-implant bone loss exceeding 2 mm was observed in a single implant in the circular neck group. Buccal bone thickness remained stable and did not differ different between the 2 groups. The peri-implant soft tissue health, PES and patient satisfaction were also comparable. Conclusions: Within the limitations of the present study, patient clinical and radiographic outcomes did not differ between triangular and circular cross-section neck implants in the posterior maxilla. [less ▲]

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See detailOral hygiene instructions and methods: a comparative survey of European general dentists, periodontists and dental hygienists
Garyga, Valentin; SEIDEL, Laurence ULiege; Gagnot, Gilles et al

in Oral Health and Preventive Dentistry (in press)

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See detailOral hygiene instructions and methods: a European survey among dental professionals – the eSIP study
Garyga, Valentin; SEIDEL, Laurence ULiege; Gagnot, Gilles et al

in Oral Health and Preventive Dentistry (in press)

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See detailUne approche en équipe pour retrouver le sourire
Mainjot, Amélie ULiege; Lambert, France ULiege

Conference (2020, October 18)

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See detailEsthétique implantaire et gestion des tissus dans le secteur antérieur.
Mainjot, Amélie ULiege; Lambert, France ULiege

Scientific conference (2020, September 25)

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See detailPractical considerations for reducing mortality rates in alloxan-induced diabetic rabbits
BACEVIC, Miljana ULiege; Rompen, Eric ULiege; RADERMECKER, Régis ULiege et al

in Heliyon (2020)

Chemically-induced diabetic animal models have been employed in many areas of diabetes mellitus (DM) research, but managing post-induction animal survival rates remains one of the main downsides. The aim ... [more ▼]

Chemically-induced diabetic animal models have been employed in many areas of diabetes mellitus (DM) research, but managing post-induction animal survival rates remains one of the main downsides. The aim of the present study was to propose a reliable approach to animal management and monitoring after DM induction in a rabbit model in order to reduce animal mortality rates. DM was induced by injecting alloxan in 12 New Zealand White rabbits. A preventive subcutaneous glucose administration to counteract a potentially lethal hypoglycemic phase following alloxan injection was performed on individual bases. Blood glucose level (BGL) was checked hourly for the first 36 hours, then every 2 hours until the hyperglycemic state was confirmed. All 12 rabbits survived a 48-hour post-induction phase. The critical hypoglycemic phase’s start points and duration differed significantly among the rabbits, lasting from 6.7 to 37 hours (19.75 ± 8.44). The rabbits entered the final hyperglycemic phase 18 hours at the earliest and 42 hours at the latest after induction (26.63 ± 7.07). The average daily BGLs throughout the study period ranged from 268 to 512 (413.73 ± 76.69). Eleven rabbits survived until the end of the experiment. The variability of rabbits’ responses to alloxan injection emphasizes the importance of monitoring rabbit behavior and thoroughly checking BGLs, followed by a preventive glucose administration based on rabbits’ individual needs for up to 36 hours after alloxan injection. The proposed approach seems to reduce animal mortality. [less ▲]

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See detailMaster Class Bone augmentation procedures.
LAMBERT, France ULiege

Conference (2020)

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See detailThe effects of abutment materials on peri-implant soft tissue integration
BACEVIC, Miljana ULiege; Dethier, Frédéric; Rompen, Eric ULiege et al

Poster (2020)

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See detailIn vitro and in vivo biocompatibility of calcium- phosphate scaffolds 3D printed by stereolithography for bone regeneration
Le Guéhennec, Laurent; Van hede, Dorien ULiege; Plougonven, Erwan ULiege et al

in Journal of Biomedical Materials Research. Part A (2019)

Stereolithography (SLA) is an interesting manufacturing technology to overcome limitations of commercially available particulated biomaterials dedicated to intra-oral bone regeneration applications. The ... [more ▼]

Stereolithography (SLA) is an interesting manufacturing technology to overcome limitations of commercially available particulated biomaterials dedicated to intra-oral bone regeneration applications. The purpose of this study was to evaluate the in vitro and in vivo biocompatibility and osteoinductive properties of two CaP-based scaffolds manufactured by SLA 3D printing. Pellets and macro-porous scaffolds were manufactured in pure hydroxyapatite (HA) and in biphasic CaP (HA:60-TCP:40). Physico- chemical characterization was performed using Micro X-ray Fluorescence (μXRF), Scanning Electron Microscopy (SEM), optical interferometry and microtomography (μCT) analyses. Osteoblast-like MG-63 cells were used to evaluate the biocompatibility of the pellets in vitro with MTS assay and the cell morphology and growth characterized by SEM and DAPI-actin staining showed similar early behavior. For in vivo biocompatibility, newly formed bone and biodegradability ofthe experimental scaffolds were evaluated in a subperiosteal cranial rat model using μCT and descriptive histology. The histological analysis has not indicated evidences of inflammation but highlighted close contacts between newly formed bone and the experimental biomaterials revealing an excellent scaffold osseointegration. This study emphasizes the relevance of SLA 3D printing of CaP-based biomaterials for intra-oral bone regeneration even if manufacturing accuracy has to be improved and further experiments using biomimetic scaffolds should be conducted. [less ▲]

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See detailBiocompatibility of stereolithography 3D-printed calcium-phosphate scaffolds for bone regeneration
Van hede, Dorien ULiege; le Guehennec, Laurent; Plougonven, Erwan ULiege et al

Conference (2019, June 20)

Objectives: The aim of this study was to evaluate the in vitrobiocompatibility and in vivobehaviors of two CaP based scaffolds manufactured by stereolithography (SLA) 3D printing technology. Methods ... [more ▼]

Objectives: The aim of this study was to evaluate the in vitrobiocompatibility and in vivobehaviors of two CaP based scaffolds manufactured by stereolithography (SLA) 3D printing technology. Methods: Pellets and macro-porous scaffolds were manufactured respectively for the in vitroand the in vivoexperiments both in pure hydroxyapatite (HA) and in biphasic CaP (HA:60-TCP:40.) The in vitro cytocompatibility was assessed by cell culture using a human osteoblastic-like cell line (MG-63). MTS assays were performed in order to evaluate cell viability. Additionally, the cell morphology and growth were characterized using SEM as well as DAPI and Actin staining. In vivobiocompatibility, newly formed bone and biodegradability of the experimental scaffolds were evaluated 3 and 6 months after implantation in a subperiosteal cranial rat model. The sample were subjected to microtomography for quantitative analyses and then, to paraffin histology for a descriptive analysis. Results: In vitro, cell viability over 75% was found in both group and no statistical difference was found between the 2 biomaterials (p= 0,07). The cells displayed similar behavior, in terms of morphology and cell growth, independently of the scaffold type. The in vivo experiments revealed an excellent osteointegration of the scaffolds and a very limited biodegradability. After 3 months, the bone volume inside pores achieved 72,78% (± 17,87%) and 60,76% (± 23,78%) respectively for HA and HA-TCP. The histological analysis did not reveal signs of inflammation and highlighted close contacts between newly formed bone and the experimental biomaterials. Conclusions: This study emphasized that SLA-3D printing of CaP based biomaterials might be relevant for intra oral bone regeneration. The cytocompatibility and in vivobiological performances in terms of graft dimensional stability and osseointegration was demonstrated. However, further experiments in larger models should be conducted. [less ▲]

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