Publications of Dominique DIVE
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See detailMultiparameter MRI quantification of microstructural tissue alterations in multiple sclerosis
LOMMERS, Emilie ULiege; Simon, Jessica ULiege; REUTER, Gilles ULiege et al

in NeuroImage: Clinical (2019), 23

Objectives: Conventional MRI is not sensitive to many pathological processes underpinning multiple sclerosis (MS) ongoing in normal appearing brain tissue (NABT). Quantitative MRI (qMRI) and a ... [more ▼]

Objectives: Conventional MRI is not sensitive to many pathological processes underpinning multiple sclerosis (MS) ongoing in normal appearing brain tissue (NABT). Quantitative MRI (qMRI) and a multiparameter mapping (MPM) protocol were used to simultaneously quantify magnetization transfer (MT) saturation, transverse relaxation rate R2* (1/T2*) and longitudinal relaxation rate R1 (1/T1), and assess differences in NABT microstructure between MS patients and healthy controls (HC). Methods: This prospective cross-sectional study involves 36 MS patients (20 females, 16 males; age range 22-63 years; 15 relapsing-remitting MS - RRMS; 21 primary or secondary progressive MS - PMS) and 36 age-matched HC (20 females, 16 males); age range 21-61 years). The qMRI maps are computed and segmented in lesions and 3 normal appearing cerebral tissue classes: normal appearing cortical grey matter (NACGM), normal appearing deep grey matter (NADGM), normal appearing white matter (NAWM). Individual median values are extracted for each tissue class and MR parameter. MANOVAs and stepwise regressions assess differences between patients and HC. Results: MS patients are characterized by a decrease in MT, R2* and R1 within NACGM (p < 0.0001) and NAWM (p < 0.0001). In NADGM, MT decreases (p < 0.0001) but R2* and R1 remain normal. These observations tend to be more pronounced in PMS. Quantitative MRI parameters are independent predictors of clinical status: EDSS is significantly related to R1 in NACGM and R2* in NADGM; the latter also predicts motor score. Cognitive score is best predicted by MT parameter within lesions. Conclusions: Multiparametric data on brain microstructure concord with the literature, predict clinical performance and suggest a diffuse reduction in myelin and/or iron content within NABT of MS patients. [less ▲]

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See detailIs the triple stimulation technique a better quantification tool of motor dysfunction than motor evoked potentials in multiple sclerosis?
GIFFROY, Xavier ULiege; DIVE, Dominique ULiege; KAUX, Jean-François ULiege et al

in Acta Neurologica Belgica (2019), 119(1), 47-54

The triple stimulation technique (TST) was rarely used in multiple sclerosis (MS). This study aimed to compare TST and motor evoked potentials (MEP) for the quantification of motor dysfunction. Central ... [more ▼]

The triple stimulation technique (TST) was rarely used in multiple sclerosis (MS). This study aimed to compare TST and motor evoked potentials (MEP) for the quantification of motor dysfunction. Central motor conduction based on MEP (four limbs) and TST (upper limbs) was assessed in 28 MS patients with a median Expanded Disability Status Scale (EDSS) of 4. EDSS, timed 25-foot walk (T25FW), grasping strength and motor components of the MS functional composite (MSFCm) were evaluated. Regression analysis was used to assess the relationship between MEP, TST and clinical findings. TST was negatively correlated with EDSS (r = -0.74, p<0.0001) and to a lesser extent with T25FW (r = -0.47, p<0.05), and grasping strength (r = -0.43, p<0.05). A multiple regression analysis underlined the better correlation between clinical data and TST (R2 = 0.56, p<0.0005) than with MEP (0.03<R2<0.22, p>0.05). This study evidenced the value of TST as a quantification tool of motor dysfunction. TST appeared to reflect a global disability since it was correlated not only to hand function but also to walking capacity. [less ▲]

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See detailIndications de l'autogreffe dans la sclérose en plaques : recommandations de la Société francophone de greffe de moelle et de thérapie cellulaire (SFGM-TC) en lien avec la Société francophone de la sclérose en plaques
Zephir, H.; Puyade, M.; Gueguen, A. et al

in Bulletin du Cancer (2019), 106

The Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) organized the 8th allogeneic hematopoietic stem cell transplantation clinical practices harmonization workshop series ... [more ▼]

The Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) organized the 8th allogeneic hematopoietic stem cell transplantation clinical practices harmonization workshop series in September 2017 in Lille, France. In this article we give the indications of autologous stem cell transplantation in multiple sclerosis as well as recommendations regarding post-transplant follow-up of patients under the hospice of the SFGM-TC and the Francophone Society of Multiple Sclerosis. © 2018 [less ▲]

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See detailThyroid dysfunction after Alemtuzumab treatment for multiple sclerosis : a report of four cases
Daniel, Sara ULiege; HANSEN, Isabelle ULiege; Dive, Dominique ULiege et al

in Acta Clinica Belgica (2018, December), 73(2),

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See detailNMOSD with anti-MOG antibodies following anti-TNFα therapy: A case report
LOMMERS, Emilie ULiege; DEPIERREUX, Frédérique ULiege; HANSEN, Isabelle ULiege et al

in Multiple Sclerosis and Related Disorders (2018), 26

Tumor necrosis factor α (TNFα) inhibitors are highly effective and a therapeutic choice for several inflammatory diseases. Their broad and long-term use is associated with a growing number of paradoxical ... [more ▼]

Tumor necrosis factor α (TNFα) inhibitors are highly effective and a therapeutic choice for several inflammatory diseases. Their broad and long-term use is associated with a growing number of paradoxical autoimmune events including demyelinating lesions of the central nervous system (CNS). We report and discuss a case of neuromyelitis optica spectrum disorder (NMOSD) with positive myelin oligodendrocyte glycoprotein antibodies (MOG-IgG1) following anti-TNFα therapy for a pustular psoriasis. [less ▲]

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See detailNeurophysiological techniques for functional quantification
DIVE, Dominique ULiege; GIFFROY, Xavier ULiege; WANG, François-Charles ULiege

Conference (2017, November 09)

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See detailDo evoked potentials contribute to the functional follow-up and clinical prognosis of multiple sclerosis?
GIFFROY, Xavier ULiege; MAES, Nathalie ULiege; Albert, Adelin ULiege et al

in Acta Neurologica Belgica (2017)

The clinical variability and complexity of multiple sclerosis (MS) challenges the individual clinical course prognostication. This study aimed to find out whether multimodal evoked potentials (EP ... [more ▼]

The clinical variability and complexity of multiple sclerosis (MS) challenges the individual clinical course prognostication. This study aimed to find out whether multimodal evoked potentials (EP) correlate with the motor components of multiple sclerosis functional composite (MSFCm) and predict clinically relevant motor functional deterioration. One hundred MS patients were assessed at baseline (T0) and about 7.5 years later (T1), with visual, somatosensory and motor EP and rated on the Expanded Disability Status Scale (EDSS) and the MSFCm, including the 9 Hole Peg Test and the Timed 25 Foot Walk (T25FW). The Spearman correlation coefficient (rS) was used to evaluate the cross-sectional and longitudinal relationship between EP Z scores and clinical findings. The predictive value of baseline electrophysiological data for clinical worsening (EDSS, 9-HPT, T25FW, MSFCm) during follow-up was assessed by logistic regression analysis. Unlike longitudinal correlations, cross-sectional correlations between EP Z scores and clinical outcomes were all significant and ranged between 0.22 and 0.67 (p\0.05). The global EP Z score was systematically predictive of EDSS and MSFCm worsening over time (all p\0.05). EP latency was a better predictor than amplitude, although weaker than latency and amplitude aggregation in the global EP Z score. The study demonstrates that EP numerical scores can be used for motor function monitoring and outcome prediction in patients with MS. [less ▲]

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See detailMultimodal evoked potentials for functional quantification and prognosis in multiple sclerosis
GIFFROY, Xavier ULiege; MAES, Nathalie ULiege; Albert, Adelin ULiege et al

in BMC Neurology (2016)

Functional biomarkers able to identify multiple sclerosis (MS) patients at high risk of fast disability progression are lacking. The aim of this study was to evaluate the ability of multimodal (upper and ... [more ▼]

Functional biomarkers able to identify multiple sclerosis (MS) patients at high risk of fast disability progression are lacking. The aim of this study was to evaluate the ability of multimodal (upper and lower limbs motor, visual, lower limbs somatosensory) evoked potentials (EP) to monitor disease course and identify patients exposed to unfavourable evolution. One hundred MS patients were assessed with visual, somatosensory and motor EP and rated on the Expanded Disability Status Scale (EDSS) at baseline (T0) and about 6 years later (T1). The Spearman correlation (rS) was used to evaluate the relationship between conventional EP scores and clinical findings. Multiple (logistic) regression analysis estimated the predictive value of baseline electrophysiological data for three clinical outcomes: EDSS, annual EDSS progression, and the risk of EDSS worsening. In contrast to longitudinal correlations, cross-sectional correlations between the different EP scores and EDSS were all significant (0.33 ≤ rS < 0.67, p < 0.001). Baseline global EP score and EDSS were highly significant predictors (p < 0.0001) of EDSS progression 6 years later. The aseline global EP score was found to be an independent predictor of the EDSS annual progression rate (p < 0.001), and of the risk of disability progression over time (p < 0.005). Based on a ROC curve determination, we defined a Global EP Score cut off point (17/30) to identify patients at high risk of disability progression illustrated by a positive predictive value of 70 %. This study provides a proof of the concept that electrophysiology could be added to MRI and used as another complementary prognostic tool in MS patients. [less ▲]

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See detailPlace de l'exploration neurophysiologique dans la SEP
DIVE, Dominique ULiege; GIFFROY, Xavier ULiege; WANG, François-Charles ULiege

Conference (2014, October 11)

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See detailCe cavernome cérébral est-il la cause d'un syndrome parkinsonien ?
Benmouna, Karim ULiege; DIVE, Dominique ULiege; WANG, François-Charles ULiege et al

in Revue Médicale de Liège (2013), 68(12), 613-616

We report the case of a patient presenting with an akineto-rigid syndrome of the left hemibody whose etiological exploration by magnetic resonance imaging showed the presence of a cavernoma located in the ... [more ▼]

We report the case of a patient presenting with an akineto-rigid syndrome of the left hemibody whose etiological exploration by magnetic resonance imaging showed the presence of a cavernoma located in the right lenticular region. The interest of this situation lies in establishing whether pathophysiological link may exist between such symptoms and the lesion. [less ▲]

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See detailPartial trisomy 4q associated with young-onset dopa-responsive parkinsonism.
Garraux, Gaëtan ULiege; CABERG, Jean-Hubert ULiege; Vanbellinghen, Jean-Francois et al

in Archives of Neurology (2012), 69(3), 398-400

OBJECTIVE: To describe a patient who developed a young-onset, dopa-responsive parkinsonism linked to a de novo heterozygous interstitial duplication 4q. DESIGN: Case report. SETTING: Movement Disorder ... [more ▼]

OBJECTIVE: To describe a patient who developed a young-onset, dopa-responsive parkinsonism linked to a de novo heterozygous interstitial duplication 4q. DESIGN: Case report. SETTING: Movement Disorder Outpatient Clinic at the University Hospital Centre, Liege, Belgium. Patient A 31-year-old woman. MAIN OUTCOME MEASURES: Clinical, neuroimaging, and genetic data. RESULTS: The duplicated region contains 150 known genes, including the alpha-synuclein (SNCA) gene locus. Motor and 6-[(18)F]fluoro-L-dopa positron emission tomography features are similar to those previously reported in heterozygote SNCA duplication carriers. Altered expression of other genes contained in the duplicated region may contribute to clinical features that are uncommon in the phenotypic spectrum of SNCA multiplications such as delayed developmental psychomotor milestones during infancy and musculoskeletal abnormalities. CONCLUSION: This case report provides new insights on the genetic basis of parkinsonism. [less ▲]

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See detailLa maladie d'Hirayama
WANG, François-Charles ULiege; GÖBELS, Catherine ULiege; TOMASELLA, Marco ULiege et al

in Lettre du Neurologue: le Courrier du Spécialiste (2011), XV(7), 246-252

La MH reste une maladie rare et sa physiopathologie, toujours incertaine, rend le choix thérapeutique quelque peu hasardeux. Le port du collier cervical semble indiqué en phase évolutive dans les formes ... [more ▼]

La MH reste une maladie rare et sa physiopathologie, toujours incertaine, rend le choix thérapeutique quelque peu hasardeux. Le port du collier cervical semble indiqué en phase évolutive dans les formes les plus typiques. Lorsque se surajoute une compression visible de la moelle cervicale en position neutre, une image cavitaire intra-médullaire ou une atteinte débordant les cornes antérieures, un geste chirurgical devra être discuté. [less ▲]

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See detailMétastase septique dorsale secondaire d’un abcès rétropharyngé responsable d’une tétraparésie
Kaux, Jean-François ULiege; LENELLE, Jacques ULiege; FRIPPIAT, Frédéric ULiege et al

in Revue Neurologique (2011), 167(8-9), 638-640

Introduction: Peri-tonsillar abscess remains one of the most frequent serous complications of oropharyngeal or dental infections. It can evolve to parapharyngeal and/or retropharyngeal spaces. It can be ... [more ▼]

Introduction: Peri-tonsillar abscess remains one of the most frequent serous complications of oropharyngeal or dental infections. It can evolve to parapharyngeal and/or retropharyngeal spaces. It can be life-threatning and, more rarely, neurological complications are described. Observations: We report the case of a 56 year old woman who developed within few days a progressive tetraparesia due to cervical medullary compression. This compression was consecutive to an epidurite which was a complication of a retropharyngeal abscess. The only surgical act was a cervicotomy to drain the abscess and identify the pathological germ. A targeted antibiotherapy was quickly begun. The recovery was obtained rather quickly and the neurological evolution was good. After one year, the cervical spine presents a post-infectious deformation without sign of root or spinal-cord compression. Conclusion: A cervical tetraparesia induced by spondylodiscitis and epiduritis following a retropharyngeal abscess with Staphylococcus aureus is a rare complication. Adequate diagnosis, as fast as possible, is mandatory in order to carry out an adapted antibiotherapy in the hopes of a complete recovery. The place of surgery on the spine remains to be specified. [less ▲]

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See detailLatence du potentiel global d’action musculaire du muscle 1er interosseux dorsal de la main
Kaux, Jean-François ULiege; Dive, Dominique ULiege; Wang, François-Charles ULiege

in Lettre du Neurologue: le Courrier du Spécialiste (2011), XV(1), 21-23

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See detailRéponses « prémotrices » du muscle premier interosseux dorsal de la main
Kaux, Jean-François ULiege; Dive, Dominique ULiege; Wang, François-Charles ULiege

in XVIIèmes Journées Francophones d'Electroneuromyographie (2010, June 11)

Introduction – Lors de l’enregistrement du potentiel global d’action musculaire (PGAM) au niveau du muscle premier interosseux dorsal de la main (PID) après stimulation du nerf ulnaire au poignet, il est ... [more ▼]

Introduction – Lors de l’enregistrement du potentiel global d’action musculaire (PGAM) au niveau du muscle premier interosseux dorsal de la main (PID) après stimulation du nerf ulnaire au poignet, il est habituel d’observer un pic positif initial (pour une amplification d’environ 1 mV par division). Objectif – Déterminer l’origine de cette déflection positive précédant le PAGM du PID lors de la stimulation du nerf ulnaire au poignet. S’agit-il d’une réponse motrice générée au voisinage de l’électrode de détection active (champ proche) ? La positivité signifiant que les plaques motrices, où est générée cette réponse, ne sont pas exactement sous l’électrode active. S’agit-il, au contraire, de la captation d’une activité générée nettement à distance du système de détection (champ lointain) ? La positivité étant alors liée à l’orientation d’un dipôle électrique par rapport au système de détection. Sujets et méthodes - Dix patients successifs, indemnes d’atteinte du nerf ulnaire, sont étudiés. Une électrode active (G1) est placée sur le PID, au sommet de la saillie musculaire provoquée par le rapprochement actif du pouce et de l’index. L’électrode de référence (G2) est placée successivement sur le pouce, l’index, l’auriculaire, l’os trapèze au poignet et sur le membre controlatéral. Une stimulation électrique percutanée est appliquée au nerf ulnaire au poignet. Le muscle abducteur du Vème doigt (AB5) est également étudié (G1 au milieu de l’éminence hypothénar et G2 sur l’auriculaire). Résultats – Le pic positif précédant le PAGM du PID est en moyenne plus ample lorsque l’électrode de référence est placée sur l’index. Le PAGM du PID débute systématiquement par une déflection négative lorsque l’électrode de référence est placée sur l’os trapèze au poignet ou sur le membre controlatéral. L’absence de positivité initiale est associée à un raccourcissement de la latence distale motrice. Lorsque le gain des réponses motrices du PID et de l’AB5 est fixé à 0,1 ou 0,2 mV/division, quel que soit le muscle étudié et quel que soit le montage G1/G2 utilisé, toutes les déflections initiales (positives ou négatives) présentent une latence identique ou presque. Discussion – La déflection positive initiale qui précède le PAGM du PID, lorsque G2 est distale par rapport à la cathode, reflète l’activité générée au niveau des autres muscles innervés par le nerf ulnaire et notamment l’AB5. L’absence de cette positivité, lorsque G2 est proximale à la cathode ou sur le membre controlatéral, est liée à une inversion de polarité de la déflection initiale. Il en résulte, une réduction artificielle de la latence distale motrice. Ce type de référence doit donc être évité dans nos examens de routine. Conclusion – Ce travail souligne d’une part, l’importance de G2 dans l’enregistrement d’un PAGM et d’autre part, que les enregistrements de surface peuvent être influencés par la contraction de muscles situés à distance du couple G1/G2, même si un seul nerf est activé par la stimulation électrique percutanée. [less ▲]

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See detailMotor neuron disorders : novel electrophysiologic approach (MUFDEC protocol)
WANG, François-Charles ULiege; Le Forestier, Nadine; WANG, Pascale ULiege et al

in Clinical Neurophysiology (2009), Suppl(Vol 60), 143-152

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