Publications of Caroline FLAGOTHIER
Bookmark and Share    
Full Text
See detailComment je traite... un intertrigo lie a l'embonpoint.
Henry, Frédérique ULiege; Pierard, Claudine ULiege; Flagothier, Caroline ULiege et al

in Revue Médicale de Liège (2007), 62(2), 67-70

Intertrigo is a common inflammatory disorder of various origins. It can represent a single skin manifestation or be part of a disorder possibly exhibiting specific manifestations on other parts of the ... [more ▼]

Intertrigo is a common inflammatory disorder of various origins. It can represent a single skin manifestation or be part of a disorder possibly exhibiting specific manifestations on other parts of the body. Hence, intertrigo may represent a sign of a peculiar disease. It may also result from physicochemical aggressions of the skin following occlusion of the large skinfolds particularly in case of stoutness. In this intance, a treatment similar to that of diaper dermatitis can be offered. A paste enriched or not with miconazole nitrate is indicated to prevent or treat most presentations of intertrigo. [less ▲]

Detailed reference viewed: 272 (4 ULiège)
Full Text
See detailComment je traite ... un psoriasis en plaques par l'association calcipotriol-dipropionate de betamethasone.
Henry, Frédérique ULiege; Flagothier, Caroline ULiege; Franchimont, Claudine ULiege et al

in Revue Médicale de Liège (2006), 61(3), 139-41

The combination of calcipotriol and betamethasone dipropionate in a single topical formulation is a recent advance in treatment of plaque type psoriasis. Studies rooted on evidence-based medicine have ... [more ▼]

The combination of calcipotriol and betamethasone dipropionate in a single topical formulation is a recent advance in treatment of plaque type psoriasis. Studies rooted on evidence-based medicine have been recently published. We report a synthesis and a critical analysis, critical analysis of these investigations, and translate their data with a view to apply them in daily practice. [less ▲]

Detailed reference viewed: 89 (1 ULiège)
Full Text
See detailNew insights into the effect of amorolfine nail lacquer.
Flagothier, Caroline ULiege; Pierard, Claudine ULiege; Pierard, Gérald ULiege

in Mycoses (2005), 48(2), 91-4

Despite improvements in antifungal strategies, the outcome of treating onychomycoses often remains uncertain. Several factors account for treatment failure, of which the pharmacokinetics and ... [more ▼]

Despite improvements in antifungal strategies, the outcome of treating onychomycoses often remains uncertain. Several factors account for treatment failure, of which the pharmacokinetics and pharmacodynamics of the antifungal are of importance. The taxonomic nature and ungual location of the fungus cannot be neglected, besides the type of nail and its growth rate. In addition, the biological cycle of the fungus and the metabolic activity of the pathogen likely play a marked influence in drug response. The presence of natural antimicrobial peptides in the nail is also probably a key feature controlling the cure rates. There are many outstanding publications that cover the full spectrum of the field. The purpose of this review is to put in perspective some facets of activity of the topical treatment using amorolfine nail laquer. The antifungal activity of the drug is likely less pronounced in onychomycosis than that expected from conventional in vitro studies. However, the nail laquer formulation should reduce the propensity to form antifungal-resistant spores and limit the risk of reinfection. [less ▲]

Detailed reference viewed: 140 (0 ULiège)
Full Text
See detailLa peau et ses nuances ethniques.
Flagothier, Caroline ULiege; Pierard, Claudine ULiege; Pierard, Gérald ULiege

in Revue Médicale de Liège (2005), 60 Suppl 1

Ethnic (racial) differences exist for a series of physiological skin characteristics. Colour is responsible for typology and resistance to ultraviolet irradiations. Other differences have also been ... [more ▼]

Ethnic (racial) differences exist for a series of physiological skin characteristics. Colour is responsible for typology and resistance to ultraviolet irradiations. Other differences have also been reported for the transepidermal water loss, the size and cohesion of corneocytes, the vascular reactiviy, the biomechanical properties, the pH, the lipidic content, the superficial microflora and the structure of mast cell granules. [less ▲]

Detailed reference viewed: 292 (3 ULiège)
Full Text
See detailLe médicament du mois. L'association calcipotriol-dipropionate de bétamethasone (dovobet).
Henry, Frédérique ULiege; Flagothier, Caroline ULiege; Delvoye, Pierre et al

in Revue Médicale de Liège (2005), 60(11), 893-5

The topical treatment of psoriasis benefits from the alternate use of dermocorticosteroids and vitamin D3 analogues. A new galenic formulation allows to combine them in a single application. Dovobet (LEO ... [more ▼]

The topical treatment of psoriasis benefits from the alternate use of dermocorticosteroids and vitamin D3 analogues. A new galenic formulation allows to combine them in a single application. Dovobet (LEO Pharma) ointment is the association of calcipotriol 50 microg/g with betamethasone dipoprionate 0.5 mg/g. This formulation boosts the therapeutic activity of calcipotriol. It also decreases the irritative inflammatory reaction due to calcipotriol without increasing the atrophogenic risk of the dermocorticoid. [less ▲]

Detailed reference viewed: 218 (4 ULiège)
Full Text
See detailStigmates cutanés du diabète.
Flagothier, Caroline ULiege; Quatresooz, Pascale ULiege; Bourguignon, Raphaël et al

in Revue Médicale de Liège (2005), 60(5-6), 553-9

A number of relationships exist between diabetes mellitus and a series of cuteanous disorders. Skin lesions may reveal diabetes in a more or less specific way. They may also represent complications ... [more ▼]

A number of relationships exist between diabetes mellitus and a series of cuteanous disorders. Skin lesions may reveal diabetes in a more or less specific way. They may also represent complications supervening in an already treated diabetic patient. Some of these dermatoses (acanthosis nigricans, purpuric and pigmented capillaritis) are markers of macrovascular complications. The same disorders and some others (xerosis, Dupuytren's disease) are more frequently associated with microangiopathy in Type II diabetes. Other skin diseases (alopecia areata, vitiligo) are markers of auto-immunity in Type I diabetes. [less ▲]

Detailed reference viewed: 483 (0 ULiège)
Full Text
See detailAcnés paroxystiques.
Flagothier, Caroline ULiege; Pierard, Claudine ULiege; Pierard, Gérald ULiege

in Revue Médicale de Liège (2004), 59(4), 177-9

Contrasting with the chronic evolution of acne vulgar, other types of acne are characterized by paroxysmal outbreaks. They can be endogenous or exogenous in origin. Each of these two groups can be further ... [more ▼]

Contrasting with the chronic evolution of acne vulgar, other types of acne are characterized by paroxysmal outbreaks. They can be endogenous or exogenous in origin. Each of these two groups can be further divided into separate entities. [less ▲]

Detailed reference viewed: 111 (1 ULiège)
Full Text
See detailComment j'explore ... les dermites des langes.
Flagothier, Caroline ULiege; Pierard, Claudine ULiege; Pierard, Gérald ULiege

in Revue Médicale de Liège (2004), 59(2), 106-9

Diaper dermatitis is a frequent condition. Several clinical types are distinguished. The most frequent type results from increased fragility of the newborn buttock skin when covered by diapers. According ... [more ▼]

Diaper dermatitis is a frequent condition. Several clinical types are distinguished. The most frequent type results from increased fragility of the newborn buttock skin when covered by diapers. According to the mechanisms involved and the severity of the dermatitis, one can distinguish the intertrigo of the chubby baby, and the so-called "W", "Y" and "red panties" types of diaper dermatitis. When the effects of occlusion are not controlled by adequate absorption by the diapers, hyperhydration of the stratum corneum occurs and progresses to maceration. As a result, the value of the coefficient of friction of the skin increases with epidermal weakening to rubbing. In addition, fecal enzymes (urease, proteases and lipases) alter urines and skin. Judicious hygiene measures and the correct choice of diapers are mandatory. Cutaneous colonization by microorganisms, the most important of which being Candida albicans, is the main complication. Adequate preventive and curative measures can combat diaper dermatitis with confidence. A miconazole paste allows to improve the tribological properties of the interface between diapers and the skin. It also abates the impact of Candida albicans in the pathogenesis of the skin disorder. [less ▲]

Detailed reference viewed: 173 (1 ULiège)
Full Text
See detailLe cas clinique du mois. La syphilis, une MST de retour en nos murs.
Flagothier, Caroline ULiege; Arrese Estrada, Jorge ULiege; Pierard, Claudine ULiege et al

in Revue Médicale de Liège (2004), 59(7-8), 426-9

Sexually transmitted diseases (STD) show frequent epidemiological changes. We report a case of secondary syphilis diagnosed in a 32-year old woman during post-partum. The disease, although showing a ... [more ▼]

Sexually transmitted diseases (STD) show frequent epidemiological changes. We report a case of secondary syphilis diagnosed in a 32-year old woman during post-partum. The disease, although showing a typical presentation, raises the problem of dating with precision the contamination time. This is of importance for treating the newborn at risk of congenital syphilis. We highlight the constant attention that should be brought to disclose this venereal disease that shows so variable clinical and histological presentations. Syphilis seems on the rise in the Mosan valley and in some cities where prostitution is imported from Eastern Europe and Africa. [less ▲]

Detailed reference viewed: 318 (2 ULiège)
Full Text
See detailComment je traite...un psoriasis du cuir chevelu.
Uhoda, I.; Flagothier, Caroline ULiege; Pierard, Claudine ULiege et al

in Revue Médicale de Liège (2004), 59(9), 481-4

Scalp involvement by psoriasis requires a ted treatment suited to the particularities of the anatomical site In course of time, the improvement of therapeutic agents and the galenic refinement have ... [more ▼]

Scalp involvement by psoriasis requires a ted treatment suited to the particularities of the anatomical site In course of time, the improvement of therapeutic agents and the galenic refinement have enhanced both the efficacy and cosmetic acceptability of the scalp care. The main therapeutic classes encompass keratolytics, dermocorticosteroids and vitamine D3 analogues. The patient compliance is reported to be best for the liquid or foam formulations. [less ▲]

Detailed reference viewed: 218 (7 ULiège)
Full Text
See detailLes toxidermies paroxystiques graves.
Paquet, Philippe ULiege; Flagothier, Caroline ULiege; Pierard, Claudine ULiege et al

in Revue Médicale de Liège (2004), 59(5), 286-92

Some drug reactions showing cutaneous expression exhibit a paroxysmal course. These diseases encompass the toxic epidermal necrolysis, the drug hypersensitivity syndrome, and the acute generalized ... [more ▼]

Some drug reactions showing cutaneous expression exhibit a paroxysmal course. These diseases encompass the toxic epidermal necrolysis, the drug hypersensitivity syndrome, and the acute generalized exanthematic pustulosis. These syndromes are associated with dismal outcome. They represent medical emergencies needing hospitalization in specialized care units. [less ▲]

Detailed reference viewed: 207 (9 ULiège)