Publications of Bernard DUCHESNE
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See detailComment je traite. Les brûlures oculaires par Holoclar®, une greffe autologue de cellules souches pour rendre la vue
TILKIN, Claire ULiege; DUCHESNE, Bernard ULiege; CAMBY, Séverine ULiege et al

in Revue Médicale de Liège (2021), 76(11), 776-782

Ocular chemical or physical burns currently represent 12 % of domestic accidents in Europe. They can lead to numerous ophthalmologic sequelae ranging from simple superficial keratitis to conjunctival ... [more ▼]

Ocular chemical or physical burns currently represent 12 % of domestic accidents in Europe. They can lead to numerous ophthalmologic sequelae ranging from simple superficial keratitis to conjunctival ischemia and the destruction of limbal corneal stem cells. This results in damages to the cornea which can progress to neovascularization and corneal invasion by conjunctival tissue. Long term consequences affect ocular function (sometimes blindness, stromal degradation, infections, or even ocular perforation). Until now, few treatments were available to restore corneal transparency after a trauma. Patients affected by post-traumatic limbal stem cell deficiency unfortunately had little prospect. Regenerative cell therapy, of which Holoclar® is a part, could revolutionize the future of these patients. [less ▲]

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See detailDECONTAMINATION OF WHOLE DONOR EYE GLOBES WITH A COMMERCIAL ANTIBIOTIC COCKTAIL MEDICAL DEVICE
LAMBERT, Vincent ULiege; MARECHAL, Amélie ULiege; MANGIONE, Julien ULiege et al

Poster (2020, January 17)

BACKGROUND : In donor cornea transplantation a decontamination step is required in order to reduce the cornea contamination. At the Eye Bank of Liege, Belgium, the decontamination is performed with 5 ... [more ▼]

BACKGROUND : In donor cornea transplantation a decontamination step is required in order to reduce the cornea contamination. At the Eye Bank of Liege, Belgium, the decontamination is performed with 5% iodopovidone solution quick wash before dissection. AIMS: To evaluate the use of decontamination solution BASE.128 (AL.CHI.MI.A. S.r.l.) for decontamination of the whole donor eye globe, before cornea recovery, at the Ophthalmic Tissue Bank of Liege University Hospital. METHODS : Human donor eye globes, unsuitable for transplantation, were recovered and transported in physiological solution. All corneas were evaluated according to SOP of the Eye Bank (Endothelial cell density (ECD), slit lamp evaluation (SL), central corneal thickness (CCT)). A microbiological test was performed on physiological transportation medium using Bact/Alert for 7 days, and a corneal swab was taken. Eye globes were immersed in BASE.128, an antibiotic cocktail containing vancomycin, gentamicin, cefotaxime, and amphotericin B deoxycholate. After decontamination phase, a microbiological and corneal swab test were repeated. Cornea was dissected and transferred in cold storage medium (EUSOL-C, AL.CHI.MI.A. S.r.l.). ECD and CCT were evaluated again. Cornea was stored for 14 days at 4°C. After 14 days of storage, ECD and CCT were determined. At day 14, a microbiological corneal swab test were repeated. RESULTS: Whole globes were initially contaminated. After decontamination, all the microbiological tests resulted negative. Corneal evaluation parameters including ECD and CCT remained unvaried according to expected values. CONCLUSIONS : Decontamination of whole donor eye globe with BASE.128 allowed total elimination of cornea contamination without altering corneal quality. [less ▲]

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See detailConjonctivite à chlamydia trachomatis.
Terlinchamp, Mathieu ULiege; Duchesne, Bernard ULiege

in Journal francais d'ophtalmologie (2020), 43(1), 21-22

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See detailRevoir au travers d'une dent : hommage au Professeur Giancarlo Falcinelli
XHAUFLAIRE, Gaël ULiege; DUCHESNE, Bernard ULiege; SOHNGEN, Pierre ULiege et al

Conference (2018, May 05)

L'osteo-odonto-keratoprothese est une procedure chirurgicale complexe cherchant à restaurer la vision dans des situations de cécité d'origine cornéenne habituellement irrémédiables telles que brûlures ... [more ▼]

L'osteo-odonto-keratoprothese est une procedure chirurgicale complexe cherchant à restaurer la vision dans des situations de cécité d'origine cornéenne habituellement irrémédiables telles que brûlures chimiques, syndromes de Lyell et de Stevens-johnson, pemphigoïdes, trachome, multiples rejets de greffes cornéennes... Elle consiste en 2 ou 3 étapes longues et fastidieuses nécessaires à implanter au travers de la cornée opaque, une optique incluse dans une dent (dent dans l'oeil). La dent est prélevée dans sa totalité, avec son ligament et son os alvéolaire. Une lamine tissulaire est ensuite affinée et perforée afin de permettre le passage d'une optique en PMMA. La lamine ainsi préparée est mise en nourrice dans la joue pour plusieurs mois, pour être enfin implantée sur l'oeil, recouverte d'une greffe de muqueuse nourricière et protectrice. Cette fabuleuse technique chirurgicale a été imaginée par le Professeur Strampelli au début des années 60. Le Professeur Giancarlo Falcinelli, notre mentor, a consacré sa carrière à l'améliorer. Nous lui rendons aujourd'hui hommage. [less ▲]

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See detailAvis N° 9140 Lentilles colorées ou de fantaisie
BORIES, Yvon; DUCHESNE, Bernard ULiege; KOPPEN, Carine et al

Book published by CONSEIL SUPERIEUR DE LA SANTE (2014)

In this scientific policy advisory report the Superior Health Council of Belgium provides an expert opinion on the safety of the use of colored and fancy contact lenses. It would like to provide to health ... [more ▼]

In this scientific policy advisory report the Superior Health Council of Belgium provides an expert opinion on the safety of the use of colored and fancy contact lenses. It would like to provide to health and consumer product safety authority and to the general population, specific recommendations on the safety and the prevention of adverse effects of these products in a form of a poster campaign. [less ▲]

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See detailNouvelles approches des greffes de cornée.
Rémont, L.; Duchesne, Bernard ULiege; La, C. et al

in Revue medicale de Liege (2014), 69(9), 490-6

Corneal transplantation or keratoplasty has rapidly developed over the last 10 years. Penetrating keratoplasty, a well-known operation consisting of full thickness replacement of the cornea, has remained ... [more ▼]

Corneal transplantation or keratoplasty has rapidly developed over the last 10 years. Penetrating keratoplasty, a well-known operation consisting of full thickness replacement of the cornea, has remained the dominant procedure for a long time. It allows appropriate therapy of most causes of corneal blindness. However, this technique is currently evolving toward slamellar keratoplasties which selectively treat the specific affected layers: deep anterior lamellar keratoplasty replaces the diseased corneal stromal layers; endothelial keratoplasty replace the affected endothelium. This article will present these techniques, and briefly discuss their advantages. [less ▲]

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See detailComment j'explore ... le diagnostic différentiel d'un oeil rouge.
Huvelle, Hélène ULiege; Duchesne, Bernard ULiege; Rakic, Jean-Marie ULiege

in Revue medicale de Liege (2013), 68(11), 593-8

As a common reason for consultation, red eye can be a symptom of benign diseases, such as conjunctivitis, subconjunctival hemorrhage, dry eye syndrome,..., which can be managed by the general practitioner ... [more ▼]

As a common reason for consultation, red eye can be a symptom of benign diseases, such as conjunctivitis, subconjunctival hemorrhage, dry eye syndrome,..., which can be managed by the general practitioner or internist. Conversely, more serious pathologies require a ophthalmologist management: these are keratitis, uveitis, acute glaucoma attack, or endophtalmitis. This article is intended to help practitioner to guide diagnosis when he's faced with a red eye. [less ▲]

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See detailComment je traite...un oeil rouge.
Huvelle, Hélène ULiege; Duchesne, Bernard ULiege; Rakic, Jean-Marie ULiege

in Revue medicale de Liege (2013), 68(12), 609-12

Before any initiation of treatment for a red eye, an accurate differential diagnosis must absolutely be done, as considered in a previous article. Red eye can result from benign diseases, but also from ... [more ▼]

Before any initiation of treatment for a red eye, an accurate differential diagnosis must absolutely be done, as considered in a previous article. Red eye can result from benign diseases, but also from serious pathologies which shouldn't be neglected, as they require a rapid ophtalmologist management. This is the case for keratitis, uveitis, acute glaucoma attack, or endophtalmitis. Treatment of red eye will just be symptomatic in benign diseases but, in contrast, will absolutely need an etiological diagnosis and therapeutic approach in more serious cases. Generally speaking, topical steroids should never be prescribed in doubt of infectious keratitis. Moreover, local anaesthetics, because of their toxicity for the cornea, should not be prescribed under any circumstances. [less ▲]

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See detailPanophtalmie post-traumatique fulgurante.
SOHNGEN, Pierre ULiege; BLAISE, Pierre ULiege; Duchesne, Bernard ULiege et al

in Revue medicale de Liege (2012), 67(9), 449-51

Panophtalmitis is an intra-ocular and intra-orbital rare infection, but its consequences are often horrendous, with loss of both function and anatomy of the eye. The surgical approach and the ... [more ▼]

Panophtalmitis is an intra-ocular and intra-orbital rare infection, but its consequences are often horrendous, with loss of both function and anatomy of the eye. The surgical approach and the antibiotherapy should be given as soon as possible, both by intra-vitreal and intra-venous injections. We report the case of a 49-year-old man who developed a Bacillus cereus panophtalmitis. A delay in the diagnosis lead to the loss of vision and the evisceration of the sick eye. Bacillus cereus panopthalmitis should be suspected in all cases of post-traumatic endophtalmitis with a soiled metallic foreign body, in patients with important local inflammatory signs as well as systemic signs. Vitrectomy, surgical extraction of the foreign body, intra-vitreal and systemic antibiotherapies should be given as soon as possible, even before the results of the bacteriological analysis. [less ▲]

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See detailUse of amniotic membrane in Malignant Pterygium Surgery : video presentation
XHAUFLAIRE, Gaël ULiege; DUCHESNE, Bernard ULiege

Conference (2010, November 25)

Limbal graft harvesting might sometimes not be possible in pterygium surgery (previous surgeries, burns, conjunctival pathology, filtering bleb...). The use of an amniotic membrane might be an alternative ... [more ▼]

Limbal graft harvesting might sometimes not be possible in pterygium surgery (previous surgeries, burns, conjunctival pathology, filtering bleb...). The use of an amniotic membrane might be an alternative to a thicker labial mucosa graft. Fibrin glue, as in conjunctival grafting, permits a surgery without stitches which is a help to the surgeon and a relief to the patient. [less ▲]

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See detailUse of fibrin glue in Pterygium Surgery : video presentation
XHAUFLAIRE, Gaël ULiege; DUCHESNE, Bernard ULiege

Conference (2010, November 25)

Conjunctival stitches might be tricky on a thin conjunctival graft. They are often responsible for ocular inflammation. The use of fibrin glue permits a conjunctival surgery without stitches. It is a real ... [more ▼]

Conjunctival stitches might be tricky on a thin conjunctival graft. They are often responsible for ocular inflammation. The use of fibrin glue permits a conjunctival surgery without stitches. It is a real improvement in pterygium surgery. It helps the surgeon and improves the patient comfort. [less ▲]

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See detailResume d'une décennie de progrès ophtalmologiques.
Rakic, Jean-Marie ULiege; COLLIGNON, Nathalie ULiege; Duchesne, Bernard ULiege et al

in Revue medicale de Liege (2007), 62(5-6), 467-70

This review summarizes the most important advances that occurred in ophthalmology during the last decade, with a focus on corneal pathology, cataract surgery, glaucoma and retinal diseases.

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See detailSpontaneous recovery in phacolytic glaucoma
Blaise, Pierre ULiege; Duchesne, Bernard ULiege; Guillaume, Serge ULiege et al

in Journal of Cataract and Refractive Surgery (2005), 31(9), 1829-1830

We report a case of phacolytic glaucoma in which spontaneous absorption of the hypermature lens allowed a patient who refused surgery to recover a normal pressure and satisfactory visual acuity.

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See detailAmniotic membrane transplantation and fibrin glue in the management of corneal ulcers and perforations - A review of 33 cases
Hick, Sybilla ULiege; Demers, P. E.; Brunette, I. et al

in Cornea (2005), 24(4), 369-377

Purpose: To evaluate the efficacy of ammotic membrane in corneal ulcers refractive to conventional treatment and amniotic membrane with fibrin glue in corneal perforations. Methods: Ammotic membrane ... [more ▼]

Purpose: To evaluate the efficacy of ammotic membrane in corneal ulcers refractive to conventional treatment and amniotic membrane with fibrin glue in corneal perforations. Methods: Ammotic membrane transplantation (AMT) was performed in 33 eyes from 32 patients for corneal ulcers refractive to conventional treatment. Fourteen ulcers were perforated and received fibrin glue and amniotic membrane. Ulcers were divided into 3 groups: neurotrophic or exposure, autoimmune, and other etiology. Results: Overall success was observed in 80% (27/33 eyes) of the cases, with success rates of 87.5% (14/16 eyes), 70% (7/10 eyes), 85.7% (6/7 eyes) in groups 1, 2, and 3, respectively. The ulcers healed in a mean time of 3.6 +/- 1.6 weeks and the follow-up was 14.8 +/- 9.9 months. Failure was noted in 6 eyes with severe neurotrophic keratitis, Stevens-Johnson syndrome, ocular cicatricial pemphigoid, and Acanthamoeba keratitis. Grafts with fibrin sealant showed a success rate of 92.9% (13/14 eyes) compared to 73.7% (14/19 eyes) for amniotic grafts alone. In patients with severe limbal damage, a success rate of only 20% (115) was observed. Conclusions: AMT is a viable option in the treatment of nonhealing corneal ulcers of various depth and etiologies. Perforations up to 3 mm can be safely managed by fibrin glue and AMT. These techniques lead to rapid reconstruction of the corneal surface and can give a good final functional result or allow keratoplasty to be done in more favorable conditions. [less ▲]

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See detailLes occlusions vasculaires retiniennes: diagnostic et prise en charge
Blaise, Pierre ULiege; Duchateau, Edouard ULiege; Duchesne, Bernard ULiege et al

in Revue de Médecine Interne (2004), 25(12), 881-90

PURPOSE: The diagnosis of retinal venous and arterial occlusions is usually easily evoked on visual symptoms and ophthalmoscopic features. However, their management (etiologic explorations and treatment ... [more ▼]

PURPOSE: The diagnosis of retinal venous and arterial occlusions is usually easily evoked on visual symptoms and ophthalmoscopic features. However, their management (etiologic explorations and treatment) has not been formally established and remains controversial. CURRENT KNOWLEDGE AND KEY POINTS: Some retinal vascular occlusions may result of loco-regional ocular causes. They more often occur in patients with cardiovascular pathologies or risk factors, or sometimes other systemic diseases that need to be recognized for a proper treatment. Therefore, a comprehensive management of patients with retinal vascular occlusions is necessary to correct associated diseases or predisposing abnormalities that could lead to local recurrences or systemic events. CONCLUSION: Along with a review of the literature, we suggest a practical approach for the management of retinal vascular occlusions, which requires a collaboration between the ophthalmologist and other physicians: general practitioner, cardiologist, internist... as appropriate according to each case. [less ▲]

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See detailMerkel cell carcinoma
Barile, Paola ULiege; Leroy, Cécile ULiege; Bolle, Stephanie et al

in Journal Français d'Ophtalmologie (2004), 27(4), 432-436

Merkel cell carcinoma is a neuroendocrine tumor of the skin, originating from neuroendocrine cells. A case report of Merkel cell carcinoma, discovered in a 77-year-old woman, was diagnosed an confirmed on ... [more ▼]

Merkel cell carcinoma is a neuroendocrine tumor of the skin, originating from neuroendocrine cells. A case report of Merkel cell carcinoma, discovered in a 77-year-old woman, was diagnosed an confirmed on a biopsy. Diagnostic and therapeutic orientations of this unusual but malignant tumor are described. [less ▲]

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See detailLe carcinome de Merkel.
Barile, Paola ULiege; Leroy, Cécile ULiege; Bolle, S. et al

in Journal Français d'Ophtalmologie (2004), 27(4), 432-6

Merkel cell carcinoma is a neuroendocrine tumor of the skin, originating from neuroendocrine cells. A case report of Merkel cell carcinoma, discovered in a 77-Year-old woman, was diagnosed and confirmed ... [more ▼]

Merkel cell carcinoma is a neuroendocrine tumor of the skin, originating from neuroendocrine cells. A case report of Merkel cell carcinoma, discovered in a 77-Year-old woman, was diagnosed and confirmed on a biopsy. Diagnostic and therapeutic orientations of this unusual but malignant tumor are described. [less ▲]

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See detailLes ulcères de cornée associés à la polyarthrite rhumatoïde.
Hick, S.; Duchesne, Bernard ULiege; Kaye, O. et al

in Revue medicale de Liege (2002), 57(4), 228-32

Keratoconjonctivitis sicca, scleritis and keratitis remain the major ocular manifestation, associated with rheumatoid arthritis. Corneal ulcers are a rare complication but can lead to perforation ... [more ▼]

Keratoconjonctivitis sicca, scleritis and keratitis remain the major ocular manifestation, associated with rheumatoid arthritis. Corneal ulcers are a rare complication but can lead to perforation. Unstable epithelial barrier and immune disorders play a key role in the pathophysiology of such corneal melting. Moreover the association with systemic vasculitis reveals the need for an appropriate immunosuppressive treatment. New surgical approaches and early immunotherapy allow to maintain ocular integrity even if the visual prognosis is poor. [less ▲]

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See detailUse of Human Fibrin Glue and Amniotic Membrane Transplant in Corneal Perforation
Duchesne, Bernard ULiege; Tahi, H.; Galand, Albert ULiege

in Cornea (2001), 20(2), 230-2

PURPOSE: To repair corneal perforation using human fibrin glue (HFG) and amniotic membrane transplant (AMT). METHODS: Three patients in whom central corneal perforations, approximately 2 mm in diameter ... [more ▼]

PURPOSE: To repair corneal perforation using human fibrin glue (HFG) and amniotic membrane transplant (AMT). METHODS: Three patients in whom central corneal perforations, approximately 2 mm in diameter, occurred after ocular or systemic disease were successfully cured using HFG and AMT. The technique consists first of using a high-viscosity sodium hyaluronate viscoelastic material to restore anterior chamber depth followed by a debridement of the ulcer. The perforation site is filled with the HFG to corneal surface level. The so-formed plug is then secured with an AMT to avoid its extrusion. An extended-wear bandage contact lens and topical antibiotics were used in these patients for 3 weeks. RESULTS: Total reepithelialization was observed after an average of 15 postoperative days. The AMT dissolved within 8 weeks to uncover a whitish scar formed within the perforation sites. No complications were observed in any patients. After a follow-up period of 195-325 days, all corneas remained stable; there was no infection or ulcer recurrence, but some corneal scar thinning was observed in all three cases. CONCLUSION: The described surgical approach using HFG and AMT allowed a successful repair of corneal perforations with a diameter of 2 mm associated with significant loss of stroma. This method may be a good alternative to delay penetrating keratoplasty for treating corneal perforations, especially in acute cases in which graft rejection risk is high. eal [less ▲]

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See detailCorneal preparation of eye bank eyes for experimental surgery.
Hamaoui, M.; Tahi, H.; Chapon, P. et al

in Cornea (2001), 20(3), 317-20

PURPOSE: To evaluate the efficacy of dextran in balanced salt solution (BSS) as a preparation of eye bank corneas for experimental surgeries. METHODS: We used 12 eye bank eyes that were unsuitable for ... [more ▼]

PURPOSE: To evaluate the efficacy of dextran in balanced salt solution (BSS) as a preparation of eye bank corneas for experimental surgeries. METHODS: We used 12 eye bank eyes that were unsuitable for transplant. The corneas were removed from the globe and affixed to a Hanna artificial anterior chamber. Four concentrations of dextran-BSS (10%, 15%, 20%, and 30% [+/-0.56%]) were used to dehydrate the corneas, and corneal thickness was assessed with an ultrasonic pachymeter (+/-5 microm) at varying time-intervals over 3 hours. RESULTS: The corneas were thinned to an average thickness of 477+/-54 microm, 430+/-54 microm, 406+/-61 microm, and 391+/-52 microm at average times of 75+/-0 minutes, 85+/-23 minutes, 60+/-12 minutes, and 45+/-0 minutes for the 10%, 15%, 20%, and 30% concentrations, respectively. Corneal thickness was stabilized in both a 15% and a 20% solution. The data was fit to exponential curves until a minimum value was reached, after which linear regression analysis was used to determine the slopes of the data. The slopes for the 15% and 20% concentrations were not significantly different from 0 (p = 0.5 and p = 0.4, respectively). The slopes for each set of data from the 10% and 30% concentrations were significantly different from each other (p = 0.010 and p = 0.001, respectively). CONCLUSIONS: A solution of 20% dextran in BSS is effective for dehydrating eye bank corneas to a quasi-normal physiologic thickness and for maintaining the thickness for a sufficient amount of time. Both the posterior and anterior sides of the cornea should be exposed to the solution for 60 minutes. [less ▲]

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