Publications of Johanne HERMESSE
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See detailCorrelation between hematological parameters and outcome in patients with locally advanced cervical cancer treated by concomitant chemoradiotherapy.
Gennigens, Christine ULiege; DE CUYPERE, Marjolein ULiege; SEIDEL, Laurence ULiege et al

in Cancer Medicine (2020)

BACKGROUND: Hemoglobin (Hb), white blood cell (WBC), and polymorphonuclear neutrophil (PMN) blood counts may be correlated with outcomes in patients with locally advanced cervical cancer. METHODS: Hb, WBC ... [more ▼]

BACKGROUND: Hemoglobin (Hb), white blood cell (WBC), and polymorphonuclear neutrophil (PMN) blood counts may be correlated with outcomes in patients with locally advanced cervical cancer. METHODS: Hb, WBC, and PMN counts were measured at diagnosis and during concomitant cisplatin-based chemoradiotherapy (CCRT) in a retrospective sample of 103 patients between 2010 and 2017. Red blood cell (RBC) transfusions were also recorded. The associations between hematological variables and patient overall survival (OS) and recurrence-free survival (RFS) were assessed by Cox regression models. RESULTS: The 3-year OS and RFS rates were 81.4% and 76.8%, respectively. In addition to tumor size and smoking, OS and RFS were found to be significantly associated with changes in WBC and PMN counts from the first to the last cisplatin cycle. Hb count throughout the treatment and RBC transfusions were not predictive of outcome. CONCLUSIONS: This study found no association between Hb count or RBC transfusions and outcome. The daily practice of maintaining the Hb count above 12 g/dL during CCRT should be weighed against the potential risks of transfusions. Drops in WBC and PMN counts during treatment positively impacted OS and RFS and could, therefore, serve as biomarkers during CCRT to adapt the follow-up and consider the need for adjuvant systemic treatments. [less ▲]

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See detailTumor total lesion glycolysis and number of positive pelvic lymph nodes on pretreatment positron emission tomography/computed tomography (PET/CT) predict survival in patients with locally advanced cervical cancer.
DE CUYPERE, Marjolein ULiege; Lovinfosse, Pierre; Gennigens, Christine ULiege et al

in International journal of gynecological cancer : official journal of the International Gynecological Cancer Society (2020), 0

OBJECTIVE: The aim of this study was to investigate the prognostic value of metabolic parameters obtained at pretreatment [(18)F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography ... [more ▼]

OBJECTIVE: The aim of this study was to investigate the prognostic value of metabolic parameters obtained at pretreatment [(18)F]fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography ([(18)F]FDG PET/CT) in patients with locally advanced cervical cancer. We hypothesize that these metabolic parameters could optimize the treatment decision and thus favor the outcome of patients suffering locally advanced cervical cancer. METHODS: Patients with locally advanced cervical cancer underwent pretreatment PET/CT. Standard uptake values (maximum, mean, peak), metabolic tumor volume, and total lesion glycolysis were measured in the tumor and in the hypermetabolic pelvic lymph nodes. The relationship between clinical, pathological, and PET/CT metabolic parameters with recurrence-free survival and overall survival was assessed by Cox regression analysis. RESULTS: 115 patients with a median age of 52 years (range 23-77) presented with locally advanced cervical cancer. After a mean follow-up of 33.0 months after initiation of therapy, 26 patients (22.6%) recurred of which 17 patients had distant metastasis; 18 (15.7%) patients died. Recurrence-free survival at 2 and 5 years was 79.2% and 72.2%, respectively. The total lesion glycolysis of the tumor and the delay between diagnosis and treatment were significantly associated with recurrence-free survival in the multivariate analysis (HR 1.00, p=0.004, and HR 2.04, p=0.02, respectively). Only the total lesion glycolysis of the tumor ≥373.54 (HR 2.49, 95% CI 1.15 to 5.38; p=0.02) remained significant after log rank testing. Overall survival at 2 and 5 years was 91.7% and 68.8%, respectively. The number of PET-positive pelvic lymph nodes was the only independent prognostic factor for overall survival in the multivariate analysis (HR 1.43, 95% CI 1.13 to 1.81; p=0.003). CONCLUSION: Tumor total lesion glycolysis and the number of positive pelvic lymph nodes on pretreatment PET/CT appear to be independent prognostic factors for recurrence and survival in patients with locally advanced cervical cancer. This may help to select patients who may benefit from therapeutic optimization and closer surveillance. [less ▲]

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See detailINDICATIONS D’UN TRAITEMENT DE RADIOTHERAPIE LOCALE APRES PROSTATECTOMIE RADICALE
HERMESSE, Johanne ULiege; WERENNE, Xavier ULiege; PHILIPPI, Sven ULiege et al

in Revue Médicale de Liège (2014), 69(Supp 1), 29-31

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See detailLA CURIETHÉRAPIE PROSTATIQUE PAR IMPLANTS PERMANENTS D'IODE 125- résultats après 10 ans d'expérience au CHU de Liège
HERMESSE, Johanne ULiege; NICKERS, Philippe; REUL, Olivier et al

in Revue Médicale de Liège (2014), 69(Supp 1), 32-36

La curiethérapie prostatique, par implantation per - manente de grains radioactifs d’iode 125, offre aux patients atteints d’un cancer localisé de la prostate une alternative attractive au traitement ... [more ▼]

La curiethérapie prostatique, par implantation per - manente de grains radioactifs d’iode 125, offre aux patients atteints d’un cancer localisé de la prostate une alternative attractive au traitement chirurgical. La survie globale et la survie sans récidive biochimique y sont superposables, mais le profil de toxicité est différent. La plus grande opportunité de préservation de la fonction érectile, la diminution du risque d’incontinence et l’hospitalisation de jour peuvent être inté - ressantes pour le patient optant pour la curiethérapie. Par contre, la présence d’un syndrome obstructif urinaire de départ devrait orienter préférentiellement vers un traitement chirurgical. Un patient doit pouvoir faire un choix éclairé entre ces différentes possibilités thérapeutiques moyennant une information transparente et complète. Dans cet exposé, nous relatons notre expérience en curiethérapie par implants permanents d’iode 125. La survie globale, la survie libre sans récidive biochimique à long terme et la toxicité enregistrée sont similaires à celles décrites dans la littérature. [less ▲]

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See detailRadiothérapie dans le cadre d’une maladie de Paget touchant la région génitale
WERENNE, Xavier ULiege; HERMESSE, Johanne ULiege; PIRET, Pascal ULiege et al

in Revue Médicale de Liège (2012), 67(2), 61-63

Une maladie de Paget urogénitale est habituellement traitée par chirurgie. Cependant, dans certains cas, que ce soit dans le contexte d’une récidive ou à l’évocation d’une chirurgie mutilante, la ... [more ▼]

Une maladie de Paget urogénitale est habituellement traitée par chirurgie. Cependant, dans certains cas, que ce soit dans le contexte d’une récidive ou à l’évocation d’une chirurgie mutilante, la radiothérapie peut être une alternative. Nous relatons le cas d’une patiente traitée avec succès par radiothérapie. [less ▲]

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See detailA dosimetric selectivity intercomparison of HDR brachytherapy, IMRT and helical tomotherapy in prostate cancer radiotherapy
Hermesse, Johanne ULiege; Biver, Sylvie; JANSEN, Nicolas ULiege et al

in Strahlentherapie und Onkologie (2009), 185(11), 736-742

Background and Purpose: Dose escalation in order to improve the biochemical control in prostate cancer requires the application of irradiation techniques with high conformality. The dosimetric selectivity ... [more ▼]

Background and Purpose: Dose escalation in order to improve the biochemical control in prostate cancer requires the application of irradiation techniques with high conformality. The dosimetric selectivity of three radiation modalities is compared: high-dose-rate brachytherapy (HDR-BT), intensity-modulated radiation radiotherapy (IMRT), and helical tomotherapy (HT). <br />Patients and Methods: Ten patients with prostate adenocarcinoma treated by a 10-Gy HDR-BT boost after external-beam radiotherapy were investigated. For each patient, HDR-BT, IMRT and HT theoretical treatment plans were realized using common contour sets. A 10-Gy dose was prescribed to the planning target volume (PTV). The PTVs and critical organs’ dose-volume histograms obtained were compared using Student’s t-test. <br />Results: HDR-BT delivers spontaneously higher mean doses to the PTV with smaller cold spots compared to IMRT and HT. 33% of the rectal volume received a mean HDR-BT dose of 3.86 ± 0.3 Gy in comparison with a mean IMRT dose of 6.57 ± 0.68 Gy and a mean HT dose of 5.58 ± 0.71 Gy (p < 0.0001). HDR-BT also enables to better spare the bladder. The hot spots inside the urethra are greater with HDR-BT. The volume of healthy tissue receiving 10% of the prescribed dose is reduced at least by a factor of 8 with HDR-BT (p < 0.0001). <br />Conclusion: HDR-BT offers better conformality in comparison with HT and IMRT and reduces the volume of healthy tissue receiving a low dose. [less ▲]

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See detailAnalysis of Dose Volume Histogram Differences between High Dose Rate Brachytherapy and Intensity Modulated Radiotherapy for Prostate Treatment
Hermesse, Johanne ULiege; Thissen, Benedicte ULiege; Warlimont, Bernard ULiege et al

in International Journal of Radiation, Oncology, Biology, Physics (2008), 72(1 (supplément)), 566

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