Publications of Jean-Marie KRZESINSKI
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See detailRenal function assessment is part of endovascular aortic aneurysm repair and its follow up.
KERZMANN, Arnaud ULiege; KRZESINSKI, Jean-Marie ULiege; Sakalihasan, Natzi ULiege et al

in Annals of Vascular Medicine and Research (2020), 7(3), 1113

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See detailThe European/International Fibromuscular Dysplasia Registry and Initiative (FEIRI)—clinical phenotypes and their predictors based on a cohort of 1000 patients.
pappaccogli, marco; Di Monaco, Silva; Warchot-Celinska, Ewa et al

in Cardiovascular Research (2020)

Aims : Since December 2015, the European/International Fibromuscular Dysplasia (FMD) Registry enrolled 1022 patients from 22 countries. We present their characteristics according to disease subtype, age ... [more ▼]

Aims : Since December 2015, the European/International Fibromuscular Dysplasia (FMD) Registry enrolled 1022 patients from 22 countries. We present their characteristics according to disease subtype, age and gender, as well as predictors of widespread disease, aneurysms and dissections. Methods and results : All patients diagnosed with FMD (string-of-beads or focal stenosis in at least one vascular bed) based on computed tomography angiography, magnetic resonance angiography, and/or catheter-based angiography were eligible. Patients were predominantly women (82%) and Caucasians (88%). Age at diagnosis was 46 ± 16 years (12%>_65 years old), 86% were hypertensive, 72% had multifocal, and 57% multivessel FMD. Compared to patients with multifocal FMD, patients with focal FMD were younger, more often men, had less often multivessel FMD but more revascularizations. Compared to women with FMD, men were younger, had more often focal FMD and arterial dissections. Compared to younger patients with FMD, patients >_65 years old had more often multifocal FMD, lower estimated glomerular filtration rate and more atherosclerotic lesions. Independent predictors of multivessel FMD were age at FMD diagnosis, stroke, multifocal subtype, presence of aneurysm or dissection, and family history of FMD. Predictors of aneurysms were multivessel and multifocal FMD. Predictors of dissections were age at FMD diagnosis, male gender, stroke, and multivessel FMD. Conclusions : The European/International FMD Registry allowed large-scale characterization of distinct profiles of patients with FMD and, more importantly, identification of a unique set of independent predictors of widespread disease, aneurysms and dissections, paving the way for targeted screening, management, and follow-up of FMD. [less ▲]

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See detailThe purple urine bag syndrome
VANDERWECKENE, Pauline ULiege; COUNASSE, Christiane; KRZESINSKI, Jean-Marie ULiege

in Global Imaging Insights (2020), 5

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See detailGestion de l’hyperkaliémie lors d’un traitement par inhibiteur du système réinine-angiotensine-aldostérone
KRZESINSKI, Jean-Marie ULiege; van der schueren, Thierry

in Revue de la Médecine Générale (2020), 369

Hyperkalemia is common in patients with chronic renal failure (CKD), diabetes and/or cardiac decompensation (CD) and increases when taking inhibitors of the renin-angiotensin-aldosterone system. Besides ... [more ▼]

Hyperkalemia is common in patients with chronic renal failure (CKD), diabetes and/or cardiac decompensation (CD) and increases when taking inhibitors of the renin-angiotensin-aldosterone system. Besides dietetics, the use of intestinal potassium chelators is frequent but often poorly tolerated. Recently, a new potassium chelator appears to be promising. [less ▲]

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See detailNouveautés dans la prise en charge de l'hypertension artérielle dans la dernière décennie
KRZESINSKI, Jean-Marie ULiege; SAINT-REMY, Annie ULiege

in Revue Médicale de Liège (2020), 75(5-6), 329-335

Hypertension remains one of the most important cardiovascular risk factors. In spite of many efforts for its management, the control of high blood pressure remains insufficient. In the last decade, no new ... [more ▼]

Hypertension remains one of the most important cardiovascular risk factors. In spite of many efforts for its management, the control of high blood pressure remains insufficient. In the last decade, no new antihypertensive drug was released. The main effort to improve blood pressure control was put on the validation of the hypertensive status, the stimulation of home blood pressure measurement and the therapeutic education of the patients. The releasing in 2018 of new guidelines, which are clear and more simple, would help more efficiently fight against hypertension, the still present silent killer. In Europe, the usual blood pressure target has been kept, i.e.a lowering of blood pressure below 140/90 mmHg in all fit patients whatever their age. Lower target could be proposed according to the patient tolerance. Treatment is decided according to cardiovascular risk evaluation. Quickly a combination of two antihypertensive agents in a single pill is proposed to improve efficacy of the treatment. We also need the help of the family, nurses and pharmacists to increase the chance of a better blood pressure control, which is necessary to get an optimal cardiovascular protection. [less ▲]

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See detailNouveautés thérapeutiques en Néphrologie : 10 ans d'avancées
BOVY, Christophe ULiege; DELANAYE, Pierre ULiege; JOURET, François ULiege et al

in Revue Médicale de Liège (2020), 75(5-6), 336-343

Chronic kidney disease (CKD) impairs the quality of life and increases the risk for cardiovascular morbimortality. Intensive research is conducted in order to slow down CKD development and progression ... [more ▼]

Chronic kidney disease (CKD) impairs the quality of life and increases the risk for cardiovascular morbimortality. Intensive research is conducted in order to slow down CKD development and progression. During the past decade, a better understanding of the pathophysiological mechanisms of glomerular diseases has highlighted the benefits of rituximab. Progresses have also been made in the understanding of the mechanisms of autosomal polycystic kidney disease, the most frequent inherited kidney disease. These observations led to the discovery and validation of tolvaptan, a blocker of the V2 receptor of the antidiuretic hormone as an innovative treatment. Type 2 diabetic disease is the leading cause worldwide of endstage kidney disease and dialysis. The development of new drugs, such as the gliflozins (inhibiting the sodium glucose reabsorption in the proximal tubule), has contributed to an improvement in the management of the cardiovascular and renal risks especially reducing congestive heart failure rate. Another important progress in nephrology since the beginning of the new century concerns a more precise estimation of the kidney function, which allows to better evaluate the slope of CKD progression and test the influence of different therapeutic approaches aiming at correcting anemia, hyperkalemia, metabolic acidosis and disturbances of calcium and phosphate. The present review summarizes all of these major advances in the field of CKD diagnosis and treatment, and envisions the future of nephrology for the next decade. [less ▲]

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See detailHow to Reduce the Risk of Acute Kidney Injury in Abdominal Aortic Aneurysm Surgery: The Quest of the Grail.
KRZESINSKI, Jean-Marie ULiege; Sakalihasan, Natzi ULiege; DEFRAIGNE, Jean ULiege

in European Journal of Vascular and Endovascular Surgery (2020), 59

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See detailArgument en faveur d'un rôle du microbiote intestinal dans la physiopathologie de l'hypertension artérielle
HUART, Justine ULiege; KRZESINSKI, Jean-Marie ULiege; JOURET, François ULiege

in Revue Médicale de Liège (2020), 75(9), 588-592

The gut microbiota refers to the community of microorganisms living in the mammalian digestive tract. Over the past decades, numerous preclinical and clinical studies have suggested that gut microbiota is ... [more ▼]

The gut microbiota refers to the community of microorganisms living in the mammalian digestive tract. Over the past decades, numerous preclinical and clinical studies have suggested that gut microbiota is involved in the physiological homeostasis of the host, particularly in the immune and metabolic systems. Furthermore, the dysfunction of gut microbiota, also called “dysbiosis”, has been associated with various diseases, such as the metabolic syndrome or chronic kidney disease. In this review, we summarize the knowledge about the possible role of gut microbiota in the development of arterial hypertension. We detail the pathophysiological mechanisms, namely involving short-chain fatty acids produced by the bacterial fermentation of food carbohydrates. These metabolites are reabsorbed by the intestinal mucosa and interact with a multitude of G-protein coupled receptors at the surface of cells involved in blood pressure regulation, including renal tubular cells. These observations open up innovative diagnostic and therapeutic approaches in arterial hypertension, which is a major public health problem. [less ▲]

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See detailLa dialyse chronique face à la COVID-19
Résimont, Guillaume ULiege; DUBOIS, Bernard ULiege; BOVY, Christophe ULiege et al

in Revue Médicale de Liège. Supplément (2020), 75(S1), 41-47

COVID-19 has been the center of global attention and concern for the last months. Patients undergoing dialysis and especially those treated at the hospital are likely to be infected, due to their ... [more ▼]

COVID-19 has been the center of global attention and concern for the last months. Patients undergoing dialysis and especially those treated at the hospital are likely to be infected, due to their mandatory presence at the hospital several times a week and due to their intrinsic fragility in regard of chronic kidney disease, often an older age, and the presence of many associated comorbidities. Thereby, patients with chonic kidney disease treated by haemodialysis have higher odds of a more severe COVID19 infection with a high mortality rate. Prevention is thus a high priority for these patients. [less ▲]

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See detailAtteintes rénales de la COVID-19
ERPICUM, Pauline ULiege; GROSCH, Stéphanie ULiege; BOUQUEGNEAU, Antoine ULiege et al

in Revue Médicale de Liège. Supplément (2020), 75(supplément 1), 109-114

The SARS-CoV-2 virus causes a respiratory distress syndrome, the main symptom of COVID-19 (for “COronaVIrus Disease 2019”). This infectious disease has been causing a major health and socio-economic ... [more ▼]

The SARS-CoV-2 virus causes a respiratory distress syndrome, the main symptom of COVID-19 (for “COronaVIrus Disease 2019”). This infectious disease has been causing a major health and socio-economic pandemic since December 2019. The pulmonary alveolus is regarded as the main target of SARS-CoV-2. However, this coronavirus is capable of directly or indirectly affecting other organs, including the kidneys. Here, we summarize the presumed pathophysiology of COVID-19 renal disease. The incidence of acute kidney injury ranges from 0,5 to 22 % of all patients infected with SARS-CoV-2. The need for renal replacement therapy is reported in 5-9 % of patients in intensive care. Histological analysis of renal biopsies mainly shows acute tubular necrosis of varying severity, as well as the congestion of glomerular and peri-tubular capillaries. Endothelitis has been described in few cases. Evidence for a factual inflammation of the glomerulus remains controversial. The medium/long term consequences of COVID-19 nephropathy are unknown and will deserve a tight follow-up. [less ▲]

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See detailQuelle quantité de sel conseiller dans une nutrition équilibrée?
Krzesinski, Jean-Marie ULiege

Conference (2019, October 17)

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See detailPrise en charge de l'HTA résistante. Quoi de neuf en 2019?
KRZESINSKI, Jean-Marie ULiege

Conference (2019, May 12)

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See detailHTA réfractaire et dénervation rénale : regain d'intérêt?
KRZESINSKI, Jean-Marie ULiege; MARTINEZ, Christophe ULiege

Conference (2019, May 11)

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See detailMyostatin and Insulin-Like Growth Factor 1 Are Biomarkers of Muscle Strength, Muscle Mass, and Mortality in Patients on Hemodialysis.
DELANAYE, Pierre ULiege; Bataille; Quinonez, Kevin et al

in Journal of Renal Nutrition (2019), 29(6), 511-520

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See detailImpact of the creatinine-based equations used on the chronic kidney disease classification in a large laboratory database
masson, grégoire; VRANKEN, Laura ULiege; KRZESINSKI, Jean-Marie ULiege et al

in Nephrology Dialysis Transplantation (2019)

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See detailA simple modification of dialysate potassium: its impact on plasma potassium concentrations and the electrocardiogram
DELANAYE, Pierre ULiege; KRZESINSKI, François ULiege; DUBOIS, Bernard ULiege et al

in Clinical Kidney Journal (2019)

Background. Sudden death is frequent in haemodialysis (HD) patients. Both hyperkalaemia and change of plasma potassium(K) concentrations induced by HD could explain this. The impact of increasing ... [more ▼]

Background. Sudden death is frequent in haemodialysis (HD) patients. Both hyperkalaemia and change of plasma potassium(K) concentrations induced by HD could explain this. The impact of increasing dialysate K by 1 mEq/L on plasma K concentrations and electrocardiogram(ECG) results before and after HD sessions was studied. Methods. Patients with pre-dialysis K>5.5 mEq/L were excluded. ECG and K measurements were obtained before and after the first session of the week for 2 weeks. Then, K in the dialysate was increased (from 1 or 3 to 2 or 4 mEq/L, respectively). Blood and ECG measurements were repeated after 2 weeks of this change. Results. Twenty-seven prevalent HD patients were included. As expected, a significant decrease in K concentrations was observed after the dialysis session, but this decrease was significantly lower after the switch to an increased dialysate K. The pre-dialysis K concentrations were not different after changing, but post-dialysis K concentrations were higher after switching (P<0.0001), with a lower incidence of post-dialysis hypokalaemia. Regarding ECG, before switching, the QT interval (QT) dispersion increased during the session, whereas no difference was observed after switching. One week after switching, post-dialysis QT dispersion [38 (34–42) ms] was lower than post-dialysis QT dispersion 2 weeks and 1 week before switching [42 (38–57) ms, P¼0.0004; and 40 (35–50) ms, P¼0.0002]. Conclusions. A simple increase of 1 mEq/L of K in the dialysate is associated with a lower risk of hypokalaemia and a lower QT dispersion after the dialysis session. Further study is needed to determine if such a strategy is associated with a lower risk of sudden death. [less ▲]

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