Publications and communications of Anne-Simone PARENT

Lopez Rodriguez, D., Franssen, D., Heger, S., & PARENT, A.-S. (September 2021). Endocrine-disrupting chemicals and their effects on puberty. Best Practice and Research. Clinical Endocrinology and Metabolism, 35 (5), 101579. doi:10.1016/j.beem.2021.101579

López-Rodríguez, D., Aylwin, C. F., Delli, V., Sevrin, E., Campanile, M., Martin, M., Franssen, D., Gérard, A., Blacher, S., Tirelli, E., Noël, A., Lomniczi, A., & PARENT, A.-S. (August 2021). Multi- and Transgenerational Outcomes of an Exposure to a Mixture of Endocrine-Disrupting Chemicals (EDCs) on Puberty and Maternal Behavior in the Female Rat. Environmental Health Perspectives, 129 (8), 87003. doi:10.1289/EHP8795

Boberg, J., Johansson, H., Franssen, D., Cramer, J., Usai, D., Pedersen, M., Parent, A.-S., & Svingen, T. (2021). Perinatal exposure to known endocrine disrupters alters ovarian development and systemic steroid hormone profile in rats. Toxicology, 458. doi:10.1016/j.tox.2021.152821

LEBRETHON, M.-C., FUDVOYE, J., & PARENT, A.-S. (December 2020). Developmental exposure to Bisphenol A : a contributing factor to the increased incidence of obesity? Belgian Journal of Paediatrics, 22 (4), 220 - 222.

LEBRETHON, M.-C., FUDVOYE, J., PARENT, A.-S., SEGHAYE, M.-C., Moline, S., WAXWEILER, C., DEWANDRE, A.-C., & LAGASSE, C. (December 2020). Interdisciplinary overweight outpatient management in pediatrics. Belgian Journal of Paediatrics, 22 (4), 240 - 242.

Duursen, M., Boberg, J., Christiansen, S., Connolly, L., Damdimopoulou, P., Filis, P., Fowler, P., Gadella, B., Holte, J., Jaager, K., Johansson, H., Li, T., Mazaud-Guittot, S., Parent, A.-S., Salumets, A., Soto, A., Svingen, T., Velthut-Meikas, A., Wedebye, E., ... Berg, M. (May 2020). Safeguarding Female Reproductive Health against Endocrine Disrupting Chemicals-The FREIA Project. International Journal of Molecular Sciences, 21 (9), 3215. doi:10.3390/ijms21093215

Johansson, H., Damdimopoulou, P., van Duursen, M., Boberg, J., Franssen, D., de Cock, M., Jaager, K., Wagner, M., Velthut-Meikas, A., Xie, Y., Connolly, L., Lelandais, P., Mazaud-Guittot, S., Salumet, A., Draskau, M., Filis, P., Fowler, P., Christiansen, S., Parent, A.-S., & Svingen, T. (2020). Putative adverse outcome pathways for female reproductive disorders to improve testing and regulation of chemicals. Archives of Toxicology, 94, 3359-3379. doi:10.1007/s00204-020-02834-y

NECHIFOR - POTORAC, I., Trehan, A., Szymanska, K., FUDVOYE, J., THIRY, A., Huhtaniemi, I. T., Daly, A., Beckers, A., Parent, A.-S., & Rivero-Muller, A. (2019). Compound heterozygous mutations in the luteinizing hormone receptor signal peptide causing 46,XY disorder of sex development. European Journal of Endocrinology. doi:10.1530/EJE-19-0170

Parent, A.-S., Zoeller, R. T., Geenen, V., Demeneix, B., Skakkebaek, N. E., & Santen, R. J. (2019). Remembering Jean-Pierre Bourguignon, MD, PhD. Eprint/Working paper retrieved from

Farhat, K., Bodart, G., Charlet-Renard, J. D. C., Desmet, C., Moutschen, M., Beguin, Y., Baron, F., Melin, P., Quatresooz, P., Parent, A.-S., Desmecht, D., Sirard, J.-C., Salvatori, R., Martens, H., & Geenen, V. (02 October 2018). Growth hormone (GH) deficient mice with GHRH ablation are severely deficient in vaccine and immune responses against Streptococcus pneumoniae. Frontiers in Immunology, 9, 2175. doi:10.3389/fimmu.2018.02175

Straetemans, S., Thomas, M., Craen, M., Rooman, R., De Schepper, J., Parent, A.-S., & LEBRETHON, M.-C. (October 2018). Poor growth response during the first year of growth hormone treatment in short prepubertal children with growth hormone deficiency and born small for gestational age: a comparison of different criteria. International Journal of Pediatric Endocrinology, 2018, 9. doi:10.1186/s13633-018-0064-3

VALDES SOCIN, H. G., HARVENGT, J., Pintiaux, A., JONAS, C., PARENT, A.-S., Geenen, V., CORMAN, V., DEBRAY, F.-G., Dideberg, V., T'sjoen, G., De Leerner, A., Beckers, D., Destree, A., Roland, D., Lederer, D., Boscolo, M., Burlacu, C., VROONEN, L., Bours, V., ... Beckers, A. (September 2018). Etude multicentrique belge chez 56 patients avec hypogonadisme hypogonadotrope congénital (HHC) : caractérisation des anomalies génétiques et cérébrales. Poster session presented at 35ème Congrès de la Société Française d'Endocrinologie, Nancy, France.

VALDES SOCIN, H. G., LIBIOULLE, C., HARVENGT, J., PINTIAUX, A., JONAS, C., Parent, A.-S., GEENEN, V., CORMAN, V., Debray, F.-G., DIDEBERG, V., T'Sjoen, G., De Leerner, A., Beckers, D., Destree, A., Roland, D., Lederer, D., Boscolo, M., Bours, V., Maiter, D., & Beckers, A. (May 2018). The first Belgian series of 56 patients with congenital hypogonadotropic hypogonadism (CHH) : genetics and brain abnormalities. Poster session presented at 20th European Congress of Endocrinology.

VALDES SOCIN, H. G., LIBIOULLE, C., HARVENGT, J., Pintiaux, A., JONAS, C., PARENT, A.-S., GEENEN, V., CORMAN, V., Debray, F.-G., DIDEBERG, V., T'Sjoen, G., De Leerner, A., Beckers, D., Destree, A., Roland, D., Lederer, D., Boscolo, M., BOURS, V., Maiter, D., & BECKERS, A. (2018). Brain imaging and genetics in patients with congenital hypogonadotropic hypogonadism: a multicenter Belgian study. In J. O. Jorgensen, NENEG Abstract Book Communications (pp. 64). Aarhus, Denmark: Pfizer.

Bourguignon, J.-P., PARENT, A.-S., Kleinjans, J. C. L., Nawrot, T., Schoeters, G., & Van Larebeke, N. (2018). Rationale for Environmental Hygiene towards global protection of fetuses and young children from adverse lifestyle factors. Environmental Health. doi:10.1186/s12940-018-0385-y

NECHIFOR, I., Trehan, A., FUDVOYE, J., Szymanska, K., THIRY, A., Huhtaniemi, I., Daly, A., Beckers, A., Parent, A.-S., & Rivero-muller, A. (2017). A compound heterozygous mutation in the luteinizing hormone/chorionic gonadotrophin receptor gene leading to Leydig cell hypoplasia type 1. In Acta Clinica Belgica.

FUDVOYE, J., LEBRETHON, M.-C., & Parent, A.-S. (March 2017). Low/medium doses of inhaled corticosteroids can cause adrenal insufficiency. Belgian Journal of Paediatrics, 19 (1).

VALDES SOCIN, H. G., Pintiaux, A., Delbaere, A., Parent, A.-S., COPPENS, L., LIBIOULLE, C., & Beckers, A. (2017). La déficience en FSH : actualités cliniques et thérapeutiques. Urologic, 13 (3), 16-22.

VALDES SOCIN, H. G., DEBRAY, F.-G., LIBIOULLE, C., Pintiaux, A., Parent, A.-S., CORMAN, V., Gellner, K., Geenen, V., VROONEN, L., DIDEBERG, V., Bours, V., & BECKERS, A. (2016). Caractérisation clinique, neuroendocrinienne, génétique et résultats thérapeutiques dans le syndrome de Kallmann et de l'hypogonadisme normosmique idiopathique : expérience liégeoise. In Annales d'Endocrinologie : 33ème congrès de la Société Française d'Endocrinologie.

FUDVOYE, J., Dehan, P., Lienard, M., Trooskens, G., GERARD, A., Bourguignon, J.-P., & PARENT, A.-S. (11 March 2016). Single nucleotide polymorphism in the promoter of the steroidogenic factor 1 (SF-1) gene after gestational exposure to Bisphenol A. Paper presented at 44 ème Congrès annuel de la société belge de pédiatrie.

Franssen, D., GERARD, A., HENNUY, B., Donneau, A.-F., Bourguignon, J.-P., & Parent, A.-S. (2016). Delayed neuroendocrine sexual maturation in female rats after a very low dose of Bisphenol A through altered GABAergic neurotransmission and opposing effects of a high dose. Endocrinology. doi:10.1210/en.2015-1937

VALDES SOCIN, H. G., LIBIOULLE, C., Debray, F.-G., Pintiaux, A., Parent, A.-S., CORMAN, V., Gellner, K., Geenen, V., Burlacu, C., JONAS, C., Maiter, D., T'Sjoen, G., Poppe, K., Brachet, C., DIDEBERG, V., Bours, V., & Beckers, A. (2016). Neuroendocrine phenotype, genetics and hormonal treatment outcome in idiopathic normosmic hypogonadism and Kallman syndrome patients : A multicenter Belgian Study. In Acta Clinical Belgica.

Wit, J. M., Sizonenko, P. C., Bourguignon, J.-P., & Parent, A.-S. (2016). Preface. Endocrine Development, 29. doi:10.1159/isbn.978-3-318-02789-1

Potorac, I., Rivero-Muller, A., Pintiaux, A., Daly, A., THIRY, A., Rydlewski, C., Nisolle, M., Parent, A.-S., Huhtaniemi, I., & Beckers, A. (2015). A novel mutation of the luteinizing hormone/choionic gonadotrophin receptor gene leading to Leydig cell hypoplasia type I. In The International Journal of The Romania Society of Endocrinology - Abstract book.

Fudvoye, J., Dehan, P., Liénard, M., Trooskens, G., GERARD, A., Bourguignon, J.-P., & Parent, A.-S. (30 April 2015). Gestational exposure to BPA is associated with alterations of DNA methylation in the rat placenta in a sexually dimorphic manner. Paper presented at 7 ème copenhague workshop on endocrine disrupters, Copenhague, Denmark.

Parent, A.-S., Franssen, D., FUDVOYE, J., GERARD, A., & Bourguignon, J.-P. (2015). Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents. Frontiers in Neuroendocrinology. doi:10.1016/j.yfrne.2014.12.004

FUDVOYE, J., Dehan, P., Trooskens, G., GERARD, A., Bourguignon, J.-P., & Parent, A.-S. (27 October 2014). Sexually dimorphic effect of gestational exposure to BPA on DNA methylation pattern in the rat placenta. Paper presented at PPTOX 4 in BOston: Environmental Stressors in Disease and Implications for Human Health, Boston, United States.

FUDVOYE, J., BOURGUIGNON, J.-P., & PARENT, A.-S. (March 2014). Normal minipuberty in a patient with DAX-1 mutation: additional evidence of a differential role for DAX-1 during development? Poster session presented at COST Training school in Berlin.

Franssen, D., GERARD, A., Hennuy, B., Parent, A.-S., & Bourguignon, J.-P. (2014). Opposing dose-related effects of neonatal BPA exposure on female pubertal timing and neuroendocrine control. Paper presented at Conference of European Comparative Endocrinologists.

FUDVOYE, J., Bourguignon, J.-P., & Parent, A.-S. (2014). Endocrine-disrupting chemicals and human growth and maturation: a focus on early critical windows of exposure. Vitamins and Hormones, 94, 1-25. doi:10.1016/B978-0-12-800095-3.00001-8

FUDVOYE, J., Franssen, D., Naveau, E., Pinson, A., GERARD, A., BOURGUIGNON, J.-P., & PARENT, A.-S. (2014). LA PERTURBATION ENDOCRINIENNE : entre enjeux de recherche, enjeux de santé publique et enjeux de pratique quotidienne. Revue Médicale de Liège.

Naveau, E., Pinson, A., GERARD, A., Nguyen, L., CHARLIER, C., Thomé, J.-P., Zoeller, R. T., BOURGUIGNON, J.-P., & Parent, A.-S. (2014). Alteration of rat fetal cerebral cortex development after prenatal exposure to polychlorinated biphenyls. PLoS ONE. doi:10.1371/journal.pone.0091903

PETIGNOT, S., NYAMUGABO MUNYERE NKANA, K., VALDES SOCIN, H. G., Parent, A.-S., & LEBRETHON, M.-C. (October 2013). L'hyperthyroidie neonatale: clinique et prise en charge therapeutique. Revue Médicale de Liège, 68 (10), 531-6.

Fumel, B., Roy, S., Fourchecourt, S., Livera, G., Parent, A.-S., Casas, F., & Guillou, F. (2013). Depletion of the p43 Mitochondrial T3 Receptor Increases Sertoli Cell Proliferation in Mice. PLoS ONE. doi:10.1371/journal.pone.0074015

Parent, A.-S. (2013). Female sexual maturation and reproduction after developmental exposure to endocrine disrupting chemicals. Paper presented at FEMREP.

FUDVOYE, J., PARENT, A.-S., & Bourguignon, J.-P. (March 2012). Delayed puberty in a girl due to an inactivating mutation of the LH receptor. Poster session presented at Congrès de la société belge de pédiatrie, Belgium.

Bourguignon, J.-P., & Parent, A.-S. (2012). The impact of endocrine disruptors on female pubertal timing. In E. Diamanti-Kandarakis & A. C. Gore, Endocrine Disruptors and Puberty (pp. 325-337). Germany: Humana Press Inc. doi:10.1007/978-1-60761-561-3_13

Sandau, U., Mungenast, A., Alderman, Z., Sardi, S., Fogel, A., Taylor, B., Parent, A.-S., Biederer, T., Corfas, G., & Ojeda, S. (June 2011). SynCAM1, a synaptic adhesion molecule, is expressed in astrocytes and contributes to erbB4 receptor-mediated control of. Endocrinology, 152, 2364-2376. doi:10.1210/en.2010-1435

Parent, A.-S., Naveau, E., & Bourguignon, J.-P. (2011). Effects of prenatal exposure to endocrine disrupters on cerebral cortex development. In J.-P. Bourguignon, B. Jégou, B. Kerdelhué, J. Toppari, ... Y. Christen, Multi-System Endocrine Disruption (pp. 43-49). Switzerland: Springer. doi:10.1007/978-3-642-22775-2_3

Parent, A.-S., Naveau, E., GERARD, A., Bourguignon, J.-P., & Westbrook, G. L. (2011). Early developmental actions of endocrine disruptors on the hypothalamus, hippocampus, and cerebral cortex. Journal of Toxicology and Environmental Health. Part B, Critical Reviews, 14 (5-7), 328-45. doi:10.1080/10937404.2011.578556

Bourguignon, J.-P., Rasier, G., Lebrethon, M.-C., Gerard, A., Naveau, E., & Parent, A.-S. (05 August 2010). Neuroendocrine disruption of pubertal timing and interactions between homeostasis. Molecular and Cellular Endocrinology, 324 (1-2), 110-120. doi:10.1016/j.mce.2010.02.033

Bourguignon, J.-P., & Parent, A.-S. (August 2010). Early homeostatic disturbances of human growth and maturation by endocrine disrupters. Current Opinion in Pediatrics, 22 (4), 470-477. doi:10.1097/MOP.0b013e32833a6eef

VALDES SOCIN, H. G., Debray, F.-G., Parent, A.-S., Lebrethon, M.-C., Bourguignon, J.-P., Bours, V., & Beckers, A. (2010). Comment j'EXPLORE ... un hypogonadisme hypogonadotrope congenital isole. Revue Médicale de Liège, 65 (11), 634-41.

Parent, A.-S., Rasier, G., Matagne, V., Lomniczi, A., LEBRETHON, M.-C., Gerard, A., Ojeda, S. R., & Bourguignon, J.-P. (March 2008). Oxytocin Facilitates Female Sexual Maturation through a Glia-to-Neuron Signaling Pathway. Endocrinology, 149 (3), 1358-65. doi:10.1210/en.2007-1054

Rasier, G., Parent, A.-S., Gerard, A., Denooz, R., Lebrethon, M.-C., Charlier, C., & Bourguignon, J.-P. (March 2008). Mechanisms of Interaction of Endocrine-Disrupting Chemicals with Glutamate-Evoked Secretion of Gonadotropin-Releasing Hormone. Toxicological Sciences, 102 (1), 33-41. doi:10.1093/toxsci/kfm285

Parent, A.-S., & Bourguignon, J.-P. (2008). Effets des perturbateurs endocriniens au cours du développement : interactions précoces et délais variables de manifestation. Percentile, 13 (6), 213-217.

Parent, A.-S., Matagne, V., Westphal, M., Heger, S., Ojeda, S., & Jung, H. (2008). Gene expression profiling of hypothalamic hamartomas: a search for genes associated with central precocious puberty. Hormone Research, 69, 114-123. doi:10.1159/000111815

Rasier, G., Parent, A.-S., Gerard, A., LEBRETHON, M.-C., & Bourguignon, J.-P. (October 2007). Early maturation of gonadotropin-releasing hormone secretion and sexual precocity after exposure of infant female rats to estradiol or dichlorodiphenyltrichloroethane. Biology of Reproduction, 77 (4), 734-742. doi:10.1095/biolreprod.106.059303

LEBRETHON, M.-C., Aganina, A., Fournier, M., Gerard, A., Parent, A.-S., & Bourguignon, J.-P. (March 2007). Effects of in vivo and in vitro administration of ghrelin, leptin and neuropeptide mediators on pulsatile gonadotrophin-releasing hormone secretion from male rat hypothalamus before and after puberty. Journal of Neuroendocrinology, 19 (3), 181-188. doi:10.1111/j.1365-2826.2006.01518.x

Parent, A.-S., Domine, F., Charlier, C., Lebrethon, M.-C., & Bourguignon, J.-P. (2007). Régulation et dérégulation de l'âge pubertaire : populations à risque ? Revue Médicale de Liège, 62, 13-17.

Parent, A.-S., Mungenast, A., Lomniczi, A., Sandau, U., Peles, E., Bosch, A., Ronnekleiv, O. K., & Ojeda, S. (2007). A contactin-receptor-like protein tyrosine phosphatase beta complex mediates adhesive communication between astroglial cells and gonadotropin-releasing hormone neurons. Journal of Neuroendocrinology, 19, 847-859. doi:10.1111/j.1365-2826.2007.01597.x

Domine, F., Parent, A.-S., Rasier, G., Lebrethon, M.-C., & Bourguignon, J.-P. (November 2006). Assessment and mechanism of variations in pubertal timing in internationally adopted children: a developmental hypothesis. European Journal of Endocrinology, 155 (Suppl. 1), 17-S25. doi:10.1530/eje.1.02252

Rasier, G., Toppari, J., Parent, A.-S., & Bourguignon, J.-P. (25 July 2006). Female sexual maturation and reproduction after prepubertal exposure to estrogens and endocrine disrupting chemicals: A review of rodent and human data. Molecular and Cellular Endocrinology, 254-255, 187-201. doi:10.1016/j.mce.2006.04.002

Ojeda, S., Lomniczi, A., Mastronardi, C., Heger, S., Roth, C., Parent, A.-S., Matagne, V., & Mungenast, A. (2006). Minireview: the neuroendocrine regulation of puberty: is the time ripe for a system biology approach? Endocrinology, 147, 1166-1174. doi:10.1210/en.2005-1136

Ojeda, S., Roth, C., Mungenast, A., Heger, S., Mastronardi, C., Parent, A.-S., Lomniczi, A., & Jung, H. (2006). Neuroendocrine mechanisms controlling female puberty: new approaches, new concepts. International Journal of Andrology, 29, 286-290. doi:10.1111/j.1365-2605.2005.00619.x

Parent, A.-S., Matagne, V., & Bourguignon, J.-P. (December 2005). Control of puberty by excitatory amino acid neurotransmitters and its clinical implications. Endocrine Journal, 28 (3), 281-285. doi:10.1385/ENDO:28:3:281

Parent, A.-S., LEBRETHON, M.-C., Gerard, A., & Bourguignon, J.-P. (January 2005). Factors accounting for perinatal occurrence of pulsatile gonadotropin-releasing hormone secretion in vitro in rats. Biology of Reproduction, 72 (1), 143-149. doi:10.1095/biolreprod.104.033167

Parent, A.-S., Rasier, G., Gerard, A., Heger, S., Roth, C., Mastronardi, C., Jung, H., Ojeda, S. R., & Bourguignon, J.-P. (2005). Early onset of puberty: Tracking genetic and environmental factors. Hormone Research, 64 (Suppl. 2), 41-47. doi:10.1159/000087753

Parent, A.-S., Teilmann, G., Juul, A., Skakkebaek, N. E., Toppari, J., & Bourguignon, J.-P. (October 2003). The timing of normal puberty and the age limits of sexual precocity: Variations around the world, secular trends, and changes after migration. Endocrine Reviews, 24 (5), 668-693. doi:10.1210/er.2002-0019

Parent, A.-S., LEBRETHON, M.-C., Gerard, A., Vandersmissen, E., & Bourguignon, J.-P. (25 August 2000). Leptin Effects on Pulsatile Gonadotropin Releasing Hormone Secretion from the Adult Rat Hypothalamus and Interaction with Cocaine and Amphetamine Regulated Transcript Peptide and Neuropeptide Y. Regulatory Peptides, 92 (1-3), 17-24. doi:10.1016/S0167-0115(00)00144-0