Publications and communications of Christophe Desmet

Van Damme, K. F. A., Sichien, D., Van der Borght, K., Van Moorleghem, J., Van Gassen, S., Jorssen, J., De Winter, S., De Leeuw, E., Wang, C., Chai, Q., Zumsteg, A. B., Schmid, M. A., Bosteels, V., De Bleser, P., Vanheerswynghels, M., De Prijck, S., Bujko, A., De Nolf, C., Schuijs, M. J., ... Lambrecht, B. N. (February 2026). Cross-species cellular mapping and humanization of Fcγ receptors to advance antibody modeling. Science Immunology, 11 (115). doi:10.1126/sciimmunol.ady7328

Moermans, C.* , Sabbe, M.* , ONSSELS, A., Bricmont, N., Bonhiver, R., REGNIER, F., Graff, S., Gerday, S., Njock, M.-S., Rosu, A., PAULUS, V., GUISSARD, F., ZIANT, S., SANCHEZ, C., Ernst, M., Desmet, C., Louis, R., & Schleich, F. (2025). Dupilumab Effectiveness in Biologic-Naïve and Switched Severe Asthma in Real Life. Allergy. doi:10.1111/all.70205

Gerday, S., Schleich, F., Sabbe, M., Moermans, C., Guissard, F., SANCHEZ, C., KENENS, S., PAULUS, V., Henket, M., Bureau, F., Desmet, C., & Louis, R. (December 2025). Transcriptomics in T2-High Severe Asthmatics Treated with Biologics: Comparison between Anti-IgE, Anti-IL-5, and Anti-IL-5 Receptor Treatments. American Journal of Respiratory Cell and Molecular Biology, 73 (6), 965 - 970. doi:10.1165/rcmb.2025-0188LE

Wathieu, C., Lavergne, A., Xu, X., Rolot, M., Nemazanyy, I., Shostak, K., El Hachem, N., Maurizy, C., Leemans, C., Close, P., Nguyen, L., Desmet, C., Tielens, S.* , Dewals, B. G.* , & Chariot, A.*. (2024). Loss of Elp3 blocks intestinal tuft cell differentiation via an mTORC1-Atf4 axis. EMBO Journal. doi:10.1038/s44318-024-00184-4

Jorssen, J.* , Van Hulst, G.* , Mollers, K., Pujol, J., Petrellis, G., Baptista, A. P., Schetters, S., Baron, F., Caers, J., Lambrecht, B. N., Dewals, B. G., Bureau, F.* , & Desmet, C.*. (2024). Single-cell proteomics and transcriptomics capture eosinophil development and identify the role of IL-5 in their lineage transit amplification. Immunity. doi:10.1016/j.immuni.2024.04.027

Burniat, A., Noël, A., Colige, A., Vanderplasschen, A., de Kerchove d'Exaerde, A., Kupper Cardozo, A., Van Keymeulen, A., Moens, A., Bondue, A., Herpain, A., Marchant, A., Loumaye, A., Beck, B., Van den Heyden, B., Corvilain, B., Lakaye, B., Rogister, B., Malgrange, B., Michiels, C., ... Brunko, E. (2023). Cent scientifiques répliquent à SEA (Suppression des Expériences sur l’Animal vivant) et dénoncent sa désinformation. La Libre Belgique.

Moes, B., Li, H., Molina Ortiz, P., Radermecker, C., Rosu, A., Vande Catsyne, C.-A., Sayyed, S. A., Fontela Joao, Duque, M., Mostafa, A., Azzi, A., Barata Joao T., Merino Ramon, Xu, C., Desmet, C., & Schurmans, S. (2023). INPP5K controls the dynamic structure and signaling of wild type and mutated, leukemia-associated IL7 receptors. Blood, 141, 1708-1717. doi:10.1182/blood.2022017819

Chen, D., Nemazanyy, I., Peulen, O., Shostak, K., Xu, X., Tang, S. C., Wathieu, C., Turchetto, S., Tielens, S., Nguyen, L., Close, P., Desmet, C., Klein, S., Florin, A., Büttner, R., Petrellis, G., Dewals, B. G., & Chariot, A. (2022). Elp3-mediated codon-dependent translation promotes mTORC2 activation and regulates macrophage polarization. EMBO Journal, 109353. doi:10.15252/embj.2021109353

Fastrès, A., Roels, E., Pirottin, D., Fievez, L., Tutunaru, A.-C., Bolen, G., Merveille, A.-C., Marichal, T., Desmet, C., Bureau, F., & Clercx, C. (2022). Osteopontin-expressing macrophages in dogs affected with canine idiopathic pulmonary fibrosis, a model for human idiopathic pulmonary fibrosis [Poster presentation]. 21st International Colloquium on Lung and Airway Fibrosis (ICLAF).

Van Hulst, G., Jorssen, J., Jacobs, N., Henket, M., Louis, R., Schleich, F., Bureau, F., & Desmet, C. (2022). Reply: Ex vivo SOCS3 gene responsiveness to alarmins in eosinophils of mepolizumab-treated patients is as yet of unknown biological significance. European Respiratory Journal, 60 (1). doi:10.1183/13993003.00981-2022

Van Hulst, G., Jorssen, J.* , Jacobs, N., Henket, M., Louis, R., Schleich, F., Bureau, F.* , & Desmet, C. (2022). Anti-IL-5 mepolizumab minimally influences residual blood eosinophils in severe asthma. European Respiratory Journal, 59, 2100935. doi:10.1183/13993003.00935-2021

Kerselidou, D., Dohai, B. S., Nelson, D. R., Daakour, S., De Cock, N., Hassoun, Z. E. O., Kim, D.-K., Olivet, J., El Assal, D. C., Jaiswal, A., Alzahmi, A., Saha, D., Pain, C., Matthijssens, F., Lemaitre, P., Herfs, M., Chapuis, J., Ghesquiere, B., Vertommen, D., ... Twizere, J.-C. (2021). Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells. Science Advances, 7 (19). doi:10.1126/sciadv.abe8349

Rapino, F.* , ZHOU, Z.* , RONCERO SANCHEZ, A. M.* , Joiret, M., Seca, C., El Hachem, N., Valenti, G., Latini, S., Shostak, K., Geris, L., Li, P., Huang, G., Mazzucchelli, G., Baiwir, D., Desmet, C., Chariot, A., Georges, M., & Close, P. (2021). Wobble tRNA modification and hydrophilic amino acid patterns dictate protein fate. Nature Communications, 12 (1), 2170. doi:10.1038/s41467-021-22254-5

Schurmans, S., Vande Catsyne, C.-A., Desmet, C., & Moes, B. (2021). The phosphoinositide 5-phosphatase INPP5K: from gene structure to in vivo functions. Advances in Biological Regulation. doi:10.1016/j.jbior.2020.100760

Van Hulst, G., Bureau, F., & Desmet, C. (2021). Eosinophils as Drivers of Severe Eosinophilic Asthma: Endotypes or Plasticity? International Journal of Molecular Sciences, 22 (18). doi:10.3390/ijms221810150

Fastrès, A., Pirottin, D., Fievez, L., Tutunaru, A.-C., Bolen, G., Merveille, A.-C., Marichal, T., Desmet, C., Bureau, F., & Clercx, C. (15 December 2020). Identification of pro-fibrotic macrophage populations by single-cell transcriptomic analysis in West Highland white terriers affected with canine idiopathic pulmonary fibrosis. Frontiers in Immunology, 11, 611749. doi:10.3389/fimmu.2020.611749

Fastrès, A., Pirottin, D., Fievez, L., Tutunaru, A.-C., Bolen, G., Merveille, A.-C., Marichal, T., Desmet, C., Bureau, F., & Clercx, C. (20 November 2020). Identification of pro-fibrotic macrophages populations by single-cell transcriptomic analysis in West Highland white terriers affected with canine idiopathic pulmonary fibrosis [Paper presentation]. 7th FARAH DAY, Liège, Belgium.

Fastrès, A., Pirottin, D., Fievez, L., Marichal, T., Desmet, C., Bureau, F., & Clercx, C. (30 July 2020). Characterization of the bronchoalveolar lavage fluid by single cell gene expression analysis in healthy dogs: a promising technique. Frontiers in Immunology, 11, 1707. doi:10.3389/fimmu.2020.01707

Fastrès, A., Pirottin, D., Fievez, L., Marichal, T., Desmet, C., Bureau, F., & Clercx, C. (2020). Characterization of the bronchoalveolar lavage fluid by single cell gene expression analysis in healthy dogs: a promising technique. Journal of Veterinary Internal Medicine, 34 (6). doi:10.1111/jvim.15924

Farhat, K., Bodart, G., Charlet-Renard, J. D. C., Desmet, C., Moutschen, M., Beguin, Y., Baron, F., Melin, P., Quatresooz, P., Parent, A.-S., Desmecht, D., Sirard, J.-C., Salvatori, R., Martens, H., & Geenen, V. (02 October 2018). Growth hormone (GH) deficient mice with GHRH ablation are severely deficient in vaccine and immune responses against Streptococcus pneumoniae. Frontiers in Immunology, 9, 2175. doi:10.3389/fimmu.2018.02175

Van hede, D., Polese, B., Humblet, C., Wilharm, A., Renoux, V., DORTU, E., de Leval, L., Delvenne, P., Desmet, C., Bureau, F., Vermijlen, D., & Jacobs, N. (June 2018). Human papillomavirus oncoproteins induce a reorganization of epithelial-associated γδ T cells promoting tumor formation [Poster presentation]. Gamma delta conferance, Bordeaux, France.

Bakker, J., Balthazart, J., Baron, F., Beguin, Y., Bettendorff, L., Blanpain, C., Bureau, F., Caers, J., Cani, P., Cataldo, D., Cornil, C., Clercx, C., Cloots, R., Colige, A., Daube, G., De Backer, O., de Kerchove d'Exaerde, A., Desmecht, D., Desmet, C., ... Wittamer, V. (2018). La souris, le patient, et le faux expert. Décryptage d'une mystification. Le Vif. L'Express.

Amorim, C., Andris, F., Arckens, L., Arnould, T., Aron, S., Bakker, J., Balligand, M., Balthazart, J., Baron, F., Beck, B., Beguin, Y., Behets, C., Bellefroid, E., Bertrand, L., Bettendorff, L., Bindels, L., Blankert, B., Blanpain, C., Bondue, A., ... Wittamer, V. (2017). L’expérimentation animale reste indispensable (OPINION). La Libre Belgique.

Farhat, K., Bodart, G., RENARD, J. D. C., Desmet, C., MOUTSCHEN, M., Beguin, Y., Baron, F., Salvatori, R., Geenen, V., & Martens, H. (23 May 2017). A surprising and dramatic neuroendocrine-immune phenotype of mice deficient in Growth Hormone-Releasing Hormone (GHRH) [Poster presentation]. European Congress of Endocrinology, Lisbonne, Portugal. doi:10.1530/endoabs.49.EP883

Farhat, K., Bodart, G., Renard, C., Desmet, C., MOUTSCHEN, M., BARON, F., Beguin, Y., Salvatori, R., Martens, H., & GEENEN, V. (May 2017). A surprising and dramatic neuroendocrine-immune phenotype of mice deficient in Growth Hormone-Releasing Hormone (GHRH) [Poster presentation]. The 19th European Congress of Endocrinology, Lisbon, Portugal.

Gallenne, T.* , Ross, K. N.* , Visser, N. L.* , Salony, * , Desmet, C., Wittner, B. S., Wessels, L. F. A., Ramaswamy, S., & Peeper, D. S. (2017). Systematic functional perturbations uncover a prognostic genetic network driving human breast cancer. Oncotarget, 8 (13), 20572-20587. doi:10.18632/oncotarget.16244

Van hede, D., Polese, B., Humblet, C., Wilharm, A., Renoux, V., Dortu, E., de Leval, L., Delvenne, P., Desmet, C., Bureau, F., Vermijlen, D., & Jacobs, N. (2017). Human papillomavirus oncoproteins induce a reorganization of epithelial-associated gammadelta T cells promoting tumor formation. Proceedings of the National Academy of Sciences of the United States of America, 114 (43), 9056-E9065. doi:10.1073/pnas.1712883114

Delaunay, S., Rapino, F., Tharun, L., Zhou, Z., Heukamp, L., Termathe, M., Shostak, K., Klevernic, I., Florin, A., Desmecht, H., Desmet, C., Nguyen, L., Leiden, S. A., Willis, A. E., Buettner, R., Chariot, A., & Close, P. (October 2016). ELP3 links tRNA modification to IRES-dependent translation of LEF-1 to promote metastasis in breast cancer. Journal of Experimental Medicine, 213, 2503-2523. doi:10.1084/jem.20160397

Frellstedt, L., Gosset, P., Kervoaze, G., Hans, A., Desmet, C., Pirottin, D., Bureau, F., Lekeux, P., & Art, T. (2015). The Innate Immune Response of Equine Bronchial Epithelial Cells is Altered by Training. Veterinary Research, 46 (3), 1-12. doi:10.1186/s13567-014-0126-3

Pirottin, D., Schurmans, S., Francois, C., Farnir, F., Closset, R., Bureau, F., & Desmet, C. (2014). Generation and validation of a mouse model for conditional inactivation of PLAGL1. In Proceedings of the 4th edition : FARAH Day 2014.

Crotta, S., Davidson, S., Mahlakoiv, T., Desmet, C., Buckwalter, M., Albert, M., Staeheli, P., & Wack, A. (2013). Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia. PLoS Pathogens. doi:10.1371/journal.ppat.1003773

El Abbas, S., Frellstedt, L., Art, T., Pirottin, D., Tosi, I., Dupuis, M.-C., Lekeux, P., Bureau, F., & Desmet, C. (19 October 2012). Characterization of T-helper lymphocytes in peripheral blood and bronchoalveolar lavage of healthy horses and in horses with recurrent airway obstruction [Poster presentation]. Proceedings of the 2nd Scientific Meeting of the Faculty of Veterinary Medicine, Liège, Belgium.

Mesnil, C.* , Sabatel, C.* , Marichal, T., Toussaint, M., Cataldo, D., Drion, P., Lekeux, P., Bureau, F.* , & Desmet, C.*. (2012). Resident CD11b(+)Ly6C(-) Lung Dendritic Cells Are Responsible for Allergic Airway Sensitization to House Dust Mite in Mice. PLoS ONE, 7 (12), 53242. doi:10.1371/journal.pone.0053242

Toussaint, M., Fievez, L., Desmet, C., Pirottin, D., Farnir, F., Bureau, F., & Lekeux, P. (2012). Increased hypoxia-inducible factor 1alpha expression in lung cells of horses with recurrent airway obstruction. BMC Veterinary Research, 8 (1), 64. doi:10.1186/1746-6148-8-64

Paulissen, G., Rocks, N., Guéders, M., Bedoret, D., Crahay, C., Quesada Calvo, F., Hacha, J., Bekaert, S., Desmet, C., Foidart, J.-M., Bureau, F., Noël, A., & Cataldo, D. (2011). ADAM-8, a metalloproteinase, drives acute allergen-induced airway inflammation. European Journal of Immunology, 41 (2), 380-91. doi:10.1002/eji.200940286

Raulier, S., Bureau, F., Desmet, C., & Pirottin, D. (2011). Etude du rôle des facteurs de transcription c-Maf et MafB dans la différenciation et la fonction des macrophages régulateurs: impact sur l'homéostasie immune mucosale. In Proceedings of the 1st FMV Scientific Meeting.

Bedoret, D., Wallemacq, H., Marichal, T., Desmet, C., Quesada Calvo, F., Henry, E., Closset, R., Dewals, B. G., Thielen, C., Gustin, P., de Leval, L., Van Rooijen, N., Le Moine, A., Vanderplasschen, A., Cataldo, D., Drion, P., Moser, M., Lekeux, P., & Bureau, F. (2009). Lung interstitial macrophages alter dendritic cell functions to prevent airway allergy in mice. Journal of Clinical Investigation, 119 (12), 3723-38. doi:10.1172/JCI39717

Fievez, L., Desmet, C., Henry, E., Pajak, B., Hegenbarth, S., Garze, V., Bex, F., Jaspar, F., Boutet, P., Gillet, L., Vanderplasschen, A., Knolle, P. A., Leo, O., Moser, M., Lekeux, P., & Bureau, F. (2007). Stat5 Is an Ambivalent Regulator of Neutrophil Homeostasis. PLoS ONE, 2 (1), 727. doi:10.1371/journal.pone.0000727

Desmet, C. (2006). Nuclear Factor-kappa B and Activator Protein-1: roles and potential as therapeutic targets in asthmatic inflammation. Annales de Médecine Vétérinaire, 150 S, 19-22.

Desmet, C., & Peeper, D. S. (2006). The neurotrophic receptor TrkB: a drug target in anti-cancer therapy ? Cellular and Molecular Life Sciences, 63 (7-8), 755-759. doi:10.1007/s00018-005-5490-8

Desmet, C., Louis, R., Lekeux, P., & Bureau, F. (2005). Le controle de la transcription genique en tant que nouvelle cible therapeutique dans le traitement de l'asthme. Revue Médicale de Liège, 60 (10), 789-795.