Publications of Philippe GILLET
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See detailClinical and radiological results with a 36-mm Cobalt-Chrome prosthetic head, cross-linked Durasul liners associated with Allofit cups: A more than 10-year follow-up period.
GEORIS, Pierre ULiege; THIRION, Thierry ULiege; GILLET, Philippe ULiege

in HIP International (2020), 30(4), 446-451

Highly cross-linked polyethylene is currently a common articulation surface used for THA. The aim of the present study is in-vivo assessment of highly cross-linked Durasul® polyethylene linear and ... [more ▼]

Highly cross-linked polyethylene is currently a common articulation surface used for THA. The aim of the present study is in-vivo assessment of highly cross-linked Durasul® polyethylene linear and volumetric wear when associated with a 36-mm prosthetic femoral head. We retrospectively reviewed clinical and radiographic data of 78 patients (81 hips) having primary THAs using Durasul® liner combined with a 36-mm CoCr prosthetic head. All of them were followed for more than 10 years. Patient outcome was assessed with the Harris Hip Score (HHS) preoperatively and at last follow-up. Two-dimensional prosthetic head penetration into polyethylene, three-dimensional wear rates and cup migration were evaluated. the preoperative and last follow-up HHS were 50.43 +/- 10.42 and 97.44 +/- 5.51 respectively. The annual penetration of the prosthetic head into Durasul® liner was 0.029 +/- 0.003 mm. The annual linear penetration and volumetric wear extrapolation rates using Charnley and Ilchmann formulas were 37.84% and 57.76% respectively of that seen with conventional polyethylene liner. At last follow-up, the total loss of material in Durasul® represents only 0.15% of the initial polyethylene mass. We did not observed any significant cup migration in the study group. Results are promising and we believe that these data authorize the continued use of highly cross-linked polyethylene liner associated with a 36-mm prosthetic head for total hip arthroplasties in older patients. More long-term follow-up studies are mandatory before we feel comfortable with the project of using cross-linked polyethylene in young and active patients instead of ceramic-on-ceramic bearings. [less ▲]

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See detailL’intérêt de la planification préopératoire d’une prothèse totale de hanche
THIRION, Thierry ULiege; GEORIS, Pierre ULiege; GILLET, Philippe ULiege

in Revue Médicale de Liège (2019), 74(11), 593-597

Total hip arthroplasty (THA) is the standard surgical procedure for the treatment of severe hip osteoar- thritis. THA can be subject to surgical and medical com- plications. One of the main expectations ... [more ▼]

Total hip arthroplasty (THA) is the standard surgical procedure for the treatment of severe hip osteoar- thritis. THA can be subject to surgical and medical com- plications. One of the main expectations of our patients is to be able to resume all their daily activities. Preoperative planning of a THA is an essential step in the procedure. The reference method remains the 2D technique using «templates» positioned on an anteroposterior digital radio- graph of the pelvis. It can also be done in 3D. In addition to the type and size of prosthetic components (cup, stem and prosthetic head), the planning allows the surgeon to restore the function through correction of any limb length and/or offset discrepancy, and soft tissue tensioning in order to reach the objectives set and to limit the risks of complications. In the opposite case, the surgeon exposes the patient to complications during or after surgery with pro- bable negative consequences on the functional result. The positioning of the acetabular and femoral components is an important factor influencing the short- and long-term survi- val of THA. All patients undergoing total hip arthroplasty should have rigorous preoperative planning. [less ▲]

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See detailCEMIP (KIAA1199) induces a fibrosis-like process in osteoarthritic chondrocytes
DEROYER, Céline ULiege; CHARLIER, Edith ULiege; NEUVILLE, Sophie ULiege et al

in Cell Death and Disease (2019)

CEMIP (for “Cell migration-inducing protein” also called KIAA1199 and Hybid for “Hyaluronan-binding protein”) expression is increased in cancers and described as a regulator of cell survival, growth and ... [more ▼]

CEMIP (for “Cell migration-inducing protein” also called KIAA1199 and Hybid for “Hyaluronan-binding protein”) expression is increased in cancers and described as a regulator of cell survival, growth and invasion. In rheumatoid arthritis, CEMIP is referred to as an angiogenic marker and participates in hyaluronic acid degradation. In this study, CEMIP expression is investigated in healthy and osteoarthritis (OA) cartilage from human and mouse. Its role in OA physiopathology is deciphered, specifically in chondrocytes proliferation and dedifferentiation and in the extracellular matrix remodeling. To this end, CEMIP, αSMA and types I and III collagen expressions were assessed in human OA and non-OA cartilage. CEMIP expression was also investigated in a mouse OA model. CEMIP expression was studied in vitro using a chondrocyte dedifferentiation model. High-throughput RNA sequencing was performed on chondrocytes after CEMIP silencing. Results showed that CEMIP was overexpressed in human and murine OA cartilage and along chondrocytes dedifferentiation. Most of genes deregulated in CEMIP-depleted cells were involved in cartilage turnover (e.g., collagens), mesenchymal transition and fibrosis. CEMIP regulated β-catenin protein level. Moreover, CEMIP was essential for chondrocytes proliferation and promoted αSMA expression, a fibrosis marker, and TGFβ signaling towards the p-Smad2/3 (Alk5/PAI-1) pathway. Interestingly, CEMIP was induced by the pSmad1/5 (Alk1) pathway. αSMA and type III collagen expressions were overexpressed in human OA cartilage and along chondrocytes dedifferentiation. Finally, CEMIP was co-expressed in situ with αSMA in all OA cartilage layers. In conclusion, CEMIP was sharply overexpressed in human and mouse OA cartilage and along chondrocytes dedifferentiation. CEMIP-regulated transdifferentiation of chondrocytes into “chondro-myo-fibroblasts” expressing α-SMA and type III collagen, two fibrosis markers. Moreover, these “chondro-myo-fibroblasts” were found in OA cartilage but not in healthy cartilage. [less ▲]

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See detailSerum starvation raises turnover of phosphorylated p62/SQSTM1 (Serine 349), reveals expression of proteasome and N-glycanase1 interactive protein RAD23B and sensitizes human synovial fibroblasts to BAY 11-7085-induced cell death.
RELIC, Biserka ULiege; CHARLIER, Anne ULiege; DEROYER, Céline ULiege et al

in Oncotarget (2018), 9(88), 35830-35843

Phosphorylation of p62/SQSTM1 (p62) on Serine 349 (P-Ser349 p62) as well as proteasome dysfunction have been shown to activate the cell protective Keap1/Nrf2 pathway. We showed previously that BAY 11-7085 ... [more ▼]

Phosphorylation of p62/SQSTM1 (p62) on Serine 349 (P-Ser349 p62) as well as proteasome dysfunction have been shown to activate the cell protective Keap1/Nrf2 pathway. We showed previously that BAY 11-7085-induced human synovial fibroblast cell death includes autophagy and p62 downregulation. In this work, we have studied expression of P-Ser349 p62 in human synovial fibroblasts. Results showed that P-Ser349 p62 was not detected in synovial cell extracts unless cells were cultured in the presence of proteasome inhibitor (MG132). MG132 revealed P-Ser349 p62 turnover, that was further increased by concomitant autophagy inhibition and markedly enhanced in serum starved cells. Starvation sensitized synovial fibroblasts to BAY 11-7085 while MG132 protected both non-starved and starved cells from BAY 11-7085-induced cell death. Lentivirus mediated overexpression of phosphorylation-mimetic p62 mutant S349E markedly protected synovial fibroblasts from BAY 11-7085. Inhibitor of Keap1-P-S349 p62 interaction, K67, had synergistic effect with MG132. Starvation increased p62 molecular weight, that was reversed by serum and bovine serum albumin re-feeding. Furthermore, starvation markedly induced RAD23B. Increased endo-beta-N-acetylglucosaminidase (ENGase) turnover was detected in starved synovial fibroblasts. PNGase F treatment produced faster migration p62 form in human synovial tissue extracts but starvation-like p62 form of higher molecular weight in synovial cell extracts. Co-transfection of NGLY1, with p62 or p62 mutants S349A and S349E markedly stabilized p62 expressions in HEK293 cells. Tunicamycin upregulated p62 and protected synovial fibroblasts from BAY 11-7085-induced cell death. These results showed that P-Ser349 p62 has pro-survival role in human synovial fibroblasts and that de-glycosylation events are involved in p62 turnover. [less ▲]

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See detailLe laboratoire d’Anatomie : un banc d’essai des nouvelles technologies
Bonnet, Pierre ULiege; Carlier, Alain ULiege; Radermecker, Marc ULiege et al

in Revue Médicale de Liège (2010), 65(Synthèse 2010), 35-40

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See detailIntérêt du suivi radiologique des prothèses totales de hanche
Thirion, Thierry ULiege; Georis, Pierre ULiege; Gillet, Philippe ULiege

in Revue Médicale de Liège (2010), 64(2), 93-97

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See detailLe cas clinique du mois. Une cause inhabituelle de sciatalgie nécessitant un traitement chirurgical : le kyste arthrosynovial lombaire
Lommers, Emilie ULiege; Gillet, Philippe ULiege

in Revue Médicale de Liège (2010), 65(12), 665-8

We describe the case of a 46-year-old woman suffering from an hyperalgic sciatica caused by a lumbar synovial cyst. These are uncommon lesions associated with degenerative spine disease. They may be ... [more ▼]

We describe the case of a 46-year-old woman suffering from an hyperalgic sciatica caused by a lumbar synovial cyst. These are uncommon lesions associated with degenerative spine disease. They may be asymptomatic or may produce symptoms resulting from nervous structures compression. They are commonly found at the L4-L5 level, the site of maximum mobility. Their etiopathogeny is still unclear but degenerative spinal instability is the strongest factor for their growth. MRI is the most effective for the diagnosis. Conservative management is usually unsuccessful. Resection with or without fusion remains the more appropriate therapeutic option. [less ▲]

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See detailBiofilms endodontiques et infections tardives des prothèses totales de hanche
Goffart, Joseph ULiege; Gillet, Philippe ULiege

in Revue Médicale de Liège (2007), 62(12), 736-42

Biofilms are well recognised in different settings. Endodontic biofilms containing bacteria responsible for bacteraemia and secondary infection of total hip arthroplasties (THA) represent a diagnostic ... [more ▼]

Biofilms are well recognised in different settings. Endodontic biofilms containing bacteria responsible for bacteraemia and secondary infection of total hip arthroplasties (THA) represent a diagnostic challenge because they are often asymptomatic. Their treatment is difficult and inadequate management of such unrecognised sources of systemic infection can lead to the devastating situation of an infected arthroplasty necessitating implant removal, long term antibiotic treatment and secondary implantation of a new prosthesis. Since about ten percent of secondary infected THA can have a dental origin, this article is intended to give guidelines to all intervening care providers: general practitioner, orthopaedic surgeon and dentist. [less ▲]

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See detailActualités thérapeutiques en chirurgie orthopédique : évolution des arthroplasties
Gillet, Philippe ULiege

in Revue Médicale de Liège (2007), 62(5-6), 335-343

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See detailActualités dans le traitement des pseudarthroses aseptiques
Van Cauwenberge, Henry ULiege; Hauzeur, Jean-Philippe ULiege; Gillet, Philippe ULiege

in Revue Médicale de Liège (2007), 62(5-6), 344-351

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See detailL'osteodensitometrie dans le depistage de l'osteoporose: le paradoxe Belge
NEUPREZ, Audrey ULiege; Gillet, Philippe ULiege; Collette, C. et al

in Revue Médicale de Liège (2006), 61(4), 249-55

Osteoporosis is considered as a major Public Health issue, in most developed countries. Bone mineral density assessment is the single best predictor of the future fracture risk for an individual. Belgium ... [more ▼]

Osteoporosis is considered as a major Public Health issue, in most developed countries. Bone mineral density assessment is the single best predictor of the future fracture risk for an individual. Belgium has the highest number of bone densitometers, per million habitants, in Europe. However, densitometry is not yet reimbursed in Belgium. This situation is rather paradoxical since the demonstration of a prevalent vertebral fracture or of a low bone mineral density is requested to obtain the reimbursement of drugs to be used for the management of osteoporosis. Hopefully, Belgium will soon be online with the requirement s of the European Commission, suggesting to make bone densitometry accessible, through reimbursement. [less ▲]

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See detailBoules et autres masses". Prise en charge rationnelle des tumeurs des tissus mous."
Kurth, William ULiege; Gillet, Philippe ULiege

in Revue Médicale de Liège (2006), 61(11), 763-70

Patients with soft-tissue tumours usually consult for a mass at the level of an extremity or the torso. This article aims to help the general practitioner and the general surgeon in the standardized setup ... [more ▼]

Patients with soft-tissue tumours usually consult for a mass at the level of an extremity or the torso. This article aims to help the general practitioner and the general surgeon in the standardized setup of these tumours. The epidemiology, clinical presentation and evaluation as well as the useful exams to be performed, including biopsy, are developped, in order to obtain rational principles for the diagnostic setup and surgical decision-making. [less ▲]

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See detailL'entorse de cheville. Prise en charge des lesions fraiches et prevention des instabilites secondaires.
Popovic, Nebojsa; Gillet, Philippe ULiege

in Revue Médicale de Liège (2005), 60(10), 783-788

Ankle sprains are among the most common musculoskeletal injuries. The vast majority of these injuries are lateral ligament sprains, resulting from inversion of the plantar-flexed foot. Initial management ... [more ▼]

Ankle sprains are among the most common musculoskeletal injuries. The vast majority of these injuries are lateral ligament sprains, resulting from inversion of the plantar-flexed foot. Initial management should include rest, ice, compression and elevation. Functional treatment proved to provide the quickest recovery and an earlier return to work without compromising the lateral mechanical stability. Surgical management of acute ankle sprains is rarely, if ever, indicated. Patients who continue to sustain multiple recurrent inversion sprains despite a supervised rehabilitation program aimed at improving proprioception and strengthening of the peroneal muscles are candidate for surgical reconstruction of the lateral ankle ligaments. [less ▲]

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See detailLa commission d'hemovigilance du CHU.
Baudoux, Etienne ULiege; Blaffart, Francine ULiege; Bouffioux, Christian ULiege et al

in Revue Médicale de Liège (2000), 55(9), 878-80

As suggested by the National Blood Council, a Hemovigilance Committee was set up in the University Hospital of Liege in 1995. A multidisciplinary discussion takes place on any action aiming at the ... [more ▼]

As suggested by the National Blood Council, a Hemovigilance Committee was set up in the University Hospital of Liege in 1995. A multidisciplinary discussion takes place on any action aiming at the improvement of transfusion safety, and the follow-up of its implementation. The first issue to be discussed was the set up of a detailed documentation of all blood transfusions. The data are now recorded on a single document allowing proper identification of people and products involved, and of the eventual incidents. This document has lead to a better transfusion safety and to an improved administrative management of blood transfusion. The Commission has been coordinating two multi-centric studies analyzing the consumption of fresh blood products and the incidence of transfusion reactions. Among blood-saving policies, autologous transfusion and volume reduction of samples drawn for laboratory purposes have been discussed. Other measures were taken to improve the labeling of samples for cross-mach and to actively follow-up transfusion reactions. By its actions and advises, the Commission aims to direct strategies towards a safe and rational use of blood products. [less ▲]

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