Publications and communications of Rahmouni, Souad

International IBD Genetics Consortium, Rahmouni, S., Georges, M., & LOUIS, E. (In press). Sequencing of over 100,000 individuals identifies multiple genes and rare variants associated with Crohns disease susceptibility. Nature Genetics. doi:10.1101/2021.06.15.21258641

Petrov, V., Sharapov, S., Shagam, L., Nostaeva, A., Pezer, M., Li, D., Hanić, M., McGovern, D., LOUIS, E., Rahmouni, S., Lauc, G., Georges, M., & Aulchenko, Y. S. (29 April 2022). Association between human gut microbiome and N-glycan composition of total plasma proteome. Frontiers in Microbiology, 13:811922.

Desmecht, S., Tashkeev, A., Nicole Marechal, N., Perée, H., Tokunaga, Y., Fombellida-Lopez, C., Polese, B., Legrand, C., Wéry, M., Mni, M., Fouillien, N., TOUSSAINT, F., Gillet, L., Bureau, F., LUTTERI, L., HAYETTE, M.-P., MOUTSCHEN, M., MEURIS, C., Desmecht, D., & DARCIS, G. (2022). Kinetics and persistence of the cellular and humoral immune responses to BNT162b2 mRNA vaccine in SARS-CoV-2-naive and -experienced subjects. Eprint/Working paper retrieved from https://orbi.uliege.be/2268/267394. doi:10.1101/2022.01.17.22269278

Nakanishi, T., Pigazzini, S., Degenhardt, F., Cordioli, M., Butler-Laporte, G., Maya-Miles, D., Nafría-Jiménez, B., Bouysran, Y., Niemi, M., Palom, A., Ellinghaus, D., Khan, A., Martínez-Bueno, M., Rolker, S., Amitano, S., Tato, L. R., Fava, F., Spinner, C. D., Prati, D., & consortium, C.-H. (October 2021). Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality. Journal of Clinical Investigation, Online ahead of print.. doi:10.1172/JCI152386

Jacques, S., Arjomand, A., Perée, H., COLLINS, P., Mayer, A., Lavergne, A., Wéry, M., Mni, M., Hego, A., Thuillier, V., Becker, G., Bahri, M. A., Plenevaux, A., Di Valentin, E., Oury, C., MOUTSCHEN, M., Delvenne, P., Paquot, N., & Rahmouni, S. (2021). Dual‑specificity phosphatase 3 deletion promotes obesity, non‑alcoholic steatohepatitis and hepatocellular carcinoma. Scientific Reports, 11, 5817. doi:10.1038/s41598-021-85089-6

Lieferinckx, C., De Grève, Z., Toubeau, J. F., Perée, H., Quertinmont, E., Tafciu, V., Minsart, C., Rahmouni, S., Georges, M., Vallée, F., & Franchimont, D. (2021). New approach to determine the healthy immune variations by combining clustering methods. Scientific Reports, 11, 8917. doi:10.1038/s41598-021-88272-x

The COVID-19 Host Genetics Initiative, Gazon, H., JUSZCZAK, D., FADEUR, M., CAMBY, S., MEURIS, C., THYS, M., JACQUES, J., HENKET, M., BEGUIN, Y., Rahmouni, S., Lebrun, M., MOUTSCHEN, M., Misset, B., DARCIS, G., GUIOT, J., AZARZAR, S., DELLOT, P., GOFFLOT, S., & HUYNEN, P. (Other coll.). (2021). Mapping the human genetic architecture of COVID-19. Nature, 600, 472-477. doi:10.1038/s41586-021-03767-x

Weersma, R., Barrett, J., Vermeire, S., Xavier, R., Anderson, C., Wijmenga, C., Daly, M., Alm, E., Raes, J., Huttenhower, C., Stappenbeck, T., Netea, M., Kaser, A., Franke, A., McGovern, D., Colombel, J., van den Brink, G., Uhlig, H., Georges, M., & Moutsianas, L. (November 2018). Multiomics Analyses to Deliver the Most Effective Treatment to Every Patient With Inflammatory Bowel Disease. Gastroenterology, 155 (5), 1-e4. doi:10.1053/j.gastro.2018.07.039

Yukihide, M., Dmitrieva, J. B., Theatre, E., Deffontaine, V., Rahmouni, S., Charloteaux, B., Crins, F., Elansary, M., Gori, A.-S., LECUT, C., Mariman, R., Mni, M., Oury, C., Altukhov, I., Alexeev, D., Aulchenko, Y., Amininejad, L., van der Meulen-de Jong, A. E., van der Woude, C. J., & Georges, M. (2018). IBD risk loci are enriched in multigenic regulatory modules encompassing causative genes. Nature Communications. doi:10.1038/s41467-018-04365-8

Vandereyken, M., Jacques, S., Van Overmeire, E., Amand, M., Rocks, N., Delierneux, C., Singh, P., Singh, M., GHUYSEN, C., Wathieu, C., Zurashvili, T., Sounni, N. E., Moutschen, M., Gilles, C., Oury, C., Cataldo, D., Van Ginderachter, J. A., & Rahmouni, S. (2017). Dusp3 deletion in mice promotes experimental lung tumour metastasis in a macrophage dependent manner. PLoS ONE. doi:10.1371/journal.pone.0185786

Vandereyken, M., Singh, P., Wathieu, C., Jacques, S., Zurashvili, T., Dejager, L., Amand, M., Musumeci, L., Singh, M., MOUTSCHEN, M., Libert, C., & Rahmouni, S. (2017). Dual-Specificity Phosphatase Deletion Protects Female, but Not Male, Mice from Endotoxemia- and Polymicrobial-Induced Septic Shock. Journal of Immunology. doi:10.4049/jimmunol.1602092

Göktuna, S., Shostak, K., Chau, T.-L., Heukamp, L., Hennuy, B., Duong, H. Q., LADANG, A., Close, P., Klevernic, I., Olivier, F., Florin, A., Ehx, G., Baron, F., Vandereyken, M., Rahmouni, S., Vereecke, L., van Loo, G., Büttner, R., Greten, F., & Chariot, A. (2016). The Prosurvival IKK-Related Kinase IKK« Integrates LPS and IL17A Signaling Cascades to Promote Wnt-Dependent Tumor Development in the Intestine. Cancer Research, 76, 2587-99. doi:10.1158/0008-5472.CAN-15-1473

Tautz, L., Rahmouni, S., Oury, C., & Musumeci, L. (27 June 2015). DUSP3 Phosphatase Deficiency or Inhibition Limits Platelet Activation and Arterial Thrombosis. Paper presented at Europhosphatase 2015: Phosphorylation switches and cellular homeostasis, Turku, Finland.

Rahmouni, S., MUSUMECI, L., Kuijpers, M. J., Gilio, K., Hego, A., Theatre, E., Senis, Y., Heemskerk, J., Thiry, M., Tautz, L., & Oury, C. (24 June 2015). DUSP3 Phosphatase Deficiency or Inhibition Limits Platelet Activation and Arterial Thrombosis. Paper presented at ISTH 2015 Congress, Toronto, Canada.

Delierneux, C., Hego, A., LECUT, C., Vandereyken, M., MUSUMECI, L., Rahmouni, S., BOURS, V., LANCELLOTTI, P., & Oury, C. (22 June 2015). CLEC-2 is required for the activation of mouseplatelets by bacterial DNA mimetics. Paper presented at ISTH 2015 Congress, Toronto, Canada.

Delierneux, C., Hego, A., LECUT, C., Vandereyken, M., MUSUMECI, L., Rahmouni, S., BOURS, V., Lancellotti, P., & Oury, C. (22 June 2015). CLEC-2 is required for the activation of mouse platelets by bacterial DNA mimetics. Paper presented at ISTH 2015 Congress, Toronto, Canada.

Vandereyken, M., Amand, M., Van Overmeire, E., Zurashvili, T., MOUTSCHEN, M., Gilles, C., Van Ginderachter, J., & Rahmouni, S. (June 2015). Genetic depletion of the dual specificity protein phosphatase DUSP3 promotes LLC Lung tumour metastasis. Paper presented at Europhosphatase 2015: Phosphorylation switches and cellular homeostasis, Turku, Finland.

Vandereyken, M., Amand, M., Van Overmeire, E., Zurashvili, T., MOUTSCHEN, M., Noël, A., Gilles, C., Van Ginderachter, J., & Rahmouni, S. (June 2015). Genetic depletion of the dual specificity protein phosphatase DUSP3 promotes LLC Lung tumour metastasis. Poster session presented at Europhosphatase 2015: Phosphorylation switches and cellular homeostasis, Turku, Finland.

Delierneux, C., Hego, A., LECUT, C., Vandereyken, M., Musumeci, L., Rahmouni, S., Thiry, M., Compère, P., BOURS, V., Lancellotti, P., & Oury, C. (27 January 2015). Bacterial DNA mimetics activate platelets and promote thrombosis via CLEC-2. Poster session presented at GIGA-DAY: Current advances in medical genetics and genomics, Liège, Belgium.

Oury, C., Rahmouni, S., & LANCELLOTTI, P. (2015). Les antiplaquettaires : quoi de neuf ? MS. Medecine Sciences. doi:10.1051/medsci/20153108006

Amand, M., Erpicum, C., BAJOU, K., Cerignoli, F., Blacher, S., Martin, M., Dequiedt, F., Drion, P., Singh, P., Zurashvili, T., Vandereyken, M., Musumeci, L., Mustelin, T., Moutschen, M., Gilles, C., Noël, A., & Rahmouni, S. (2014). DUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase. Molecular Cancer. doi:10.1186/1476-4598-13-108

Singh, M., Singh, P., VAIRA, D., Amand, M., Rahmouni, S., & Moutschen, M. (2014). Minocycline attenuates HIV-1 infection and suppresses chronic immune activation in humanized NOD/LtsZ-scidIL-2Rgamma(null) mice. Immunology, 142 (4), 562-72. doi:10.1111/imm.12246

Musumeci, L., Maurissen, L., Kuijpers, M. J., Senis, Y., MOUTSCHEN, M., Mustelin, T., Heemskerk, J. W., Oury, C., & Rahmouni, S. (02 July 2013). Genetic deletion of Vaccinia H1-related (VHR) phosphatase inhibits collagen-induced platelet activation and thrombus formation without affecting bleeding time in mice. Paper presented at XXIVth Congress of the ISTH, Amsterdam, Netherlands.

Rahmouni, S., Singh, P., Dejager, L., Singh, M., Amand, M., Musumeci, L., Moutschen, M., Mustelin, T., & Libert, C. (2013). Dual-specificity phosphatase 3 knockout female mice are resistant to LPS and to polymicrobial induced septic shock in TNF dependent manner. Journal of Immunology.

Bruck, F.* , Belle, L.* , LECHANTEUR, C., de Leval, L., Hannon, M., DUBOIS, S., CASTERMANS, E., Humblet-Baron, S., Rahmouni, S., Beguin, Y., BRIQUET, A.* , & Baron, F.*. (March 2013). Impact of bone marrow-derived mesenchymal stromal cells on experimental xenogeneic graft-versus-host disease. Cytotherapy, 15 (3), 267-279. doi:10.1016/j.jcyt.2012.09.003

Tautz, L., Vang, T., Liu, W., Delacroix, L., Wu, S., Vasile, S., Dahl, R., Yang, L., MUSUMECI, L., Francis, D., Landskron, J., Tasken, K., Tremblay, M., Lie, B., Page, R., Mustelin, T., Rahmouni, S., & Rickert, R. (April 2012). Dynamic interaction between lymphoid tyrosine phosphatase and C-terminal Src kinase controls T cell activation. FASEB Journal, 26.

Bruck, F., de Leval, L., Belle, L., LECHANTEUR, C., Hannon, M., BRIQUET, A., Dubois, S., CASTERMANS, E., Humblet-Baron, S., Rahmouni, S., BEGUIN, Y., & BARON, F. (2012). Bone marrow-derived mesenchymal stromal cells failed to prevent experimental xenogeneic graft-versus-host disease. Poster session presented at Belgian Hematological Society General Annual Meeting.

Singh, M., Singh, P., Gaudray, G., Musumeci, L., Thielen, C., VAIRA, D., Vandergeeten, C., Delacroix, L., Van Gulck, E., Vanham, G., de Leval, L., Rahmouni, S., & MOUTSCHEN, M. (2012). An improved protocol for efficient engraftment in NOD/LTSZ-SCIDIL-2Rgammanull mice allows HIV replication and development of anti-HIV immune responses. PLoS ONE, 7 (6), 38491. doi:10.1371/journal.pone.0038491

Singh, M., Singh, P., VAIRA, D., Tasken, K., Rahmouni, S., & Moutschen, M. (03 October 2011). Humanized mice as a useful model to study HIV-1 induced immune activation, its mechanisms and potential therapeutic approaches. Retrovirology, 8, 62.

Mosenden, R.* , Singh, P.* , Cornez, I., Heglind, M., Ruppelt, A., MOUTSCHEN, M., Enerbäck, S., Rahmouni, S., & Tasken, K. (2011). Mice with Disrupted Type I Protein Kinase A Anchoring in T Cells Resist Retrovirus-Induced Immunodeficiency. Journal of Immunology, 186 (9), 5119-30. doi:10.4049/jimmunol.1100003

Charlier, E., Condé, C., Zhang, J., Deneubourg, L., Di Valentin, E., Rahmouni, S., Chariot, A., Agostinis, P., Pang, P.-C., Haslam, S., Dell, A., Penninger, J., Erneux, C., Piette, J., & Gloire, G. (2010). SHIP-1 inhibits CD95/APO-1/Fas-induced apoptosis in primary T lymphocytes and T leukemic cells by promoting CD95 glycosylation independently of its phosphatase activity. Leukemia. doi:10.1038/leu.2010.9

Geenen, V., Mottet, M., Dardenne, O., Kermani, H., Martens, H., François, J.-M., Galleni, M., Hober, D., Rahmouni, S., & Moutschen, M. (2010). Thymic self-antigens for the design of a negative/tolerogenic self-vaccination against type 1 diabetes. Current Opinion in Pharmacology, 10, 461-472. doi:10.1016/j.coph.2010.04.005

Wu, S.* , Vossius, S.* , Rahmouni, S.* , Miletic, A. V., Vang, T., Vazquez-Rodriguez, J., Cerignoli, F., Arimura, Y., Williams, S., Hayes, T., Moutschen, M., Vasile, S., Pellecchia, M., Mustelin, T., & Tautz, L. (12 November 2009). Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells. Journal of Medicinal Chemistry, 52 (21), 6716-23. doi:10.1021/jm901016k

Tautz, L., Mustelin, T., Wu, S., Vossius, S., Rahmouni, S., Vasile, S., Sergienko, E., Stonich, D., Yuan, H., Su, H., Dahl, Y., Mostofi, Y., & Chung, T. D. (2009). Small-Molecule Inhibitors of Vaccinia-H1-Related Phosphatase VHR. Bethesda, United States: National Center for Biotechnology Information (US).

Chandrika, K., Dellot, P., Frippiat, F., Giot, J.-B., Leonard, P., Marée, R., Mayasi, N., Meuris, C., Mukeba Tshialala, D., Rahmouni, S., Uurlings, F., Vaira, D., Wehenkel, L., Demonty, J., & Moutschen, M. (2007). Nouvelles approches dans la prise en charge de l'infection a VIH. Revue Médicale de Liège, 62 Spec No, 47-50.

Zeddou, M., Rahmouni, S., Vandamme, A., Jacobs, N., Frippiat, F., Leonard, P., SCHAAF-LAFONTAINE, N., Vaira, D., Boniver, J., & Moutschen, M. (2007). Downregulation of CD94/NKG2A inhibitory receptors on CD8+ T cells in HIV infection is more pronounced in subjects with detected viral load than in their aviraemic counterparts. Retrovirology, 4, 72. doi:10.1186/1742-4690-4-72

Zeddou, M., Boniver, J., Moutschen, M., & Rahmouni, S. (February 2006). Prostanglandin E2 induces the expression of functional inhibitory CD94/NKG2A receptors in human CD8+ T lymphocytes by a cAMP-dependent protein kinase A type I pathway. Paper presented at Keystone Symposia - Innate Immunity, Banff, Canada.

Zeddou, M., Rahmouni, S., VANDAMME, A., Schaaf-Lafontaine, N., & Moutschen, M. (2006). HIV viraemic patients downregulate CD94/NKG2A inhibitory receptors on NK as well as CD8 T cells in comparison with aviraemic counterparts. Poster session presented at AIDS 2006 - XVI International AIDS Conference.

tasken, K., MOUTSCHEN, M., Rahmouni, S., Aandahl, E. M., Aukurst, P., Froland, S., Johansson, C., Hansson, V., & Klaveness, J. (29 April 2004). Use of COX-2 inhibitors for preventing immunodeficiency.

Mustelin, T., Rahmouni, S., Alonso, A., Williams, S., Van Stipdonk, M., Soncini, C., & Schoenberger, S. (2004). Removal of C-terminal Src kinase from the immune synapse by a new binding protein. Cancer Research, 45.