Publications of Etienne CAVALIER
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See detailHypercalcémie aggravée par l’administration de vitamine D chez un patient adulte révélant une mutation hétérozygote composite CYP24A1 : réponse et traitement à long terme par rifampicine.
Parotte, Marie Christine; VALDES SOCIN, Hernan Gonzalo ULiege; CAVALIER, Etienne ULiege

in Annales d'Endocrinologie (2021, October 01), 82

Cas clinique : un patient de 61 ans est hospitalisé avec une perte de poids (10kg) et une insuffisance rénale aigue. Il prenait de la vitamine D 800 UI/j depuis quelques mois. A l’admission : Calcium : 4 ... [more ▼]

Cas clinique : un patient de 61 ans est hospitalisé avec une perte de poids (10kg) et une insuffisance rénale aigue. Il prenait de la vitamine D 800 UI/j depuis quelques mois. A l’admission : Calcium : 4.2 mmol/L (2.1-2.5), PTH : 5ng/ml, PTH-Rp <20 pg/ml, 25-hydroxy-vitD3(cholécalciférol) : 76 ng/ml (<60), PO4 : 1.1 mmol/L (0.8-1.45), ACE <25, normo calciurie, pas de lithiases rénales. On note une ostéoporose lombaire et une ostéopénie fémorale sévère. Le PET scan corps entier exclu une lésion néoplasique. Une fibrose pulmonaire interstitielle idiopathique est décelée. Des prélèvements ganglionnaires excluent une sarcoïdose. L’hydratation, la calcitonine, les corticoïdes et l’acide zoledronique ne normalisent pas la calcémie. La 1,25-dihydroxy-vitD3(calcitriol) : 161 ng/ml (29-82) et le FGF23 : 284 pg/ml (23-95) font suspecter un déficit fonctionnel de la CYP24A1, enzyme responsable de la dégradation du cholécalciférol et du calcitriol. Une analyse génétique par NSG confirme une mutation hétérozygote de CYP24A1 combinant : c.62del (p.Pro21ArFs 8) et c.428_430 del (p.Glu143del), mutations décrites de classe V. Depuis 1 an, l’administration de rifampicine 300 mgx2/J permet de normaliser le bilan phosphocalcique : calcium 2.6 mmol/L, PTH 15 ng/ml, 1-25 vitD 46 pg/ml. Conclusions : Les mutations inactivantes de CYP24A1 sont une cause rare d’hypercalcémie : elles contre indiquent la supplémentation en vitamine D et l’exposition solaire. La rifampicine, inducteur enzymatique stimulant la CYP3A4 et favorisant le catabolisme des métabolites de vitamine D, est un traitement efficace et bien toléré pour cette affection (Hawkes & al. J ClinEndocMetab 2017). [less ▲]

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See detailHow can the orthopedic surgeon ensure optimal vitamin D status in patients operated for an osteoporotic fracture?
Chevalley, T; Brandi, ML; Cavalier, Etienne ULiege et al

in Osteoporosis International (2021), 32(10), 1921-1935

In this narrative review, the role of vitaminD deficiency in the pathophysiology, healing of fragility fractures, and rehabilitation is discussed. Vitamin D status can be assessed by measuring serum 25(OH ... [more ▼]

In this narrative review, the role of vitaminD deficiency in the pathophysiology, healing of fragility fractures, and rehabilitation is discussed. Vitamin D status can be assessed by measuring serum 25(OH)-vitamin D level with standardized assays. There is a high prevalence of vitamin D insufficiency (25(OH)D < 50 nmol/l (i.e., 20 ng/mL)) or deficiency (25(OH)D < 25 nmol/l (i.e., 10 ng/mL)) in patients with fragility fractures and especially in those with a hip fracture. The evidence on the effects of vitamin D deficiency and/or vitamin D supplementation on fracture healing and material osseointegration is still limited. However, it appears that vitamin D have a rather positive influence on these processes. The fracture liaison service (FLS) model can help to inform orthopedic surgeons, all caregivers, and fractured patients about the importance of optimal vitamin D status in the management of patients with fragility fractures. Therefore, vitamin D status should be included in Capture the Fracture® program as an outcome of FLS in addition to dual-energy X-ray absorptiometry (DXA) and specific antiosteoporosis medication. Vitamin D plays a significant role in the pathophysiology and healing of fragility fractures and in rehabilitation after fracture. Correction of vitamin D deficiency should be one of the main outcomes in fracture liaison services. [less ▲]

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See detailProteinuria in COVID‑19: prevalence, characterization and prognostic role
HUART, Justine ULiege; BOUQUEGNEAU, Antoine ULiege; Lutteri, Laurence ULiege et al

in Journal of Nephrology (2021), 34(3), 355-364

Abstract Background Proteinuria has been commonly reported in patients with COVID-19. However, only dipstick tests have been frequently used thus far. Here, the quantifcation and characterization of ... [more ▼]

Abstract Background Proteinuria has been commonly reported in patients with COVID-19. However, only dipstick tests have been frequently used thus far. Here, the quantifcation and characterization of proteinuria were investigated and their association with mortality was assessed. Methods This retrospective, observational, single center study included 153 patients, hospitalized with COVID-19 between March 28th and April 30th, 2020, in whom total proteinuria and urinary α1-microglobulin (a marker of tubular injury) were measured. Association with mortality was evaluated, with a follow-up until May 7th, 2020. Results According to the Kidney Disease Improving Global Outcomes staging, 14% (n=21) of the patients had category 1 proteinuria (<150 mg/g of urine creatinine), 42% (n=64) had category 2 (between 150 and 500 mg/g) and 44% (n=68) had category 3 proteinuria (over 500 mg/g). Urine α1-microglobulin concentration was higher than 15 mg/g in 89% of patients. After a median follow-up of 27 [14;30] days, the mortality rate reached 18%. Total proteinuria and urinary α1-microglobulin were associated with mortality in unadjusted and adjusted models. This association was stronger in subgroups of patients with normal renal function and without a urinary catheter. Conclusions Proteinuria is frequent in patients with COVID-19. Its characterization suggests a tubular origin, with increased urinary α1-microglobulin. Tubular proteinuria was associated with mortality in COVID-19 in our restropective, observational study. [less ▲]

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See detailArguments for an age-adapted definition of chronic kidney disease
DELANAYE, Pierre ULiege; CAVALIER, Etienne ULiege

in Portuguese Journal of nephrology and hypertension (2021), 35(4), 261-262

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See detailIohexol plasma clearance: impact of weighing the syringe
DELANAYE, Pierre ULiege; Melsom, T; CAVALIER, Etienne ULiege et al

in Kidney International Reports (2021), 6(9), 2478-2480

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See detailComparison of plasma clearance with early-compartment correction equations and urinary clearance in high GFR ranges
DELANAYE, Pierre ULiege; Vidal-Petiot; Stehlé, T et al

in Kidney International Reports (2021), 6(6), 1622-1628

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See detailCA19.9 assays provide clinically different results for the patients
Schoneveld, Lauranne ULiege; LUKAS, Pierre ULiege; CAVALIER, Etienne ULiege et al

Poster (2020, November 20)

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See detailCarence en vitamine B12 : diagnostic et prise en charge
DELANNOY, Pauline ULiege; VRANKEN, Laura ULiege; CAVALIER, Etienne ULiege et al

in Tempo Médical (2020)

Les seuls êtres vivants capables de synthétiser la vitamine B12 (ou cobalamine) sont des bactéries filogénétiquement très anciennes, appelées archéobactéries. La cobalamine est pourtant essentielle pour ... [more ▼]

Les seuls êtres vivants capables de synthétiser la vitamine B12 (ou cobalamine) sont des bactéries filogénétiquement très anciennes, appelées archéobactéries. La cobalamine est pourtant essentielle pour l’homme. En effet, elle intervient en tant que coenzyme dans deux voies clés du métabolisme cellulaire aboutissant à la synthèse de l’ADN et de la méthionine, à partir de l’homocystéine. Une carence B12 est souvent observée chez les végétariens, les personnes âgées, les patients avec un bypass gastrique, avec une gastrite chronique auto-immune, les patients atteints de maladies inflammatoires intestinales ou traités par metformine, par exemple. Pour ces groupes à risque, il peut donc être justifié, surtout après des manifestations biologiques et cliniques, de prendre des compléments contenant de la vitamine B12, tout en veillant à des apports suffisants en acide folique. [less ▲]

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See detailLa chromatographie liquide couplée à un spectromètre de masse en tandem (LC-MS/MS) : une révolution dans le laboratoire de chimie clinique.
Cavalier, Etienne ULiege; Le Goff, Caroline ULiege

in Revue medicale de Liege (2020), 75(5-6), 457-459

Manual or automated immunoassays are largely used in clinical chemistry laboratories for measuring various compounds like steroid or peptide hormones. However, these methods can lack sensibility and ... [more ▼]

Manual or automated immunoassays are largely used in clinical chemistry laboratories for measuring various compounds like steroid or peptide hormones. However, these methods can lack sensibility and specificity. Hence, during this last decade, tandem-mess spectrometry coupled with liquid chromatography (LC-MS/MS) have emerged as a technique of choice to precisely quantify those molecules. However, these instruments remain quite expensive and need highly trained people. [less ▲]

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See detailIntense sport practices and cardiac biomarkers
LE GOFF, Caroline ULiege; Farre Segura, Jordi ULiege; Dufour, Patrice ULiege et al

in Clinical Biochemistry (2020), 79

Biomarkers are well established for the diagnosis of myocardial infarction, heart failure and cardiac fibrosis. Different papers on cardiac biomarker evolution during exercise have been published in the ... [more ▼]

Biomarkers are well established for the diagnosis of myocardial infarction, heart failure and cardiac fibrosis. Different papers on cardiac biomarker evolution during exercise have been published in the literature and generally show mild to moderate elevations. However, the mechanism responsible for these elevations, reflecting physiological or even pathophysiological changes, still has to be clearly elucidated. There are also indications of higher cardiac risk in poorly trained athletes than in well-trained athletes. Whether regular repetition of intensive exercise might lead, in the longer term, to fibrosis and heart failure remains to be determined. In this review, we summarized the main research about the effects of intense exercise (in particular, running) on cardiac biomarkers (including troponins, natriuretic peptides, etc.). We found that cardiac fibrosis biomarkers seemed to be the most informative regarding the biological impact of intense physical activity. [less ▲]

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See detailThe pathway through LC-MS method development: in-house or ready-to-use kit-based methods?
LE GOFF, Caroline ULiege; Farre Segura, Jordi ULiege; STOJKOVIC, Violeta ULiege et al

in Clinical Chemistry and Laboratory Medicine (2020)

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See detailMortality in malnourished older adults diagnosed by ESPEN and GLIM criteria in the SarcoPhAge study
Sanchez Rodriguez, Maria Dolores Carmen ULiege; Locquet, Médéa ULiege; Reginster, Jean-Yves ULiege et al

in Journal of Cachexia, Sarcopenia and Muscle (2020), 11(5), 1200-1211

Background: The Global Leadership Initiative on Malnutrition (GLIM) criteria have been recently launched by consensus of the major nutrition societies. GLIM criteria are partly constructed on the previous ... [more ▼]

Background: The Global Leadership Initiative on Malnutrition (GLIM) criteria have been recently launched by consensus of the major nutrition societies. GLIM criteria are partly constructed on the previous definition of malnutrition developed by the European Society of Clinical Nutrition and Metabolism (ESPEN). We aimed to assess malnutrition according to the ESPEN and GLIM criteria at baseline and to determine the corresponding risk of mortality during a 4-year follow-up in community-dwelling older adults from the SarcoPhAge (Sarcopenia and Physical Impairment with advancing Age) study. The relationship between malnutrition and incidence of 4-year adverse health consequences (institutionalization, hospitalization, falls, and fractures) was assessed. Methods: This prospective population-based cohort was part of SarcoPhAge, which included 534 older adults in Belgium, followed up from 2013 to 2019. Community-dwelling healthy volunteers ≥65 years old were recruited. Mortality and adverse health consequences were collected annually by interview or phone call. Baseline malnutrition was defined according to the GLIM and ESPEN criteria. Agreement between the two definitions was reported by Cohen's kappa coefficient. Adjusted Cox regression and Kaplan–Meier survival curves were performed for malnutrition. Logistic regression was used for the other outcomes. Results: From 534 subjects in SarcoPhAge, the records for 411 participants (73.2 ± 6.05 years old; 55.7% women) had all the variables needed to apply the GLIM criteria. Prevalence of baseline malnutrition was 23.4% for GLIM and 7% for ESPEN criteria (k = 0.30, low agreement). The adjusted Cox regression showed a significant increased mortality risk according to malnutrition status as defined by the GLIM [adjusted hazard ratio = 4.41 (95% confidence interval: 2.17–8.97)] and ESPEN [adjusted hazard ratio = 2.76 (95% confidence interval: 1.16–6.58)] criteria. Survival curves differed significantly between malnourished and non-malnourished groups, regardless of the definition used (log rank P < 0.001 for both). No association was found between baseline malnutrition according to these two criteria and 4-year risk of institutionalization, hospitalization, falls, or fractures (all P > 0.05). Conclusions: Malnutrition according to the GLIM criteria was associated with a 4.4-fold higher mortality risk, double that of the ESPEN criteria, during a 4-year follow-up. No association was found between malnutrition according to these two criteria and incidence of other health adverse consequences. GLIM criteria anticipate mortality and might guide interventions, with important implications for clinical practice and research. © 2020 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders [less ▲]

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See detailComparison of early-compartment correction equations for GFR measurements
DELANAYE, Pierre ULiege; Dubourg, Laurence; Flamant, Martin et al

in Kidney International Reports (2020), 5(7), 1079-1081

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See detailHow to manage osteoporosis before the age of 50
Rozenberg, S.; Bruyère, Olivier ULiege; Bergmann, P. et al

in Maturitas (2020), 138

This narrative review discusses several aspects of the management of osteoporosis in patients under 50 years of age. Peak bone mass is genetically determined but can also be affected by lifestyle factors ... [more ▼]

This narrative review discusses several aspects of the management of osteoporosis in patients under 50 years of age. Peak bone mass is genetically determined but can also be affected by lifestyle factors. Puberty constitutes a vulnerable period. Idiopathic osteoporosis is a rare, heterogeneous condition in young adults due in part to decreased osteoblast function and deficient bone acquisition. There are no evidence-based treatment recommendations. Drugs use can be proposed to elderly patients at very high risk. Diagnosis and management of osteoporosis in the young can be challenging, in particular in the absence of a manifest secondary cause. Young adults with low bone mineral density (BMD) do not necessarily have osteoporosis and it is important to avoid unnecessary treatment. A determination of BMD is recommended for premenopausal women who have had a fragility fracture or who have secondary causes of osteoporosis: secondary causes of excessive bone loss need to be excluded and treatment should be targeted. Adequate calcium, vitamin D, and a healthy lifestyle should be recommended. In the absence of fractures, conservative management is generally sufficient, but in rare cases, such as chemotherapy-induced osteoporosis, antiresorptive medication can be used. Osteoporosis in young men is most often of secondary origin and hypogonadism is a major cause; testosterone replacement therapy will improve BMD in these patients. Diabetes is characterized by major alterations in bone quality, implying that medical therapy should be started sooner than for other causes of osteoporosis. Primary hyperparathyroidism, hyperthyroidism, Cushing's syndrome and growth hormone deficiency or excess affect cortical bone more often than trabecular bone. © 2020 The Authors [less ▲]

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See detailClinical application of bone turnover markers in postmenopausal osteoporosis
Lorentzon, M.; Branco, J.; Brandi, M.L. et al

in Osteoporosis International (2020), 31(S1), 65-66

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See detailClinical Inference of Serum and Bone Sclerostin Levels in Patients with End-Stage Kidney Disease
De Maré, Annelies; Verhulst, Anja; CAVALIER, Etienne ULiege et al

in Journal of Clinical Medicine (2019), 8(12), 2027

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