Publications of Luc COPPENS
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See detailPatient Satisfaction and Retrospective Evaluation of Benefits of Penile Prosthetic Implantation Surgery: the OEDIPUS Study
ANDRIANNE, Robert ULiege; Pairoux, Jean-François ULiege; DEBOIS, Christine ULiege et al

in Annals of Medicine and Medical Research (2018), 1

Introduction: Penile Prosthetic Implantation (PPI) is the method of choice for patients not responding to or contra indicated for conservative treatment of Erectile Dysfunction (ED). Complete satisfaction ... [more ▼]

Introduction: Penile Prosthetic Implantation (PPI) is the method of choice for patients not responding to or contra indicated for conservative treatment of Erectile Dysfunction (ED). Complete satisfaction has not been expressed in all cases. Aim: Using validated questionnaires, this study sought to assess the satisfaction of patients who underwent PPI and of their partners, along with potential determinants of satisfaction. It also assessed the benefits afforded by PPI on the subjects’ and their partners' sexual satisfaction, general mood, and quality of life. Methods: This was a retrospective, single-center, open label study, including patients who had undergone PPI between 2009 and 2012 at our center. Main outcome measures: Patient/partner satisfaction with PPI was assessed using the EDITS scale. Patient and partner attitude towards PPI were evaluated using the API and AAPPI scales, respectively. Each subject’s satisfaction with PPI size was assessed with answer grades ranging from 1 to 5. Patient and partner personal, sexual, and relationship well-beings were evaluated using an answer scoring system. Results: Study questionnaire responses were received from 96 patients who underwent PPI at our center, and from 56 partners. The mean EDITS scores of patients and partners were 82.78 (± 15.58) and 83.30 (± 15.41), respectively, suggesting high satisfaction. The mean attitude score towards PPI of patients and partners were 18.87 (± 8.42) and 14.45 (± 5.06), on the API and AAPI scales, respectively. EDITS scores significantly correlated with the patients' satisfaction with the implanted penis size, and patients' and partners' attitudes towards PPI, on the API and AAPIP scores, respectively. Conclusions: PPI exerts an excellent impact on patient and partner satisfaction, sex-life, and overall quality of life. [less ▲]

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See detailLa déficience en FSH : actualités cliniques et thérapeutiques
VALDES SOCIN, Hernan Gonzalo ULiege; Pintiaux, Axelle ULiege; Delbaere, Anne et al

in Urologic (2017), 13(3), 16-22

L'hormone lutéinisante (LH) et l'hormone folliculostimulante (FSH) - hormones glycoprotéiques hypophysaires - régulent de concert la production de stéroïdes sexuels et la reproduction. Les stéroïdes ... [more ▼]

L'hormone lutéinisante (LH) et l'hormone folliculostimulante (FSH) - hormones glycoprotéiques hypophysaires - régulent de concert la production de stéroïdes sexuels et la reproduction. Les stéroïdes sexuels sont indispensables à la virilisation et à la féminisation, et participent également à la gamétogenèse (spermatogenèse chez l'homme et folliculogenèse chez la femme). Cet article sur le déficit en FSH fait suite à un article précédent publié dans Urologic décrivant le déficit en LH et ses conséquences sur la reproduction. [less ▲]

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See detail192ir Low Dose Rate Brachytherapy for Boosting Locally Advanced Prostate Cancers after External Beam Radiotherapy: A Phase Ii Trial
Nickers, Philippe ULiege; Coppens, Luc ULiege; De Leval, Jean ULiege et al

in Radiotherapy and Oncology (2006), 79(3), 329-34

BACKGROUND AND PURPOSE: To evaluate on 201 locally advanced prostatic cancers prospectively treated in a phase II trial, the efficacy of a combination of external beam radiotherapy (39.6 Gy) and (192)Ir ... [more ▼]

BACKGROUND AND PURPOSE: To evaluate on 201 locally advanced prostatic cancers prospectively treated in a phase II trial, the efficacy of a combination of external beam radiotherapy (39.6 Gy) and (192)Ir low dose rate brachytherapy (Bt) (40-45 Gy). PATIENTS AND METHODS: Sixty-four patients were included in the intermediate prognosis group with only one of the following adverse factors (PSA > 10 ng/ml, Gleason score > or = 7 or clinical stage > or =T2b) and 137 in the unfavourable group when at least two of these factors were present. RESULTS: The actuarial 4 years biochemical no evidence of disease is 82.8% for the entire population. It is, respectively, 97 and 76% in the intermediate and unfavourable prognosis groups (P < 0.0001). Grade > or =3 late urinary complications occurred in 13 patients (6.5%). Eight patients (4%) presented late grade 2 rectal complications but no grades 3-5 was observed. CONCLUSIONS: Even if an alpha/beta of 1.5-3 Gy theoretically favours the use of a high dose rate mode of irradiation, the early results presented here are as good as those reported for similar groups of patients with high dose rate treatments. Late toxicity is identical but our urinary toxicity is within the less favourable and rectal toxicity within the most favourable results. We can postulate that while inducing very high hyperdosage regions (V150) mainly focused on the peripheral zone, most of the Bt techniques consist of a more ablative treatment. Many of the radiobiological studies on Bt did not in fact take into account the heterogeneity of irradiation inside the CTV. This study highlights the need to explore pulsed dose rate therapies, permanent implant and new available radioisotopes such as (169)Ytterbium that will offer the safety of low and lower dose rates. The actual late toxicity of the different Bt techniques is not yet inexistent indeed. [less ▲]

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