Publications and communications of Frédéric Kerff

Lupo, V., Roomans, C., Royen, E., Ongena, L., Jacquemin, O., Mullender, C., Kerff, F., & Baurain, D. (18 March 2025). Identification and characterization of archaeal pseudomurein biosynthesis genes through pangenomics. mSystems, 10 (3), 0140124. doi:10.1128/msystems.01401-24

Joiret, M., Kerff, F., Rapino, F., Close, P., & Geris, L. (31 May 2024). Reversing the relative time courses of the peptide bond reaction with oligopeptides of different lengths and charged amino acid distributions in the ribosome exit tunnel. Computational and Structural Biotechnology Journal, 23, 2453-2464. doi:10.1016/j.csbj.2024.05.045

Kerff, F., Jourdan, S., Francis, I. M., Deflandre, B., Ribeiro Monteiro, S., Stulanovic, N., Loria, R., & Rigali, S. (2023). Common scab disease: structural basis of elicitor recognition in pathogenic Streptomyces species. Microbiology Spectrum, 0197523. doi:10.1128/spectrum.01975-23

Joiret, M., Kerff, F., Rapino, F., Close, P., & Geris, L. (July 2023). A simple geometrical model of the electrostatic environment around the catalytic center of the ribosome and its significance for the elongation cycle kinetics. Computational and Structural Biotechnology Journal, 21, 3768-3795. doi:10.1016/j.csbj.2023.07.016

Francis, I. M., Bergin, D., Deflandre, B., Gupta, S., Salazar, J. J. C., Villagrana, R., Stulanovic, N., Ribeiro Monteiro, S., Kerff, F., Loria, R., & Rigali, S. (01 February 2023). Role of Alternative Elicitor Transporters in the Onset of Plant Host Colonization by Streptomyces scabiei 87-22. Biology, 12 (2), 234. doi:10.3390/biology12020234

Robert, C., Kerff, F., Bouillenne, F., Gavage, M., Vandevenne, M., Filée, P., & Matagne, A. (2023). Structural analysis of the interaction between human cytokine BMP-2 and the antagonist Noggin reveals molecular details of cell chondrogenesis inhibition. Journal of Biological Chemistry, 102892. doi:10.1016/j.jbc.2023.102892

Deflandre, B., Jadot, C., Planckaert, S., Thiébaut, N., Stulanovic, N., Herman, R., Devreese, B., Kerff, F., & Rigali, S. (01 August 2022). Structure and Function of BcpE2, the Most Promiscuous GH3-Family Glucose Scavenging Beta-Glucosidase. MBio, 13 (4), 0093522. doi:10.1128/mbio.00935-22

Léonard, R., Sauvage, E., Lupo, V., Perrin, A., Sirjacobs, D., Charlier, P., Kerff, F., & Baurain, D. (18 February 2022). Was the last bacterial common ancestor a monoderm after all? Genes, 13. doi:10.3390/genes13020376

Joiret, M., Kerff, F., Rapino, F., Close, P., & Geris, L. (13 January 2022). Ribosome exit tunnel electrostatics. Physical Review. E, 105 (1), 014409-1 - 014409-43. doi:10.1103/PhysRevE.105.014409

Janssen-Weets, B., Kerff, F., Swiontek, K., Kler, S., Czolk, R., Revets, D., Kuehn, A., Bindslev-Jensen, C., Ollert, M., & Hilger, C. (2022). Mammalian derived lipocalin and secretoglobin respiratory allergens strongly bind ligands with potentially immune modulating properties. Frontiers in Allergy, 3, 958711. doi:10.3389/falgy.2022.958711

Lupo, V., Mercuri, P., Frère, J.-M., Joris, B., Galleni, M., Baurain, D.* , & Kerff, F.*. (2022). An Extended Reservoir of Class-D Beta-Lactamases in Non-Clinical Bacterial Strains. Microbiology Spectrum, 10 (2), 0031522. doi:10.1128/spectrum.00315-22

Papp-Wallace, K. M., Docquier, J.-D., Kerff, F., & Power, P. (2022). Editorial: Structural and Biochemical Aspects of the Interaction of β-Lactamases With State-of-the-Art Inhibitors. Frontiers in Microbiology, 13, 849324. doi:10.3389/fmicb.2022.849324

Piccirilli, A., Mercuri, P., Segatore, B., Galleni, M., Brisdelli, F., Kerff, F., Amicosante, G., & Perilli, M. (June 2021). Laboratory Variants GESG170L, GESG170K, and GESG170H Increase Carbapenem Hydrolysis and Confer Resistance to Clavulanic Acid. Antimicrobial Agents and Chemotherapy, 65 (6), 01931-20. doi:10.1128/AAC.01931-20

Léonard, R., Leleu, M., Van Vlierberghe, M., Cornet, L., Kerff, F., & Baurain, D. (05 May 2021). ToRQuEMaDA: tool for retrieving queried Eubacteria, metadata and dereplicating assemblies. PeerJ, 9, 11348. doi:10.7717/peerj.11348

Lupo, V., Van Vlierberghe, M., Vanderschuren, H., Kerff, F., Baurain, D., & Cornet, L. (2021). Contamination in Reference Sequence Databases: Time for Divide-and-Rule Tactics. Frontiers in Microbiology, 12, 755101. doi:10.3389/fmicb.2021.755101

vettore, N., Moray, J., Brans, A., Herman, R., Charlier, P., kumita, J., Kerff, F., Dobson, C., & Dumoulin, M. (2021). Characterisation of the structural, dynamic and aggregation properties of the W64R amyloidogenic variant of human lysozyme. Biophysical Chemistry. doi:10.1016/j.bpc.2021.106563

Boes, A., Brunel, J. M., Derouaux, A., Kerff, F., Bouhss, A., Touze, T., Breukink, E., & Terrak, M. (2020). Squalamine and Aminosterol Mimics Inhibit the Peptidoglycan Glycosyltransferase Activity of PBP1b. Antibiotics. doi:10.3390/antibiotics9070373

Mercuri, P., Esposito, R., Blétard, S., Di Costanzo, S., Perilli, M., Kerff, F., & Galleni, M. (2020). Mutational Effects on Carbapenem Hydrolysis of YEM-1, a New Subclass B2 Metallo-β-Lactamase from Yersinia mollaretii. Antimicrobial Agents and Chemotherapy. doi:10.1128/AAC.00105-20

Azarkan, M., Maquoi, E., Delbrassine, F., Herman, R., M'Rabet, N., Calvo-Esposito, R., Charlier, P., & Kerff, F. (2020). Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity. Scientific Reports. doi:10.1038/s41598-020-76172-5

Boes, A., Kerff, F., Herman, R., Touze, T., Breukink, E., & Terrak, M. (2020). The bacterial cell division protein fragment (E)FtsN binds to and activates the major peptidoglycan synthase PBP1b. Journal of Biological Chemistry, 295 (52), 18256-18265. doi:10.1074/jbc.RA120.015951

Tian, X., Auger, R., Manat, G., Kerff, F., Mengin-Lecreulx, D., & Touzé, T. (2020). Insight into the dual function of lipid phosphate phosphatase PgpB involved in two essential cell-envelope metabolic pathways in Escherichia coli. Scientific Reports, 10 (1), 13209. doi:10.1038/s41598-020-70047-5

Azarkan, M., Feller, G., Vandenameele, J., Herman, R., El Mahyaoui, R., Sauvage, E., Vanden Broeck, A., Matagne, A., Charlier, P., & Kerff, F. (2018). Biochemical and structural characterization of a mannose binding jacalin-related lectin with two-sugar binding sites from pineapple (Ananas comosus) stem. Scientific Reports. doi:10.1038/s41598-018-29439-x

El Ghachi, M., Howe, N., Huang, C.-Y., Olieric, V., Warshamanage, R., Touze, T., Weichert, D., Stansfeld, P. J., Wang, M., Kerff, F., & Caffrey, M. (2018). Crystal structure of undecaprenyl-pyrophosphate phosphatase and its role in peptidoglycan biosynthesis. Nature Communications, 9 (1), 1078. doi:10.1038/s41467-018-03477-5

Rodríguez, M. M., Herman, R., Ghiglione, B., Kerff, F., D'Amico González, G., Bouillenne, F., Galleni, M., Handelsman, J., Charlier, P., Gutkind, G., Sauvage, E., & Power, P. (July 2017). Crystal Structure and Kinetic Analysis of the Class B3 Di-Zinc Metallo-β-Lactamase LRA-12 from an Alaskan Soil Metagenome. PLoS ONE, 12 (7), 0182043. doi:10.1371/journal.pone.0182043

El Ghachi, M., Howe, N., Auger, R., Lambion, A., Guiseppi, A., Delbrassine, F., Manat, G., Roure, S., Peslier, S., Sauvage, E., Vogeley, L., Rengifo-Gonzalez, J.-C., Charlier, P., Mengin-Lecreulx, D., Foglino, M., Touze, T., Caffrey, M., & Kerff, F. (2017). Crystal structure and biochemical characterization of the transmembrane PAP2 type phosphatidylglycerol phosphate phosphatase from Bacillus subtilis. Cellular and Molecular Life Sciences. doi:10.1007/s00018-017-2464-6

Dagnino-Leone, J., Figueroa, M., Mella, C., Vorphal, M. A., Kerff, F., Vasquez, A. J., Bunster, M., & Martinez-Oyanedel, J. (2017). Structural models of the different trimers present in the core of phycobilisomes from Gracilaria chilensis based on crystal structures and sequences. PLoS ONE, 12 (5), 0177540. doi:10.1371/journal.pone.0177540

Jourdan, S.* , Francis, I.* , Kim, M., Salazar, J., Planckaert, S., Frère, J.-M., Matagne, A., Kerff, F., Devreese, B., Loria, R., & Rigali, S. (2016). The CebE/MsiK Transporter is a Doorway to the Cello-oligosaccharide-mediated Induction of Streptomyces scabies Pathogenicity. Scientific Reports. doi:10.1038/srep27144

Marcoccia, F., Bottoni, C., Sabatini, A., Colapietro, M., Mercuri, P., Galleni, M., Kerff, F., Matagne, A., Celenza, G., Amicosante, G., & Perilli, M. (2016). Kinetic Study of Laboratory Mutants of NDM-1 Metallo-beta-Lactamase and the Importance of an Isoleucine at Position 35. Antimicrobial Agents and Chemotherapy, 60 (4), 2366-72. doi:10.1128/AAC.00531-15

Manat, G., El Ghachi, M., Auger, R., Baouche, K., Olatunji, S., Kerff, F., Touze, T., Mengin-Lecreulx, D., & Bouhss, A. (2015). Membrane Topology and Biochemical Characterization of the Escherichia coli BacA Undecaprenyl-Pyrophosphate Phosphatase. PLoS ONE, 10 (11), 0142870. doi:10.1371/journal.pone.0142870

Ruggiero, M., Kerff, F., Herman, R., Sapunaric, F., Galleni, M., Gutkind, G., Charlier, P., Sauvage, E., & Power, P. (2014). Crystal Structure of the Extended-Spectrum β -Lactamase PER-2 and Insights into the Role of Specific Residues in the Interaction with β -Lactams and β -Lactamase Inhibitors. Antimicrobial Agents and Chemotherapy, 58 (10), 5994-6002. doi:10.1128/AAC.00089-14

Sauvage, E., Derouaux, A., Fraipont, C., Joris, M., Herman, R., Rocaboy, M., Schloesser, M., Dumas, J., Kerff, F., Nguyen-Distèche, M., & Charlier, P. (2014). Crystal structure of penicillin-binding protein 3 (PBP3) from Escherichia coli. PLoS ONE. doi:10.1371/journal.pone.0098042

Dzhekieva, L., Adediran, S. A., Herman, R., Kerff, F., Duez, C., Charlier, P., Sauvage, E., & Pratt, R. F. (2013). Inhibition of dd-Peptidases by a Specific Trifluoroketone: Crystal Structure of a Complex with the Actinomadura R39 dd-Peptidase. Biochemistry. doi:10.1021/bi400048s

Rocaboy, M., Herman, R., Sauvage, E., Remaut, H., Moonens, K., Terrak, M., Charlier, P., & Kerff, F. (2013). The crystal structure of the cell division amidase AmiC reveals the fold of the AMIN domain, a new peptidoglycan binding domain. Molecular Microbiology. doi:10.1111/mmi.12361

Zervosen, A., Herman, R., Kerff, F., Herman, A., Bouillez, A., Prati, F., Pratt, R. F., Frère, J.-M., Joris, B., Luxen, A., Charlier, P., & Sauvage, E. (2011). Unexpected tricovalent binding mode of boronic acids within the active site of a penicillin binding protein. Journal of the American Chemical Society. doi:10.1021/ja200696y

Sauvage, E., Zervosen, A., Dive, G., Herman, R., Amoroso, A. M., Joris, B., Fonzé, E., Pratt, R., Luxen, A., Charlier, P., & Kerff, F. (2009). Structural basis of the inhibition of class A beta-lactamases and penicillin-binding proteins by 6-beta-iodopenicillanate. Journal of the American Chemical Society, 131 (42), 15262-15269. doi:10.1021/ja9051526

Bebrone, C., Anne, C., Kerff, F., Garau, G., De Vriendt, K., Lantin, R., Devreese, B., Van Beeumen, J., Dideberg, O., Frère, J.-M., & Galleni, M. (2008). Mutational analysis of the zinc- and substrate-binding sites in the CphA metallo-beta-lactamase from Aeromonas hydrophila. Biochemical Journal, 414 (1), 151-9. doi:10.1042/BJ20080375

Michaux, C., Massant, J., Kerff, F., Frère, J.-M., Docquier, J.-D., Vandenberghe, I., Samyn, B., Pierrard, A., Feller, G., Charlier, P., Van Beeumen, J., & Wouters, J. (2008). Crystal structure of a cold-adapted class C beta-lactamase. FEBS Journal, 275 (8), 1687-97. doi:10.1111/j.1742-4658.2008.06324.x

Sauvage, E., Duez, C., Herman, R., Kerff, F., Petrella, S., Anderson, J. W., Adediran, S. A., Pratt, R. F., Frère, J.-M., & Charlier, P. (10 August 2007). Crystal structure of the Bacillus subtilis penicillin-binding protein 4a, and its complex with a peptidoglycan mimetic peptide. Journal of Molecular Biology, 371 (2), 528-539. doi:10.1016/j.jmb.2007.05.071

Sauvage, E., Kerff, F., Fonze, E., Herman, R., Schoot, B., Marquette, J. P., Taburet, Y., Prevost, D., Dumas, J., Stefanic, P., Coyette, J., Charlier, P., & Leonard, G. (2002). The 2.4-A crystal structure of the penicillin-resistant penicillin-binding protein PBP5fm from Enterococcus faecium in complex with benzylpenicillin. Cellular and Molecular Life Sciences, 59 (7), 1223-32. doi:10.1007/s00018-002-8500-0