Publications of Jorge ARRESE ESTRADA
Bookmark and Share    
Full Text
See detailSimultaneous condylomata acuminata and squamous cell carcinoma of the penis with different HPV genotypes
LEBAS, Eve ULiege; DORMAL, Martin ULiege; Herfs, Michael ULiege et al

in European Journal of Dermatology (2019), 29(4), 433-435

Penile cancer occurs predominantly in elderly men and is associated with a high morbidity and mortality rate. Invasive penile squamous cell cancer (pSCC) accounts for around 90% of all penile cancers ... [more ▼]

Penile cancer occurs predominantly in elderly men and is associated with a high morbidity and mortality rate. Invasive penile squamous cell cancer (pSCC) accounts for around 90% of all penile cancers. pSCC is associated in about40%of the cases with the presence of high-risk human papillomaviruses (HR-HPV), in particular, the oncogenic genotypes. In general, in less differentiated SCC, the incidence of HR-HPV is lower than in well differentiated SCC. [less ▲]

Detailed reference viewed: 42 (7 ULiège)
Full Text
See detailEPIDERMODYSPLASIA VERRUCIFORMIS
Absil, Gilles ULiege; TASSOUDJI, Nazli ULiege; ARRESE ESTRADA, Jorge ULiege et al

Conference (2019, February 02)

Detailed reference viewed: 35 (2 ULiège)
Full Text
See detailGranulomatous reactions from tattoos following BRAF inhibitor therapy
GIET, Gabrielle ULiege; LEBAS, Eve ULiege; RORIVE, Andrée ULiege et al

in Case Reports in Dermatology (2019), 11

Detailed reference viewed: 35 (4 ULiège)
Full Text
See detailPachyderma in primary cutaneous NK and T-cell lymphoma and leukemia cutis
LEBAS, Eve ULiege; CHIAN, Cesar; TASSOUDJI, Nazli ULiege et al

in Case Reports in Dermatology (2017), 9(3), 151-157

Detailed reference viewed: 22 (2 ULiège)
Full Text
See detailNon-dermatophyte Dermatoses Mimicking Dermatophytoses in Humans
Libon, Florence ULiege; TASSOUDJI, Nazli ULiege; NIKKELS, Arjen ULiege et al

in Mycopathologia (2017), 182(1-2), 101-111

Human dermatophytic cutaneous infections usually present as single or multiple slowly progressing annular erythemato-squamous lesions with a tendency to central healing on the hairless skin. In the ... [more ▼]

Human dermatophytic cutaneous infections usually present as single or multiple slowly progressing annular erythemato-squamous lesions with a tendency to central healing on the hairless skin. In the intertriginous regions (feet, inguinal, axillar, submammary), dermatophytic colonisations and infections manifest as whitish, slightly hyperkeratotic, pruritic and sometimes fissurated lesions. On the scalp, dermatophytic infections commonly lead to single or multiple more or less inflammatory and alopecic lesions. On the plantar and palmar aspects of the feet and hand, dermatophytosis presents as an eczema-like chronic dermatosis. Abscess-like lesions may occur due to zoophilic dermatomycosis. Dermatophytic infections of the nails reveal ill-defined whitish-yellowish colorations of the distal end or the lateral aspects of the nails, sometimes combined with partial nail embrittlement or even complete destruction. Despite the ubiquity of dermatophytic skin infections and their usually highly typical clinical features, a differential diagnosis has to be considered, in particular when treatment is not efficient or when treatment resistance occurs. This review presents the differential diagnosis in terms of frequency as well as the diagnostic methods permitting the distinction of annular, intertriginous, alopecic, palmoplantar, abscess-like and onychodystrophic lesions. [less ▲]

Detailed reference viewed: 18 (3 ULiège)
Full Text
See detailEruptive Seborrheic Keratoses Restricted to Plaque/Patch-Stage Mycosis Fungoides
Quatresooz, Pascale ULiege; ARRESE ESTRADA, Jorge ULiege; Nikkels, Arjen ULiege et al

in Case Reports in Dermatology (2017)

Eruptive seborrheic keratoses (ESK) are rare in dermatology. They are usually inflammatory in nature and may be encountered as Leser-Trélat sign. ESK may also be simultaneously observed with hepatic ... [more ▼]

Eruptive seborrheic keratoses (ESK) are rare in dermatology. They are usually inflammatory in nature and may be encountered as Leser-Trélat sign. ESK may also be simultaneously observed with hepatic angiomas, chemotherapy, segmental neurofibromatosis, HIV or erythrodermic pityriasis rubra pilaris, psoriasis, and drug eruption. ESK may be transient and self-healing. Others recede after successful treatment of the underlying disease. In some instances, seborrheic keratoses may follow an isotopic response and remain strictly restricted to sites of previous eczema, photo-exposition or tattoos. A patient with patch/plaque lesions of classic-type mycosis fungoides (MF) presented sudden ESK that were exclusively limited to the MF lesions. In conclusion, this patient combined an isotopic response and ESK. © 2017 The Author(s). Published by S. Karger AG, Basel [less ▲]

Detailed reference viewed: 43 (7 ULiège)
Full Text
See detailProspective pilot evaluation of the efficacy and safety of topical ingenol mebutate gel for localized patch/plaque stage mycosis fungoides
CASTRONOVO, Charlotte ULiege; ARRESE ESTRADA, Jorge ULiege; Libon, Florence ULiege et al

in Open Dermatology Journal (2017), 11

Background: Mycosis Fungoides (MF) is the most frequent type of the primary cutaneous NK/T-cell lymphomas. Ingenol mebutate (IM) displays in vitro pro-apoptotic properties on neoplastic lymphocytes ... [more ▼]

Background: Mycosis Fungoides (MF) is the most frequent type of the primary cutaneous NK/T-cell lymphomas. Ingenol mebutate (IM) displays in vitro pro-apoptotic properties on neoplastic lymphocytes. Objectives: To evaluate the efficacy and safety of IM gel as topical treatment for MF. Materials and Methods: Ten male patients with longstanding classic type MF (n=9) and follicular MF (FMF; n=1), T2bN0M0B0, stage Ib, resistant to systemic methotrexate or acitretin therapies for at least 3 months, were included in this pilot study. In these patients, 11 target patch/plaque stage lesions with an area ≤ 25 cm2 were selected for IM therapy (0,05%, 2 weekly applications). The primary endpoint was the improvement of the CAILS scores. Biopsies were performed before and after treatment from 10 target lesions. Relapse rates were evaluated at 6 months. Results: The mean CAILS score of treated target lesions was reduced by 58.2%. The mean erythema, scaling and plaque elevation scores were improved by 73.6%, 93.9% and 97.9% (p<0.0001), respectively, while the lesion size remained unchanged (p=0.34). A complete or partial clearance of histological and immunohistochemical features was observed in 6/10 (60%) and 4/10 (40%) of the MF or FMF target lesions, respectively. Monoclonal TCR rearrangement was evidenced in 100% (7/7) of the patients and in 3/7 (43%) after treatment. The relapse rate at 6 months was 18%. All the patients experienced burning sensations, oozing and crusting. Conclusion: IM gel warrants further investigation and development as a potential topical treatment for localized patch/plaque stage MF and FMF. © 2017 Lebas et al. [less ▲]

Detailed reference viewed: 63 (16 ULiège)
Full Text
See detailNON-DERMATOPHYTE DERMATOSES MIMICKING DERMATOPHYTOSES IN HUMANS
Libon, Florence ULiege; TASSOUDJI, Nazli ULiege; DEZFOULIAN, Bita ULiege et al

in Mycopathologia (2016)

Human dermatophytic cutaneous infections usually present as single or multiple slowly progressing annular erythemato-squamous lesions with a tendency to central healing on the hairless skin. In the ... [more ▼]

Human dermatophytic cutaneous infections usually present as single or multiple slowly progressing annular erythemato-squamous lesions with a tendency to central healing on the hairless skin. In the intertriginous regions (feet, inguinal, axillar, submammary), dermatophytic colonisations and infections manifest as whitish, slightly hyperkeratotic, pruritic and sometimes fissurated lesions. On the scalp, dermatophytic infections commonly lead to single or multiple more or less inflammatory and alopecic lesions. On the plantar and palmar aspects of the feet and hand, dermatophytosis presents as an eczema-like chronic dermatosis. Abscess-like lesions may occur due to zoophilic dermatomycosis. Dermatophytic infections of the nails reveal ill-defined whitish-yellowish colorations of the distal end or the lateral aspects of the nails, sometimes combined with partial nail embrittlement or even complete destruction. Despite the ubiquity of dermatophytic skin infections and their usually highly typical clinical features, a differential diagnosis has to be considered, in particular when treatment is not efficient or when treatment resistance occurs. This review presents the differential diagnosis in terms of frequency as well as the diagnostic methods permitting the distinction of annular, intertriginous, alopecic, palmoplantar, abscess-like and onychodystrophic lesions. [less ▲]

Detailed reference viewed: 44 (10 ULiège)
Full Text
See detailLocalized Eruptive Blue Nevi after Herpes Zoster
COLSON, Fany ULiege; ARRESE ESTRADA, Jorge ULiege; NIKKELS, Arjen ULiege

in Case Reports in Dermatology (2016)

A 52-year-old White man presented with a dozen small, well-restricted, punctiform, asymptomatic, blue-gray macules on the left shoulder. A few months earlier, he had been treated with oral acyclovir for ... [more ▼]

A 52-year-old White man presented with a dozen small, well-restricted, punctiform, asymptomatic, blue-gray macules on the left shoulder. A few months earlier, he had been treated with oral acyclovir for herpes zoster (HZ) affecting the left C7–C8 dermatomes. All the blue macules appeared over a short period of time and then remained stable. The patient had not experienced any previous trauma or had tattooing in this anatomical region. The clinical diagnosis suggested blue nevi. Dermatoscopy revealed small, well-limited, dark-blue, compact, homogeneous areas evoking dermal blue nevi. An excisional biopsy was performed and the histological examination confirmed a blue nevus. As far as we are aware of, this is the first report of eruptive blue nevi following HZ, and it should be included in the differential diagnosis of zosteriform dermatoses responding to an isotopic pathway. In addition, a brief review concerning eruptive nevi is presented. [less ▲]

Detailed reference viewed: 30 (4 ULiège)
Full Text
See detailA One-year Survey of Microsporum audouinii infections in Belgium: epidemiological and genotypic characterisation
SACHELI, Rosalie ULiege; ADJETEY BAHUN, Akolé ULiege; DARFOUF, Rajae ULiege et al

in Clinical Microbiology and Infection (2016), 22(3), 2859-28517

During recent years the proportion of tinea capitis (TC) infections due to Microsporum audouinii (M. audouinii) has increased both in Belgium and other European countries. To better understand the ... [more ▼]

During recent years the proportion of tinea capitis (TC) infections due to Microsporum audouinii (M. audouinii) has increased both in Belgium and other European countries. To better understand the emergence of this species in the country, the Belgian National Reference Center (NRC) for dermatophytes launched an epidemiological survey on the main anthropophilic dermatophytes causing TC in Belgium and including the genomic characterization of M. audouinii isolates. In total, 116 strains of M. audouinii were confirmed and characterized by the DiversiLab® system (bioMérieux). Six genotypic variants were identified, among which one major group included 90 isolates and the reference strain. Another variant group (11 strains) was exclusively confined to a geographical region in South Belgium. Analysis of epidemiological characteristics of the infected population showed that the main age category concerned 5-9 year-old children with a sex ratio (Male/Female) of 1.97. Data concerning the geographic origin of the family revealed a majority of Belgian nationality (44.7%), suggesting that the contamination has originated in Belgium. Other nationalities primarily originated from Africa. At this time, no clear correlation has been established between one particular strain and a specific country of origin. [less ▲]

Detailed reference viewed: 88 (12 ULiège)
Full Text
See detailRISK FACTORS FOR SKIN INFECTIONS IN MYCOSIS FUNGOIDES
LEBAS, Eve ULiege; ARRESE ESTRADA, Jorge ULiege; NIKKELS, Arjen ULiege

in Dermatology (2016), 232(6), 731-737

Background: Mycosis fungoides (MF) is the most frequent type of primary cutaneous natural killer and T-cell lymphoma. MF-required immunosuppressive therapies and MF-related immunosuppressive ... [more ▼]

Background: Mycosis fungoides (MF) is the most frequent type of primary cutaneous natural killer and T-cell lymphoma. MF-required immunosuppressive therapies and MF-related immunosuppressive characteristics render patients with MF more prone to infections. Aim: To describe the clinical features of cutaneous infections observed in MF patients. Materials and Methods: A series of 56 MF patients were followed prospectively over 3 years and screened for cutaneous infections. Type of Study: Prospective observational study. Results: Four herpes simplex virus type-I (HSV-I), 2 staphylococcal (S. aureus) impetiginizations and 2 Malassezia infections were detected in single isolated plaque/patch stage MF as well as 1 varicella zoster virus infection (herpes zoster, HZ) and 2 cases of cellulitis in 10 patients. All patients presented advanced MF. All the diagnoses were delayed due to atypical clinical presentations. Conclusions: Patients with advanced MF should be particularly monitored for skin infections, especially by HSV and S. aureus. Unexplained exacerbation or the sudden appearance of oozing or ulcerations in MF lesions should initiate a search for viral or bacterial agents. Cellulitis and HZ can be severer and prolonged in MF patients. [less ▲]

Detailed reference viewed: 20 (6 ULiège)
Full Text
See detailLICHEN ET DERMATOSES LICHENOIDES - SPECTRE CLINIQUE ET BREF RAPPEL DE LA PRISE EN CHARGE
COLSON, Fany ULiege; CAO, Sandrine ULiege; MANSUY, Marion ULiege et al

in Skin (2016)

Bien connu dans sa forme typique, le lichen peut présenter des visages très variés dans ses formes atypiques (1-4). La reconnaissance de celles-ci est importante pour orienter le diagnostic et la prise en ... [more ▼]

Bien connu dans sa forme typique, le lichen peut présenter des visages très variés dans ses formes atypiques (1-4). La reconnaissance de celles-ci est importante pour orienter le diagnostic et la prise en charge. le mot lichen vient du Grec et signifie plante parasite. Le lichen a été décrit pour la première fois sous le nom de "lichen ruber" par Ferdinand Von Hebra en 1860. En effet, le réseau blanchâtre à la surface des lésions papuleuses ressemble au champignon lichen qui forme une symbiose avec un partenaire capable de photosynthèse (souvent une algue verte), généralement observée à la surface des rochers. L'appellation "lichen planus" a été proposée par Erasmus Wilson en 1866. Le lichen constitue le prototype de dermatoses lichénoïdes (Tableau 1). Ces maladies inflammatoires sont caractérisées, d'un point de vue clinique, par des lésions papuleuses et, d'un point de vue histologique, par un dense infiltrat lymphocytaire en bande dans le derme superficiel avec lésions des couches kératinocytaires inférieures de l'épiderme. [less ▲]

Detailed reference viewed: 247 (22 ULiège)
Full Text
See detailMelanoma masquerading as nomelanocytic lesions
DETRIXHE, Audrey ULiege; Libon, Florence ULiege; MANSUY, Marion ULiege et al

in Melanoma Research (2016)

Increased awareness among dermatologists as well as the development of dermoscopy and sequential dermoscopy have contributed significantly toward an increase in the diagnostic accuracy of pigmented ... [more ▼]

Increased awareness among dermatologists as well as the development of dermoscopy and sequential dermoscopy have contributed significantly toward an increase in the diagnostic accuracy of pigmented melanoma and even of amelanotic melanoma. However, the dermatologist's nightmare is the small group of melanomas that present as common skin diseases, often associated with a significant delay in diagnosis and hence a poor prognosis. The study was carried out to prospectively assess the number of melanomas lacking any clinical suspicion of melanoma and to describe their clinical and histological features over a 6-year observation period in an University Tertiary Skin Cancer Center. Out of 502 cases of newly diagnosed cases of melanoma, seven (1.4%) nonpigmented and nonamelanotic cases of melanoma were identified. The mean age of the patients was 69 years (two females/five males). All cases were discovered by chance on a punch biopsy. The clinical diagnostic suspicions were basal cell carcinoma, fungal intertrigo, keratoacanthoma, lichenoid keratoma, diabetic foot ulcer, eczema, and necrotic pressure ulcer. Dermoscopy, performed after the punch biopsies, was only partially contributive. The mean histological thickness was 2.7 mm, the mean number of mitoses was 7/mm, local micrometastases were present in 5/7 (71%), the mean Ki67 count was 18.9%, and a positive sentinel lymph node was observed in 4/6 (66%) cases. Nonpigmented and nonamelanotic melanomas are rare, are at high risk, and have a poor prognosis because of a delayed diagnosis. Dermoscopy is only of partial diagnostic aid. Treatment resistance or atypical behavior of the above-mentioned lesions should lead to biopsy. [less ▲]

Detailed reference viewed: 94 (25 ULiège)
Full Text
See detailEpidemiological aspects and genotypic characterization of T.violaceum strains collected during a Belgian National survey on anthropophilic tinea
SACHELI, Rosalie ULiege; Dekkers, Charlotte; GRAIDE, Hélène ULiege et al

in Mycoses (2015, October), 58(Supplement 4), 189

Objectives The last two years, clinical cases of tinea capitis caused by Trichophyton violaceum (T. violaceum), have been identified in Belgium. To better understand the emergence of this species in the ... [more ▼]

Objectives The last two years, clinical cases of tinea capitis caused by Trichophyton violaceum (T. violaceum), have been identified in Belgium. To better understand the emergence of this species in the population, the Belgian National Reference Center (NRC Liège) launched a one-year national survey in 2013. Epidemiological aspects and genotypic characterization of the strains were included. Methods The study was conducted from March 2013 up to February 2014. All Belgian laboratories were asked to send M. audouinii and T. violaceum strains isolated from hair to the NRC with a form to fill in including epidemiological data. The fungal strains were identified by microscopy or ITS sequencing in case of doubtful identification. The genotypic analysis was performed by the DiversiLab® system (bioMérieux) for DNA fingerprinting and analysis. Epidemiological data were analyzed with the help of a biostatistician. Results Amongst the collected isolates, 23 strains were confirmed as T.violaceum (results concerning the 116 M. audouinii strains have already been reported). Analysis of the epidemiological characteristics of the infected population shows that the main age category concerns 0-4 year-old children (n=9, 39,1%) with a sex-ratio M/F of 1.875. Data concerning the geographic origin of the family were present in 82,6% of the cases and reveal that patients were mainly of Ethiopian origin (n=8, 57,9% of known cases). One patient was also from Burundi showing that T. violaceum strains probably circulate mainly in East Africa. The genotypic analysis led to the distinction of 2 variants of T. violaceum. The major group was composed of 17 strains which were mainly collected in the North of Belgium and included also the reference strain (18/23, 83,3%). The other group (6 strains) was close to the major group but the analysis of the spectral superposition showed some differences between these two groups, defining two distinct variants of T. violaceum in the Belgian population. This second variant was mainly recovered from South Belgium (5/6, 83,3%). No correlation could be made between the genotypic group and a particular ethnical origin as Ethiopian subjects were found in both groups. Conclusion The DiversiLab® system proved to be an efficient method to investigate the molecular epidemiology of dermatophytes infections as reported previously for M. audouinii. These results show that two distinct isolates co-exist in Belgium providing evidence of genetic heterogeneity and a possible spread of one genotypic variant in a restricted geographic area or the co-existence of two variants circulating in different African communities. However, no clear correlation could be established between the appartenance to a group and epidemiological factors, such as age or ethnical origin. [less ▲]

Detailed reference viewed: 54 (20 ULiège)
Full Text
See detailEpidemiological aspects and genotypic characterization of strains of Microsporum audouinii isolated in the context of a Belgian National survey on anthropophilic tinea
SACHELI, Rosalie ULiege; Dekkers, Charlotte; DARFOUF, Rajae ULiege et al

Poster (2015, May)

Objectives The last two years, clinical cases of tinea capitis caused by Microsporum audouinii (M. audouinii), have increased in Belgium. To better understand the emergence of this species in the ... [more ▼]

Objectives The last two years, clinical cases of tinea capitis caused by Microsporum audouinii (M. audouinii), have increased in Belgium. To better understand the emergence of this species in the population, the Belgian National Reference Center (NRC) for dermatophytes launched a national survey in 2013. Epidemiological aspects and genotypic characterization of the strains were included. Methods The study was conducted from March 2013 up to February 2014. All Belgian laboratories were asked to send M. audouinii strains isolated from hair to the NRC with a form to fill in including epidemiological informations. The fungal strains were identified by microscopy or ITS sequencing in case of doubt. The genotypic analysis was performed by the DiversiLab® system (bioMérieux) for DNA fingerprinting and analysis. Epidemiological informations were analyzed with the help of a biostatistician. Results Among the collected isolates, 117 strains have been currently confirmed as M. audouinii. Analysis of the epidemiological characteristics of the infected population shows that the main age category concerns 5-9 year-old children (64%, p< 0,0001) with a sex-ratio M/F of 1.97. Data concerning the geographic origin of the family have been obtained in only 33,6% of the cases. It reveals that strains have been mainly isolated from patients with a Belgian nationality (43,6%) suggesting bias in the data collection. The geographic origin of the remaining group includes several African countries such as Congo (20,61%), Guinea (12,8%) and Burundi (5,12%). The genotypic analysis led to the distinction of 6 genotypic variants of M. audouinii. One of these variants was exclusively recovered from South Belgium (11 strains). The major group was composed of 96 strains, well distributed in different Belgium locations. Two other groups of three strains each were close to the major group but the analysis of the spectral superposition showed some differences between these groups. The two last groups were clearly different from the major group but species identification was confirmed by ITS sequencing. Conclusion The results of the genomic analysis by Diversilab, show that several groups of M. audouinii isolates co-exist in Belgium providing evidence of genetic heterogeneity. However, no clear correlation could be established between the appartenance to a group and epidemiological factors, such as the age or ethnical origin. ________________________________________ [less ▲]

Detailed reference viewed: 112 (22 ULiège)
Full Text
See detailLes kératoses actiniques : généralités
Libon, Florence ULiege; TASSOUDJI, Nazli ULiege; DEZFOULIAN, Bita ULiege et al

in Skin (2015)

Les kératoses actiniques représentent un motif fréquent, et toujours croissant, de consultation en dermatologie. Cet ensemble d'articles résume l'histoire naturelle de cette affection, rappelant la ... [more ▼]

Les kératoses actiniques représentent un motif fréquent, et toujours croissant, de consultation en dermatologie. Cet ensemble d'articles résume l'histoire naturelle de cette affection, rappelant la définition, l'évolution, la pathogenèse, l'épidémiologie, les facteurs de prédisposition, de transformation maligne, la topographie, les manifestations cliniques, les caractéristiques histologiques et le diagnostic différentiel. Dans un deuxième article sont passées en revue les différentes options thérapeutiques, leurs avantages et leurs inconvénients, et la gestion du patient atteint de kératoses actiniques en pratique quotidienne. [less ▲]

Detailed reference viewed: 18 (1 ULiège)