Publications of Jean-Luc NIZET
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See detailUtilisation des pansements à base de miel dans le traitement des plaies
Nizet, Océane ULiege; CAMBY, Séverine ULiege; NIZET, Jean-Luc ULiege

in Revue Médicale de Liège (2020), 75(12), 797-801

Le miel est utilisé en médecine traditionnelle depuis longtemps pour un grand nombre de lésions. Il a bénéficié d’un regain d’intérêt pour un usage médical depuis l’émergence de résistances bactériennes ... [more ▼]

Le miel est utilisé en médecine traditionnelle depuis longtemps pour un grand nombre de lésions. Il a bénéficié d’un regain d’intérêt pour un usage médical depuis l’émergence de résistances bactériennes aux antibiotiques. Il est connu, notamment, pour ses propriétés antibactériennes, pro-cicatrisantes et immunomodulatrices. Bien que les mécanismes et composés bioactifs à l’origine de ces propriétés soient encore mal compris, le miel apparaît comme un agent thérapeutique dans la prise en charge d’une grande variété de plaies. Depuis peu, des pansements à base de miel médical ont été développés. Cet article décrit les principales propriétés attribuées aux pansements à base de miel et leur utilisation dans le traitement des plaies. [less ▲]

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See detailApport de la technologie 3D en chirurgie maxillo-faciale
Jaumotte, Martin ULiege; Grobet, Paul ULiege; PEPINSTER, Florence ULiege et al

in Revue Médicale de Liège (2020), 75(4), 240-242

Depuis quelques années, la technologie dite «conception et impression 3D» s’utilise avec succès dans les interventions de reconstruction osseuse maxillo-faciale. Nous en avons apprécié les bénéfices dans ... [more ▼]

Depuis quelques années, la technologie dite «conception et impression 3D» s’utilise avec succès dans les interventions de reconstruction osseuse maxillo-faciale. Nous en avons apprécié les bénéfices dans la confection d’implants faciaux sur mesure. La finesse de leur réalisation permet d’obtenir une parfaite congruence anatomique avec la meilleure biocompatibilité. Au sein du service de Chirurgie plastique et maxillo-faciale du CHU de Liège, nous avons effectué deux interventions avec implants 3D redéfinissant le squelette facial. Le but de cet article est de mettre en évidence les possibilités actuelles des implants faciaux via les nouvelles technologies 3D, mais également les avantages et les complications éventuelles de ce type de chirurgie. [less ▲]

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See detailContralateral vascularized lymph node transfer : an optimized mouse model
VOTTERO, Giulia ULiege; MORFOISSE, Florent; Durré, Tania ULiege et al

in Journal of Reconstructive Microsurgery Open (2019), 4

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See detailDescription of Two Cases of Anaplastic Large Cell Lymphoma Associated with a Breast Implant
Crèvecoeur, Julie; Jossa, Véronique; SOMJA, Joan ULiege et al

in Case Reports in Radiology (2019)

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See detailBruxisme Nocturne: Actualités et prise en charge
Grobet, P.; Gilon, Yves ULiege; Bruwier, Annick ULiege et al

in Revue Médicale de Liège (2017), 72(9), 410-415

Although well studied since the 50's, bruxism remains a largely unknown pathology. Its origin is complex, mixing psychological as well as neurological, odontological and hypnic aspects. However, the few ... [more ▼]

Although well studied since the 50's, bruxism remains a largely unknown pathology. Its origin is complex, mixing psychological as well as neurological, odontological and hypnic aspects. However, the few analyzes performed on this topic have allowed to set convincing etiopathological hypotheses, including central dysregulation of the dopaminergic system as well as of the neuro-masticatory system. To avoid harmful consequences as headaches, temporomandibular disorders and premature dental scuffs / fractures, it is mandatory to diagnose bruxism as early as possible. For this purpose, and in addition to anamnestic and clinical data, the practitioner can confirm diagnosis with polysomnography, including electromyographic study of masticatory muscles and audiovisual recording. Some orthodontic, pharmacological and psychological solutions have already proved efficient. Nevertheless, a better knowledge of causative neurobiological mechanisms would allow to foresee etiology-based treatments. [less ▲]

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See detailNouveaux paradigmes et métaphores du traitement du mélanome cutané
PIERARD, Gérald ULiege; NIZET, Jean-Luc ULiege; HUMBERT, P.

in Revue Médicale de Liège (2016), 71(12), 562-566

In recent years, new drugs have been designed for treating advanced cutaneous malignant melanoma, in particular the metastases. They afford modest benefits despite the fact they are commonly heralded as ... [more ▼]

In recent years, new drugs have been designed for treating advanced cutaneous malignant melanoma, in particular the metastases. They afford modest benefits despite the fact they are commonly heralded as breakthroughs in the lay press and by some medical opinion leaders. Unfortunately, the use of inflated descriptors of the drug efficacy leads to misunderstandings among the clinicians in charge of patients. Currently, vemurafenib, ipilimumab, pembrolizumab and nivolumab have demonstrated their relative activity in the control of advanced malignant melanoma. The results expected from surrogate markers of efficacy are magnified and idealized regarding the expectations from many patients. The recent therapeutic advance improves the median overall survival for a few months. Some combined treatments could possibly boost the current beneficial effects. [less ▲]

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See detailComment j'explore... une dysmorphose dento-maxillo-faciale.
Urbain, Valérie; GILON, Yves ULiege; BRUWIER, Annick ULiege et al

in Revue Médicale de Liège (2016), 71(9), 394-399

Dento-maxillofacial dysmorphoses represent a considerable area of maxillofacial surgery. Their incidence has constantly been on the rise since the beginning of the century. This can be explained by ... [more ▼]

Dento-maxillofacial dysmorphoses represent a considerable area of maxillofacial surgery. Their incidence has constantly been on the rise since the beginning of the century. This can be explained by variations in the food and society habits.We will first discuss the various causes (congenital and environnemental) and the pathophysiology of these disorders. Then, we will separate them according to the skeletal and Angle’s classifications. We will examine the predictive criteria of these dysmorphoses from the youngest age and consider their clinical and cephalometrical diagnosis We will envisage their functional and aesthetic consequences and expose the preventive options. Finally, we will describe the orthodontic and surgical treatment available today and conclude that surgery remains the gold standard by restoring the conventional axis. [less ▲]

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See detailConsequences metaboliques et cardiovasculaires de la lipoaspiration : revue systematique de la litterature.
Crahay, F.-X.; Nizet, Jean-Luc ULiege

in Annales de Chirurgie Plastique Esthetique (2016), 61(4), 270-86

BACKGROUND: Suction-assisted lipectomy is one of the most frequent procedures in plastic surgery. The aim of this study was to investigate whether suction-assisted lipectomy causes changes in the ... [more ▼]

BACKGROUND: Suction-assisted lipectomy is one of the most frequent procedures in plastic surgery. The aim of this study was to investigate whether suction-assisted lipectomy causes changes in the carbohydrates and lipid metabolism and the potential effects on cardiovascular risk factors. METHODS: We interrogated five databases: Medline, American College of Physicians Journal Club Database, Cochrane central register of controlled trials, Cochrane database of systematic reviews, Database of abstracts of reviews of effects. A systematic review of the literature was performed in order to compare results of randomized controlled trials and observational studies concerning changes in weight, metabolism, endocrinology, inflammatory markers and cardiovascular risk factors after suction-assisted lipectomy. All articles were assessed by criteria from Oxford Center For Evidence Based Medicine (OCEBM). RESULTS: The search resulted in 40 articles: 12 experimental animal studies and 28 human studies. CONCLUSION: Different metabolic parameters are affected by suction-assited lipectomy. First, all articles point out a decrease of body weight after suction-assisted lipectomy. Weight lost only affects fat mass without any change of lean mass. The potential compensatory growth of visceral fat seems to be counteracted by physical activity. Then, resting energy expenditure seems to be stable or decrease after the surgery. This reduction is significantly related to the decrease of leptin levels and also seems to be counteracted by physical activity. About adipocytokines, leptin level decreases after suction-assisted lipectomy while results are contradictory about adiponectin and resistin levels. However adiponectin seems to tend to increase after surgery. Inflammatory markers seem to increase within first hours after surgery. Then they seem to decrease or remain at the preoperative levels. Fasting insulin level decreases and is linked to the aspirated volume. So insulin sensitivity seems to be improved. Concerning lipid profil, it tends to remain the same or to be improved by suction-assisted lipectomy. In conclusion, regarding all the literature, there is still debate about metabolic effect of suction-assisted lipectomy. Prospective clinical studies are needed to confirm or invalidate some hypotheses. These studies must consider some potential biases as physical activity, diet and medical treatment modifications (statins). [less ▲]

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See detailCOMMENT JE TRAITE ... des plaies mineures superficielles.
Hermanns-Lê, Trinh ULiege; Nizet, Jean-Luc ULiege; Pierard-Franchimont, Claudine ULiege et al

in Revue Médicale de Liège (2016), 71(3), 116-9

Superficial minor wounds represent frequent events in daily practice. Their evolution is often favourable and without any mishap. However, they possibly evolve to some serious episodes. Normal healing ... [more ▼]

Superficial minor wounds represent frequent events in daily practice. Their evolution is often favourable and without any mishap. However, they possibly evolve to some serious episodes. Normal healing develops in three successive phases. They correspond to the inflammatory, proliferative and remodeling phases, respectively. Their treatments are distinct. The major active agents are cleaning products, antiseptics, corticosteroids and silicone gels. By contrast products claiming some healing properties are disappointing in most cases, and in some instances, they are of no use. [less ▲]

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See detailComment je traite... la reconstruction du nez
RENWART, Ludovic ULiege; NIZET, Jean-Luc ULiege

in Revue Médicale de Liège (2015), 70(10), 481-485

Les pertes de substance sont une pathologie fréquente en chirurgie plastique, principalement après l'exérèse de cancer de la peau. Les résultats de la reconstruction nasale doivent répondre à des ... [more ▼]

Les pertes de substance sont une pathologie fréquente en chirurgie plastique, principalement après l'exérèse de cancer de la peau. Les résultats de la reconstruction nasale doivent répondre à des exigences esthétiques et fonctionnelles élevées. Une analyse minutieuse de la perte de substance est impérative pour évaluer les déficits anatomiques et esthétiques. Toute perte osseuse, cartilagineuse ou de la muqueuse doit être restaurée. Les lambeaux locaux permettent de couvrir les pertes de substances limitées. Le lambeau frontal est le lambeau de référence pour les plaies complexes. [less ▲]

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See detailComment je traite... la luxation condylienne mandibulaire antérieure
GILON, Yves ULiege; Johnen, Julien ULiege; NIZET, Jean-Luc ULiege

in Revue Médicale de Liège (2015), 70(9), 411-414

The anterior dislocation of the temporomandibular joint is not uncommon and requires prompt management. A dislocation reduction defect can lead to severe functional impairment of complex joint and often ... [more ▼]

The anterior dislocation of the temporomandibular joint is not uncommon and requires prompt management. A dislocation reduction defect can lead to severe functional impairment of complex joint and often active. The focus is clinical and diagnostically relatively obvious. It is performed by medical teams frontline, general practitioner or Emergency doctor. The recurrent cases are a matter for maxillofacial surgeons. This article describes a conventional technique for anterior dislocation reduction, to achieve urgently. The second part of the article deals with the treatment of relapsing forms, business specialist and their surgical techniques. [less ▲]

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See detailOncological and surgical outcome after oncoplastic breast surgery
NIZET, Jean-Luc ULiege; MAWEJA, Sylvie ULiege; LAKOSI, Ferenc ULiege et al

in Acta Chirurgica Belgica (2015), 115

BACKGROUND: Oncoplastic surgery combines breast-conserving treatment and plastic surgery techniques. The aim of the study was to identify breast and tumor-related characteristics that contribute to the ... [more ▼]

BACKGROUND: Oncoplastic surgery combines breast-conserving treatment and plastic surgery techniques. The aim of the study was to identify breast and tumor-related characteristics that contribute to the rate of complications and recurrence. METHODS: This retrospective study included 72 patients with a median follow-up of 32 months. For each patient, a comprehensive set of data was collected, including epidemiology, tumor characteristics, preoperative information, detailed pathology reports, radiotherapy treatment and type of surgical technique. The rate of complications, recurrence and survival were studied. RESULTS: Complete tumor removal was performed with clear margins in all patients but in 25 of them margins were less than 2 mm. One patient had local recurrence and another developed distant metastases. The study showed that the size of the margin was not predictive of recurrence as long as not positive; the greater the resection volume, the larger the excision margin. The resection size was the only factor influencing complications and no specific tumor-related factor significantly increased the complication rate. Surgical complications did not delay the initiation of chemotherapy and radiotherapy. CONCLUSIONS: This is the first oncoplastic study where both tumor and breast characteristics were analyzed using the most recent criteria of the literature. Oncoplastic surgery can be considered as oncologically safe. The resection size was the sole significant risk factor for postoperative complications. Complications after oncoplastic breast surgery did not differ neoadjuvant therapy. Long-term event-free survival was excellent (96% at 7 years). [less ▲]

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See detailPrise en charge d'un cancer du sein chez une femme porteuse de prothèses mammaires
REMACLE, Sarah; LIFRANGE, Eric ULiege; NIZET, Jean-Luc ULiege

in Revue Médicale de Liège (2015), 70

The incidence of breast cancer, currently one woman on eight, also concerns patients who underwent augmentation surgery. Breast implants have already been the subject of numerous publications concerning ... [more ▼]

The incidence of breast cancer, currently one woman on eight, also concerns patients who underwent augmentation surgery. Breast implants have already been the subject of numerous publications concerning the risk of inducing breast cancer or delaying the diagnosis, however, no significant causal relationship has been established. The purpose of this article is to assess the diagnostic and therapeutic consequences when breast cancer is identified in a patient with breast implants. [less ▲]

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See detailLa vignette diagnostique de l'étudiant. Diagnostic et évolution d'une chéloïde.
FRANCHIMONT, Claudine ULiege; Hermanns-Lê, Trinh ULiege; NIZET, Jean-Luc ULiege et al

in Revue Médicale de Liège (2014), 69

Une chéloïde est une formation saillante, fibreuse hypertrophique du derme. Elle est très ferme au toucher. Il en existe deux types cliniques qui correspondent, d’une part, à une évolution particulière ... [more ▼]

Une chéloïde est une formation saillante, fibreuse hypertrophique du derme. Elle est très ferme au toucher. Il en existe deux types cliniques qui correspondent, d’une part, à une évolution particulière d’une cicatrice et, d’autre part, à une apparition présumée spontanée. Cette lésion est caractérisée par des dépôts massifs de faisceaux de collagène. Cet aspect la distingue de la cicatrice hypertrophique qui représente, de manière primordiale, une accumulation de fibroblastes et de petits vaisseaux. [less ▲]

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See detailA methodological evaluation of volumetric measurement techniques including three-dimensional imaging in breast surgery
HOEFFELIN, Harry; JACQUEMIN, Denise ULiege; Defaweux, Valérie ULiege et al

in BioMed Research International (2014), 2014

Breast surgery currently remains very subjective and each intervention depends on the ability and experience of the operator. To date, no objective measurement of this anatomical region can codify surgery ... [more ▼]

Breast surgery currently remains very subjective and each intervention depends on the ability and experience of the operator. To date, no objective measurement of this anatomical region can codify surgery. In this light, we wanted to compare and validate a new technique for 3D scanning (LifeViz 3D) and its clinical application. Materials and methods. - We tested the use of the 3D LifeViz system (Quantificare) to perform volumetric calculations in various settings ("in situ" in cadaveric dissection, of control prostheses and in clinical patients) and we compared this system to other techniques (CT scanning and Archimedes' principle) under the same conditions. Results. - We were able to identify the benefits (feasibility, safety, portability, low patient stress) and limitations (underestimation of the “in situ” volume, subjectivity of contouring, and patient selection) of the LifeViz 3D system, concluding that the results are comparable with other measurement techniques. Conclusion. - The prospects of this technology seem promising in numerous applications in clinical practice to limit the subjectivity of breast surgery. [less ▲]

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See detailTowards targeted early burn care: lessons from a European survey.
ROUSSEAU, Anne-Françoise ULiege; MASSION, Paul ULiege; LAUNGANI, Alexis ULiege et al

in Journal of Burn Care and Research (2014), 35

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See detailTransferts graisseux au niveau du sein: implications oncologiques.
NIZET, Jean-Luc ULiege; Gonzalez, Arnaud ULiege; Peulen, Olivier ULiege et al

in Revue Médicale de Liège (2011), 66(5-6), 362-6

Autologous fat grafting for breast is increasing dramatically. This fat injection needs accurate technical conditions, and shows very good and long-lasting clinical results. Nevertheless, in breast ... [more ▼]

Autologous fat grafting for breast is increasing dramatically. This fat injection needs accurate technical conditions, and shows very good and long-lasting clinical results. Nevertheless, in breast conservative treatment sequellae, fat injection could lead to difficulties in breast imaging, but also there is some concerns about the potential oncologic risks of these procedures. [less ▲]

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See detailLa chirurgie oncoplastique du sein.
BOUS, Aurélie ULiege; NARDELLA, Daniele ULiege; MAWEJA, Sylvie ULiege et al

in Revue Médicale de Liège (2011), 66(5-6), 341-50

Oncoplastic surgery combines large lumpectomy and defect remodeling by different plastic surgery methods. These procedures improve the cosmetic result after partial mastectomy and widens the possibilities ... [more ▼]

Oncoplastic surgery combines large lumpectomy and defect remodeling by different plastic surgery methods. These procedures improve the cosmetic result after partial mastectomy and widens the possibilities for conservative treatment. Different techniques are used from simple glandular remodeling to more difficult techniques for breast plasties with or without simultaneous controlateral symetrisation procedure. The surgical option depends especially on the ratio between the volume of the tumor and the volume of the breast and the position of the tumor. This more effective conservative treatment facilitates also postoperative radiotherapy, reduces the sequellae and the psychological impact of breast cancer treatment. [less ▲]

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See detailReconstruction mammaire immédiate et radiothérapie post-opératoire : une mise au point
NARDELLA, Daniele ULiege; LAUNGANI, Alexis ULiege; LIFRANGE, Eric ULiege et al

in Revue Médicale de Liège (2011), 66(5-6), 368-361

La reconstruction mammaire est actuellement partie intégrante de la prise en charge du cancer du sein. Lorsqu’elle est proposée en immédiat, plusieurs contraintes se présentent au chirurgien plasticien ... [more ▼]

La reconstruction mammaire est actuellement partie intégrante de la prise en charge du cancer du sein. Lorsqu’elle est proposée en immédiat, plusieurs contraintes se présentent au chirurgien plasticien. La prise en charge des patientes devant bénéficier d’une mastectomie se complique par les traitements complémentaires de radiothérapie. Nous proposons, dans ce travail, une prise en charge multidisciplinaire des patientes en les adressant à des sous-groupes spécifiques. Une reconstruction immédiate sera proposée à certaines patientes compte tenu des traitements complémentaires par radiothérapie. Les choix d’orientation sont complexes et une littérature pauvre à ce sujet ne nous permet pas d’orienter de façon systématique toutes les patientes. De nouvelles études, notamment prospectives, sont nécessaires pour orienter les patientes désirant une reconstruction immédiate associée à une radiothérapie post-mastectomie. [less ▲]

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