Publications and communications of Guillaume Marcion

Bocuzzi, V., Marcion, G., Withofs, N., Hustinx, R., D'huyvetter, M., Navarro, L., Dumoulin, M., Caers, J., & Bridoux, J. (28 January 2026). From Alpacas to Marie Curie: can radioactivity save the world? Detection and Destruction: CD38-Directed sdAb 2F8 Enables Targeted α-Therapy [Poster presentation]. Télévie seminar 2026, Bruxelles, Belgium.

Jassin, M., Onkelinx, C., Bocuzzi, V., E Silva, B., Kwan, O., Block, A., Dubois, S., Daulne, C., Marcion, G., Ormenese, S., Di Valentin, E., Baron, F., GREGOIRE, C., Ehx, G., Nguyen, T. T., & Caers, J. (08 December 2025). Comparing a Novel Anti-BCMA NanoCAR with a Conventional ScFv-Based CAR for the Treatment of Multiple Myeloma. Cells, 14 (24), 1944. doi:10.3390/cells14241944

Jassin, M., Onkelinx, C., E Silva, B., Bocuzzi, V., Block, A., Marcion, G., Baron, F., Di Valentin, E., Ehx, G., Nguyen, T. T., & Caers, J. (18 November 2025). Design of a novel NanoCAR construct that compares well with a conventional ScFv-based CAR targeting BCMA on multiple myeloma [Poster presentation]. Bis annual meeting.

Bocuzzi, V., Marcion, G., Withofs, N., Hustinx, R., D'Huyvetter, M., Caers, J., Bridoux, J., Navarro, L. (Other coll.), & Dumoulin, M. (Other coll.). (29 September 2025). Development of a Single-Domain Antibody-Based Radiopharmaceutical for Targeted Alpha Therapy of Multiple Myeloma [Poster presentation]. Single Domain Antibodies Conference 2025, Utrecht, Netherlands.

Bocuzzi, V., Marcion, G., Withofs, N., Hustinx, R., D'Huyvetter, M., Navarro, L., Dumoulin, M., Jassin, M., Caers, J., & Bridoux, J. (11 March 2025). Development of a Single-Domain Antibody-Based Radiopharmaceutical for Targeted Alpha Therapy of Multiple Myeloma [Poster presentation]. European Molecular Imaging Meeting (EMIM), Bilbao, Spain.

Jassin, M., E Silva, B., Bocuzzi, V., Block, A., Marcion, G., Baron, F., Di Valentin, E., Ehx, G., Caers, J., Nguyen, T. T., & Onkelinx, C. (06 February 2025). CAR-T and nanoCAR-T for multiple myeloma: Does smaller mean smarter ? [Poster presentation]. 7th European CAR T-cell Meeting, Strasbourg, France.

Bocuzzi, V., Marcion, G., Withofs, N., Hustinx, R., D'Huyvetter, M., Navarro, L., Dumoulin, M., Jassin, M., Caers, J., & Bridoux, J. (29 January 2025). CD38-based Targeted Alpha Therapy for the treatment of multiple myeloma [Poster presentation]. Seminaire Télévie, 4000 - Liège, Belgium.

Jassin, M., Onkelinx, C., E Silva, B., Bocuzzi, V., Marcion, G., Ehx, G., Baron, F., Di Valentin, E., Caers, J., & Nguyen, T. T. (29 January 2025). CAR-T and nanoCAR-T for multiple myeloma: Does smaller mean smarter ? [Poster presentation]. Séminaire Télévie 2025, Liège, Belgium.

Bocuzzi, V., Bridoux, J., PIROTTE, M., Withofs, N., Hustinx, R., D'Huyvetter, M., Caers, J., & Marcion, G. (05 November 2024). CD38 as theranostic target in oncology. Journal of Translational Medicine, 22 (1), 998. doi:10.1186/s12967-024-05768-6

Bocuzzi, V., Marcion, G., Withofs, N., Hustinx, R., D'Huyvetter, M., Navarro, L., Dumoulin, M., Caers, J., & Bridoux, J. (10 October 2024). Targeted Alpha Therapy for the treatment of multiple myeloma using CD38-targeting sdAb 2F8 [Poster presentation]. Belgian Association for Cancer Research annual meeting (BACR), Bruxelles, Belgium.

Jassin, M., E Silva, B., Bocuzzi, V., Marcion, G., Ehx, G., Baron, F., Di Valentin, E., Caers, J., Nguyen, T. T., & Onkelinx, C. (31 May 2024). CAR-T and nanoCAR-T for multiple myeloma: Does smaller mean smarter ? [Poster presentation]. Recent insights into Immuno-Oncology, Anvers, Belgium.

Bocuzzi, V., Marcion, G., Withofs, N., Hustinx, R., D'Huyvetter, M., Navarro, L., Dumoulin, M., Caers, J., & Bridoux, J. (30 May 2024). Targeted Alpha Therapy for the treatment of multiple myeloma using CD38-targeting sdAb 2F8 [Poster presentation]. Interuniversity PhD student day, Louvain-La-Neuve, Belgium.

Jassin, M., Onkelinx, C., E Silva, B., Bocuzzi, V., Marcion, G., Ehx, G., Baron, F., Di Valentin, E., Caers, J., & Nguyen, T. T. (23 May 2024). Production and development of a new immunotherapeutic targeting multiple myeloma [Paper presentation]. EDT - Immunology Day 2024, Liège, Belgium.

Jassin, M., Bocuzzi, V., Nguyen, T. T., Onkelinx, C., E Silva, B., Marcion, G., Ehx, G., Baron, F., Di Valentin, E., & Caers, J. (22 April 2024). Production and development of a new immunotherapeutic targeting multiple myeloma [Paper presentation]. YBis Research Seminars: Immunology-Oncology, Liège, Belgium.

Jassin, M., Chloé Onkelinx, E Silva, B., Bocuzzi, V., Marcion, G., Ehx, G., Baron, F., Di Valentin, E., Caers, J., & Nguyen, T. T. (15 February 2024). CAR-T and nanoCAR-T for multiple myeloma: Does smaller mean smarter ? [Poster presentation]. EBMT - EHA 6th European CAR T-cell Meeting, Valence, Spain.

Bocuzzi, V., Marcion, G., Withofs, N., Hustinx, R., D'Huyvetter, M., Navarro, L., Brans, A., Dumoulin, M., Caers, J., & Bridoux, J. (06 February 2024). CD38-based Targeted Alpha Therapy for the treatment of multiple myeloma [Poster presentation]. Congrès Télévie 2024, Bruxelles, Belgium.

Jassin, M., Chloé Onkelinx, E Silva, B., Bocuzzi, V., Marcion, G., Ehx, G., Baron, F., Di Valentin, E., Caers, J., & Nguyen, T. T. (06 February 2024). CAR-T and nanoCAR-T for multiple myeloma: Does smaller mean smarter ? [Poster presentation]. Séminaire Télévie 2024.

Bocuzzi, V., Bridoux, J., PIROTTE, M., Withofs, N., Hustinx, R., D'Huyvetter, M., Caers, J., & Marcion, G. (2024). Correction to: CD38 as theranostic target in oncology (Journal of Translational Medicine, (2024), 22, 1, (998), 10.1186/s12967-024-05768-6). Journal of Translational Medicine, 22 (1), 1113. doi:10.1186/s12967-024-05959-1

Caers, J., Duray, E., Vrancken, L., Marcion, G., Bocuzzi, V., De Veirman, K., Krasniqi, A., Lejeune, M., Withofs, N., Devoogdt, N., Dumoulin, M., Karlström, A. E., & D'Huyvetter, M. (2022). Radiotheranostic Agents in Hematological Malignancies. Frontiers in Immunology, 13, 911080. doi:10.3389/fimmu.2022.911080

Privat, M., Bellaye, P.-S., Lescure, R., Massot, A., Baffroy, O., Moreau, M., Racoeur, C., Marcion, G., Denat, F., Bettaieb, A., Collin, B., Bodio, E., Paul, C., & Goze, C. (12 August 2021). Development of an Easily Bioconjugatable Water-Soluble Single-Photon Emission-Computed Tomography/Optical Imaging Bimodal Imaging Probe Based on the aza-BODIPY Fluorophore. Journal of Medicinal Chemistry, 64 (15), 11063-11073. doi:10.1021/acs.jmedchem.1c00450

Marcion, G., Hermetet, F., Neiers, F., Uyanik, B., Dondaine, L., Dias, A. M. M., Da Costa, L., Moreau, M., Bellaye, P.-S., Collin, B., Gobbo, J., Briand, L., Seigneuric, R., Kitten, O., Cinier, M., & Garrido, C. (15 June 2021). Nanofitins targeting heat shock protein 110: An innovative immunotherapeutic modality in cancer. International Journal of Cancer, 148 (12), 3019-3031. doi:10.1002/ijc.33485

Dias, A. M. M., Douhard, R., Hermetet, F., Regimbeau, M., Lopez, T. E., Gonzalez, D., Masson, S., Marcion, G., Chaumonnot, K., Uyanik, B., Causse, S. Z., Rieu, A., Hadi, T., Basset, C., Chluba, J., Grober, J., Guzzo, J., Neiers, F., Ortega-Deballon, P., ... Garrido, C. (May 2021). Lactobacillus stress protein GroEL prevents colonic inflammation. Journal of Gastroenterology, 56 (5), 442-455. doi:10.1007/s00535-021-01774-3

Guillem, F., Dussiot, M., Colin, E., Suriyun, T., Arlet, J. B., Goudin, N., Marcion, G., Seigneuric, R., Causse, S., Gonin, P., Gastou, M., Deloger, M., Rossignol, J., Lamarque, M., Choucair, Z. B., Gautier, E. F., Ducamp, S., Vandekerckhove, J., Moura, I. C., ... Hermine, O. (01 September 2020). XPO1 regulates erythroid differentiation and is a new target for the treatment of β-thalassemia. Haematologica, 105 (9), 2240-2249. doi:10.3324/haematol.2018.210054

Boutanquoi, P.-M., Burgy, O., Beltramo, G., Bellaye, P.-S., Dondaine, L., Marcion, G., Pommerolle, L., Vadel, A., Spanjaard, M., Demidov, O., Mailleux, A., Crestani, B., Kolb, M., Garrido, C., Goirand, F., & Bonniaud, P. (June 2020). TRIM33 prevents pulmonary fibrosis by impairing TGF-β1 signalling. European Respiratory Journal, 55 (6). doi:10.1183/13993003.01346-2019

Chanteloup, G., Cordonnier, M., Isambert, N., Bertaut, A., Marcion, G., Garrido, C., & Gobbo, J. (2020). Membrane-bound exosomal HSP70 as a biomarker for detection and monitoring of malignant solid tumours: a pilot study. Pilot and Feasibility Studies, 6, 35. doi:10.1186/s40814-020-00577-2

Gozzi, G. J., Gonzalez, D., Boudesco, C., Dias, A. M. M., Gotthard, G., Uyanik, B., Dondaine, L., Marcion, G., Hermetet, F., Denis, C., Hardy, L., Suzanne, P., Douhard, R., Jego, G., Dubrez, L., Demidov, O. N., Neiers, F., Briand, L., Sopková-de Oliveira Santos, J., ... Garrido, C. (January 2020). Selecting the first chemical molecule inhibitor of HSP110 for colorectal cancer therapy. Cell Death and Differentiation, 27 (1), 117-129. doi:10.1038/s41418-019-0343-4

Causse, S. Z., Marcion, G., Chanteloup, G., Uyanik, B., Boudesco, C., Grigorash, B. B., Douhard, R., Dias, A. M. M., Dumetier, B., Dondaine, L., Gozzi, G. J., Moussay, E., Paggetti, J., Mirjolet, C., de Thonel, A., Dubrez, L., Demidov, O. N., Gobbo, J., & Garrido, C. (April 2019). HSP110 translocates to the nucleus upon genotoxic chemotherapy and promotes DNA repair in colorectal cancer cells. Oncogene, 38 (15), 2767-2777. doi:10.1038/s41388-018-0616-2

Glorian, V., Allègre, J., Berthelet, J., Dumetier, B., Boutanquoi, P.-M., Droin, N., Kayaci, C., Cartier, J., Gemble, S., Marcion, G., Gonzalez, D., Boidot, R., Garrido, C., Michaud, O., Solary, E., & Dubrez, L. (25 May 2017). DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues. Cell Death and Disease, 8 (5), 2816. doi:10.1038/cddis.2017.222

Seignez, A., Joly, A.-L., Chaumonnot, K., Hazoumé, A., Sanka, M., Marcion, G., Boudesco, C., Hammann, A., Seigneuric, R., Jégo, G., Ducoroy, P., Delarue, P., Senet, P., Castilla-Llorente, C., Solary, E., Durey, M.-A., Rubio, M.-T., Hermine, O., Kohli, E., & Garrido, C. (23 March 2017). Serum Gp96 is a chaperone of complement-C3 during graft-versus-host disease. JCI Insight, 2 (6), 90531. doi:10.1172/jci.insight.90531

Dufour, F., Rattier, T., Shirley, S., Picarda, G., Constantinescu, A. A., Morlé, A., Zakaria, A. B., Marcion, G., Causse, S., Szegezdi, E., Zajonc, D. M., Seigneuric, R., Guichard, G., Gharbi, T., Picaud, F., Herlem, G., Garrido, C., Schneider, P., Benedict, C. A., & Micheau, O. (March 2017). N-glycosylation of mouse TRAIL-R and human TRAIL-R1 enhances TRAIL-induced death. Cell Death and Differentiation, 24 (3), 500-510. doi:10.1038/cdd.2016.150

Berthenet, K., Dem Bokhari, A., Lagrange, A., Marcion, G., Boudesco, C., Causse, S., De Thonel, A., Svrcek, M., Goloudina, A. R., Dumont, S., Hammann, A., Biard, D. S., Seigneuric, R., Duval, A., Collura, A., Jego, G., Garrido, C., & Jego Or Dr, G. (07 November 2016). HSP110 promotes colorectal cancer growth through STAT3 activation. Oncogene, 36 (16), 2328-2336. doi:10.1038/onc.2016.403

Briand, L., Marcion, G., Kriznik, A., Heydel, J. M., Artur, Y., Garrido, C., Seigneuric, R., & Neiers, F. (09 September 2016). A self-inducible heterologous protein expression system in Escherichia coli. Scientific Reports, 6 (1). doi:10.1038/srep33037

Gobbo, J., Marcion, G., Cordonnier, M., Dias, A. M. M., Pernet, N., Hammann, A., Richaud, S., Mjahed, H., Isambert, N., Clausse, V., Rébé, C., Bertaut, A., Goussot, V., Lirussi, F., Ghiringhelli, F., de Thonel, A., Fumoleau, P., Seigneuric, R., & Garrido, C. (March 2016). Restoring Anticancer Immune Response by Targeting Tumor-Derived Exosomes With a HSP70 Peptide Aptamer. Journal of the National Cancer Institute, 108 (3). doi:10.1093/jnci/djv330

Barrichon, M., Hadi, T., Wendremaire, M., Ptasinski, C., Seigneuric, R., Marcion, G., Delignette, M., Marchet, J., Dumas, M., Sagot, P., Bardou, M., Garrido, C., & Lirussi, F. (June 2015). Dose-dependent biphasic leptin-induced proliferation is caused by non-specific IL-6/NF-κB pathway activation in human myometrial cells. British Journal of Pharmacology, 172 (12), 2974-90. doi:10.1111/bph.13100

Marcion, G., Seigneuric, R., Chavanne, E., Artur, Y., Briand, L., Hadi, T., Gobbo, J., Garrido, C., & Neiers, F. (January 2015). C-terminal amino acids are essential for human heat shock protein 70 dimerization. Cell Stress and Chaperones, 20 (1), 61-72. doi:10.1007/s12192-014-0526-3

Arlet, J.-B., Ribeil, J.-A., Guillem, F., Negre, O., Hazoume, A., Marcion, G., Beuzard, Y., Dussiot, M., Moura, I. C., Demarest, S., de Beauchêne, I. C., Belaid-Choucair, Z., Sevin, M., Maciel, T. T., Auclair, C., Leboulch, P., Chretien, S., Tchertanov, L., Baudin-Creuza, V., ... Courtois, G. (09 October 2014). HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia. Nature, 514 (7521), 242-6. doi:10.1038/nature13614

Collura, A., Lagrange, A., Svrcek, M., Marisa, L., Buhard, O., Guilloux, A., Wanherdrick, K., Dorard, C., Taieb, A., Saget, A., Loh, M., Soong, R., Zeps, N., Platell, C., Mews, A., Iacopetta, B., De Thonel, A., Seigneuric, R., Marcion, G., ... Duval, A. (February 2014). Patients with colorectal tumors with microsatellite instability and large deletions in HSP110 T17 have improved response to 5-fluorouracil–based chemotherapy. Gastroenterology, 146 (2), 401-11.e1. doi:10.1053/j.gastro.2013.10.054