Publications of Bita DEZFOULIAN
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See detailDermatite atopique
DEZFOULIAN, Bita ULiege

Conference (2021, October 28)

La dermatite atopique est une pathologie complexe et hétérogène avec de multiples présentations cliniques. Il est maintenant reconnu que ces variations sont en lien avec des profils génétiques et ... [more ▼]

La dermatite atopique est une pathologie complexe et hétérogène avec de multiples présentations cliniques. Il est maintenant reconnu que ces variations sont en lien avec des profils génétiques et immunologiques (ou endo-phénotypes), différents. On distingue ainsi la dermatite atopique extrinsèque ("allergique"), qui est associée à des hauts taux d'IgE sériques et qui s'inscrit dans un contexte de diathèse atopique à d'autres manifestations atopiques (rhino-conjonctivite allergique, asthme allergique et allergies alimentaires), de la dermatite atopique intrinsèque ("non allergique"), où le taux d'IgE sériques est normal et où il n'y a pas d'autre pathologie atopique associée. C'est la forme extrinsèque qui est la plus fréquente, touchant près de 80% des patients atteints de dermatite atopique. La dysfonction de la barrière cutanée retrouvée chez les patients atopiques, entraine non seulement la perte d'eau trans-épidermique mais, également, la pénétration de triggers environnementaux (allergènes, microorganismes et irritants divers) qui peuvent alors interagir avec le système immunitaire et provoquer le développement de diverses sensibilisations. Les allergènes alimentaires sont considérées comme le principal trigger externe de la dermatite atopique. A l'instar des allergènes alimentaires, les aéroallergènes peuvent éliciter des réactions d'hypersensibilités immédiates ou retardées chez les patients atopiques. Dermatite de contact allergique. La dermatite de contact allergique (DCA) est une réaction d'hypersensibilité retardée (type IV) survenant chez un individu préalablement sensibilisé aux haptènes. La sélection des allergènes est un processus critique et individuel à chaque patient, qui doit faire intervenir la localisation géographique, les expositions liées au métier ainsi qu'aux hobbys du patient ainsi que les autres expositions potentielles. [less ▲]

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See detailA rare malignant skin infiltrate
Bailleux, Sophie ULiege; Cao, Sandrine; DEZFOULIAN, Bita ULiege et al

Conference (2021, October)

A 9-month-old boy presented with urticaria-like cutaneous lesions. They appeared, for the first time, at the age of 5 months. The first clinical diagnosis was a mast cell disorder or urticaria pigmentosa ... [more ▼]

A 9-month-old boy presented with urticaria-like cutaneous lesions. They appeared, for the first time, at the age of 5 months. The first clinical diagnosis was a mast cell disorder or urticaria pigmentosa although antihistamines were not efficacious. Previously, the child was treated for thrombocytopenic purpura. A complete work up and systemic evaluation revealed severe thrombopenia. The bone marrow biopsy revealed no dyspoiesis in any of the cell lines. The final diagnosis was severe thrombocytopenic purpura in the context of an influenza-like syndrome. The treatment included systemic corticosteroids, sirolimus, rituximab, intravenous immunoglobulins and romiplostim. This immunosuppressive treatment led to a complete resolution of the skin lesions although recurrence was observed at treatment withdrawal. The clinical examination evidenced brownish and erythematous granulomatous plaques of the back, shoulders, face and thighs. A skin biopsy revealed a lymphoblastic infiltrate with blast cells sparing the dermis. Immunohistochemistry revealed a positivity for CD45, PAX5n CD79a, CD43 and CD34. The morphology and immunohistochemical profile were in favor of a cutaneous localization of an acute B-type lymphoblastic leukemia versus a B-type lymphoblastic lymphoma. The systemic workup showed no immunophenotyping abnormalities in the bone marrow and no malignant cells in the central nervous system but a tumefaction of both testicles. The testicular biopsy revealed an infiltration by a blastoid population expressing CD45, CD19 and CD34 whereas the cytogenetic revealed the presence of a partial 19p deletion and a MLL-AF10 rearrangement in 62% of nuclei. The child was treated by chemotherapy following the diagnosis of aleukemic leukemia cutis CD19+CD10-CD34+ CD20- with a testicular involvement and showed a good response. Aleukemic leukemia cutis is defined as a cutaneous infiltration of leukemic cells in the absence of both blood and bone marrow involvement. It is still not clear whether the malignant cells originate from the skin or spread from the bone marrow. The immature blast cells in the dermis and hypodermis clinically present as unspecific papules, nodules and plaques. Although rare and poorly characterized, recognition of this disease is important for early treatment. The management remains controversial. A diagnostic workup should include a blood test, bone marrow studies, FISH and cytogenetics. The treatment is similar as that for acute leukemia consisting in an induction and consolidation chemotherapy. [less ▲]

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See detailProduits iodés de contraste et réactions allergiques: Etat de la question et expérience liégeoise
DEZFOULIAN, Bita ULiege; Vanhakendover, Louise ULiege; BAGHAIE, Mahmoud ULiege

Scientific conference (2021, September 11)

Les examens radiologiques avec injection de PCI sont largement utilisés (>75 millions examens/an dans le monde) ; La fréquence des réactions allergiques est assez faible (1-3%/ administrations) ; La ... [more ▼]

Les examens radiologiques avec injection de PCI sont largement utilisés (>75 millions examens/an dans le monde) ; La fréquence des réactions allergiques est assez faible (1-3%/ administrations) ; La fréquence d'HS immédiate : 3,8-12,7% avec PCI ioniques, 0,7-3,1% PCI non ioniques ; Malgré tout, une mortalité due à une réaction anaphylactique existe (1/100 000-1/10 000 000). [less ▲]

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See detailLe phénomène de Köbner en Dermatologie
GIET, Gabrielle ULiege; SENTERRE, Yseult ULiege; LEBAS, Eve ULiege et al

in Revue Médicale de Liège (2021), 76(9), 651-656

Köbner's phenomenon and its related phenomena are dermatological curiosities that are still partially misunderstood. The Köbner phenomenon is by far the best known and the most studied. It is ... [more ▼]

Köbner's phenomenon and its related phenomena are dermatological curiosities that are still partially misunderstood. The Köbner phenomenon is by far the best known and the most studied. It is characterized as the appearance of an inflammatory or infectious dermatosis in an area of healthy skin after skin trauma. The dermatoses most frequently concerned are psoriasis, lichen planus and vitiligo. The inverse Köbner phenomenon and the Renbök phenomenon are two very similar phenomena. The first represents the disappearance of a skin lesion after skin trauma. The second is characterized by a skin trauma that is more specifically induced by another dermatosis. Finally, the Wolf's isotopic phenomenon corresponds to the appearance of a new dermatosis on an area of the skin that was previously the site of another healed dermatosis. [less ▲]

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See detailLe dupilumab diminue la fréquence et la sévérité des infections herpétiques chez les patients atteints de dermatite atopique
Libon, Florence ULiege; DEZFOULIAN, Bita ULiege; NIKKELS, Arjen ULiege

Conference (2021, May 27)

L'anticorps monoclonal dupilumab est un antagoniste de l'IL 4 et de l'IL 13, approuvé pour la dermatite atopique (DA) modérée à sévère. La DA est caractérisée, via les altérations structurelles de la ... [more ▼]

L'anticorps monoclonal dupilumab est un antagoniste de l'IL 4 et de l'IL 13, approuvé pour la dermatite atopique (DA) modérée à sévère. La DA est caractérisée, via les altérations structurelles de la barrière épidermique, par une susceptibilité accrue pour les infections cutanées virales et bactériennes. La littérature est cependant controversée au sujet de l'incidence des infections herpétiques récurrentes chez les patients ayant une DA traités par dupilumab. [less ▲]

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See detailA phalanx abnormality in a newborn
Jouret, Gaëlle ULiege; CAO, Sandrine ULiege; NIKKELS, Arjen ULiege et al

Conference (2021, January 23)

Case report : A two-month-old boy was referred to the dermatology outpatients for a nail disorder since birth. Surgical correction of a pyloric stenosis was his only medical history. Her mother had been ... [more ▼]

Case report : A two-month-old boy was referred to the dermatology outpatients for a nail disorder since birth. Surgical correction of a pyloric stenosis was his only medical history. Her mother had been treated with Metformin for a hyperinsulinism before the conception and during the pregnancy. The parents are not consanguineous. The clinical examination revealed anonychia of the right second toenail and micronychia of the left one. Left finger index showed micronychia and seemed shorter. Hai and eyebrows were normal. Patellas were palpated. X-ray was made and highlighted an insufficient development of the extremities of second fingers and toes. [less ▲]

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See detailComment je traite… le mycosis fongoïde : à propos du brentuximab védotine, une nouvelle arme thérapeutique
LEBAS, Eve ULiege; COLLINS, Patrick ULiege; BONNET, Christophe ULiege et al

in Revue Médicale de Liège (2021), 76(4), 224-231

Récemment, le brentuximab védotine (BV) (Adcetris®) a obtenu le remboursement en Belgique pour le traitement du lymphome cutané primitif de type mycosis fongoïde (MF), du lymphome anaplasique à larges ... [more ▼]

Récemment, le brentuximab védotine (BV) (Adcetris®) a obtenu le remboursement en Belgique pour le traitement du lymphome cutané primitif de type mycosis fongoïde (MF), du lymphome anaplasique à larges cellules et de la papulose lymphomatoïde de type A. Le BV est un anticorps monoclonal dirigé contre le CD30 exprimé par les cellules T tumorales. L’inhibition de cette voie de signalisation induit un processus d’apoptose et conduit à la mort cellulaire. Le BV est remboursé après l’échec d’un autre traitement systémique et lorsque le nombre de cellules T atypiques exprimant le CD30 en immunohistochimie excède 10 % de la population totale sur une biopsie cutanée. Le BV est administré par voie intraveineuse toutes les 3 semaines à la posologie de 1,8 mg/kg, avec un maximum de 16 cures. Les taux de réponse globale excèdent 75 %. Certains patients négatifs pour le CD30 ont également montré une réponse thérapeutique intéressante. Les principaux effets indésirables du BV sont la neutropénie et la neuropathie périphérique. Les cas de deux patients avec un MF de longue date et multi-résistant, ayant répondu favorablement au BV, sont présentés dans cet article. [less ▲]

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See detailAllergic reactions to COVID-19 vaccines: statement of the Belgian Society for Allergy and Clinical Immunology (BelSACI)
Tuyls, Sebastiaan; Van Der Brempt, Xavier; Faber, Margaretha et al

in Acta Clinica Belgica (2021)

Vaccination against COVID-19 constitutes a huge hope and a major challenge. For the first time in modern history, a global vaccination campaign has started worldwide in a short period of time and with ... [more ▼]

Vaccination against COVID-19 constitutes a huge hope and a major challenge. For the first time in modern history, a global vaccination campaign has started worldwide in a short period of time and with products that were recently developed. Consequently, legitimate concerns regarding the safety and tolerability of COVID-19 vaccines arise.In line with international allergy societies, the Belgian Society for Allergy and Clinical Immunology (BelSACI) provides this statement to guide health care providers (general practitioners, specialists including allergists) and stakeholders.In this statement, we first review current evidence on allergic reactions to vaccines and the potential risk factors that have been identified.Second, we provide a risk stratification method that may be used as a worksheet during the vaccination campaign.Finally, we discuss the management of suspected or confirmed allergic reactions following vaccination. [less ▲]

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See detailFixed Drug Eruption to Piroxicam : About two cases
Absil, Gilles ULiege; Libon, Florence ULiege; NIKKELS, Arjen ULiege et al

Conference (2020, October 24)

Clinical case 5: Erythème pigmenté fixe à propos de 2 cas.

Detailed reference viewed: 49 (3 ULiège)
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See detailCas clinique : La mastocytose cutanée pédiatrique.
VAN RYMENAM, Adeline ULiege; SACRE, Jean-Paul ULiege; DEZFOULIAN, Bita ULiege et al

in Revue medicale de Liege (2020), 75(10), 636-638

Mastocytosis are orphan diseases characterized by the accumulation of mast cells in one or more organs. A distinction is made between systemic forms (10 %) and pure cutaneous forms (90 %), the latter ... [more ▼]

Mastocytosis are orphan diseases characterized by the accumulation of mast cells in one or more organs. A distinction is made between systemic forms (10 %) and pure cutaneous forms (90 %), the latter being mainly pediatric and generally having a spontaneously favourable prognosis. In the absence of a systemic sign, the diagnostic criteria for cutaneous mastocytosis are Darier's sign, in principle, pathognomonic, as well as skin histology confirming mast cell infiltration. The treatment is essentially preventive (avoidance of factors triggering degranulation) and symptomatic (antihistamine agents). [less ▲]

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See detailAllergy to metacresol in a type 2 diabetes patient
COLSON, Fany ULiege; NIKKELS, Arjen ULiege; DEZFOULIAN, Bita ULiege

in Contact Dermatitis (2020), 82

Since the introduction of human insulin, the incidence of allergic reactions has decreased from 50% to 1%-2.4%. The culprit may be insulin or an excipient.

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See detailLes traitements actuels du psoriasis : de l’étanercept aux antagonistes anti-IL17 et -IL23
Libon, Florence ULiege; LEBAS, Eve ULiege; EL HAYDERI, Lara ULiege et al

in Revue Médicale de Liège (2020), 75(5-6), 376-381

Psoriasis is a chronic inflammatory skin disease affecting around 2-3 % of the population. The disease spectrum evolves from to the knees and elbows limited disease to erythrodermic psoriasis. The impact ... [more ▼]

Psoriasis is a chronic inflammatory skin disease affecting around 2-3 % of the population. The disease spectrum evolves from to the knees and elbows limited disease to erythrodermic psoriasis. The impact on the quality of life, the pruritus, the pain from palmo-plantar disease, arthropathic psoriasis and the comorbidities are the major complaints of the patients. The treatment relies on topical treatments with dermocorticosteroids with or without vitamin D derivatives, UVA or UVB phototherapy, conventional treatments including methotrexate, ciclosporin and acitretin, and, since around 15 years, biological treatments. The biological treatments for moderate to severe psoriasis progressed in a spectacular way with an improvement of clinical results and an amelioration of the safety profile at every step. This article discusses these developments from the TNFα antagonists, including etanercept, adalimumab and infliximab to the newly arrivals, the anti-IL17 and anti- IL23 antagonists, the anti-PDE-4 antagonists and the JAK inhibitors. [less ▲]

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See detailDUPIXENT (dupilumab) A New Era in the Treatment of Severe Atopic Dermatitis
DEZFOULIAN, Bita ULiege; Libon, Florence ULiege

Scientific conference (2020, February 20)

Program : Practical Management of Severe AD with Dupilumab ; Workshop : Diagnosis and Assessment of Atopic Dermatitis Using scoring Systems.

Detailed reference viewed: 52 (8 ULiège)
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See detailA hemangioendothelioma like no other...
GIET, Gabrielle ULiege; CAO, Sandrine ULiege; Willemaers, V. et al

Conference (2020, January 25)

Detailed reference viewed: 28 (1 ULiège)
See detailNouveaux traitements de la dermatite atopique
DEZFOULIAN, Bita ULiege

Conference (2019, November 16)

La dermatite atopique est une maladie inflammatoire chronique et systémique qui atteint la peau. Elle est caractérisée par un prurit persistant et un érythème intense. La dermatite atopique est associée à ... [more ▼]

La dermatite atopique est une maladie inflammatoire chronique et systémique qui atteint la peau. Elle est caractérisée par un prurit persistant et un érythème intense. La dermatite atopique est associée à une augmentation des risques d'infections cutanées et une réduction de la qualité de vie des patients. [less ▲]

Detailed reference viewed: 82 (6 ULiège)
See detailTables rondes "AbbVie en dermatologie"
Libon, Florence ULiege; NIKKELS, Arjen ULiege; DEZFOULIAN, Bita ULiege

Conference (2019, November 14)

Physiopathologie du psoriasis ; Nouvelles données cliniques ; Dermatite atopique et les options de traitement.

Detailed reference viewed: 38 (12 ULiège)
See detailAssessment of hypersentivity reactions to iodinated contrast medias : Monocentric retrospective study
Vanhakendover, Louise ULiege; NIKKELS, Arjen ULiege; DEZFOULIAN, Bita ULiege

in BCEDG - Belgian Contact and Environmental Dermatis Group (2019, October 19)

In recent years, there has been a marked increase in the number of patients referred for the suspicion of hypersensitivity reactions to iodinated contrast media (ICM). There are immediate reactions ... [more ▼]

In recent years, there has been a marked increase in the number of patients referred for the suspicion of hypersensitivity reactions to iodinated contrast media (ICM). There are immediate reactions occurring less than 1 hour and delayed reactions appearing from less than 1 hour up to 7 days, after ICM injection. Although rare, anaplylaxis to ICM could be lige-threatening. It is important to identify the offending product and refer the patient to safer alternatives. However, due to a lack of data on the negative predictive value of skin tests, recommendations for diagnostic tests remain controversial. [less ▲]

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See detailAssessment of immediate hypersensitivity reactions (IHSR) to iodinated contrast medias (ICM) : Retrospective study
Vanhakendover, Louise ULiege; NIKKELS, Arjen ULiege; DEZFOULIAN, Bita ULiege

in GOOD CLINICAL PRACTICE IN ALLERGOLOGY (2019, September 21)

The number of patients referred for HSR to ICM in increasing. Immediate reactions (<1h) are more commun. Although rare, anaphylaxis could be lifé-threatening. We should identify the offending product and ... [more ▼]

The number of patients referred for HSR to ICM in increasing. Immediate reactions (<1h) are more commun. Although rare, anaphylaxis could be lifé-threatening. We should identify the offending product and find safer alternatives. Unfortunately, recommendations for diagnostic tests remain controversial. [less ▲]

Detailed reference viewed: 33 (2 ULiège)
See detailPitfalls when reading the drug skin tests
DAMSIN, Thomas ULiege; NIKKELS, Arjen ULiege; DEZFOULIAN, Bita ULiege

in BelSACI Annual Symposium : GOOD CLINICAL PRACTICE IN ALLERGOLOGY (2019, September 21)

Detailed reference viewed: 27 (1 ULiège)