Publications and communications of Luc Willems

Doucet, F.* , Fontaine, A.* , Hamaïdia, M.* , Jacques, J.-R.* , Jouant, T.* , Mhaidly, N.* , Qin, S.* , Terres, R.* , Saintmard, X.* , Willems, L.* , & Zwaenepoel, M.*. (12 December 2025). The Complexity of Bovine Leukemia Virus Oncogenesis. Viruses, 17 (12), 1609. doi:10.3390/v17121609

Yang, N., Li, Y., Cai, Y., Liu, Y., Zhang, Y., Fu, Y., Tan, C., Willems, L., & Liu, G. (23 December 2024). A mucus layer derived from porcine intestinal organoid air-liquid interface monolayer attenuates swine enteric coronavirus infection by antiviral activity of Muc2. BMC Biology, 22 (1), 297. doi:10.1186/s12915-024-02094-7

Joris, T., Jouant, T., Jacques, J.-R., Gouverneur, L., Saintmard, X., Vilanova Mana, L., Jamakhani, M., Reichert, M., & Willems, L. (November 2024). Reduction of antisense transcription affects bovine leukemia virus replication and oncogenesis. PLoS Pathogens, 20 (11), 1012659. doi:10.1371/journal.ppat.1012659

Willems, M.* , Hamaïdia, M.* , Fontaine, A., Grégoire, M., Halkin, L., Vilanova Mana, L., Terres, R., Jamakhani, M., Deshayes, S., Brostaux, Y., HEINEN, V., LOUIS, R., Duysinx, B., Jean, D., Wasielewski, E., Scherpereel, A., Blanquart, C., & Willems, L. (28 October 2024). The impact of Charcot-Leyden Crystal protein on mesothelioma chemotherapy: targeting eosinophils for enhanced chemosensitivity. EBioMedicine, 109, 105418. doi:10.1016/j.ebiom.2024.105418

Wang, J., Sun, C., Hu, Z., Wang, F., Chang, J., Gao, M., Ye, D., Jia, Q., Zou, H., Willems, L., Jiang, Z., & Yin, X. (2024). Development of a novel monoclonal antibody-based competitive ELISA for antibody detection against bovine leukemia virus. International Journal of Biological Macromolecules, 131446. doi:10.1016/j.ijbiomac.2024.131446

Wang, X.-W., Madeddu, L., Spirohn, K., Martini, L., Fazzone, A., Becchetti, L., Wytock, T., Kovács, I., Balogh, O., Benczik, B., Pétervári, M., Ágg, B., Ferdinandy, P., Vulliard, L., Menche, J., Colonnese, S., Petti, M., Scarano, G., Cuomo, F., ... Liu, Y.-Y. (22 March 2023). Assessment of community efforts to advance network-based prediction of protein-protein interactions. Nature Communications, 14 (1), 1582. doi:10.1038/s41467-023-37079-7

Beauvois, A.* , Gazon, H.* , Chauhan, P. S., Jamakhani, M., Jacques, J.-R., Thiry, M., Dejardin, E., Di Valentin, E., Twizere, J.-C., Péloponèse, J.-M., Njock, M.-S., Yasunaga, J.-I., Matsuoka, M., Hamaïdia, M.* , & Willems, L.*. (2023). The helicase-like transcription factor redirects the autophagic flux and restricts human T-cell leukemia virus type 1 infection. Proceedings of the National Academy of Sciences of the United States of America, 120 (31), 2216127120. doi:10.1073/pnas.2216127120

Porquet, F., Weidong, L., Jehasse, K., Gazon, H., Kondili, M., Blacher, S., Massotte, L., Di Valentin, E., Furling, D., Gillet, N., Klein, A. F.* , Seutin, V.* , & Willems, L.*. (2023). Specific DMPK-promoter targeting by CRISPRi reverses myotonic dystrophy type 1-associated defects in patient muscle cells. Molecular Therapy: Nucleic Acids, 32, 857 - 871. doi:10.1016/j.omtn.2023.05.007

Willems, M., Scherpereel, A., Wasielewski, E., Raskin, J., Brossel, H., Fontaine, A., Grégoire, M., Halkin, L., Jamakhani, M., Heinen, V., Louis, R., Duysinx, B., Hamaïdia, M.* , & Willems, L.*. (2023). Excess of blood eosinophils prior to therapy correlates with worse prognosis in mesothelioma. Frontiers in Immunology, 14, 1148798. doi:10.3389/fimmu.2023.1148798

Kim, D.-K., Weller, B., Lin, C.-W., Sheykhkarimli, D., Knapp, J. J., Dugied, G., Zanzoni, A., Pons, C., Tofaute, M. J., Maseko, S. B., Spirohn, K., Laval, F., Lambourne, L., Kishore, N., Rayhan, A., Sauer, M., Young, V., Halder, H., la Rosa, N. M.-D., ... Falter-Braun, P. (10 October 2022). A proteome-scale map of the SARS-CoV-2–human contactome. Nature Biotechnology, 41 (1), 140-149. doi:10.1038/s41587-022-01475-z

Hoyos, C.* , Fontaine, A.* , Jacques, J.-R., Heinen, V., Louis, R., Duysinx, B., Scherpereel, A., Wasielewski, E., Jamakhani, M.* , Hamaïdia, M.* , & Willems, L.*. (2022). HDAC Inhibition with Valproate Improves Direct Cytotoxicity of Monocytes against Mesothelioma Tumor Cells. Cancers, 14 (9), 2164. doi:10.3390/cancers14092164

Suárez Archilla, G., Gutiérrez, G., Camussone, C., Calvinho, L., Abdala, A., Alvarez, I., Petersen, M., Franco, L., Destefano, G., Monti, G., Jacques, J.-R., Joris, T., Willems, L.* , & Trono, K.*. (2022). A safe and effective vaccine against bovine leukemia virus. Frontiers in Immunology, 13, 980514. doi:10.3389/fimmu.2022.980514

Li, Y., Yang, S., Huang, X., Yang, N., Wang, C., Zhao, J., Jing, Z., Willems, L., & Liu, G. (24 December 2021). MyD88 Mediates Colitis- and RANKL-Induced Microfold Cell Differentiation. Veterinary Sciences, 9. doi:10.3390/vetsci9010006

Hoyos, C., Fontaine, A., Brossel, H., Willems, M., Jamakhani, M., Vandermeers, F., Safari, R., HEINEN, V., LOUIS, R., DUYSINX, B., Scherpereel, A., Wasielewski, E., Mascaux, C., Hamaïdia, M.* , & Willems, L.*. (14 December 2021). Contribution of lysine deacetylases to the therapy of malignant pleural mesothelioma [Poster presentation]. Giga Cancer Day, Liège, Belgium.

Willems, M., Jamakhani, M., Scherpereel, A., Wasielewski, E., Brossel, H., Fontaine, A., Hoyos, C., Grégoire, M., Louis, R., Duysinx, B., Hamaïdia, M.* , & Willems, L.*. (14 December 2021). Eosinophils inhibit malignant pleural mesothelioma response to chemotherapy [Poster presentation]. GIGA-Cancer Day, Liège, Belgium.

Pluta, A., Blazhko, N. V., Ngirande, C., Joris, T., Willems, L., & Kuźmak, J. (20 February 2021). Analysis of Nucleotide Sequence of Tax, miRNA and LTR of Bovine Leukemia Virus in Cattle with Different Levels of Persistent Lymphocytosis in Russia. Pathogens, 10, 246. doi:10.3390/pathogens10020246

Brossel, H.* , Fontaine, A.* , Hoyos, C.* , Jamakhani, M.* , Willems, M.* , Hamaïdia, M., & Willems, L. (2021). Activation of DNA Damage Tolerance Pathways May Improve Immunotherapy of Mesothelioma. Cancers, 13, 3211. doi:10.3390/cancers13133211

Hu, X., Xing, Y., Ren, L., Wang, Y., Li, Q., Yang, Q., Du, M., Xu, L., Willems, L., Li, J., & Zhang, L. (20 October 2020). bta-miR-23a Regulates the Myogenic Differentiation of Fetal Bovine Skeletal Muscle-Derived Progenitor Cells by Targeting MDFIC Gene. Genes, 20, 1232. doi:10.3390/genes11101232

Pluta, A., Willems, L., Douville, R. N., & Kuzmak, J. (13 October 2020). Effects of Naturally Occurring Mutations in Bovine Leukemia Virus 50 -LTR and Tax Gene on Viral Transcriptional Activity. Pathogens, 9 (10), 836. doi:10.3390/pathogens9100836

Safari, R., Jacques, J.-R., Brostaux, Y., & Willems, L. (2020). Ablation of non-coding RNAs affects bovine leukemia virus B lymphocyte proliferation and abrogates oncogenesis. PLoS Pathogens, 16. doi:10.1371/journal.ppat.1008502

Sheynkman, G. M., Tuttle, K. S., Laval, F., Tseng, E., Underwood, J. G., Yu, L., Dong, D., Smith, M. L., Sebra, R., Willems, L., Hao, T., Calderwood, M. A., Hill, D. E., & Vidal, M. (2020). ORF Capture-Seq as a versatile method for targeted identification of full-length isoforms. Nature Communications, 11 (1). doi:10.1038/s41467-020-16174-z

Staumont, B., Jamakhani, M., Costa, C., Vandermeers, F., Sriramareddy, S. N., Redouté, G., Mascaux, C., Delvenne, P., Hubert, P., Safari, R., & Willems, L. (2020). TGFα Promotes Chemoresistance of Malignant Pleural Mesothelioma. Cancers, 12 (6), 1484. doi:10.3390/cancers12061484

Hu, X., Xing, Y., Ren, L., Wang, Y., Li, Q., Fu, X., Yang, Q., Xu, L., Willems, L., Li, J., & Zhang, L. (2019). Bta-miR-24-3p Controls the Myogenic Differentiation and Proliferation of Fetal, Bovine, Skeletal Muscle-Derived Progenitor Cells by Targeting ACVR1B. Animals. doi:10.3390/ani9110859

Abdala, A., Alvarez, I., Brossel, H., Calvinho, L., Carignano, H., Franco, L., Gazon, H., Gillissen, C., Hamaïdia, M., Hoyos, C., Jacques, J.-R., Joris, T., Laval, F., Petersen, M., Porquet, F., Porta, N., Ruiz, V., Safari, R., Suárez Archilla, G., ... Willems, L. (2019). BLV: lessons on vaccine development. Retrovirology, 2019 (16), 26. doi:10.1186/s12977-019-0488-8

Hamaïdia, M., Gazon, H., Hoyos, C., Hoffmann, G. B., Louis, R., Duysinx, B., & Willems, L. (2019). Inhibition of EZH2 methyltransferase decreases immunoediting of mesothelioma cells by autologous macrophages through a PD-1-dependent mechanism. JCI Insight, 4 (18), 128474. doi:10.1172/jci.insight.128474

Gazon, H., Chauhan, P. S., Hamaïdia, M., Hoyos, C., Li, L., Safari, R., & Willems, L. (2018). How Does HTLV-1 Undergo Oncogene-Dependent Replication Despite a Strong Immune Response? Frontiers in Microbiology, 8, 2684. doi:10.3389/fmicb.2017.02684

Xiukun, S., Ting, X., Xiaoyu, G., Hong, J., Ming, L., Xintao, G., Jing, W., Yitong, J., Willems, L., Hongfei, Z., & Shaohua, H. (2018). Genomic characterization and pathogenic study of two porcine reproductive and respiratory syndrome viruses with different virulence in Fujian, China. Journal of Veterinary Science, 19 (3), 339-349. doi:10.4142/jvs.2018.19.3.339

Gallo, R., Willems, L., & Tagaya, Y. (22 September 2017). Time to Go Back to the Original Name. Frontiers in Microbiology, 8, 1800. doi:10.3389/fmicb.2017.01800

Li, B., Leblois, J., Taminiau, B., Willems, L., Beckers, Y., Bindelle, J., & Everaert, N. (08 May 2017). The effect of inulin and/or wheat bran in the diet during early life on intestinal health of broiler chicks [Paper presentation]. 21st European Symposium on Poultry Nutrition (ESPN 2017).

Gillet, N., Hamaïdia, M., De Brogniez, A., Gutierrez, G., Renotte, N., Reichert, M., Trono, K., & Willems, L. (28 April 2016). Bovine Leukemia Virus Small Noncoding RNAs Are Functional Elements That Regulate Replication and Contribute to Oncogenesis In Vivo. PLoS Pathogens, 12 (4), 1005588. doi:10.1371/journal.ppat.1005588

De Brogniez, A., Mast, J., & Willems, L. (2016). Determinants of the Bovine Leukemia Virus envelope glycoproteins involved in infectivity, replication and pathogenesis. Viruses, 8 (4), 88. doi:10.3390/v8040088

Gillet, N., & Willems, L. (2016). Whole genome sequencing of 51 breast cancers reveals that tumors are devoid of bovine leukemia virus DNA. Retrovirology, 13:75. doi:10.1186/s12977-016-0308-3

Hamaïdia, M., Barez, P.-Y., Carpentier, A., Lebecque, S., Miazek, K., Paul, A., Neelature Sriramareddy, S., Staumont, B., Danthine, S., Deleu, M., Frederich, M., De Pauw, E., Delaplace, P., Delvigne, F., Goffin, D., Ongena, M., Duysinx, B., Louis, R., cosse, J.-P., & Willems, L. (2016). From Valeriana officinalis to cancer therapy: the success of a bio-sourced compound. Biotechnologie, Agronomie, Société et Environnement, 20 (S1), 314-320. doi:10.25518/1780-4507.12739

Miazek, K., Lebecque, S., Hamaïdia, M., Paul, A., Danthine, S., Willems, L., Frederich, M., De Pauw, E., Deleu, M., Richel, A., & Goffin, D. (2016). Sphingolipids: Promising lipid-class molecules with potential applications for industry. A review. Biotechnologie, Agronomie, Société et Environnement, 20 (S1), 321-336. doi:10.25518/1780-4507.13071

Paul, A., Frederich, M., Uyttenbroeck, R., Hatt, S., Malik, P., Lebecque, S., Hamaïdia, M., Miazek, K., Goffin, D., Willems, L., Deleu, M., Fauconnier, M.-L., Richel, A., De Pauw, E., Blecker, C., Monty, A., Francis, F., Haubruge, E., & Danthine, S. (2016). Grasshoppers as a food source? A review. Biotechnologie, Agronomie, Société et Environnement, 20 (AgricultureIsLife), 337-352. doi:10.25518/1780-4507.12974

Barez, P.-Y., De Brogniez, A., Carpentier, A., Gazon, H., Gillet, N., Gutiérrez, G., Hamaïdia, M., Jacques, J.-R., Perike, S., Neelature Sriramareddy, S., Renotte, N., Staumont, B., Reichert, M., Trono, K., & Willems, L. (24 November 2015). Recent advances in BLV research. Viruses, 7 (11), 6080-6088. doi:10.3390/v7112929

Berghmans, T., Lafitte, J.-J., Scherpereel, A., Ameye, L., Paesmans, M., Meert, A.-P., Colinet, B., Tulippe, C., Willems, L., Leclercq, N., & Sculier, J.-P. (19 October 2015). VAC chemotherapy with valproic acid for refractory/relapsing small cell lung cancer: a phase II study. ERJ Open Research, 1 (2). doi:10.1183/23120541.00029-2015

Hubaux, R., Vandermeers, F., Cosse, J.-P., Crisanti, C., Kapoor, V., Albelda, S. M., Mascaux, C., Delvenne, P., Hubert, P., & Willems, L. (19 October 2015). Valproic acid improves second-line regimen of small cell lung carcinoma in preclinical models. ERJ Open Research, 1 (2), 00028. doi:10.1183/23120541.00028-2015

Carpentier, A., Barez, P.-Y., Hamaïdia, M., Gazon, H., De Brogniez, A., Perike, S., Gillet, N., & Willems, L. (07 July 2015). Modes of Human T Cell Leukemia Virus Type 1 Transmission, Replication and Persistence. Viruses, 7, 3603-3624. doi:10.3390/v7072793

Willems, L., & Gillet, N. (11 June 2015). APOBEC3 Interference during Replication of Viral Genomes. Viruses, 7, 2999-3018. doi:10.3390/v7062757

Berghmans, T., Ameye, L., Lafitte, J.-J., Colinet, B., Cortot, A., CsToth, I., Holbrechts, S., Lecomte, J., Mascaux, C., Meert, A.-P., Paesmans, M., Richez, M., Scherpereel, A., Tulippe, C., Willems, L., Dernies, T., Leclercq, N., & Sculier, J.-P. (28 January 2015). Prospective validation obtained in a similar group of patients and with similar high throughput biological tests failed to confirm signatures for prediction of response to chemotherapy and survival in advanced NSCLC: a prospective study from the European Lung Cancer Working Party. Frontiers in Oncology, 4. doi:10.3389/fonc.2014.00386

Gillet, N., Hamaïdia, M., De Brogniez, A., Gutierrez, G., Renotte, N., Reichert, M., Trono, K., & Willems, L. (2015). The bovine leukemia virus microRNAs permit escape from innate immune response and contribute to viral replication in the natural host. Retrovirology, 12.

Elemans, M., Florins, A., Willems, L., & Asquith, B. (03 April 2014). Rates of CTL Killing in Persistent Viral Infection In Vivo. PLoS Computational Biology, 4. doi:10.1371/journal.pcbi.1003534

Sainvitu, P., Nasir, M. N., Crowet, J.-M., Willems, L., Lins, L., & Deleu, M. (07 February 2014). Interactions between new phenolic glycolipids and model membrane [Poster presentation]. 19th NATIONAL SYMPOSIUM on APPLIED BIOLOGICAL SCIENCES, Gembloux, Belgium.

Barez, P.-Y., Carpentier, A., Boxus, M., & Willems, L. (2014). The Tax protein and the minichromosome maintenance protein complex MCM2-7 affect cell replication and viral transcription. Retrovirology, 11 (S1), 96. doi:10.1186/1742-4690-11-S1-P96

Carpentier, A., Barez, P.-Y., Boxus, M., & Willems, L. (2014). Checkpoints modulation by the Human T-lymphotropic virus type 1 Tax protein. Retrovirology, 11 (S1), 90. doi:10.1186/1742-4690-11-S1-P90

De Brogniez, A., Bouzar, A.-B., Jacques, J.-R., Gillet, N., Pritsh, O., Tomé, L., Reichert, M., & Willems, L. (2014). Hyper-replicative bovine leukemia virus by mutation of an envelope N-linked glycosylation site. Retrovirology, 11 (1), 141. doi:10.1186/1742-4690-11-S1-P141

Gutierrez, G., Rodriguez, S. M., De Brogniez, A., Gillet, N., Golime, R., Burny, A., Jaworski, J.-P., Alvarez, I., Vagnoni, L., Trono, K., & Willems, L. (2014). Vaccination against delta-Retroviruses: The Bovine Leukemia Virus Paradigm. Viruses, 6 (6), 2416-2427. doi:10.3390/v6062416

Lodewick, J., Sampaio, C., Boxus, M., Rinaldi, A.-S., Coulonval, K., Willems, L., Roger, P., & Bex, F. (23 July 2013). Acetylation at lysine 346 controls the transforming activity of the HTLV-1 Tax oncoprotein in the Rat-1 fibroblast model. Retrovirology, 2013 (10), 75. doi:10.1186/1742-4690-10-75

Sainvitu, P., Nasir, M. N., Draguet, F., Nott, K., Lins, L., Crowet, J.-M., Willems, L., Cosse, J.-P., Jérôme, C., & Deleu, M. (30 May 2013). Novel phenolic glycolipids: antioxidant activity and effect on membrane models [Poster presentation]. Knowledge for Growth, Ghent, Belgium.

Sainvitu, P., Nasir, M. N., Draguet, F., Nott, K., Lins, L., Crowet, J.-M., Willems, L., Cosse, J.-P., Jérôme, C., & Deleu, M. (15 May 2013). Biophysical characterization of the interaction of novel aromatic glycolipid surfactants with membrane models [Poster presentation]. ICBCBBE 2013 : International Conference on Bioinformatics, Computational Biology and Biomedical Engineering, Amsterdam, Netherlands.

Sainvitu, P., Nasir, M. N., Nott, K., Lins, L., Crowet, J.-M., Nicks, F., Laurent, P., Willems, L., Cosse, J.-P., Jérôme, C., & Deleu, M. (May 2013). Biophysical characterization of the interaction of novel aromatic glycolipid surfactants with membrane models. World Academy of Science, Engineering and Technology, 77, 840.

Sainvitu, P., Nasir, M. N., Nott, K., Lins, L., Crowet, J.-M., Willems, L., Cosse, J.-P., Jérôme, C., & Deleu, M. (May 2013). Biophysical characterization of the interaction of novel aromatic glycolipid surfactants with membrane models. World Academy of Science, Engineering and Technology, 77, 840.

Gillet, N., Gutiérrez, G., Rodriguez, S., De Brogniez, A., Renotte, N., Alvarez, I., Trono, K., & Willems, L. (2013). Massive Depletion of Bovine Leukemia Virus Proviral Clones Located in Genomic Transcriptionally Active Sites During Primary Infection. PLoS Pathogens, 9 (10). doi:10.1371/journal.ppat.1003687

Gillet, N., Carpentier, A., Barez, P.-Y., & Willems, L. (21 December 2012). WIP1 deficiency inhibits HTLV-1 Tax oncogenesis: novel therapeutic prospects for treatment of ATL? Retrovirology, 9 (1), 115. doi:10.1186/1742-4690-9-115

Sainvitu, P., Nott, K., Nicks, F., Laurent, P., Willems, L., Cosse, J.-P., Crowet, J.-M., Lins, L., Jérôme, C., & Deleu, M. (16 November 2012). Synthesis and physico-chemical characterization of fatty esters [Poster presentation]. Journée scientifique SFM-BBM, Louvain-la-neuve, Belgium.

Gillet, N., Vandermeers, F., De Brogniez, A., Florins, A., Nigro, A., François, C., Bouzar, A.-B., Verlaeten, O., Stern, E., Lambert, D., Wouters, J., & Willems, L. (2012). Chemoresistance to Valproate Treatment of Bovine Leukemia Virus-Infected Sheep; Identification of Improved HDAC Inhibitors. Pathogens, (2012-1), 65-82. doi:10.3390/pathogens1020065

Boxus, M., & Willems, L. (05 January 2012). How the DNA damage response determines the fate of HTLV-1 Tax-expressing cells. Retrovirology, 9 (2). doi:10.1186/1742-4690-9-2

Rodriguez, S., Florins, A.-F., Gillet, N., De Brogniez, A., Sanchez-Alcaraz, M.-T., Boxus, M., Boulanger, F., Gutiérrez, G., Trono, K., Alvarez, I., Vagnoni, L., & Willems, L. (19 July 2011). Preventive and Therapeutic Strategies for Bovine Leukemia Virus: Lessons for HTLV. Viruses, 3 (7), 1210-1248. doi:10.3390/v3071210

Bouzar, A., Boxus, M., Florins, A.-F., Francois, C., Reichert, M., & Willems, L. (2009). Reduced levels of reactive oxygen species correlate with inhibition of apoptosis, rise in thioredoxin expression and increased bovine leukemia virus proviral loads. Retrovirology, 6, 102. doi:10.1186/1742-4690-6-102

Florins, A.-F., Reichert, M., Asquith, B., Bouzar, A., Jean, G., Francois, C., Jasik, A., Burny, A., Kettmann, R., & Willems, L. (2009). Earlier onset of delta-retrovirus-induced leukemia after splenectomy. PLoS ONE, 4 (9), 6943. doi:10.1371/journal.pone.0006943

Pomier, C., Alcaraz, M. T. S., Debacq, C. P., Lancon, A., Kerkhofs, P., Willems, L., Wattel, E., & Mortreux, F. (2009). A Dose-Effect Relationship For Deltaretrovirus-Dependent Leukemogenesis In Sheep. Retrovirology, 6. doi:10.1186/1742-4690-6-30

Willems, L. (2009). The 14th International Conference on Human Retrovirology: HTLV and related retroviruses (July 1-4, 2009; Salvador, Brazil). Retrovirology, 6, 77. doi:10.1186/1742-4690-6-77

Bouzar, A., & Willems, L. (2008). How HTLV-1 may subvert miRNAs for persistence and transformation. Retrovirology, 5, 101. doi:10.1186/1742-4690-5-101

Boxus, M., Twizere, J.-C., Legros, S., Dewulf, J.-F., Kettmann, R., & Willems, L. (2008). The HTLV-1 Tax interactome. Retrovirology, 5, 76. doi:10.1186/1742-4690-5-76

Pomier, C., Alcaraz, M. T. S., Debacq, C., Lancon, A., Kerkhofs, P., Willems, L., Wattel, E., & Mortreux, F. (2008). Early and transient reverse transcription during primary deltaretroviral infection of sheep. Retrovirology, 5, 16. doi:10.1186/1742-4690-5-16

Vandermeers, F., Kettmann, R., & Willems, L. (2008). Implication des modifications épigénétiques dans les cancers : développement de nouvelles approches thérapeutiques. Biotechnologie, Agronomie, Société et Environnement, 12 (2).

Burteau, C., Willems, L., & Kettmann, R. (2007). Les chémokines et leurs récepteurs : rôle dans les infections virales et dans les pathologies cancéreuses. Biotechnologie, Agronomie, Société et Environnement.

Florins, A.-F., Gillet, N., Asquith, B., Boxus, M., Burteaux, C., Twizere, J.-C., Urbain, P., Vandermeers, F., Debacq, C., Sanchez-alcaraz, M. T., Schwartz-Cornil, I., Kerkhofs, P., Jean, G., Thewis, A., Hay, J., Mortreux, F., Wattel, E., Reichert, M., Burny, A., ... Willems, L. (2007). Cell dynamics and immune response to BLV infection: a unifying model. Frontiers in Bioscience-Landmark, 12, 1520-1531. doi:10.2741/2165

Florins, A.-F., Kettmann, R., & Willems, L. (2007). Le virus de la leucemie bovine et l'homeostasie du compartiment lymphocytaire peripherique. Biotechnologie, Agronomie, Société et Environnement, 11 (1), 69-78.

Gillet, N., Florins, A.-F., Boxus, M., Burteau, C., Nigro, A., Vandermeers, F., Balon, H., Bouzar, A., Defoiche, J., Burny, A., Reichert, M., Kettmann, R., & Willems, L. (2007). Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human. Retrovirology, 4 (1), 18. doi:10.1186/1742-4690-4-18

Gillet, N., Kettmann, R., & Willems, L. (2007). Homologies entre les deux retrovirus BLV et HTLV-1 et developpement d'une nouvelle approche therapeutique basee sur la levee de la latence virale. Biotechnologie, Agronomie, Société et Environnement, 11 (2), 151-157.

Twizere, J.-C., Springael, J.-Y., Boxus, M., Burny, A., Dequiedt, F., Dewulf, J.-F., Duchateau, J., Portetelle, D., Urbain, P., Van Lint, C., Green, P. L., Mahieux, R., Parmentier, M., Willems, L., & Kettmann, R. (2007). Human T-cell leukemia virus type-1 Tax oncoprotein regulates G-protein signaling. Blood, 109 (3), 1051-60. doi:10.1182/blood-2006-06-026781

Debacq, C., Gillet, N., Asquith, B., Sanchez-Alcaraz, M. T., Florins, A.-F., Boxus, M., Schwartz-Cornil, I., Bonneau, M., Jean, G., Kerkhofs, P., Hay, J., Thewis, A., Kettmann, R., & Willems, L. (2006). Peripheral blood B-cell death compensates for excessive proliferation in lymphoid tissues and maintains homeostasis in bovine leukemia virus-infected sheep. Journal of Virology, 80 (19), 9710-9719. doi:10.1128/JVI.01022-06

Twizere, J.-C., Lefebvre, L., Collete, D., Debacq, C., Urbain, P., Heremans, H., Jauniaux, J.-C., Burny, A., Willems, L., & Kettmann, R. (2005). The homeobox protein MSX2 interacts with tax oncoproteins and represses their transactivation activity. Journal of Biological Chemistry, 280 (33), 29804-11. doi:10.1074/jbc.M503674200

Debacq, C., Sanchez Alcaraz, M. T., Mortreux, F., Kerkhofs, P., Kettmann, R., & Willems, L. (2004). Reduced proviral loads during primo-infection of sheep by Bovine Leukemia virus attenuated mutants. Retrovirology, 1 (1), 31. doi:10.1186/1742-4690-1-31

Twizere, J.-C., Kruys, V., Lefebvre, L., Vanderplasschen, A., Collete, D., Debacq, C., Lai, W. S., Jauniaux, J.-C., Bernstein, L. R., Semmes, O. J., Burny, A., Blackshear, P. J., Kettmann, R., & Willems, L. (2003). Interaction of retroviral Tax oncoproteins with tristetraprolin and regulation of tumor necrosis factor-alpha expression. Journal of the National Cancer Institute, 95 (24), 1846-59. doi:10.1093/jnci/djg118

Twizere, J.-C., Kerkhofs, P., Burny, A., Portetelle, D., Kettmann, R., & Willems, L. (2000). Discordance between bovine leukemia virus tax immortalization in vitro and oncogenicity in vivo. Journal of Virology, 74 (21), 9895-902. doi:10.1128/JVI.74.21.9895-9902.2000

GATOT, J.-S., Callebaut, I., Mornon, J., Portetelle, D., Burny, A., Kerkhofs, P., Kettmann, R., & Willems, L. (1998). Conservative Mutations In The Immunosuppressive Region Of The Bovine Leukemia Virus Transmembrane Protein Affect Fusion But Not Infectivity In Vivo. Journal of Biological Chemistry, 273 (21), 12870-12880. doi:10.1074/jbc.273.21.12870

Willems, L., Grimonpont, C., Kerkhofs, P., Capiau, C., Gheysen, D., Conrath, K., Roussef, R., Mamoun, R., Portetelle, D., Burny, A., Adam, E., Lefebvre, L., Twizere, J.-C., Heremans, H., & Kettmann, R. (1998). Phosphorylation of bovine leukemia virus Tax protein is required for in vitro transformation but not for transactivation. Oncogene, 16 (17), 2165-76. doi:10.1038/sj.onc.1201765

Burny, A., Kettmann, R., Mammerickx, M., Portetelle, D., Willems, L., Cleuter, Y., Dandoy, C., Marbaix, G., & van den Broeke, A. (1986). La leucemie bovine: systeme modele de leucemogenisation par un retrovirus. Annales de Médecine Vétérinaire, 130 (4), 287-294.