Publications and communications of Keith Durkin

Karpe, S. D., Artesi, M., Wayet, J., Durkin, K., Hahaut, V., Uchimaru, K., Makiyama, J., Iwanaga, M., Utsunomiya, A., Kolijn, P. M., Langerak, A. W., Burny, A., Marçais, A., Hermine, O., Watanabe, T., Georges, M., & Van den Broeke, A. (November 2025). A viral clonality evenness score to predict progression to adult T-cell leukaemia in asymptomatic carriers of human T-lymphotropic virus type 1 in Japan: a retrospective longitudinal cohort study. The Lancet Microbe, 6 (11), 101198. doi:10.1016/j.lanmic.2025.101198

Mouraux, C., FOUQUET, C., Durkin, K., Dideberg, V., Bulk, S., Aktan, D., Artesi, M., & Depierreux, F. (27 October 2025). Homozygous Pathogenic MYH3 Variants Associated With Arthrogryposis and Lingual Dystonia. Tremor and Other Hyperkinetic Movements, 15, 53. doi:10.5334/tohm.1079

Grentzinger, V., PALMEIRA, L., Durkin, K., Artesi, M., & Bours, V. (22 July 2025). Lifting the veil on Challenging Medically Relevant Genes [Poster presentation]. Intelligent Systems for Molecular Biology/European Conference on Computational Biology (ISMB/ECCB), Liverpool, United Kingdom.

Grentzinger, V., PALMEIRA, L., Durkin, K., Artesi, M., & Bours, V. (20 July 2025). Lifting the veil on Challenging Medically Relevant Genes [Paper presentation]. Intelligent Systems for Molecular Biology/European Conference on Computational Biology (ISMB/ECCB), Liverpool, United Kingdom.

Grentzinger, V., PALMEIRA, L., Durkin, K., Artesi, M., & Bours, V. (06 July 2025). Lifting the veil on Challenging Medically Relevant Filaggrin Gene [Poster presentation]. Journées Ouvertes en Biologie, Informatique et Mathématiques - JOBIM 2025, Bordeaux, France.

Grentzinger, V., PALMEIRA, L., Durkin, K., Artesi, M., & Bours, V. (07 May 2025). Lifting the veil on Challenging Medically Relevant Genes [Paper presentation]. International Symposium on Human Genomics, Paris, France.

Grentzinger, V., PALMEIRA, L., Durkin, K., Artesi, M., CHARLOTEAUX, B., Dideberg, V., & Bours, V. (07 May 2025). A Needle in a Haystack: Improving Genetic Analysis of Challenging Medically Relevant MUC1 Gene [Poster presentation]. International Symposium on Human Genomics, Paris, France.

Freire, M. V., Thissen, R., Martin, M., Fasquelle, C., HELOU, L., Durkin, K., Artesi, M., Lumaka, A., LEROI, N., Segers, K., DEBERG, M., Gatot, J.-S., Habran, L., Palmeira, L., Josse, C., & Bours, V. (January 2025). Genetic evaluation of patients with multiple primary cancers. Oncology Letters, 29 (1), 4. doi:10.3892/ol.2024.14750

Grentzinger, V., Artesi, M., Palmeira, L., Durkin, K., & Bours, V. (15 November 2024). Waiting on the Dark Side of the Moon: Novel Variable Number Tandem Repeat Alleles of Medically Relevant FLG Gene discovered by using Long-Read Sequencing [Poster presentation]. SFMBBM PhD Day 2024, Namur, Belgium.

Holtz, A., Van Weyenbergh, J., Hong, S. L., Cuypers, L., O'Toole, Á., Dudas, G., Gerdol, M., Potter, B. I., Ntoumi, F., Mapanguy, C. C. M., Vanmechelen, B., Wawina-Bokalanga, T., Van Holm, B., Menezes, S. M., Soubotko, K., Van Pottelbergh, G., Wollants, E., Vermeersch, P., Jacob, A.-S., ... Baele, G.*. (10 October 2024). Emergence of the B.1.214.2 SARS-CoV-2 lineage with an Omicron-like spike insertion and a unique upper airway immune signature. BMC Infectious Diseases, 24 (1), 1139. doi:10.1186/s12879-024-09967-w

Grentzinger, V., Artesi, M., Palmeira, L., Dideberg, V., Olivier, S., Bours, V., & Durkin, K. (24 April 2024). Hidden in Plain Sight: Homologous Recombination masks Filaggrin Alleles of Potential Clinical Significance [Poster presentation]. byteMAL 2024, Maastricht, Netherlands.

Tang, L., Swedlund, B., Dupont, S., Harland, C., Costa Monteiro Moreira, G., Durkin, K., Artesi, M., Mullaart, E., Sartelet, A., Karim, L., Coppieters, W., Georges, M., & Charlier, C. (09 March 2024). GWAS reveals determinants of mobilization rate and dynamics of an active endogenous retrovirus of cattle. Nature Communications, 15 (1), 2154. doi:10.1038/s41467-024-46434-1

El Moussaoui, M., Bontems, S., Meex, C., Hayette, M.-P., LEJEUNE, M., Hong, S. L., Dellicour, S., Moutschen, M., CAMBISANO, N., Renotte, N., Bours, V., Darcis, G., Artesi, M.* , & Durkin, K.*. (04 March 2024). Intrahost evolution leading to distinct lineages in the upper and lower respiratory tracts during SARS-CoV-2 prolonged infection. Virus Evolution, 10 (1), 073. doi:10.1093/ve/veae073

Grentzinger, V., Durkin, K. W., Palmeira, L., Artesi, M., Olivier, S., & Bours, V. (24 November 2023). Identification of novel haplotypes within the challenging medically relevant FLG gene [Poster presentation]. SFMBBM PhD Day, Liège, Belgium.

Rudin, C., Bollen, N., Hong, S. L., Wegner, F., Politi, L., Mellou, K., Geenen, C., Gorissen, S., Verhasselt, B., Durkin, K., Henin, C., Logist, A.-S., Dellicour, S., Resa, T., Stadler, T., Maes, P., Cuypers, L., André, E., Egli, A., & Baele, G. (November 2023). Investigation of an international water polo tournament in Czechia as a potential source for early introduction of the SARS-CoV-2 Omicron variant into Belgium, Switzerland and Germany, November 2021. Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, 28 (45). doi:10.2807/1560-7917.ES.2023.28.45.2300018

Kremer, C., Torneri, A., Libin, P. J. K., Meex, C., Hayette, M.-P., Bontems, S., Durkin, K. W., Artesi, M., Bours, V., Lemey, P., Darcis, G., Hens, N., & Meuris, C. (16 June 2023). Reconstruction of SARS-CoV-2 outbreaks in a primary school using epidemiological and genomic data. Epidemics, 44, 100701. doi:10.1016/j.epidem.2023.100701

Grentzinger, V., GRISART, B., Meynsbrughen, M., Artesi, M., Palmeira, L., Dideberg, V., CHARLOTEAUX, B., Durkin, K. W., Brysse, A., & Bours, V. (25 May 2023). Detecting pathogenic variants in chronic kidney disease using long-read sequencing [Paper presentation]. Annual Meeting @ Living Tomorrow Vilvoorde, Vilvoorde, Belgium.

Cuypers, L., Keyaerts, E., Hong, S. L., Gorissen, S., Menezes, S. M., Starick, M., Van Elslande, J., Weemaes, M., Wawina-Bokalanga, T., Marti-Carreras, J., Vanmechelen, B., Van Holm, B., Bloemen, M., Dogne, J.-M., Dufrasne, F., Durkin, K., Ruelle, J., De Mendonca, R., Wollants, E., ... Van Weyenbergh, J. (22 May 2023). Immunovirological and environmental screening reveals actionable risk factors for fatal COVID-19 during post-vaccination nursing home outbreaks. Nature Aging, 3 (6), 722 - 733. doi:10.1038/s43587-023-00421-1

Cuypers, L., Dellicour, S., Hong, S. L., Potter, B. I., Verhasselt, B., Vereecke, N., Lambrechts, L., Durkin, K., Bours, V., Klamer, S., Bayon-Vicente, G., Vael, C., Ariën, K. K., De Mendonca, R., Soetens, O., Michel, C., Bearzatto, B., Naesens, R., Gras, J., ... Baele, G. (20 October 2022). Two Years of Genomic Surveillance in Belgium during the SARS-CoV-2 Pandemic to Attain Country-Wide Coverage and Monitor the Introduction and Spread of Emerging Variants. Viruses, 14 (10), 2301. doi:10.3390/v14102301

El Moussaoui, M., Maes, N., Hong, S. L., Lambert, N., Gofflot, S., DELLOT, P., Belhadj, Y., Huynen, P., Hayette, M.-P., Meex, C., Bontems, S., Defêche, J., Godderis, L., Molenberghs, G., Meuris, C., Artesi, M., Durkin, K., Rahmouni, S., GREGOIRE, C., ... DARCIS, G. (14 June 2022). Evaluation of Screening Program and Phylogenetic Analysis of SARS-CoV-2 Infections among Hospital Healthcare Workers in Liège, Belgium. Viruses, 14 (6), 1302. doi:10.3390/v14061302

Saegerman, C., Nguyet Diep, A., Renault, V., Donneau, A.-F., Stamatakis, L., Coppieters, W., Michel, F., Breuer, C., Dandoy, M., Ek, O., Gourzonès, C., Schyns, J., Goffin, E., Minner, F., Durkin, K., Artesi, M., Bours, V., Bureau, F., & Gillet, L. (2022). A 2-month field cohort study of SARS-CoV-2 in saliva of BNT162b2 vaccinated nursing home workers. Communications Medicine. doi:10.1038/s43856-021-00067-3

Thissen, R., ARTESI, M., Durkin, K., JOSSE, C., PALMEIRA, L., & BOURS, V. (24 December 2021). Comprehensive detection of homologous recombination deficiency by Nanopore sequencing [Poster presentation]. GIGA cancer day, Liège, Belgium.

Durkin, K., Artesi, M., VAN DEN BROEKE, A., Bours, V., Hahaut, V., & Georges, M. (21 June 2021). Pooled crispr inverse pcr sequencing (pcip-seq): simultaneous sequencing of viral insertion points and the integrated viral genomes with long reads.

Van Campenhout, C., De Mendonça, R., Alexiou, B., De Clercq, S., Racu, M.-L., Royer-Chardon, C., Rusu, S., Van Eycken, M., ARTESI, M., Durkin, K., Mardulyn, P., BOURS, V., Decaestecker, C., Remmelink, M., Salmon, I., & D'Haene, N. (2021). Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Genome Sequencing from Post-Mortem Formalin-Fixed, Paraffin-Embedded Lung Tissues. The Journal of Molecular Diagnostics. doi:10.1016/j.jmoldx.2021.05.016

Artesi, M.* , Hahaut, V.* , Cole, B.* , Lambrechts, L., Ashrafi, F., Marçais, A., Hermine, O., Griebel, P., Arsic, N., van der Meer, F., Burny, A., Bron, D., BIANCHI, E., DELVENNE, P., BOURS, V., Charlier, C., Georges, M., Vandekerckhove, L.* , Van den Broeke, A.* , & Durkin, K.*. (2021). PCIP-seq: simultaneous sequencing of integrated viral genomes and their integration sites with long reads. Genome Biology, 22, 97. doi:10.1186/s13059-021-02307-0

Bollen, N., Artesi, M., Durkin, K., Hong, S. L., Potter, B., Boujemla, B., Vanmechelen, B., Martí-Carreras, J., Wawina-Bokalanga, T., Meex, C., Bontems, S., Hayette, M.-P., André, E., Maes, P., Bours, V., Baele, G., & Dellicour, S. (2021). Exploiting genomic surveillance to map the spatio-temporal dispersal of SARS-CoV-2 spike mutations in Belgium across 2020. Scientific Reports, 11 (1), 18580. doi:10.1038/s41598-021-97667-9

Butera, Y., Mukantwari, E., Artesi, M., Umuringa, J. D. A., O'Toole, Á. N., Hill, V., Rooke, S., Hong, S. L., Dellicour, S., Majyambere, O., Bontems, S., Boujemla, B., Quick, J., Resende, P. C., Loman, N., Umumararungu, E., Kabanda, A., Murindahabi, M. M., Tuyisenge, P., ... Rujeni, N.*. (2021). Genomic sequencing of SARS-CoV-2 in Rwanda reveals the importance of incoming travelers on lineage diversity. Nature Communications, 12 (1), 5705. doi:10.1038/s41467-021-25985-7

Dellicour, S., Durkin, K., Hong, S., Vanmechelen, B., Marti-Carreras, J., Gill, M., Meex, C., Bontems, S., André, E., Gilbert, M., Walker, C., De Maio, N., Hadfield, J., Hayette, M.-P., Bours, V., Wawina-Bokalanga, T., Artesi, M., Baele, G., Maes, P., & Faria, N. R. (2021). A phylodynamic workflow to rapidly gain insights into the dispersal history and dynamics of SARS-CoV-2 lineages. Molecular Biology and Evolution. doi:10.1093/molbev/msaa284

Maclot, F., Bontems, S., Meex, C., Artesi, M., Beckers, P., Bours, V., Durkin, K., & Hayette, M.-P. (2021). Development of a multiplex RT-qPCR using the drop out strategy to screen the SARS-CoV-2 South African 501Y.V2 variant. Journal of Infection, 83 (1), 19-e21. doi:10.1016/j.jinf.2021.04.035

Marçais, A., Lhermite, L., Artesi, M., Laurent, C., Durkin, K., Hahaut, V., Rosewick, N., Suarez, F., Sibon, D., Cheminant, M., Avettand-Fenoël, V., Bruneau, J., Georges, M., Pique, C., Van den Broeke, A.* , Asnafi, V.* , & Hermine, O.*. (2021). Targeted deep sequencing reveals clonal and subclonal mutational signatures in Adult T-cell leukemia/lymphoma and defines an unfavorable indolent subtype. Leukemia, 35, 764-776. doi:10.1038/s41375-020-0900-3

Meuris, C., Kremer, C., Geerinck, A., Locquet, M., Bruyère, O., Defêche, J., Meex, C., Hayette, M.-P., Duchene, L., Dellot, P., Azarzar, S., Maréchal, N., Sauvage, A.-S., Frippiat, F., Giot, J.-B., Léonard, P., Fombellida, K., Moutschen, M., Durkin, K., ... Darcis, G. (2021). Transmission of SARS-CoV-2 After COVID-19 Screening and Mitigation Measures for Primary School Children Attending School in Liège, Belgium. JAMA Network Open, 4 (10), 2128757. doi:10.1001/jamanetworkopen.2021.28757

Rosewick, N.* , Hahaut, V.* , Durkin, K., Artesi, M., Karpe, S., Wayet, J., Griebel, P., Arsic, N., Marçais, A., Hermine, O., Burny, A., Georges, M., & Van den Broeke, A. (2020). An Improved Sequencing-Based Bioinformatics Pipeline to Track the Distribution and Clonal Architecture of Proviral Integration Sites. Frontiers in Microbiology, 11, 587306. doi:10.3389/fmicb.2020.587306

Artesi, M., Hahaut, V., Ashrafi, F., Marcais, A., Hermine, O., Griebel, P., Arsic, N., van der Meer, F., Burny, A., Bron, D., Charlier, C., Georges, M., Van den Broeke, A., & Durkin, K. (2019). Pooled CRISPR Inverse PCR sequencing (PCIP-seq): simultaneous sequencing of retroviral insertion points and the associated provirus in thousands of cells with long reads 558130. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/237583. doi:10.1101/558130

Rosewick, N.* , Durkin, K.* , Artesi, M.* , Marçais, A., Hahaut, V., Griebel, P., Avettand-Fenoel, V., Burny, A., Charlier, C., Hermine, O., Georges, M., & Van den Broeke, A. (23 May 2017). Cis-perturbation of cancer drivers by the HTLV-1/BLV proviruses is an early determinant of leukemogenesis. Nature Communications, 8. doi:10.1038/ncomms15264

Artesi, M., Marcais, A., Durkin, K., Rosewick, N., Hahaut, V., Suarez, F., Trinquand, A., Lhermitte, L., Asnafi, V., Avettand-Fenoel, V., Burny, A., Georges, M., Hermine, O., & Van den Broeke, A. (2017). Monitoring molecular response in adult T-cell leukemia by high-throughput sequencing analysis of HTLV-1 clonality. Leukemia, 31 (11), 2532-2535. doi:10.1038/leu.2017.260

Durkin, K., Rosewick, N., Artesi, M., Hahaut, V., Griebel, P., Arsic, N., Burny, A., Georges, M., & Van den Broeke, A. (2016). Characterization of novel Bovine Leukemia Virus (BLV) antisense transcripts by deep sequencing reveals constitutive expression in tumors and transcriptional interaction with viral microRNAs. Retrovirology, 13 (1), 33. doi:10.1186/s12977-016-0267-8

Durkin, K., Artesi, M., Rosewick, N., Marçais, A., Hermine, O., Georges, M., & Van den Broeke, A. (28 August 2015). Improving the methodology for the detection of proviral integration sites in the host genome via high throughput sequencing. Retrovirology, 12 (1).

Rosewick, N., Durkin, K., Marçais, A., Artesi, M., Hermine, O., Charlier, C., Georges, M., & Van den Broeke, A. (28 August 2015). HTLV-1/BLV antisense-RNA dependent host gene perturbation in pre-leukemic and leukemic clones. Retrovirology, 12 (1).

Durkin, K., Rosewick, N., Momont, M., Thys, W., Burny, A., Georges, M., & Van den Broeke, A. (07 January 2014). Elucidating the role of Bovine Leukemia Virus encoded micro-RNAs. Retrovirology, 11 (1), 62.