Publications of Marie DETROZ
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See detailEye movement responses to caloric vestibular irrigations reveal the contribution of voluntary processes to autonomic reflexes
Koroma, Matthieu ULiege; Delcamp, Clément; Mortaheb, Sepehr ULiege et al

Scientific conference (2021, May 28)

Can autonomic reflexes inform us about higher-order cognitive processes ? To address this issue, we studied habituation (a form of non-associative learning) of the slow, uncontrolled eye movement response ... [more ▼]

Can autonomic reflexes inform us about higher-order cognitive processes ? To address this issue, we studied habituation (a form of non-associative learning) of the slow, uncontrolled eye movement response (nystagmus) following repetitive caloric (warm water) vestibular irrigation. After a 30s irrigation trial (total trials=6), participants (n=26) either kept their gaze fixated, or let their gaze free, testing voluntary adaptations of the nystagmus response measured with electrooculography (EOG). Participants also reported the intensity of the vertigo that they experienced after each irrigation. We found that the amplitude of the nystagmus response decreased over repetitive irrigations, revealing a clear habituation (repeated measures ANOVA with participants as random factor, F(5)=-18.8, p<0.001). We further showed that the amplitude of nystagmus is reduced after the gaze fixation condition compared to the freely moving gaze (interaction between irrigation and fixation, F(5,1)=5.1, p=0.025). Finally, by relying on a model comparison approach, we demonstrate that the oculomotor response holds partial information on the decrease of the vertigo experienced over successive irrigations, suggesting a bi-directional interaction between central and autonomic processes (Likelihood-ratio chi-squared test between mixed-models predicting vertigo response and including or excluding the duration of nystagmus, 𝜒2(12)=11.96, p=0.013). These findings suggest that reflexes carry partial information about voluntary processes. From the interoceptive active inference framework, these results might be relevant for evidencing signs of sentience when this cannot be communicated overtly. [less ▲]

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See detailENT Service during the COVID-19 pandemic: a cross-sectional study in 572 patients.
Peigneux, Nicolas ULiege; Benchimol, Lionel ULiege; BENDAVID, Guillaume ULiege et al

in B-ENT (2021), 16(4),

Objective: To provide objective data on the impact of COVID-19 crisis on our ENT practice. Methods: 572 consecutive patients presenting to the ENT clinic and ENT operating theatre from March 16, 2020 to ... [more ▼]

Objective: To provide objective data on the impact of COVID-19 crisis on our ENT practice. Methods: 572 consecutive patients presenting to the ENT clinic and ENT operating theatre from March 16, 2020 to May 3, 2020 were prospectively included. Demographic and clinical data, admission time, paraclinic testing, management, outcome and follow’up were recorded. Retrospective search for comparison to past year over the same period of time was carried out. Results: Coronavirus crisis and the strict lockdown rules led to a severe disruption of the ENT service. A drop in overall activity of 91.1% was observed ; compared to the 6,454 patients who had been treated in 2019 over the same period, appointments and procedures were restricted to 572 patients in this study. Mortality rates increased from 0.82% to 4.55%. While some patients in real need may not have been able to be seen, others presented without ground. More than a quarter of admissions (n=157, 27.6%) resulted in no specific ENT treatment. Patient selection improved when patients had a recent ENT history (OR=2.39 [1.50-3.81], p=0.0003) or were referred by a physician (OR=5.30 [3.69-7.61], p<0.0001). Conclusions: Our data suggested impaired healthcare of all ENT patients. Special attention should be paid to non-Covid otolaryngology patients. [less ▲]

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See detailHigh detection rate of osteoporosis with screening of a general hospitalized population: a 6-year study in 6406 patients in a university hospital setting.
Malaise, Olivier ULiege; Detroz, Marie ULiege; Leroy, Mathieu ULiege et al

in BMC Musculoskeletal Disorders (2020), 21(1), 90

BACKGROUND: Osteoporosis is a highly prevalent disease identified by Dual Energy X-ray Absorptiometry (DEXA) that can be performed in an ambulatory (out-patient) or hospitalized population. We evaluated ... [more ▼]

BACKGROUND: Osteoporosis is a highly prevalent disease identified by Dual Energy X-ray Absorptiometry (DEXA) that can be performed in an ambulatory (out-patient) or hospitalized population. We evaluated the use of baseline in-hospital DEXA screening to identify osteoporosis in ambulatory care and hospitalized patients; we also assessed specific risk factors for osteoporosis among these populations. METHODS: We included a baseline initial DEXA from 6406 consecutive patients at our tertiary referral University Hospital. RESULTS: Osteoporosis was diagnosed in 22.3% of the study population. In univariate analysis, osteoporosis risk factors were age, fracture history and low BMI (for all 3 sites), but also corticotherapy (lumbar spine and femoral neck) and male (lumbar spine). In multivariate analysis, age, fracture history, low BMI, and male increased osteoporosis risk. In-hospital screening yielded a higher percentage of osteoporosis positive scans than ambulatory care screening (31.8% vs 18.5%, p < 0.001). In-hospital screening targeted an older and more predominantly male population with a higher fracture history. Z-scores revealed that this difference was not only due to an older age of the population and mainly concerned cortical bone. CONCLUSIONS: In-hospital osteoporosis screening revealed more osteoporosis than screening in ambulatory practice and could be an additional tool to improve the identification and management of osteoporosis. In addition to typical risk factors, we identified male gender as associated with osteoporosis detection in our cohort. [less ▲]

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