Publications and communications of Robert Brasseur

Steinhauer, S., Crowet, J.-M., Brasseur, R., & Lins, L. (2016). GROMPALA: a membrane-implicit modelling method to screen lipid-interacting molecules. In A. Mukhametov, Software and techniques for Bio-molecular modeling (pp. 8-18). Austin publishing group.

Crowet, J.-M., Sinnaeve, D., Fehér, K., Brasseur, R., Martins, J., & Lins, L. (April 2016). Modeling of the cyclic lipodepsipeptide Pseudodesmin A self-assembly through molecular dynamic simulations [Poster presentation]. Joint Meeting of the Membrane Sections of the French and German Biophysical Societies.

Crowet, J.-M., Sinnaeve, D., Fehér, K., Brasseur, R., Martins, J., & Lins, L. (October 2015). Modeling of the cyclic lipodepsipeptide Pseudodesmin A self- assembly through molecular dynamic simulations [Poster presentation]. 11th GERLI lipidomics meeting.

Crowet, J.-M., Dony, N., Joris, B., Brasseur, R., & Lins, L. (28 November 2014). Structure predictions of membrane domains of proteins from the Divisome and BlaR [Poster presentation]. IAP 7/44 Meeting: Integrative Protein Science: from small molecules to complex biological systems - iPros Date(s) de la manifestation.

Dony, N., Crowet, J.-M., Joris, B., Brasseur, R., & Lins, L. (May 2013). SAHBNET, an Accessible Surface-Based Elastic Network: An Application to Membrane Protein. International Journal of Molecular Sciences, 14 (6), 11510-26. doi:10.3390/ijms140611510

Deleu, M., Lorent, J., Lins, L., Brasseur, R., Braun, N., El Kirat, K., Nylander, T., Dufrene, Y. F., & Mingeot-Leclercq, M.-P. (2013). Effects of surfactin on membrane models displaying lipid phase separation. Biochimica et Biophysica Acta, 1828 (2), 801-815. doi:10.1016/j.bbamem.2012.11.007

Charlois, Y., Lins, L., & Brasseur, R. (2011). A new in-silico method for determination of helical transmembrane domains based on the PepLook scan: application to IL-2Rbeta and IL-2Rgammac receptor chains. BMC Structural Biology, 11, 26. doi:10.1186/1472-6807-11-26

Staes, E., Absil, P.-A., Lins, L., Brasseur, R., Deleu, M., Lecouturier, N., Fievez, V., des Rieux, A., Mingeot-Leclercq, M.-P., Raussens, V., & Préat, V. (2010). Acylated and unacylatedghrelin binding to membranes and to ghrelin receptor: Towards a better understanding of the underlying mechanisms. Biochimica et Biophysica Acta. Biomembranes, 1798, 2102-2113. doi:10.1016/j.bbamem.2010.07.002

Colinet, F., Vanderick, S., Charloteaux, B., Eggen, A., Gengler, N., Renaville, B., Brasseur, R., Portetelle, D., & Renaville, R. (2009). Genomic location of the bovine growth hormone secretagogue receptor (Ghsr) gene and investigation of genetic polymorphism. Animal Biotechnology, 20 (1), 28-33. doi:10.1080/10495390802602926

Adam, B., Charloteaux, B., Beaufays, J., Vanhamme, L., Godfroid, E., Brasseur, R., & Lins, L. (2008). Distantly related lipocalins share two conserved clusters of hydrophobic residues: use in homology modeling. BMC Structural Biology, 8 (1-2), 1. doi:10.1186/1472-6807-8-1

Beaufays, J., Adam, B., Decrem, Y., Prevot, P.-P., Santini, S., Brasseur, R., Brossard, M., Lins, L., Vanhamme, L., & Godfroid, E. (2008). Ixodes ricinus Tick Lipocalins: Identification, Cloning, Phylogenetic Analysis and Biochemical Characterization. PLoS ONE, 3 (12), 3941. doi:10.1371/journal.pone.0003941

Beaufays, J., Adam, B., Menten, C., Fievez, L., Grosjean, A., Decrem, Y., Prevot, P.-P., Santini, S., Brasseur, R., Brossard, M., Vanhaeverbeek, M., Bureau, F., Heinen, E., Lins, L., Vanhamme, L., & Godfroid, E. (2008). Ir-LBP, an ixodes ricinus tick salivary LTB4-binding lipocalin, interferes with host neutrophil function. PLoS ONE, 3 (12), 3987. doi:10.1371/journal.pone.0003987

Bensikaddour, H., Fa, N., Burton, I., Deleu, M., Lins, L., Schanck, A., Brasseur, R., Dufrene, Y. F., Goormaghtigh, E., & Mingeot-Leclercq, M.-P. (2008). Characterization of the interactions between fluoroquinolone antibiotics and lipids: a multitechnique approach. Biophysical Journal, 94 (8), 3035-46. doi:10.1529/biophysj.107.114843

Brasseur, R., Deleu, M., Mingeot-Leclercq, M.-P., Francius, G., & Dufrene, Y. (2008). Probing Peptide-Membrane Interactions Using Afm. Surface and Interface Analysis, 40 (3-4), 151-156. doi:10.1002/sia.2682

Decaffmeyer, M., Thomas, A., & Brasseur, R. (2008). Peptides As Drugs: Myth Or Reality? Biotechnologie, Agronomie, Société et Environnement, 12 (1), 81-88.

Mingeot-Leclercq, M.-P., Deleu, M., Brasseur, R., & Dufrene, Y. F. (2008). Atomic force microscopy of supported lipid bilayers. Nature Protocols, 3 (10), 1654-9. doi:10.1038/nprot.2008.149

Vandermoten, S., Charloteaux, B., Santini, S., Sen, S., Beliveau, C., Vandenbol, M., Francis, F., Brasseur, R., Cusson, M., & Haubruge, E. (2008). Characterization of a novel aphid prenyltransferase displaying dual geranyl/farnesyl diphosphate synthase activity. FEBS Letters, 582 (16), 2471-2471. doi:10.1016/j.febslet.2008.04.043

Crowet, J.-M., Lins, L., Dupiereux-Fettweis, I., Elmoualij, B., Lorin, A., Charloteaux, B., Stroobant, V., Heinen, E., & Brasseur, R. (September 2007). In Silico tilted properties of the 67-78 fragment of alpha-synuclein are responsible for membrane destabilization and neurotoxicity. Proteins, 68 (4), 936-947. doi:10.1002/prot.21483

Bouffioux, O., Berquand, A., Eeman, M., Paquot, M., Dufrene, Y. F., Brasseur, R., & Deleu, M. (2007). Molecular organization of surfactin-phospholipid monolayers: Effect of phospholipid chain length and polar head. Biochimica et Biophysica Acta. Biomembranes, 1768 (7), 1758-1768. doi:10.1016/j.bbamem.2007.04.015

Brasseur, R., Braun, N., El Kirat, K., Deleu, M., Mingeot-Leclercq, M.-P., & Dufrene, Y. (2007). The Biologically Important Surfactin Lipopeptide Induces Nanoripples In Supported Lipid Bilayers. Langmuir, 23 (19), 9769-9772. doi:10.1021/la7014868

Leimanis, S., Hoyez, N., Hubert, S., Laschet, M., Sauvage, E., Brasseur, R., & Coyette, J. (September 2006). PBP5 complementation of a PBP3 deficiency in Enterococcus hirae. Journal of Bacteriology, 188 (17), 6298-6307. doi:10.1128/JB.00334-06

Brasseur, R. (09 October 2004). New tools for membrane peptide simulation using angular dynamics [Paper presentation]. Peptide-Membrane interactions, Namur, Belgium.

Brasseur, R., & Thomas, A. (09 October 2004). Pex, analytical tools for PDB structures [Paper presentation]. Peptide-Membrane interactions, Namur, Belgium.

Crowet, J.-M., Brasseur, R., & Lins, L. (October 2004). The presence and potential role of tilted peptides in amyloidogenic proteins [Paper presentation]. Peptide-Membrane interactions, Namur, Belgium.

Dewson, G., Lins, L., Brasseur, R., & Kluck, R. M. (October 2004). Are titled peptides in Bax and Bak responsible for mitochondria permeability during apoptosis? [Paper presentation]. Peptide-Membrane interactions, Namur, Belgium.

El Kirat-Chatel, K., Lins, L., Brasseur, R., & Dufrêne, Y. F. (October 2004). Atomic force microscopy imaging of the interaction between tilted peptides and supported lipid bilayers [Paper presentation]. Peptide-Membrane interactions, Namur, Belgium.

Frédéric, B., Thomas, A., & Brasseur, R. (October 2004). The distribution of amino acids for membrane protein within a model of bilayer [Paper presentation]. Peptide-Membrane interactions, Namur, Belgium.

Lins, L., & Brasseur, R. (October 2004). Tilted peptides : from viral fusion to amyloidosis [Paper presentation]. Peptide/membrane interactions, Namur (Wepion), Belgium.

Ravault, S., Lins, L., Milon, A., & Brasseur, R. (October 2004). The beta-stranded Abeta 29-42 peptide is bound to membrane [Paper presentation]. Peptide-Membrane interactions, Namur, Belgium.

Spies, B., DECAFFMEYER, M., & Brasseur, R. (October 2004). Angular dynamic simulates incorporation of peptides into implicit lipid bilayer [Paper presentation]. Peptide-Membrane interactions, Namur, Belgium.

Talmud, P. G., Putt, W., Benhizia, F., Lins, L., & Brasseur, R. (October 2004). Common variants in signal peptide sequences; modelling effects and relationship to function [Paper presentation]. Peptide-Membrane interactions, Namur, Belgium.

Tcheremenskaia, O., Lins, L., Brasseur, R., Giuliani, A., & Tomasi, M. (October 2004). Is paramyxovirus hemagglutinin transmembrane domain involved in virus-cell fusion? Computational studies of hydrophobic profile and membrane orientation depict similarities with F protein fusion peptide [Paper presentation]. Peptide-Membrane interactions, Namur, Belgium.

Didier, B., Thomas, A., & Brasseur, R. (2004). Study of the progression of peptides in the nascent peptide tunnel of the ribosome [Paper presentation]. Peptide-Membrane interactions, Namur, Belgium.

Veracini, L., Simon, V., Herrada, G., Roche, S., Horjsi, V., Brasseur, R., Lins, L., & Bénistant, C. (2004). Is a putative tilted sequence in the transmembrane domain of the transmembrane adaptor proteins involved in their raft location and function? [Paper presentation]. Peptide-Membrane interactions, Namur, Belgium.

Arnould, D., Delsaux, N., Leroux, J., Bouffioux, O., Thomas, A., & Brasseur, R. (May 2003). Statistical study of membrane and soluble protein-protein and protein-nucleic acid interaction [Paper presentation]. 4th Conference of the FNRS Structural Biology Contact Group, Gembloux, Belgium.

Bastogne, D., Thomas, A., & Brasseur, R. (May 2003). Protein folding, an hypothesis [Paper presentation]. 4th Conference of the FNRS Structural Biology Contact Group, Gembloux, Belgium.

Heinen, C., Lins, L., & Brasseur, R. (May 2003). Design of tilted peptide using molecular modeling techniques [Paper presentation]. 4th Conference of the FNRS Structural Biology Contact Group, Gembloux, Belgium.

Lorin, A., Lins, L., Thomas, A., & Brasseur, R. (May 2003). Is conformational instability related to asymmetric distribution of hydrophobic residues? [Paper presentation]. 4th Conference of the FNRS Structural Biology Contact Group, Gembloux, Belgium.

Meurisse, R., Brasseur, R., & Thomas, A. (May 2003). Proximity of aromatic residues in the sequence: does it induce the secondary structure or not? [Paper presentation]. 4th Conference of the FNRS Structural Biology Contact Group, Gembloux, Belgium.

Spies, B., Thomas, A., & Brasseur, R. (May 2003). New relation between glycine and secondary structure [Paper presentation]. 4th Conference of the FNRS Structural Biology Contact Group, Gembloux, Belgium.

Deleu, M., Bouffioux, O., Razafindralambo, H., Paquot, M., Hbid, C., Thonart, P., Jacques, P., & Brasseur, R. (2003). Interaction Of Surfactin With Membranes: A Computational Approach. Langmuir, 19 (8), 3377-3385. doi:10.1021/la026543z

Deleu, M., Nott, K., Brasseur, R., Jacques, P., Thonart, P., & Dufrene, Y. F. (2001). Imaging Mixed Lipid Monolayers By Dynamic Atomic Force Microscopy. Biochimica et Biophysica Acta. Biomembranes, 1513 (1), 55-62. doi:10.1016/S0005-2736(01)00337-6

Arnould, S., Zhang, J., Nermut, M., Wattiez, R., Brasseur, R., Burny, A., & Bex, F. (June 1999). Inhibition of SIV Gag particles assembly at the plasma membrane by Gag products translated from internal methionine codons [Paper presentation]. Folding of soluble and membrane proteins, Gembloux, Belgium.

Bouffioux, O., Lacapere, J. J., Thomas-Soumarmon, A., & Brasseur, R. (June 1999). Molecular modelling insight into membrane-detergent interactions [Paper presentation]. Folding of soluble and membrane proteins, Gembloux, Belgium.

Brasseur, R. (June 1999). Simulation of hydrogen bonds and solvation in ab initio caulculation protein folds [Paper presentation]. Folding of soluble and membrane proteins, Gembloux, Belgium.

Gallet, X., Thomas-Sumarmon, A., & Brasseur, R. (June 1999). A fast method to predict protein-protein interaction sites from sequence analysis [Paper presentation]. Folding of soluble and membrane proteins, Gembloux, Belgium.

Lins, L., Nicole, P., Laburthe, M., Couvineau, A., Martinez, J., Thomas, A., & Brasseur, R. (June 1999). AI anine-scanning of the neuropeptide VIP: molecular modeling and experimental approaches allow to discriminate the residues important for structure and/or activity [Paper presentation]. Folding of soluble and membrane proteins, Gembloux, Belgium.

Michel, G., Baudoux, G., Culot, C., Durant, F., & Brasseur, R. (June 1999). Molecular modeling contribution to the elaboration of a 3D model for lecithin cholesterol acyl transferase (LCAT) [Paper presentation]. Folding of soluble and membrane proteins, Gembloux, Belgium.

Peelman, F., Vanloo, B., Verschelde, J.-L., Vandekerckhove, J., Brasseur, R., Tavernier, J., & Rosseneu, M. (June 1999). Molecular modeling of LCAT and natural mutants [Paper presentation]. Folding of soluble and membrane proteins, Gembloux, Belgium.

Gallet, X., Deleu, M., Razafindralambo, H., Jacques, P., Thonart, P., Paquot, M., & Brasseur, R. (1999). Computer Simulation Of Surfactin Conformation At A Hydrophobic/Hydrophilic Interface. Langmuir, 15 (7), 2409-2413. doi:10.1021/la980954r

Labeur, C., Decout, A., Vanloo Berlinda, Goethals, M., Brasseur, R., Vandekerckhove, J., & Rosseneu, M. (1999). Lipid-peptide interactions and membrane stability [Paper presentation]. Folding of soluble and membrane proteins, Gembloux, Belgium.

Deleu, M., Wathelet, B., Paquot, M., & Brasseur, R. (1998). Apercu des techniques d'analyse conformationnelle des macromolecules biologiques. Biotechnologie, Agronomie, Société et Environnement, 2 (4), 234-247.

De Pauw, M., Vanloo, B., Dergunov, A. D., Devreese, A. M., Baert, J., Brasseur, R., & Rosseneu, M. (March 1997). Composition and structural and functional properties of discoidal and spherical phospholipid-apoE3 complexes. Biochemistry, 62 (3), 251 - 263.

Hardt, K., Joris, B., Lepage, S., Brasseur, R., Lampen, J. O., Frère, J.-M., Fink, A. L., & Ghuysen, J.-M. (1997). The Penicillin sensory transducer, blar, involved in the inducibility of beta-lactamase synthesis in bacillus licheniformis is embedded in the plasma membrane via a four-alpha-helix bundle. Molecular Microbiology, 23 (5), 935-944. doi:10.1046/j.1365-2958.1997.2761642.x

Pillot, T., Brasseur, R., Vandekerckhove, J., & Rosseneu, M. (1997). Apolipoprotein E inhibits liposome fusion induced by the alzheimer's beta-amyloid peptide. Nutrition, Metabolism, and Cardiovascular Diseases, 276-280.

Mingeot-Leclercq, M. P., Brasseur, R., & Schanck, A. (March 1995). Molecular parameters involved in aminoglycoside nephrotoxicity. Journal of Toxicology and Environmental Health, 44 (3), 263 - 300. doi:10.1080/15287399509531960

Martin, I., Defrise-Quertain, F., Nielsen, N. M., Saermark, T., Burny, A., Brasseur, R., Vandenbranden, M., & Ruysschaert, J.-M. (1992). Study of the interaction between lipids and the NH2-terminal peptide of simian immunodeficiency virus fusion protein. In R. C. Aloia & C. C. Curtain (Eds.), Membrane Interaction of HIV : Implications for pathogenesis and therapy in AIDS (pp. 365-376). New-York, United States - New York: John wiley & sons, inc.

Brasseur, R. (25 August 1991). Differentiation of lipid-associating helices by use of three-dimensional molecular hydrophobicity potential calculations. Journal of Biological Chemistry, 266 (24), 16120-16127. doi:10.1016/s0021-9258(18)98524-8

Goormaghtigh, E., Huart, P., Praet, M., Brasseur, R., & Ruysschaert, J. M. (April 1990). Structure of the adriamycin-cardiolipin complex. Role in mitochondrial toxicity. Biophysical Chemistry, 35 (2-3), 247 - 257. doi:10.1016/0301-4622(90)80012-v

Brasseur, R., & Ruysschaert, J. M. (15 August 1986). Conformation and mode of organization of amphiphilic membrane components: a conformational analysis. Biochemical Journal, 238 (1), 1 - 11. doi:10.1042/bj2380001

Deleers, M., Grognet, P., & Brasseur, R. (01 November 1985). Structural considerations for calcium ionophoresis by prostaglandins. Biochemical Pharmacology, 34 (21), 3831 - 3836. doi:10.1016/0006-2952(85)90431-9

Vandenbranden, M., De Gand, G., Brasseur, R., Defrise-Quertain, F., & Ruysschaert, J.-M. (June 1985). Hydrolysis of phosphatidylcholine liposomes by lysosomal phospholipase A is maximal at the phase transition temperature of the lipid substrate. Bioscience Reports, 5 (6), 477 - 482. doi:10.1007/BF01116946

Brasseur, R., Ruysschaert, J.-M., & Chatelain, P. (28 May 1985). Semi-empirical conformational analysis of propranolol interacting with dipalmitoylphosphatidylcholine. Biochimica et Biophysica Acta, 815 (3), 341 - 350. doi:10.1016/0005-2736(85)90360-8

Brasseur, R., Carlier, M. B., Laurent, G., Claes, P. J., Vanderhaeghe, H. J., Tulkens, P. M., & Ruysschaert, J. M. (01 April 1985). Interaction of streptomycin and streptomycylamine derivatives with negatively charged lipid layers. Correlation between binding, conformation of complexes and inhibition of lysosomal phospholipase activities. Biochemical Pharmacology, 34 (7), 1035 - 1047. doi:10.1016/0006-2952(85)90607-0

Brasseur, R., Cabiaux, V., Huart, P., Castagna, M., Baztar, S., & Ruysschaert, J. M. (29 March 1985). Structural analogies between protein kinase C activators. Biochemical and Biophysical Research Communications, 127 (3), 969 - 976. doi:10.1016/s0006-291x(85)80039-5

Brasseur, R., Chatelain, P., Goormaghtigh, E., & Ruysschaert, J.-M. (1985). A semi-empirical conformation analysis of the interaction of n-alkanols with dipalmitoyphosphatidylcholine. Biochimica et Biophysica Acta, 814, 227-236.

Brasseur, R., & Ruysschaert, J.-M. (November 1984). Evidence of a thromboxane A2-Ca2+ complex: a conformational approach. Research Communications in Chemical Pathology and Pharmacology, 46 (2), 175 - 185.

Brasseur, R., Deleers, M., & Ruysschaert, J.-M. (August 1984). Sequence of ionophore conformational changes induced by a simulated membrane/water interface. Bioscience Reports, 4 (8), 651 - 658. doi:10.1007/BF01121018

Huart, P., Brasseur, R., Goormaghtigh, E., & Ruysschaert, J. M. (15 June 1984). Antimitotics induce cardiolipin cluster formation. Possible role in mitochondrial enzyme inactivation. Biochimica et Biophysica Acta, 799 (2), 199 - 202. doi:10.1016/0304-4165(84)90296-4

Brasseur, R., Ruysschaert, J. M., & Chatelain, P. (01 April 1984). Conformational analysis of suloctidil and derivatives inserted in lipid layers. Biochemical Pharmacology, 33 (7), 1015 - 1021. doi:10.1016/0006-2952(84)90508-2

Brasseur, R., Laurent, G., Ruysschaert, J. M., & Tulkens, P. (15 February 1984). Interactions of aminoglycoside antibiotics with negatively charged lipid layers. Biochemical and conformational studies. Biochemical Pharmacology, 33 (4), 629 - 637. doi:10.1016/0006-2952(84)90319-8

Brasseur, R., & Deleers, M. (November 1983). Theoretical study on conformation-related activity of hypoglycemic sulfonylureas. Pharmacological Research Communications, 15 (10), 901 - 907. doi:10.1016/s0031-6989(83)80020-4

Deleers, M., Brasseur, R., & Malaisse, W. J. (November 1983). Stoichiometry of calcium binding by hypoglycemic sulfonylureas. Research Communications in Chemical Pathology and Pharmacology, 42 (2), 181 - 201.

Brasseur, R., De Meutter, J., Goormaghtigh, E., & Ruysschaert, J.-M. (15 September 1983). Mode of organization of galactolipids: a conformational analysis. Biochemical and Biophysical Research Communications, 115 (2), 666 - 672. doi:10.1016/s0006-291x(83)80196-x

Deleers, M., Grognet, P., Mahy, M., Brasseur, R., & Malaisse, W. J. (September 1983). Synergistic effect of hypoglycemic sulfonylureas and negative phospholipids on calcium transport: ionic and conformational aspects. Research Communications in Chemical Pathology and Pharmacology, 41 (3), 407 - 424.

Brasseur, R., Notredame, M., & Ruysschaert, J. M. (29 July 1983). Lipid-water interface mediates reversible ionophore conformational change. Biochemical and Biophysical Research Communications, 114 (2), 632 - 637. doi:10.1016/0006-291x(83)90827-6

Brasseur, R., Vandenbosch, C., Van den Bossche, H., & Ruysschaert, J. M. (15 July 1983). Mode of insertion of miconazole, ketoconazole and deacylated ketoconazole in lipid layers. A conformational analysis. Biochemical Pharmacology, 32 (14), 2175 - 2180. doi:10.1016/0006-2952(83)90223-x

Brasseur, R., Deleers, M., Ruysschaert, J. M., & Malaisse, W. J. (July 1983). Conformational analysis of mixed monolayers of phorbol ester and phospholipid. Biochemistry International, 7 (1), 71 - 78.

Deleers, M., Brasseur, R., & Malaisse, W. J. (July 1983). Calcium transport by a beta-diketone in model membranes. Chemistry and Physics of Lipids, 33 (1), 11 - 20. doi:10.1016/0009-3084(83)90003-8

Deleers, M., Brasseur, R., Ruysschaert, J. M., & Malaisse, W. J. (June 1983). Conformational analysis of phorbol esters at a simulated membrane/water interface. Biophysical Chemistry, 17 (4), 313 - 319. doi:10.1016/0301-4622(83)80016-7

Brasseur, R., & Hurwitz, H. D. (1983). A conformational analysis of propylene carbonate molecules adsorbed at the mercury electrode. Journal of Electroanalytical Chemistry, 148 (2), 249 - 270. doi:10.1016/S0022-0728(83)80401-X

Ferreira, J., Caspers, J., Goormaghtigh, E., Brasseur, R., & Ruysschaert, J.-M. (1983). Etude de divers ionophores au sein de modeles de membrane : une approche basée sur la couche monomoleculaire. In G. Spach, Physicla chemistry of transmembrane ion motions. Amsterdam, Netherlands: Elsevier science publisher B.V.

Brasseur, R., Deleers, M., Ruysschaert, J.-M., & Malaisse, W. J. (1982). Conformational analysis of phorbol esters monolayers. Biochemistry International.