Publications of Jean DE LEVAL
Bookmark and Share    
Full Text
See detailLa place des spasmolytiques dans la colique néphrétique
Duquenne, Sébastien ULiege; Hellel, Majed; Godinas, Laurent ULiege et al

in Revue Médicale de Liège (2009), 64(1), 43-46

Les différents spasmolytiques sont souvent prescrits par les médecins généralistes ou dans les services d’urgence dès que le diagnostic de colique néphrétique est posé. Une pratique cependant contestée ... [more ▼]

Les différents spasmolytiques sont souvent prescrits par les médecins généralistes ou dans les services d’urgence dès que le diagnostic de colique néphrétique est posé. Une pratique cependant contestée. Cet article a pour but de faire une revue de la littérature de l’efficacité des spasmolytiques dans la colique néphrétique, et d’opposer celle-ci à la pratique quotidienne, ainsi que de faire le point sur les effets secondaires. Conclusion : la revue de l’EBM sur le sujet ne permet pas de prouver l’efficacité des spasmolytiques, et montre qu’il est préférable d’utiliser le diclofenac en monothérapie et de traiter les patients non contrôlés par tramadol et antalgiques. Il faudra adjoindre du tamsulosine pour les calculs du bas uretère. [less ▲]

Detailed reference viewed: 97 (2 ULiège)
Full Text
See detail192ir Low Dose Rate Brachytherapy for Boosting Locally Advanced Prostate Cancers after External Beam Radiotherapy: A Phase Ii Trial
Nickers, Philippe ULiege; Coppens, Luc ULiege; De Leval, Jean ULiege et al

in Radiotherapy and Oncology (2006), 79(3), 329-34

BACKGROUND AND PURPOSE: To evaluate on 201 locally advanced prostatic cancers prospectively treated in a phase II trial, the efficacy of a combination of external beam radiotherapy (39.6 Gy) and (192)Ir ... [more ▼]

BACKGROUND AND PURPOSE: To evaluate on 201 locally advanced prostatic cancers prospectively treated in a phase II trial, the efficacy of a combination of external beam radiotherapy (39.6 Gy) and (192)Ir low dose rate brachytherapy (Bt) (40-45 Gy). PATIENTS AND METHODS: Sixty-four patients were included in the intermediate prognosis group with only one of the following adverse factors (PSA > 10 ng/ml, Gleason score > or = 7 or clinical stage > or =T2b) and 137 in the unfavourable group when at least two of these factors were present. RESULTS: The actuarial 4 years biochemical no evidence of disease is 82.8% for the entire population. It is, respectively, 97 and 76% in the intermediate and unfavourable prognosis groups (P < 0.0001). Grade > or =3 late urinary complications occurred in 13 patients (6.5%). Eight patients (4%) presented late grade 2 rectal complications but no grades 3-5 was observed. CONCLUSIONS: Even if an alpha/beta of 1.5-3 Gy theoretically favours the use of a high dose rate mode of irradiation, the early results presented here are as good as those reported for similar groups of patients with high dose rate treatments. Late toxicity is identical but our urinary toxicity is within the less favourable and rectal toxicity within the most favourable results. We can postulate that while inducing very high hyperdosage regions (V150) mainly focused on the peripheral zone, most of the Bt techniques consist of a more ablative treatment. Many of the radiobiological studies on Bt did not in fact take into account the heterogeneity of irradiation inside the CTV. This study highlights the need to explore pulsed dose rate therapies, permanent implant and new available radioisotopes such as (169)Ytterbium that will offer the safety of low and lower dose rates. The actual late toxicity of the different Bt techniques is not yet inexistent indeed. [less ▲]

Detailed reference viewed: 141 (13 ULiège)
Full Text
See detailLe TVT: traitement revolutionnaire de l'incontinence urinaire
Sanjurjo, Sylvia ULiege; Ben Younes, A.; Bonnet, Pierre ULiege et al

in Revue Médicale de Liège (2002), 57(12), 765-70

Stress urinary incontinence represents an important, often unknown and, yet, certainly most unpleasant pathology. Over years, several different surgical techniques have been proposed and reported to have ... [more ▼]

Stress urinary incontinence represents an important, often unknown and, yet, certainly most unpleasant pathology. Over years, several different surgical techniques have been proposed and reported to have variable success. TVT, a simple and reproducible technique, aims at stabilizing mid-urethra, and not bladder-neck. Our own clinical experience amounts to 139 cases. All these patients were evaluated by clinical examination and, subjectively, by a questionnaire. 89.2% were cured and 6.5% improved. The most frequent complication was bladder perforation (6.5%), but it had no incidence on the final results. Morbidity was low. This revolutionary technique is very promising and our own results are similar to those reported by others. [less ▲]

Detailed reference viewed: 707 (4 ULiège)
Full Text
See detailVesical varices in a patient with portal hypertension.
Gaspar, Yves; Detry, Olivier ULiege; de Leval, Jean ULiege

in New England Journal of Medicine (2001), 345(20), 1503-4

Detailed reference viewed: 79 (14 ULiège)
Full Text
See detailBenign Prostatic Hyperplasia and Normal Prostate Aging: Differences in Types I and Ii 5 Alpha-Reductase and Steroid Hormone Receptor Messenger Ribonucleic Acid (Mrna) Levels, but Not in Insulin-Like Growth Factor Mrna Levels
Bonnet, Pierre ULiege; Reiter, E.; Bruyninx, M. et al

in Journal of Clinical Endocrinology and Metabolism (1993), 77(5), 1203-8

Benign prostatic hyperplasia (BPH) is so common in elderly men that the development of adenomatous nodules in this organ can be seen as a normal age-dependent process. In this work, we used Northern ... [more ▼]

Benign prostatic hyperplasia (BPH) is so common in elderly men that the development of adenomatous nodules in this organ can be seen as a normal age-dependent process. In this work, we used Northern blotting to compare the levels of androgen, estrogen, and insulin-like growth factor-I (IGF-I) receptor in young (age range, 23-33; n = 3), old normal (age range, 52-80; n = 3), and BPH-affected subjects (age range, 66-87; n = 15). We have also investigated in these groups the expression of genes coding for the two 5 alpha-reductases (types I and II), aromatase, IGF-I, and IGF-II. Our results show significantly increased levels of IGF mRNA in old healthy and BPH-affected subjects; the respective rises for IGF-I, IGF-II, and IGF-I receptor mRNAs were 3.0-, 2.9-, and 1.5-fold (BPH) and 2.7-, 2.4-, and 1.8-fold (old normal controls). For estrogen receptor, androgen receptor, and type I and II 5 alpha-reductase mRNAs, a marked but opposite effect was observed in adenomatous tissues only; the respective levels were 2.2-, 1.8-, 3.9-, and 1.7-fold lower than those in young adult subjects, whereas no significant differences were recorded between the two normal groups. Morphometric analysis of each tissue specimen confirmed the significantly lower epithelium/stroma ratio in adenomas compared to young or old healthy tissues. Together, these observations suggest that prostatic adenomas may result from at least two conjugate processes: one characterized by a drop in the mRNA levels of steroid hormone receptors, which might be associated with a lower epithelium/stroma ratio, and another characterized by normal aging phenomena, of which the increased production of IGFs and IGF-I receptor transcripts could be biochemical markers. [less ▲]

Detailed reference viewed: 75 (13 ULiège)
Full Text
See detailPlasmocytome solitaire de l'urètre
Bonnet, Pierre ULiege; de Leval, Jean ULiege; Fillet, Georges ULiege et al

in Acta Urologica Belgica (1988), 51

Solitary extra-medullary plasmocytomas are mostly located in the upper respiratory airways. Genito-urinary localizations have been rarely described. The authors report one case of solitary plasmocytoma of ... [more ▼]

Solitary extra-medullary plasmocytomas are mostly located in the upper respiratory airways. Genito-urinary localizations have been rarely described. The authors report one case of solitary plasmocytoma of the urethra which was treated by external radiotherapy and surgery. A review of the diagnosis, treatment, evolution and prognosis is given. [less ▲]

Detailed reference viewed: 125 (1 ULiège)