Publications and communications of Benjamin G Dewals

Dewals, B. G.* , Lastik, D.* , Zhao, H., Piedfort, O., Flih, M., Maréchal, F., Deiana, M., Morris, E., Maziarski, O. K., Compère, P., Buonfrate, D., Bradbury, R. S.* , & Hunt, V. L.*. (2026). Genomic and morphologic characterization of Strongyloides nasua causing fatal strongyloidiasis in coatis (Nasua nasua). ORBi-University of Liège. https://orbi.uliege.be/handle/2268/347477. doi:10.21203/rs.3.rs-9890174/v1

Yang, B., & Dewals, B. G. (March 2026). Going Virtual as a Memory-Phenotype T Lymphocyte. European Journal of Immunology, 56 (3), 70174. doi:10.1002/eji.70174

Chasseur, A. S., Bellefroid, M., Galais, M., Gong, M., Lombard, P., Mathieu, S., Pecquet, A., Plant, E., Ponsard, C., Vreux, L., Yague-Sanz, C., Dewals, B. G., Gillet, N. A., Muylkens, B., Van Lint, C. M., & Coupeau, D. (September 2025). Unbiased and comprehensive identification of virus-derived circular RNAs in a large range of viral species and families. PLoS Pathogens, 21 (9), 1013448. doi:10.1371/journal.ppat.1013448

Yang, B., Piedfort, O., Sanchez-Sanchez, G., Lavergne, A., Gong, M., Peng, G., Madrigal, A., Petrellis, G., Katsandegwaza, B., Rodriguez, L. R., Balthazar, A., Meyer, S. J., Van Isterdael, G., Van Duyse, J., Andris, F., Bai, Q., Marichal, T., Machiels, B., Nitschke, L., ... Dewals, B. G. (07 February 2025). IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells. Science Immunology, 10 (104), 4841. doi:10.1126/sciimmunol.adk4841

Manurung, M. D., Sonnet, F., Hoogerwerf, M.-A., Janse, J. J., Kruize, Y., Bes-Roeleveld, L. D., König, M., Loukas, A., Dewals, B. G., Supali, T., Jochems, S. P., Roestenberg, M., Coppola, M., & Yazdanbakhsh, M. (December 2024). Controlled human hookworm infection remodels plasmacytoid dendritic cells and regulatory T cells towards profiles seen in natural infections in endemic areas. Nature Communications, 15 (1). doi:10.1038/s41467-024-50313-0

Gong, M.* , Myster, F.* , Azouz, A., Sanchez Sanchez, G., Li, S., CHARLOTEAUX, B., Yang, B., Nichols, J., Lefevre, L., Javaux, J., Leemans, S., Nivelles, O., van Campe, W., Roels, S., Mostin, L., van den Berg, T., Davison, A. J., Gillet, L., Connelley, T., ... Dewals, B. G. (06 August 2024). Unraveling clonal CD8 T cell expansion and identification of essential factors in γ-herpesvirus-induced lymphomagenesis. Proceedings of the National Academy of Sciences of the United States of America, 121 (32), 2404536121. doi:10.1073/pnas.2404536121

Ruscitti, C., Abinet, J., Maréchal, P., Meunier, M., de Meeûs, C., Vanneste, D., Janssen, P., Dourcy, M., Thiry, M., Bureau, F., Schneider, C., Machiels, B., Hidalgo, A., Ginhoux, F., Dewals, B. G., Guiot, J., Schleich, F., Garigliany, M.-M., Bellahcene, A., ... Marichal, T.*. (02 August 2024). Recruited atypical Ly6G+ macrophages license alveolar regeneration after lung injury. Science Immunology, 9 (98), 1227. doi:10.1126/sciimmunol.ado1227

Wathieu, C., Lavergne, A., Xu, X., Rolot, M., Nemazanyy, I., Shostak, K., El Hachem, N., Maurizy, C., Leemans, C., Close, P., Nguyen, L., Desmet, C., Tielens, S.* , Dewals, B. G.* , & Chariot, A.*. (2024). Loss of Elp3 blocks intestinal tuft cell differentiation via an mTORC1-Atf4 axis. EMBO Journal. doi:10.1038/s44318-024-00184-4

Jorssen, J.* , Van Hulst, G.* , Mollers, K., Pujol, J., Petrellis, G., Baptista, A. P., Schetters, S., Baron, F., Caers, J., Lambrecht, B. N., Dewals, B. G., Bureau, F.* , & Desmet, C.*. (2024). Single-cell proteomics and transcriptomics capture eosinophil development and identify the role of IL-5 in their lineage transit amplification. Immunity. doi:10.1016/j.immuni.2024.04.027

Egyptien, S., Brutinel, F., Dewals, B. G., & Deleuze, S. (03 September 2023). Validation of Calcein Violet as a marker of Apis mellifera semen viability in flow cytometry : preliminary results [Paper presentation]. Apimondia International Apicultural Congress, Santiago, Chile.

Egyptien, S., Dewals, B. G., Ectors, F., Brutinel, F., Ponthier, J., & Deleuze, S. (2023). Validation of Calcein Violet as a New Marker of Semen Membrane Integrity in Domestic Animals. Animals, (Animal Reproduction). doi:10.3390/ani13111874

Petrellis, G., Rolot, M., Preure, A., Wathieu, C., Dougal, A., Chetty, A., Chariot, A., Horsnell, W., & Dewals, B. G. (01 May 2023). IL-4 RECEPTOR SIGNALING REGULATES LUNG MACROPHAGES DURING HELMINTH COINFECTION RESULTING IN ENHANCED GAMMAHERPESVIRUS PERMISSIVENESS. Journal of Immunology, 210 (1_Supplement), 72.36-72.36. doi:10.4049/jimmunol.210.supp.72.36

Dewals, B. G., Yang, B., Sanchez, G. S., Lavergne, A., Piedfort, O., Peng, G., Aguirre, A. M., Petrellis, G., Katsandegwaza, B., Isterdael, G. V., Duyse, J. V., Bai, Q., Marichal, T., Machiels, B., Nitschke, L., Najafabadi, H., King, I., & Vermijlen, D. (2023). IL-4 induces CD22 expression to restrain the effector program of self-reactive virtual memory T cells. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/304430. doi:10.21203/rs.3.rs-2747693/v1

Yang, B., Dewals, B. G., Piedfort, O., Petrellis, G., & Katsandegwaza, B. (2023). IL-4 induces CD22 expression to restrain the effector program of self-reactive virtual memory T cells. Research Square.

Petrellis, G., Piedfort, O., Katsandegwaza, B., & Dewals, B. G. (2023). Parasitic worms affect virus coinfection: a mechanistic overview. Trends in Parasitology. doi:10.1016/j.pt.2023.02.007

Gong, M., Myster, F., Van Campe, W., Roels, S., Mostin, L., Van Den Berg, T., Vanderplasschen, A., & Dewals, B. G. (13 February 2023). Wildebeest-Derived Malignant Catarrhal Fever: A Bovine Peripheral T Cell Lymphoma Caused by Cross-Species Transmission of Alcelaphine Gammaherpesvirus 1. Viruses, 15 (2), 526. doi:10.3390/v15020526

Katsandegwaza, B., & Dewals, B. G. (12 December 2022). A history of helminth exposure protects against pneumovirus infection in an IL-4Rα-independent manner [Poster presentation]. Type 2 Immunity in Homeostasis and Disease, Ghent, Belgium.

Katsandegwaza, B., Dewals, B. G., Dougall, A., Rolot, M., & Preure, A. (12 December 2022). A history of helminth exposure protects against pneumovirus infection in an IL 4 R α independent manner [Poster presentation]. Type 2 Immunity in Homeostasis and Disease, Ghent, Belgium.

Chen, D., Nemazanyy, I., Peulen, O., Shostak, K., Xu, X., Tang, S. C., Wathieu, C., Turchetto, S., Tielens, S., Nguyen, L., Close, P., Desmet, C., Klein, S., Florin, A., Büttner, R., Petrellis, G., Dewals, B. G., & Chariot, A. (2022). Elp3-mediated codon-dependent translation promotes mTORC2 activation and regulates macrophage polarization. EMBO Journal, 109353. doi:10.15252/embj.2021109353

Chetty, A., Darby, M. G., Vornewald, P. M., Martín-Alonso, M., Filz, A., Ritter, M., McSorley, H. J., Masson, L., Smith, K., Brombacher, F., O'Shea, M. K., Cunningham, A. F., Ryffel, B., Oudhoff, M. J., Dewals, B. G., Layland, L. E., & Horsnell, W. G. C. (2021). Il4ra-independent vaginal eosinophil accumulation following helminth infection exacerbates epithelial ulcerative pathology of HSV-2 infection. Cell Host and Microbe, 29 (4), 579-593.e5. doi:10.1016/j.chom.2021.02.004

Razafimahefa, R. M., Ludwig-Begall, L., Diallo, M. A., Dewals, B. G., Vanderplasschen, A., Nivelles, O., Deketelaere, C., Mauroy, A., & Thiry, E. (2021). Development of a Specific Anti-capsid Antibody- and Magnetic Bead-Based Immunoassay to Detect Human Norovirus Particles in Stool Samples and Spiked Mussels via Flow Cytometry. Food and Environmental Virology. doi:10.1007/s12560-021-09494-w

Mbow, M., Lell, B., Jochems, S. P., Cisse, B., Mboup, S., Dewals, B. G., Jaye, A., Dieye, A., & Yazdanbakhsh, M. (2020). COVID-19 in Africa: Dampening the storm? Science, 369 (6504), 624-626. doi:10.1126/science.abd3902

Myster, F., Gong, M., Javaux, J., Suárez, N., Wilkie, G., Connelley, T., Vanderplasschen, A., & Dewals, B. G. (2020). Alcelaphine herpesvirus 1 genes A7 and A8 regulate viral spread and are essential for malignant catarrhal fever. PLoS Pathogens. doi:10.1371/journal.ppat.1008405

Rolot, M., & Dewals, B. G. (2020). Unconventional CD45RA+ memory CD8 T cells to control HIV infection during antiretroviral therapy. Cellular and Molecular Immunology. doi:10.1038/s41423-020-0478-8

Darby, M. G., Chetty, A., Mrjden, D., Rolot, M., Smith, K., MacKowiak, C., Sedda, D., Nyangahu, D., Jaspan, H., Toellner, K.-M., Waisman, A., Quesniaux, V., Ryffel, B., Cunningham, A. F., Dewals, B. G., Brombacher, F., & Horsnell, W. G. C. (2019). Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring. Science Advances, 5 (5). doi:10.1126/sciadv.aav3058

Sorel, O., & Dewals, B. G. (January 2019). The Critical Role of Genome Maintenance Proteins in Immune Evasion During Gammaherpesvirus Latency. Frontiers in Microbiology, 9 (3315). doi:10.3389/fmicb.2018.03315

Dewals, B. G., Layland, L. E., Prazeres da Costa, C., & Horsnell, W. G. (2018). Maternal helminth infections and the shaping of offspring immunity. Parasite Immunology, 12599. doi:10.1111/pim.12599

Machiels, B., Dourcy, M., Xiao, X., Javaux, J., Mesnil, C., Sabatel, C., Desmecht, D., LALLEMAND, F., Martinive, P., Hammad, H., Guilliams, M., Dewals, B., Vanderplasschen, A., Lambrecht, B. N., Bureau, F., & Gillet, L. (2018). Correction to: A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes (Nature Immunology, (2017), 18, 12, (1310-1320), 10.1038/ni.3857). Nature Immunology, 19 (9), 1035. doi:10.1038/s41590-017-0024-8

Rolot, M., & Dewals, B. G. (2018). Macrophage Activation and Functions during Helminth Infection: Recent Advances from the Laboratory Mouse. Journal of Immunology Research, 2018, 2790627. doi:10.1155/2018/2790627

Rolot, M., Dougall, A. M., Chetty, A., Javaux, J., Chen, T., Xiao, X., Machiels, B., Selkirk, M. E., Maizels, R. M., Hokke, C., Denis, O., Brombacher, F., Vanderplasschen, A., Gillet, L., Horsnell, W. G. C., & Dewals, B. G. (2018). Helminth-induced IL-4 expands bystander memory CD8(+) T cells for early control of viral infection. Nature Communications, 9 (1), 4516. doi:10.1038/s41467-018-06978-5

Sorel, O., Chen, T., Myster, F., Javaux, J., Vanderplasschen, A., & Dewals, B. G. (23 October 2017). Macavirus latency-associated protein evades immune detection through regulation of protein synthesis in cis depending upon its glycin/glutamate-rich domain. PLoS Pathogens, 13 (10), 1006691. doi:10.1371/journal.ppat.1006691

Webb, L. M.* , Lundie, R. J.* , Borger, J. G., Brown, S. L., Connor, L. C., Cartwright, A. N. R., Dougall, A. M., Wilbers, R. H. P., Cook, P. C., Jackson-Jones, L. H., Phytian-Adams, A. T., Johansson, C., Davis, D. M., Dewals, B. G., Ronchese, F., & MacDonald, A. S. (15 August 2017). A central role for Type I IFN in Th2 response induction by dendritic cells. EMBO Journal, 36 (16), 2404-2418.

Cunha, C. W., Taus, N. S., Dewals, B. G., Vanderplasschen, A., Knowles, D. P., & Li, H. (03 August 2016). Replacement of Glycoprotein B in Alcelaphine Herpesvirus 1 by Its Ovine Herpesvirus 2 Homolog : Implications in Vaccine Development for Sheep-Associated Malignant Catarrhal Fever. mSphere, 1 (4), 00108-16. doi:10.1128/mSphere.00108-16

Myster, F., van Beurden, S. J., Sorel, O., Suarez, N. M., Vanderplasschen, A., Davison, A. J., & Dewals, B. G. (2016). Genomic duplication and translocation of reactivation transactivator and bZIP-homolog genes is a conserved event in alcelaphine herpesvirus 1. Scientific Reports, 6, 38607. doi:10.1038/srep38607

Sorel, O., & Dewals, B. G. (2016). MicroRNAs in large herpesvirus DNA genomes: recent advances. Biomolecular Concepts, 7 (4), 229-39. doi:10.1515/bmc-2016-0017

Dourcy, M., Machiels, B., Zeippen, C., Desmecht, D., Vanderplasschen, A., Dewals, B. G., Gillet, L., Dumoulin, J. (Other coll.), & Javaux, J. (Other coll.). (12 December 2014). Murid herpesvirus 4 infection protects mice from the development of an anti-pneumovirus vaccine-induced TH2 immunopathology [Poster presentation]. Cell Symposia: The Multifaceted Roles of Type 2 Immunity, Bruges, Belgium.

Horsnell, W. G. C., Darby, M. G., Hoving, J. C., Nieuwenhuizen, N., McSorley, H. J., Ndlovu, H., Bobat, S., Kimberg, M., Kirstein, F., Cutler, A. J., Dewals, B. G., Cunningham, A. F., & Brombacher, F. (October 2013). IL-4Ralpha-associated antigen processing by B cells promotes immunity in Nippostrongylus brasiliensis infection. PLoS Pathogens, 9 (10), 1003662. doi:10.1371/journal.ppat.1003662

Dewals, B. G., & Vanderplasschen, A. (2011). Malignant catarrhal fever induced by Alcelaphine herpesvirus 1 is characterized by an expansion of activated CD3+CD8+CD4- T cells expressing a cytotoxic phenotype in both lymphoid and non-lymphoid tissues. Veterinary Research, 42 (1), 95. doi:10.1186/1297-9716-42-95

Li, H., Cunha, C. W., Gailbreath, K. L., O'Toole, D., White, S. N., Vanderplasschen, A., Dewals, B. G., Knowles, D. P., & Taus, N. S. (2011). Characterization of ovine herpesvirus 2-induced malignant catarrhal fever in rabbits. Veterinary Microbiology, 150 (3-4), 270-277. doi:10.1016/j.vetmic.2011.02.016

Dewals, B. G., Marillier, R. G., Hoving, J. C., Leeto, M., Schwegmann, A., & Brombacher, F. (2010). IL-4Ralpha-independent expression of mannose receptor and Ym1 by macrophages depends on their IL-10 responsiveness. PLoS Neglected Tropical Diseases, 4 (5), 689. doi:10.1371/journal.pntd.0000689

Marillier, R. G., Brombacher, T. M., Dewals, B. G., Leeto, M., Barkhuizen, M., Govender, D., Kellaway, L., Horsnell, W. G. C., & Brombacher, F. (2010). IL-4R{alpha}-responsive smooth muscle cells increase intestinal hypercontractility and contribute to resistance during acute Schistosomiasis. American Journal of Physiology - Gastrointestinal and Liver Physiology, 298 (6), 943-51. doi:10.1152/ajpgi.00321.2009

Bedoret, D., Wallemacq, H., Marichal, T., Desmet, C., Quesada Calvo, F., Henry, E., Closset, R., Dewals, B. G., Thielen, C., Gustin, P., de Leval, L., Van Rooijen, N., Le Moine, A., Vanderplasschen, A., Cataldo, D., Drion, P., Moser, M., Lekeux, P., & Bureau, F. (2009). Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice. Journal of Clinical Investigation, 119 (12), 3723-38. doi:10.1172/JCI39717

Dewals, B. G., Hoving, J. C., Leeto, M., Marillier, R. G., Govender, U., Cutler, A. J., Horsnell, W. G. C., & Brombacher, F. (2009). IL-4Ralpha responsiveness of non-CD4 T cells contributes to resistance in schistosoma mansoni infection in pan-T cell-specific IL-4Ralpha-deficient mice. American Journal of Pathology, 175 (2), 706-16. doi:10.2353/ajpath.2009.090137

Dewals, B. G., Boudry, C., Farnir, F., Drion, P., & Vanderplasschen, A. (2008). Malignant catarrhal fever induced by alcelaphine herpesvirus 1 is associated with proliferation of CD8+ T cells supporting a latent infection. PLoS ONE, 3 (2), 1627. doi:10.1371/journal.pone.0001627

Marillier, R. G., Michels, C., Smith, E. M., Fick, L. C. E., Leeto, M., Dewals, B. G., Horsnell, W. G. C., & Brombacher, F. (2008). IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections. BMC Immunology, 9, 11. doi:10.1186/1471-2172-9-11

Dewals, B. G., Boudry, C., Markine-Goriaynoff, N., Desmecht, D., Pastoret, P.-P., & Vanderplasschen, A. (2003). L'herpèsvirus alcélaphin 1, l'agent responsable de la forme africaine du coryza gangreneux. Annales de Médecine Vétérinaire, 147 (1, FEB-MAR), 1-15.