Publications and communications of Jean Defourny

Defourny, J. (2022). Considering gene therapy to protect from X‐linked deafness DFNX2 and associated neurodevelopmental disorders. Ibrain. doi:10.1002/ibra.12068

Defourny, J., & Thiry, M. (2022). Recent insights into gap junction biogenesis in the cochlea. Developmental Dynamics. doi:10.1002/dvdy.538

Defourny, J. (2022). Le système auditif et la surdité: causes, conséquences et perspectives thérapeutiques [Paper presentation]. Université du troisième âge, Liège, Belgium.

Defourny, J. (01 September 2021). Efnb2 haploinsufficiency induces early gap junction plaque disassembly and endocytosis in the cochlea [Paper presentation]. Présentation à l'Institut de l'Audition - Institut Pasteur, Paris, France.

Saume, A., Thiry, M., & Defourny, J. (2021). LDLR expression in the cochlea suggests a role in endolymph homeostasis and cochlear amplification. Hearing Research. doi:10.1016/j.heares.2021.108311

Thelen, N., Defourny, J., Lafontaine, D., & Thiry, M. (2021). Visualization of chromatin in the yeast nucleus and nucleolus using hyperosmotic shock. International Journal of Molecular Sciences. doi:10.3390/ijms22031132

Defourny, J., Audouard, C., Davy, A., & Thiry, M. (2021). Efnb2 haploinsufficiency induces early gap junction plaque disassembly and endocytosis in the cochlea. Brain Research Bulletin. doi:10.1016/j.brainresbull.2021.06.008

Petit, C., Delmaghani, S., Defourny, J., & Aghaie, A. (28 May 2020). Combination of pejvakin and LC3B for treating hearing losses.

Defourny, J., & Thiry, M. (2020). Tricellular adherens junctions provide a cell surface delivery platform for connexin 26/30 oligomers in the cochlea. Hearing Research, 400, 108137. doi:10.1016/j.heares.2020.108137

Bartholomé, O., Franck, C., Piscicelli, P., Lalun, N., Defourny, J., Renauld, J., Thelen, N., Lamaye, F., Ploton, D., & Thiry, M. (September 2019). Relationships between the structural and functional organization of the turtle cell nucleolus. Journal of Structural Biology, 208 (3), 107398. doi:10.1016/j.jsb.2019.09.015

Defourny, J. (2019). Eph/ephrin signalling in the development and function of the mammalian cochlea. Developmental Biology. doi:10.1016/j.ydbio.2019.02.004

Defourny, J., Aghaie, A., Perfettini, I., Avan, P., Delmaghani, S., & Petit, C. (2019). Pejvakin-mediated pexophagy protects auditory hair cells against noise-induced damage. Proceedings of the National Academy of Sciences of the United States of America. doi:10.1073/pnas.1821844116

Defourny, J., Peuckert, C., Kullander, K., & Malgrange, B. (2019). EphA4-ADAM10 Interplay Patterns the Cochlear Sensory Epithelium through Local Disruption of Adherens Junctions. iScience, 11, 246-257. doi:10.1016/j.isci.2018.12.017

Defourny, J., Thelen, N., & Thiry, M. (2019). Cochlear connexin 30 homomeric and heteromeric channels exhibit distinct assembly mechanisms. Mechanisms of Development. doi:10.1016/j.mod.2018.10.001

Defourny, J., Thelen, N., & Thiry, M. (2019). Actin-independent trafficking of cochlear connexin 26 to non-lipid raft gap junction plaques. Hearing Research. doi:10.1016/j.heares.2019.01.020

Defourny, J., Thelen, N., & Thiry, M. (19 October 2018). Molecular mechanisms of gap junction assembly in the cochlea [Poster presentation]. Belgian Brain Congress 2018. doi:10.3389/conf.fnins.2018.95.00004

Delmaghani, S., Defourny, J., Safieddine, S., Avan, P., & Petit, C. (15 September 2016). Noise-induced hearing loss due to impaired proliferation of peroxisomes [Paper presentation]. 5th Open European Peroxisome Meeting, Vienna, Austria.

Petit, C., Avan, P., Delmaghani, S., Defourny, J., Aghaie, A., Safieddine, S., & Emptoz, A. (25 August 2016). Prevention and/or treatment of hearing loss or impairment.

Petit, C., Delmaghani, S., Defourny, J., & Avan, P. (15 June 2016). Peroxisome proliferation: an anti-oxidant defense against noise-induced hearing loss [Paper presentation]. 17th International Conference on Oxidative Stress Reduction, Redox Homeostasis & Antioxidants, Paris, France.

Delmaghani, S., Defourny, J., Safieddine, S., Avan, P., & Petit, C. (21 February 2016). Hypervulnerability to sound-exposure through impaired adaptive proliferation of peroxisomes [Paper presentation]. 39th ARO Annual Midwinter Meeting, San Diego, California, United States.

Delmaghani, S., Defourny, J., Aghaie, A., Beurg, M., Dulon, D., Thelen, N., Perfettini, I., Zelles, T., Meyer, A., Emptoz, A., Thiry, M., Safieddine, S., Hardelin, J.-P., Avan, P., & Petit, C. (20 February 2016). Noise-induced hearing loss due to pejvakin defect: from pathogenesis to treatment [Poster presentation]. 39th ARO Annual Midwinter Meeting, San Diego, California, United States.

Delmaghani, S., Defourny, J., Aghaie, A., Beurg, M., Dulon, D., Thelen, N., Perfettini, I., Zelles, T., Aller, M., Meyer, A., Emptoz, A., Giraudet, F., Leibovici, M., Dartevelle, S., Soubigou, G., Thiry, M., Vizi, E. S., Safieddine, S., Hardelin, J.-P., ... Petit, C. (November 2015). Hypervulnerability to Sound Exposure through Impaired Adaptive Proliferation of Peroxisomes. Cell, 163 (4), 894-906. doi:10.1016/j.cell.2015.10.023

Defourny, J., Mateo Sanchez, S., Schoonaert, L., Robberecht, W., Davy, A., Nguyen, L., & Malgrange, B. (2015). Cochlear supporting cell transdifferentiation and integration into hair cell layers by inhibition of ephrin-B2 signalling. Nature Communications. doi:10.1038/ncomms8017

Defourny, J., Delacroix, L., & Malgrange, B. (2014). Chapter 7 – Neuronal Circuitries During Inner Ear Development. In R. Romand & I. Varela-Nieto (Eds.), Development of auditory and vestibular systems (pp. 189-212). Elsevier. doi:10.1016/B978-0-12-408088-1.00007-5

Defourny, J. (2013). Contribution of Eph/ephrin signalling in the development and function of the cochlea in mammals [Doctoral thesis, ULiège - Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/255897

Defourny, J., Poirrier, A.-L., Lallemend, F., Mateo Sanchez, S., Neef, J., Vanderhaeghen, P., Soriano, E., Peuckert, C., Kullander, K., Fritzsch, B., Nguyen, L., Moonen, G., Moser, T., & Malgrange, B. (2013). Ephrin-A5/EphA4 signalling controls specific afferent targeting to cochlear hair cells. Nature Communications, 4, 1438. doi:10.1038/ncomms2445

POIRRIER, A.-L., Van Den Ackerveken, P., Defourny, J., LEFEBVRE, P., & Malgrange, B. (2013). In vivo protection of spiral ganglion neurons by bryostatin 1: preliminary results. Advances in Cellular and Molecular Otolaryngology, 1.

Defourny, J., Moser, T., Soriano, E., Nguyen, L., Vanderhaeghen, P., Moonen, G., & Malgrange, B. (31 January 2011). Differential expressions of ephrin and Eph genes are required for specific afferent targeting to hair cells in the cochlea [Poster presentation]. GIGA-Day 2011, Liège, Belgium.

Defourny, J., Lallemend, F., & Malgrange, B. (2011). Structure and development of cochlear afferent innervation in mammals. American Journal of Physiology - Cell Physiology, 301 (4), 750-61. doi:10.1152/ajpcell.00516.2010

Defourny, J., Hadjab, S., Lallemend, F., Bodson, M., LEFEBVRE, P., & Malgrange, B. (2009). Role of ephrin-A5 in the survival and connectivity of spiral ganglion neurons [Poster presentation]. 8th BSN meeting.

Defourny, J., POIRRIER, A.-L., Hadjab, S., Lallemand, F., Bodson, M., LEFEBVRE, P., & Malgrange, B. (2009). Role of ephrin-A5 in the survival and connectivity of spiral ganglion neurons [Poster presentation]. 7th Molecular Biology of Hearing and Deafness, Boston, United States.

Defourny, J., Hadjab, S., Lallemend, F., Borgs, L., Vandenbosch, R., Beukelaers, P., Bodson, M., Breuskin, I., POIRRIER, A.-L., LEFEBVRE, P., & Malgrange, B. (2007). Role of ephrin-A5 in the survival and connectivity of spiral ganglion neurons [Poster presentation]. 7th BSN meeting.

Defourny, J., Hadjab, S., Lallemend, F., Borgs, L., Vandenbosch, R., Bodson, M., Breuskin, I., POIRRIER, A.-L., LEFEBVRE, P., & Malgrange, B. (10 November 2006). Role of ephrin-A5 forward signaling in the survival of post-natal auditory neurons [Poster presentation]. NeuroBelgium 2006.