Publications of Céline KEMPENEERS
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See detailDiffuse alveolar haemorrhage in infants: Report of five cases
Gkogkou, Efthymia ULiege; roux, Isabelle; KEMPENEERS, Céline ULiege et al

in Respiratory Medicine Case Reports (2020)

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See detailAvancées thérapeutiques et évolution vers une médecine personnalisée pour les patients atteints de mucoviscidose
BOBOLI, Hedwige ULiege; Pirson, Jessica; SEGHAYE, Marie-Christine ULiege et al

in Revue Médicale de Liège (2020)

Cystic fibrosis is a genetic disorder responsible for the production of a defective transmembrane protein. In recent years, new protein modulators have been developed. They aim to treat the underlying ... [more ▼]

Cystic fibrosis is a genetic disorder responsible for the production of a defective transmembrane protein. In recent years, new protein modulators have been developed. They aim to treat the underlying cause of the disease. The results on the biomarkers of the function of the CFTR protein and on the clinical outcomes are very encouraging. However, there is an individual heterogeneity in the response to modulators within a same genotype. Furthermore, clinical trials focus on the most common mutations in the CFTR gene, in particular DF508. Intestinal organoids, a new model of ex vivo study, could offer a quick approach to increase access to effective treatment for all patients with cystic fibrosis regardless of their CFTR genotype. Organoids could enable personalized treatment of cystic fibrosis. [less ▲]

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See detailDiffuse alveolar hemorrhage in infants : Report of five cases
Gkogkou, Efthymia ULiege; BROUX, Isabelle ULiege; KEMPENEERS, Céline ULiege et al

in Respiratory Medicine Case Reports (2020), 31

Diffuse alveolar hemorrhage (DAH) is a rare life-threatening condition in children. In this entity, the bleeding originates from the pulmonary microvasculature as a result of microvascular damage leading ... [more ▼]

Diffuse alveolar hemorrhage (DAH) is a rare life-threatening condition in children. In this entity, the bleeding originates from the pulmonary microvasculature as a result of microvascular damage leading to blood leakage into the alveolar spaces. DAH can occur as an isolated medical entity or may be associated with other organ system injury or dysfunction. The classic triad of symptoms includes hemoptysis, anemia and diffuse pulmonary infiltrates. Hemoptysis is the usual presenting symptom but is not constant. A variety of diseases is associated with the development of DAH. Current classification organize the etiologies of diffuse alveolar hemorrhage based on the presence of severe immune disorders (such as systemic vasculitis and collagenosis) or non-immunodeficiency disorders (with an identified cardiac or non-cardiac origin, or idiopathic). The five cases of DAH presented in this study were all diagnosed in full-term infants, four males and one female, with normal neonatal adaptation and without family history of notable diseases. In all cases the diagnosis was made between the age of three and eighteen weeks-old. Moreover, all five patients, at the time of diagnosis, presented with hemoptysis, mild or severe dyspnea, anemia and abnormal chest X-rays. Consequently, the diagnosis of DAH was strongly suspected and, eventually, confirmed by bronchoscopy. Additional laboratory tests, as well as selected serologic and radiographic studies were performed in order to identify a specific etiology. The final diagnoses reflect a variety of causes: infections, idiopathic pulmonary hemosiderosis, accidental suffocation and Heiner syndrome. Treatment included oral corticosteroids except from one patient that received antimicrobial therapy. [less ▲]

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See detailTotal absence of the pericardium associated with hypogammaglobulinemia and bronchiectasis in a girl
KINUANI MULASI, Rachel ULiege; BRUYERE, Pierre-Julien ULiege; Schoysman, Laurent et al

in Paediatric Reports (2019), 11(8250),

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See detailCiliary Functional Analysis: Beating a path towards standardisation
KEMPENEERS, Céline ULiege; Seaton, Claire; Garcia Espinosa, Bernardo et al

Poster (2019, October 18)

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See detailChronic cough in Pediatrics: Algorithms
KEMPENEERS, Céline ULiege

Speech/Talk (2018)

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See detailToux chronique chez l’enfant
KEMPENEERS, Céline ULiege

Speech/Talk (2018)

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See detailEtude rétrospective des lymphomes de l'enfant. A propos de 27 cas traités dans une méme institution
KEMPENEERS, Céline ULiege; FORGET, Patricia ULiege; DRESSE, Marie-Françoise ULiege et al

in Revue Médicale de Liège (2005), 60(11), 855-862

Childhood lymphomas represent a heterogeneous group of disorders that are quite different from adult lymphomas. Over the past three decades, empirical chemotherapeutic management has transformed survival ... [more ▼]

Childhood lymphomas represent a heterogeneous group of disorders that are quite different from adult lymphomas. Over the past three decades, empirical chemotherapeutic management has transformed survival figures, and more recently greater understanding of the biology is offering hope for improved management of resistant disease. We present here the experience of a single institution in the management of 27 childhood lymphomas; epidemiological and clinical characteristics are described as well as survival rates. The median follow up of the patients is 4 years 7 months. The five-year overall survival for the entire group is more than 95 %; the 5-year disease free survival is 91,6 % for Hodgkin's lymphomas, 92,8% for non Hodgkin's lymphomas and 100% for Burkitt diseases. Two relapses have occurred and all of them appeared within the 18 months of the diagnosis. No toxic death has been reported. [less ▲]

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