Publications of Jean-Marie KRZESINSKI
Bookmark and Share    
Full Text
See detailPolykystose rénale autosomique dominante : perspective pédiatrique
DACHY, Angélique ULiege; COLLARD, Laure ULiege; KRZESINSKI, Jean-Marie ULiege et al

in Revue Médicale de Liège (2020), 75(12), 775-780

Polycystic kidney disease (PKD) is the most prevalent inherited kidney disease. The disease is usually asymptomatic until adulthood. End-stage renal disease occurs generally after the age of 55 years ... [more ▼]

Polycystic kidney disease (PKD) is the most prevalent inherited kidney disease. The disease is usually asymptomatic until adulthood. End-stage renal disease occurs generally after the age of 55 years, with a large inter-individual variability. Renal cyst formation begins early in life, and animal models have shown that treatments able to prevent the cyst growth slow down the renal function decline. A treatment by tolvaptan is currently used in adults to decelerate PKD progression. Until now there is no consensus about the appropriate time to screen for PKD in children. However, these scientific progresses raise the interest of determining early (i.e. pediatric) predictive markers of renal function decline. [less ▲]

Detailed reference viewed: 41 (10 ULiège)
Full Text
See detailRenal function assessment is part of endovascular aortic aneurysm repair and its follow up.
KERZMANN, Arnaud ULiege; KRZESINSKI, Jean-Marie ULiege; Sakalihasan, Natzi ULiege et al

in Annals of Vascular Medicine and Research (2020), 7(3), 1113

Detailed reference viewed: 37 (9 ULiège)
Full Text
See detailThe European/International Fibromuscular Dysplasia Registry and Initiative (FEIRI)—clinical phenotypes and their predictors based on a cohort of 1000 patients.
pappaccogli, marco; Di Monaco, Silva; Warchot-Celinska, Ewa et al

in Cardiovascular Research (2020)

Aims : Since December 2015, the European/International Fibromuscular Dysplasia (FMD) Registry enrolled 1022 patients from 22 countries. We present their characteristics according to disease subtype, age ... [more ▼]

Aims : Since December 2015, the European/International Fibromuscular Dysplasia (FMD) Registry enrolled 1022 patients from 22 countries. We present their characteristics according to disease subtype, age and gender, as well as predictors of widespread disease, aneurysms and dissections. Methods and results : All patients diagnosed with FMD (string-of-beads or focal stenosis in at least one vascular bed) based on computed tomography angiography, magnetic resonance angiography, and/or catheter-based angiography were eligible. Patients were predominantly women (82%) and Caucasians (88%). Age at diagnosis was 46 ± 16 years (12%>_65 years old), 86% were hypertensive, 72% had multifocal, and 57% multivessel FMD. Compared to patients with multifocal FMD, patients with focal FMD were younger, more often men, had less often multivessel FMD but more revascularizations. Compared to women with FMD, men were younger, had more often focal FMD and arterial dissections. Compared to younger patients with FMD, patients >_65 years old had more often multifocal FMD, lower estimated glomerular filtration rate and more atherosclerotic lesions. Independent predictors of multivessel FMD were age at FMD diagnosis, stroke, multifocal subtype, presence of aneurysm or dissection, and family history of FMD. Predictors of aneurysms were multivessel and multifocal FMD. Predictors of dissections were age at FMD diagnosis, male gender, stroke, and multivessel FMD. Conclusions : The European/International FMD Registry allowed large-scale characterization of distinct profiles of patients with FMD and, more importantly, identification of a unique set of independent predictors of widespread disease, aneurysms and dissections, paving the way for targeted screening, management, and follow-up of FMD. [less ▲]

Detailed reference viewed: 35 (3 ULiège)
Full Text
See detailThe purple urine bag syndrome
VANDERWECKENE, Pauline ULiege; COUNASSE, Christiane; KRZESINSKI, Jean-Marie ULiege

in Global Imaging Insights (2020), 5

Detailed reference viewed: 28 (7 ULiège)
Full Text
See detailGestion de l’hyperkaliémie lors d’un traitement par inhibiteur du système réinine-angiotensine-aldostérone
KRZESINSKI, Jean-Marie ULiege; van der schueren, Thierry

in Revue de la Médecine Générale (2020), 369

Hyperkalemia is common in patients with chronic renal failure (CKD), diabetes and/or cardiac decompensation (CD) and increases when taking inhibitors of the renin-angiotensin-aldosterone system. Besides ... [more ▼]

Hyperkalemia is common in patients with chronic renal failure (CKD), diabetes and/or cardiac decompensation (CD) and increases when taking inhibitors of the renin-angiotensin-aldosterone system. Besides dietetics, the use of intestinal potassium chelators is frequent but often poorly tolerated. Recently, a new potassium chelator appears to be promising. [less ▲]

Detailed reference viewed: 82 (1 ULiège)
Full Text
See detailNouveautés dans la prise en charge de l'hypertension artérielle dans la dernière décennie
KRZESINSKI, Jean-Marie ULiege; SAINT-REMY, Annie ULiege

in Revue Médicale de Liège (2020), 75(5-6), 329-335

Hypertension remains one of the most important cardiovascular risk factors. In spite of many efforts for its management, the control of high blood pressure remains insufficient. In the last decade, no new ... [more ▼]

Hypertension remains one of the most important cardiovascular risk factors. In spite of many efforts for its management, the control of high blood pressure remains insufficient. In the last decade, no new antihypertensive drug was released. The main effort to improve blood pressure control was put on the validation of the hypertensive status, the stimulation of home blood pressure measurement and the therapeutic education of the patients. The releasing in 2018 of new guidelines, which are clear and more simple, would help more efficiently fight against hypertension, the still present silent killer. In Europe, the usual blood pressure target has been kept, i.e.a lowering of blood pressure below 140/90 mmHg in all fit patients whatever their age. Lower target could be proposed according to the patient tolerance. Treatment is decided according to cardiovascular risk evaluation. Quickly a combination of two antihypertensive agents in a single pill is proposed to improve efficacy of the treatment. We also need the help of the family, nurses and pharmacists to increase the chance of a better blood pressure control, which is necessary to get an optimal cardiovascular protection. [less ▲]

Detailed reference viewed: 112 (5 ULiège)
Full Text
See detailNouveautés thérapeutiques en Néphrologie : 10 ans d'avancées
BOVY, Christophe ULiege; DELANAYE, Pierre ULiege; JOURET, François ULiege et al

in Revue Médicale de Liège (2020), 75(5-6), 336-343

Chronic kidney disease (CKD) impairs the quality of life and increases the risk for cardiovascular morbimortality. Intensive research is conducted in order to slow down CKD development and progression ... [more ▼]

Chronic kidney disease (CKD) impairs the quality of life and increases the risk for cardiovascular morbimortality. Intensive research is conducted in order to slow down CKD development and progression. During the past decade, a better understanding of the pathophysiological mechanisms of glomerular diseases has highlighted the benefits of rituximab. Progresses have also been made in the understanding of the mechanisms of autosomal polycystic kidney disease, the most frequent inherited kidney disease. These observations led to the discovery and validation of tolvaptan, a blocker of the V2 receptor of the antidiuretic hormone as an innovative treatment. Type 2 diabetic disease is the leading cause worldwide of endstage kidney disease and dialysis. The development of new drugs, such as the gliflozins (inhibiting the sodium glucose reabsorption in the proximal tubule), has contributed to an improvement in the management of the cardiovascular and renal risks especially reducing congestive heart failure rate. Another important progress in nephrology since the beginning of the new century concerns a more precise estimation of the kidney function, which allows to better evaluate the slope of CKD progression and test the influence of different therapeutic approaches aiming at correcting anemia, hyperkalemia, metabolic acidosis and disturbances of calcium and phosphate. The present review summarizes all of these major advances in the field of CKD diagnosis and treatment, and envisions the future of nephrology for the next decade. [less ▲]

Detailed reference viewed: 130 (5 ULiège)
Full Text
See detailHow to Reduce the Risk of Acute Kidney Injury in Abdominal Aortic Aneurysm Surgery: The Quest of the Grail.
KRZESINSKI, Jean-Marie ULiege; Sakalihasan, Natzi ULiege; DEFRAIGNE, Jean ULiege

in European Journal of Vascular and Endovascular Surgery (2020), 59

Detailed reference viewed: 28 (2 ULiège)
Full Text
See detailArgument en faveur d'un rôle du microbiote intestinal dans la physiopathologie de l'hypertension artérielle
HUART, Justine ULiege; KRZESINSKI, Jean-Marie ULiege; JOURET, François ULiege

in Revue Médicale de Liège (2020), 75(9), 588-592

The gut microbiota refers to the community of microorganisms living in the mammalian digestive tract. Over the past decades, numerous preclinical and clinical studies have suggested that gut microbiota is ... [more ▼]

The gut microbiota refers to the community of microorganisms living in the mammalian digestive tract. Over the past decades, numerous preclinical and clinical studies have suggested that gut microbiota is involved in the physiological homeostasis of the host, particularly in the immune and metabolic systems. Furthermore, the dysfunction of gut microbiota, also called “dysbiosis”, has been associated with various diseases, such as the metabolic syndrome or chronic kidney disease. In this review, we summarize the knowledge about the possible role of gut microbiota in the development of arterial hypertension. We detail the pathophysiological mechanisms, namely involving short-chain fatty acids produced by the bacterial fermentation of food carbohydrates. These metabolites are reabsorbed by the intestinal mucosa and interact with a multitude of G-protein coupled receptors at the surface of cells involved in blood pressure regulation, including renal tubular cells. These observations open up innovative diagnostic and therapeutic approaches in arterial hypertension, which is a major public health problem. [less ▲]

Detailed reference viewed: 11 (0 ULiège)
Full Text
See detailSodium and Potassium Intake: A New Statistical Model to Test Their Effects on Health Outcomes.
Dériaz, Denis ULiege; MAES, Nathalie ULiege; Kolh, Philippe ULiege et al

in Kidney International Reports (2020), 5(12), 2403

Detailed reference viewed: 29 (8 ULiège)
Full Text
See detailLa dialyse chronique face à la COVID-19
Résimont, Guillaume ULiege; DUBOIS, Bernard ULiege; BOVY, Christophe ULiege et al

in Revue Médicale de Liège. Supplément (2020), 75(S1), 41-47

COVID-19 has been the center of global attention and concern for the last months. Patients undergoing dialysis and especially those treated at the hospital are likely to be infected, due to their ... [more ▼]

COVID-19 has been the center of global attention and concern for the last months. Patients undergoing dialysis and especially those treated at the hospital are likely to be infected, due to their mandatory presence at the hospital several times a week and due to their intrinsic fragility in regard of chronic kidney disease, often an older age, and the presence of many associated comorbidities. Thereby, patients with chonic kidney disease treated by haemodialysis have higher odds of a more severe COVID19 infection with a high mortality rate. Prevention is thus a high priority for these patients. [less ▲]

Detailed reference viewed: 52 (7 ULiège)
Full Text
See detailAtteintes rénales de la COVID-19
ERPICUM, Pauline ULiege; GROSCH, Stéphanie ULiege; BOUQUEGNEAU, Antoine ULiege et al

in Revue Médicale de Liège. Supplément (2020), 75(supplément 1), 109-114

The SARS-CoV-2 virus causes a respiratory distress syndrome, the main symptom of COVID-19 (for “COronaVIrus Disease 2019”). This infectious disease has been causing a major health and socio-economic ... [more ▼]

The SARS-CoV-2 virus causes a respiratory distress syndrome, the main symptom of COVID-19 (for “COronaVIrus Disease 2019”). This infectious disease has been causing a major health and socio-economic pandemic since December 2019. The pulmonary alveolus is regarded as the main target of SARS-CoV-2. However, this coronavirus is capable of directly or indirectly affecting other organs, including the kidneys. Here, we summarize the presumed pathophysiology of COVID-19 renal disease. The incidence of acute kidney injury ranges from 0,5 to 22 % of all patients infected with SARS-CoV-2. The need for renal replacement therapy is reported in 5-9 % of patients in intensive care. Histological analysis of renal biopsies mainly shows acute tubular necrosis of varying severity, as well as the congestion of glomerular and peri-tubular capillaries. Endothelitis has been described in few cases. Evidence for a factual inflammation of the glomerulus remains controversial. The medium/long term consequences of COVID-19 nephropathy are unknown and will deserve a tight follow-up. [less ▲]

Detailed reference viewed: 84 (12 ULiège)
Full Text
See detailIl faut protéger le rein du patient diabétique!
KRZESINSKI, Jean-Marie ULiege

Scientific conference (2019, December 07)

Detailed reference viewed: 37 (2 ULiège)
See detailLa radiothérapie centrée sur le rein atténue les lésions d'ischémie-reperfusion rénale chez la souris
Khbouz, Badr ULiege; Pascal, Rowart; LALLEMAND, François ULiege et al

Conference (2019, December 04)

Introduction: L'irradiation corporelle engendre un conditionnement ischémique rénal. L’impact fonctionnel et pathophysiologique d’une radiothérapie centrée sur les reins est cependant inconnu. Méthodes ... [more ▼]

Introduction: L'irradiation corporelle engendre un conditionnement ischémique rénal. L’impact fonctionnel et pathophysiologique d’une radiothérapie centrée sur les reins est cependant inconnu. Méthodes: Expérience 1: Sous anesthésie, 2 faisceaux de rayons X (225Kv, 13mA) ciblent spécifiquement les reins pour une dose totale de 8,56Gy. Trente jours plus tard, une néphrectomie droite est réalisée et une ischémie du rein gauche est induite pendant 30min. Après 48h de reperfusion, le rein gauche et le sang sont prélevés (n=6 souris). Un groupe témoin (n=6) subit une I/R rénale similaire sans irradiation préalable. Expérience 2: Une irradiation unilatérale des reins gauches (8,56Gy) est réalisée (n=11). Trente jours plus tard, le rein gauche est prélevé. Le rein gauche de souris non irradiées (n=5) est utilisé comme contrôle. L’ARN des reins irradiés et contrôles est extrait pour une transcriptomique comparative (BaseSpace Illumina; DAVID program). Résultats: À la suite d’une I/R rénale, le taux d’urée était significativement plus bas chez les animaux pré-irradiées (148±93mg/dl), comparativement aux contrôles (496±33, p<0,01). Le nombre de cellules en prolifération (PCNA-positives) était significativement inférieur chez les pré-irradiées par rapport aux témoins (131±53 vs. 545±257/mm², p<0,001). L'infiltration rénale par les cellules CD11b-positives (90±32 vs. 414±149/mm²) et les macrophages F4-80 (81±23 vs 179±68/mm²) était significativement réduite dans le groupe irradié. L’analyse transcriptomique montre une up-régulation des voies de signalisation de l'angiogenèse (Hmox1) et de la réponse au stress (Hspa1a, Hspa1b), et une down-régulation de l'oxydoréduction (Nox4). Conclusion: L'irradiation rénale induit un pré-conditionnement ischémique chez la souris, avec une fonction rénale préservée et une inflammation atténuée après I/R rénale. Les voies de signalisation susmentionnées, modulées lors de l’irradiation, participent probablement à la résistance du rein à l'I/R. [less ▲]

Detailed reference viewed: 58 (21 ULiège)
See detailKidney targeted radiotherapy attenuates the renal ischemia-reperfusion injury in mice
Khbouz, Badr ULiege; Rowart, Pascal; LALLEMAND, François ULiege et al

Poster (2019, November 07)

BACKGROUND Whole-body irradiation has been associated with renal ischemic preconditioning in mice. Here, we investigate the functional and fundamental impact of radiotherapy centered on the kidneys before ... [more ▼]

BACKGROUND Whole-body irradiation has been associated with renal ischemic preconditioning in mice. Here, we investigate the functional and fundamental impact of radiotherapy centered on the kidneys before renal ischemia/reperfusion (I/R) in mice. METHODS Experience1: Animals (n=6) were anesthetized and placed in the irradiator. Two beams of X-rays (225Kv, 13 mA) specifically targeted both kidneys to deliver a dose a 8,56Gy. One month later, a right nephrectomy was performed, and a left renal ischemia was induced for 30min. After 48 hours of reperfusion, the left kidney was collected, as well as blood. Control group (n=6) underwent a similar renal I/R procedure, with no prior irradiation. Experience 2: Unilateral irradiation of the left kidney (8.56 Gy) was performed in mice (n=10). One month later, the left (irradiated) kidney was collected. Additionally, the left kidneys were collected from non-irradiated mice (n=5). Total RNAs were extracted from irradiated and control kidneys to perform comparative high-throughput RNA-Seq. BaseSpace Sequence Hub Illumina was used. Functional enrichment analysis was performed using DAVID program. Both experimental protocols have been approved by the IACUC of ULiège, Liège, Belgium. RESULTS Following kidney I/R, blood urea nitrogen (BUN) levels were significantly lower in pre-irradiated mice (148.4±93.1) compared to controls (495.7±33.3, p<0.01). The number of PCNA-positive proliferating cells was significantly lower in pre-irradiated mice (130.8±52.7) compared to controls (545.4±257.3, p<0.001). The renal infiltration by inflammatory CD11b-positive cells (90.2±32.2 vs. 414.5±148.6) and F4-80-positive macrophages (80.6±22.9 vs. 178.5±68) was significantly reduced in pre-irradiated animals vs. controls. Comparative transcriptomics showed a significant up-regulation of various signaling pathways, including angiogenesis (HMOX1) and stress response (HSPA1A, HSPA1B), and a down-regulation of oxidoreduction (NOX4). CONCLUSION Kidney irradiation induces ischemic preconditioning in mice, with improved renal function and decreased inflammation following renal I/R. The aforementioned signaling pathways may play a role in irradiation-associated kidney resistance to I/R. [less ▲]

Detailed reference viewed: 58 (18 ULiège)
Full Text
See detailQuelle quantité de sel conseiller dans une nutrition équilibrée?
Krzesinski, Jean-Marie ULiege

Conference (2019, October 17)

Detailed reference viewed: 37 (3 ULiège)