Publications of Claudine FRANCHIMONT
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See detailL'ALCOOL ET LA PEAU
FRANCHIMONT, Claudine ULiege; NIKKELS, Arjen ULiege; PIERARD, Gérald ULiege

in Revue Médicale de Liège (2019), 74(1), 1-6

Les manifestations cutanées en relation avec la consommation et l'abus d'alcool sont multiples. Il s'agit essentiellement de manifestations vasculaires et de signes cutanés en relation avec l'atteinte ... [more ▼]

Les manifestations cutanées en relation avec la consommation et l'abus d'alcool sont multiples. Il s'agit essentiellement de manifestations vasculaires et de signes cutanés en relation avec l'atteinte hépatique. La consommation d'alcool constitue, par ailleurs, un facteur aggravant de plusieurs maladies cutanées, dont le psoriasis, au cours duquel sa prévalence est élevée. D'autres répercussions cutanées, en relation avec la prise d'alcool, sont également discutées. [less ▲]

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See detailCutaneous Melanocytomas: Variants and Caveats
Pierard, Gérald ULiege; Franchimont, Claudine ULiege

in Austin Journal of Cancer and Clinical Research (2015), 2(3), 1035

There is a regular improvement in the early clinical disclosure of various atypical melanocytic neoplasms (AMN). The histopathological examination of AMN remains mandatory for establishing their diagnosis ... [more ▼]

There is a regular improvement in the early clinical disclosure of various atypical melanocytic neoplasms (AMN). The histopathological examination of AMN remains mandatory for establishing their diagnosis and proper management. Panels of experts in AMN diagnosis report only moderate agreement in a diversity of puzzling cases. Some AMN have been differently designated in the literature including atypical Spitz tumor, metastasizing Spitz tumor, borderline and intermediate melanocytic tumor, malignant Spitz nevus and pigmented epithelioid melanocytoma or animal-type melanoma. Some acronyms have been further offered such as MELTUMP (after “melanocytic tumor of uncertain malignant potential”) and STUMP (after “Spitzoid melanocytic tumor of uncertain malignant potential”). In this review, such AMN at the exclusion of cutaneous malignant melanoma (MM) variants, are grouped under the tentative broad heading cutaneous melanocytoma. These lesions typically follow an indolent course, although they exhibit an atypical and sometimes worrisome patterns or cytologic aspects. Rare cases of cutaneous melanocytomas progress to locoregional clusters of lesions (agminate lesions), and even to regional lymph nodes. At times, the distinction between a cutaneous melanocytoma and MM remains problematic and even proves to be merely impossible. However, multipronged immunohistochemistry helps assessing the malignancy risk. [less ▲]

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See detailSweat Gland Awakening on Physical Training: A Skin Capacitance Mapping Observation
Pierard-Franchimont, Claudine ULiege; Pierard, Gérald ULiege

in Clinical Research in Dermatology (2015), 2

Skin capacitance mapping (SCM) is an established real-time noninvasive method useful in the assessment of sweat production. We presently review and explore the sweat gland production following a mild 10 ... [more ▼]

Skin capacitance mapping (SCM) is an established real-time noninvasive method useful in the assessment of sweat production. We presently review and explore the sweat gland production following a mild 10-min physical training on a cycloergometer. Sprouts of sweat vapor are progressively increased by recruiting increasing numbers of active sweat pores. An overall moisturization of the stratum corneum ensues, and liquid sweat appears in a further step. These aspects are conveniently assessed using SCM while blind assessments of the skin surface water loss cannot distinguish these functional features. [less ▲]

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See detailLes cheveux et leur environnement.
Pierard-Franchimont, Claudine ULiege; Pierard, Gérald ULiege

in Revue Médicale de Liège (2015), 70(2), 70-2

Hair is influenced by the effects of the daily environment. Some toxic xenobiotics slow down or block the cell renewal of the hair matrix, thus inhibiting hair growth. The ultraviolet light obviously ... [more ▼]

Hair is influenced by the effects of the daily environment. Some toxic xenobiotics slow down or block the cell renewal of the hair matrix, thus inhibiting hair growth. The ultraviolet light obviously influences the physical structure and physiology of the hair follicle. Tobacco is similarly responsible for negative influences on the evolution of various alopecias. Several cosmetic procedures for maintaining and making hair more attractive are not always harmless, and they occasionally represent a possible origin for alopecia. [less ▲]

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See detailComment je traite... une onychomycose par voie topique.
Pierard, Gérald ULiege; Pierard-Franchimont, Claudine ULiege

in Revue Médicale de Liège (2015), 70(1), 5-11

Onychomycosis is a frequent and challenging disease to treat. Well conducted oral therapies are commonly quite effective for a short term period. However, recurrences are frequent. Topical therapies ... [more ▼]

Onychomycosis is a frequent and challenging disease to treat. Well conducted oral therapies are commonly quite effective for a short term period. However, recurrences are frequent. Topical therapies appear globally less active. Studies in this field are rare, although the promotional advertisements to the general public abound nowadays. Various microscopic fungi (dermatophytes, yeasts, molds) should be targeted by the treatment, In addition, the distinct activity conditions of both growth and quiescence of the pathogen fungi should be influenced by the treatments. This is not frequently considered by drug companies and encountered in practice. The antifungal drug penetration inside all the nail layers is important to be performed. [less ▲]

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See detailRegarder dans une boule de cristal et dépister des sujets à risque pour le mélanome cutané
Pierard, Gérald ULiege; Franchimont, Claudine ULiege; Hermanns-Lê, Trinh ULiege et al

in Revue Médicale de Liège (2015), 70

Cutaneous melanoma is the deadliest skin cancer showing an increasingly growing incidence in white populations of Europe and United States. Intensive research in recent years has begun to unlock its ... [more ▼]

Cutaneous melanoma is the deadliest skin cancer showing an increasingly growing incidence in white populations of Europe and United States. Intensive research in recent years has begun to unlock its molecular pathogenesis. Screening the neoplasm at an early stage remains primordial. Hence, targeting populations at risk is likely efficient. In such an attempt, the regular clinical examination benefits from a series of non invasive procedures such as skin surface biopsies, in vivo confocal microscopy, dermoscopy and specular fluorescent light reflectance. [less ▲]

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See detailSimulants of malignant melanoma
Pierard, Gérald ULiege; Pierard-Franchimont, Claudine ULiege; Delvenne, Philippe ULiege

in Oncology Reviews (2015), 9

During the recent period, dermoscopy has yielded improvement in the early disclosure of various atypical melanocytic neoplasms (AMN) of the skin. Beyond this clinical procedure, AMN histopathology remains ... [more ▼]

During the recent period, dermoscopy has yielded improvement in the early disclosure of various atypical melanocytic neoplasms (AMN) of the skin. Beyond this clinical procedure, AMN histopathology remains mandatory for establishing their precise diagnosis. Of note, panels of experts in AMN merely report moderate agreement in various puzzling cases. Divergences in opinion and misdiagnosis are likely increased when histopathological criteria are not fine-tuned and when facing a diversity of AMN types. Furthermore, some AMN have been differently named in the literature including atypical Spitz tumor, metastasizing Spitz tumor, borderline and intermediate melanocytic tumor, malignant Spitz nevus, pigmented epithelioid melanocytoma or animal-type melanoma. Some acronyms have been further suggested such as MELTUMP (after melanocytic tumor of uncertain malignant potential) and STUMP (after Spitzoid melanocytic tumor of uncertain malignant potential). In this review, such AMN at the exclusion of cutaneous malignant melanoma (MM) variants, are grouped under the tentative broad heading skin melanocytoma. Such set of AMN frequently follows an indolent course, although they exhibit atypical and sometimes worrisome patterns or cytological atypia. Rare cases of skin melanocytomas progress to loco regional clusters of lesions (agminate melanocytomas), and even to regional lymph nodes. At times, the distinction between a skin melanocytoma and MM remains puzzling. However, multipronged immunohistochemistry and emerging molecular biology help profiling any malignancy risk if present. [less ▲]

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See detailComment j'explore ... le "cheetah-look". Regard sur la peau sous des longueurs d'ondes particulieres de la lumiere.
Pierard-Franchimont, Claudine ULiege; Hermanns-Lê, Trinh ULiege; Pierard, Gérald ULiege et al

in Revue Médicale de Liège (2015), 70(4), 204-6

The melanotic facial pigmentation of each individual is frequently heterogeneous, even when this condition remains imperceptible under natural ambient light. However, with aging, this aspect may appear to ... [more ▼]

The melanotic facial pigmentation of each individual is frequently heterogeneous, even when this condition remains imperceptible under natural ambient light. However, with aging, this aspect may appear to everybody. The melanin heterochromia has various origins including ethnicity, the hormonal impact, the influence of various inflammatory, toxic and drug-induced disorders, as well as the impact of photoaging. The cheetah-look aspect is thus established and well identified under ultraviolet light or using an ingenious trick selecting some wavelengths of visible light. [less ▲]

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See detailSyndrome d'Ehlers-Danlos de type hypermobile: une atteinte multisystémique. Apport de l'ultrastructure cutanée pour une prise en charge personnalisée
Hermanns-Lê, Trinh ULiege; PIERARD, Gérald ULiege; PIERARD-FRANCHIMONT, Claudine ULiege et al

in Revue Médicale de Liège (2015), 70(5-6), 325-330

Ehlers-Danlos syndrome (EDS) represents a heterogenous group of disorders of the connective tissue structure. Currently, several types are distinguish following a limited set of clinical signs and genetic ... [more ▼]

Ehlers-Danlos syndrome (EDS) represents a heterogenous group of disorders of the connective tissue structure. Currently, several types are distinguish following a limited set of clinical signs and genetic mutations. However, there is a lack of specificity of most recognized genetic alterations with the current clinical typing. In addition, the criteria from dermatopathology, ultrastructure and biomechanics are not considered. In addition, the establish frontiers are hazardous because a series of anatomo-clinical signs are not considered in the classical EDS concept. The hypermobile type EDS represents an example of the diagnostic uncertainties. It results that guidelines based on evidence-based medecine cannot be established. Only an individual management can be offerted to the concerned patients. [less ▲]

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See detailThe conundrum of toxic epidermal necrolysis
Pierard, Gérald ULiege; PAQUET, Philippe ULiege; Jennes, Serge et al

Book published by Novapublishers - Nova Biomedical (2015)

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See detailCOSMÉTIQUES, SANTÉ ET ENVIRONNEMENT Actualisation d’une diatribe justifiée ou exagérée ?
Pierard, Gérald ULiege; Pierard-Franchimont, Claudine ULiege; Lesuisse, Marianne et al

in Revue Médicale de Liège (2015), 70

In recent years, the population and producers of consumer products became aware of deleterious effects of some substances on human health and environment. Cosmetic products are part of such concern. What ... [more ▼]

In recent years, the population and producers of consumer products became aware of deleterious effects of some substances on human health and environment. Cosmetic products are part of such concern. What are the risks currently involved? The so-called «natural», «bio» or «green» products, do they represent an ideal panacea ? This topic has a complex issue because documents available for the general public are of unequal quality, and objective scientifc publications remain rare and prone to controversies. [less ▲]

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See detailFrom observational to analytical morphology of the stratum corner: progress avoiding hazardous animal and human testings.
PIERARD, Gérald ULiege; Courtois, J.; Ritacco, C. et al

in Clinical, Cosmetic and Investigational Dermatology (2015), 8

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See detailNail surface topography and onychochronobiology.
PIERARD, Gérald ULiege; Franchimont, Claudine ULiege

in Berardesca, E.; Wilhelm, K.P.; Maibach, H.I. (Eds.) Non invasive diagnostic techniques in clinical dermatology. (2014)

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See detailComment j'explore ... Votre patient se plaint d’une perte de cheveux Contribution de la biopsie cutanée dans le diagnostic des alopécies non cicatricielles
Pierard-Franchimont, Claudine ULiege; Pierard, Gérald ULiege

in Revue Médicale de Liège (2014), 69(12), 686-91

The diagnosis of most alopecia problems is based on the clinical history and a well conducted clinical examination. The additional contributions of dermoscopy, trichoscopy and trichogram are helpful ... [more ▼]

The diagnosis of most alopecia problems is based on the clinical history and a well conducted clinical examination. The additional contributions of dermoscopy, trichoscopy and trichogram are helpful. However, a scalp biopsy is occasionally necessary to establish the correct diagnosis. The main noncicatricial alopecias are represented by androgenetic alopecia, alopecia areata, trichotillomania, traction and pressure alopecia, temporal triangular alopecia, ageing alopecia, loose anagen syndrome, telogen effluvium and anagen effluvium. [less ▲]

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See detailLa dermocosmétique en appui de traitements oncologiques ciblés.
FRANCHIMONT, Claudine ULiege; Lesuisse, Marianne; PIERARD, Gérald ULiege

in Revue Médicale de Liège (2014), 69(1), 35-37

Some recently introduced targeted treatments in cancerology are responsible for adverse effects on the skin. These events alter the patient well-being. Adequate dermocosmetic management allows to curb the ... [more ▼]

Some recently introduced targeted treatments in cancerology are responsible for adverse effects on the skin. These events alter the patient well-being. Adequate dermocosmetic management allows to curb the unwanted skin conditions without interfering with the targeted therapeutic effects. However, evidence-based support for using dermocosmetic products as adjunctive cancer treatment remains scarce. It remains nonetheless that the clinical perception is unanimously favourable for such procedure. [less ▲]

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See detailLe point de rosée en berne et la couche cornée hivernale.
PIERARD, Gérald ULiege; FRANCHIMONT, Claudine ULiege; Delvenne, Philippe ULiege

in Revue Médicale de Liège (2014), 69(2), 68-71

The frontier between the human body and the environment is largely represented by the stratum corneum. It is obvious that the skin aspect on some body sites appears dry and rough in some predisposed ... [more ▼]

The frontier between the human body and the environment is largely represented by the stratum corneum. It is obvious that the skin aspect on some body sites appears dry and rough in some predisposed individuals during winter season. The reductions in the outdoor temperature, ambient moisture and dew point are the main physical factors involved in this process. We present the aspects seen under ultraviolet light and scanning electron microscopy. Keywords : Stratum corneum - Dew point [less ▲]

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See detailLa vignette diagnostique de l'étudiant. Diagnostic et évolution d'une gale.
Franchimont, Claudine ULiege; Hermanns-Lê, Trinh ULiege; PIERARD, Gérald ULiege

in Revue Médicale de Liège (2014), 69

Human scabies is an ectoparasitosis affecting any individual at any age. The level of infestation by Sarcoptes scabiei var. hominis is influenced by any defect in immune response. Several clinical types ... [more ▼]

Human scabies is an ectoparasitosis affecting any individual at any age. The level of infestation by Sarcoptes scabiei var. hominis is influenced by any defect in immune response. Several clinical types of scabies are described including baby scabies, profuse scabies of immunodepression, norvegian scabies and sarcoptic mange. Onchocerciasis dermatitis is a tropical microfilariosis completely distinct by its parasitIc nature. [less ▲]

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See detailAsymmetric facial skin viscoelasticity during climacteric aging.
Pierard, Gérald ULiege; Hermanns-Lê, Trinh ULiege; Gaspard, Ulysse ULiege et al

in Clinical, Cosmetic and Investigational Dermatology (2014), 7

BACKGROUND: Climacteric skin aging affects certain biophysical characteristics of facial skin. The purpose of the present study was to assess the symmetric involvement of the cheeks in this stage of the ... [more ▼]

BACKGROUND: Climacteric skin aging affects certain biophysical characteristics of facial skin. The purpose of the present study was to assess the symmetric involvement of the cheeks in this stage of the aging process. METHODS: Skin viscoelasticity was compared on both cheeks in premenopausal and post-menopausal women with indoor occupational activities somewhat limiting the influence of chronic sun exposure. Eighty-four healthy women comprising 36 premenopausal women and 48 early post-menopausal women off hormone replacement therapy were enrolled in two groups. The tensile characteristics of both cheeks were tested and compared in each group. A computerized suction device equipped with a 2 mm diameter hollow probe was used to derive viscoelasticity parameters during a five-cycle procedure of 2 seconds each. Skin unfolding, intrinsic distensibility, biological elasticity, and creep extension were measured. RESULTS: Both biological elasticity and creep extension were asymmetric on the cheeks of the post-menopausal women. In contrast, these differences were more discrete in the premenopausal women. CONCLUSION: Facial skin viscoelasticity appeared to be asymmetric following menopause. The possibility of asymmetry should be taken into account in future studies of the effects of hormone replacement therapy and any antiaging procedure on the face in menopausal women. [less ▲]

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See detailGynecologic and obstetric impact of the Ehlers-Danlos syndrome: clues from scrutinizing dermal ultrastructural alterations.
Hermanns-Lê, Trinh ULiege; PIERARD, Gérald ULiege; FRANCHIMONT, Claudine ULiege et al

in Gynecology (2014), 2(1),

Background: The Ehlers-Danlos syndrome (EDS) represents a heterogenous group of heritable connective tissue disorders chiefly characterized by joint laxity, increased skin distensibility and connective ... [more ▼]

Background: The Ehlers-Danlos syndrome (EDS) represents a heterogenous group of heritable connective tissue disorders chiefly characterized by joint laxity, increased skin distensibility and connective tissue fragility. Each EDS type corresponds to a multisystemic disorder with widespread implications. Physicians evoke the EDS diagnosis in presence of some typical cutaneous signs, such as atrophic scars and frequent hematomas. Methods: To revisit the transmission electron microscopy support from skin biopsies when screening EDS in gynecology-obstetrics. Results: EDS women commonly suffer from a series of gynecologic and obstetric disorders. Dermal ultrastructural changes are keynote features suggesting some EDS types. Conclusion: Gene mutations are mostly identified in the classic and vascular EDS types, but only in sporadic cases of the hypermobile EDS type which apparently represents the most frequent type. Dermal ultrastructural changes represent relevant diagnostic clues for the practitioner. Preconception counseling about possible complications is welcome. Management requires precise diagnosis of the EDS type. [less ▲]

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See detailLa vignette diagnostique de l'étudiant. Diagnostic et évolution d'une chéloïde.
FRANCHIMONT, Claudine ULiege; Hermanns-Lê, Trinh ULiege; NIZET, Jean-Luc ULiege et al

in Revue Médicale de Liège (2014), 69

Une chéloïde est une formation saillante, fibreuse hypertrophique du derme. Elle est très ferme au toucher. Il en existe deux types cliniques qui correspondent, d’une part, à une évolution particulière ... [more ▼]

Une chéloïde est une formation saillante, fibreuse hypertrophique du derme. Elle est très ferme au toucher. Il en existe deux types cliniques qui correspondent, d’une part, à une évolution particulière d’une cicatrice et, d’autre part, à une apparition présumée spontanée. Cette lésion est caractérisée par des dépôts massifs de faisceaux de collagène. Cet aspect la distingue de la cicatrice hypertrophique qui représente, de manière primordiale, une accumulation de fibroblastes et de petits vaisseaux. [less ▲]

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