Publications and communications of Dominique de Seny

Veiga, R.* , De Vuyst, L.* , Poulet, C.* , Neumann, J., Bücken, L., Prezzemolo, T., Willemsen, M., Vanderschueren, S., Matthys, P., Chabaane, E., Fleron, M., Cobraiville, G., Baiwir, D., Mazzucchelli, G., Immunome Project Consortium for Autoinflammatory Disorders (ImmunAID), Fautrel, B., Wouters, C., de Seny, D.* , Humblet-Baron, S.* , & Liston, A.*. (2026). Adult patients with autoinflammation of unknown origin partially phenocopy the immune presentation of Still's disease. Nature Communications. doi:10.1038/s41467-026-70895-1

Paulissen, G., Malaise, O., Deroyer, C., Charlier, E., Neuville, S., Plener, Z., Thirion, T., Daniel, C., Ribbens, C., & de Seny, D. (2025). JAK inhibitors alleviate metabolic dysregulation, inflammation and fibrosis in osteoarthritis: insights from human joint cells and synovium. Rheumatology. doi:10.1093/rheumatology/keaf298

Guiot, J., André, B., Potjewijd, J., JACQUERIE, P., Cremers, S., Henket, M., Idoufkir, L., Remacle, C., Tobal, R., GILTAY, L., Moermans, C., GESTER, F., Polese, B., Hamaïdia, M., Struman, I., Louis, E., Malaise, M., de Seny, D., van Paassen, P., ... Njock, M.-S. (2025). Association of fibrotic-related extracellular vesicle microRNAs with lung involvement in systemic sclerosis. European Respiratory Journal, 2400276. doi:10.1183/13993003.00276-2024

JACQUERIE, P., André, B., de Seny, D., Henket, M., GILTAY, L., Ernst, M., Louis, R., Malaise, M., Ribbens, C., & Guiot, J. (03 November 2023). Reproducibility of pulmonary function tests in patients with systemic sclerosis. Scientific Reports, 13 (1), 18960. doi:10.1038/s41598-023-45881-y

Fusi, G., Constantinides, M., Fissoun, C., Pichard, L., Pers, Y.-M., Ferreira-Lopez, R., Pantesco, V., Poulet, C., Malaise, O., de Seny, D., Lemaitre, J.-M., Jorgensen, C., & Brondello, J.-M. (14 July 2023). Senescence-Driven Inflammatory and Trophic Microenvironment Imprints Mesenchymal Stromal/Stem Cells in Osteoarthritic Patients. Biomedicines, 11 (7), 1994. doi:10.3390/biomedicines11071994

DE SENY, D., Baiwir, D., BIANCHI, E., COBRAIVILLE, G., DEROYER, C., Poulet, C., MALAISE, O., PAULISSEN, G., KAISER, M.-J., Hauzer, J.-P., Mazzucchelli, G., DELVENNE, P., & MALAISE, M. (2022). New Proteins Contributing to Immune Cell Infiltration and Pannus Formation of Synovial Membrane from Arthritis Diseases. International Journal of Molecular Sciences, 23 (1), 434. doi:10.3390/ijms23010434

DEROYER, C., Poulet, C., PAULISSEN, G., Ciregia, F., MALAISE, O., PLENER, Z., COBRAIVILLE, G., DANIEL, C., GILLET, P., MALAISE, M., & DE SENY, D. (2022). CEMIP (KIAA1199) regulates inflammation, hyperplasia and fibrosis in osteoarthritis synovial membrane. Cellular and Molecular Life Sciences. doi:10.1007/s00018-022-04282-6

Papagiannopoulos, O. D., Papaloukas, C., Pezoulas, V. C., Van De Werken, H. J. G., Poulet, C., Mueller, Y. M., Katsikis, P. D., de Seny, D., & Fotiadis, D. I. (2022). Comparison of Proteomic Approaches in Autoinflammatory Disease Classification. In BHI-BSN 2022 - IEEE-EMBS International Conference on Biomedical and Health Informatics and IEEE-EMBS International Conference on Wearable and Implantable Body Sensor Networks, Symposium Proceedings. Institute of Electrical and Electronics Engineers Inc. doi:10.1109/BHI56158.2022.9926877

MALAISE, O.* , PAULISSEN, G.* , DEROYER, C., Ciregia, F., Poulet, C., NEUVILLE, S., PLENER, Z., DANIEL, C., Gillet, P., LECHANTEUR, C., Brondello, J.-M., DE SENY, D.* , & MALAISE, M.*. (16 November 2021). Influence of Glucocorticoids on Cellular Senescence Hallmarks in Osteoarthritic Fibroblast-like Synoviocytes. Journal of Clinical Medicine, 10 (22), 5331. doi:10.3390/jcm10225331

CIREGIA, F., Nys, G., Cobraiville, G., Badot, V., Di Romana, S., Sidiras, P., Sokolova, T., Durez, P., Fillet, M., Malaise, M., & de Seny, D. (2021). A Cross-Sectional and Longitudinal Study to Define Alarmins and A-SAA Variants as Companion Markers in Early Rheumatoid Arthritis. Frontiers in Immunology. doi:10.3389/fimmu.2021.638814

JACQUERIE, P., HENKET, M., André, B., MOERMANS, C., DE SENY, D., GESTER, F., LOUIS, R., MALAISE, M., & GUIOT, J. (21 May 2021). Inflammatory profile of induced sputum composition in systemic sclerosis and comparison with healthy volunteers. Scientific Reports, 11 (1), 10679. doi:10.1038/s41598-021-87701-1

Ciregia, F., DEROYER, C., COBRAIVILLE, G., PLENER, Z., MALAISE, O., GILLET, P., Fillet, M., MALAISE, M., & DE SENY, D. (2021). Modulation of αVβ6 integrin in osteoarthritis-related synovitis and the interaction with VTN (381-397 a.a.) competing for TGF-β1 activation. Experimental and Molecular Medicine. doi:10.1038/s12276-021-00558-2

GUIOT, J., NJOCK, M.-S., ANDRE, B., GESTER, F., HENKET, M., DE SENY, D., MOERMANS, C., MALAISE, M., & LOUIS, R. (2021). Serum IGFBP-2 in systemic sclerosis as a prognostic factor of lung dysfunction. Scientific Reports, 11 (1), 10882. doi:10.1038/s41598-021-90333-0

RELIC, B., DEROYER, C., MALAISE, O., Plener, Z., Gillet, P., de Seny, D., & Malaise, M. (2021). TFEB phosphorylation on Serine 211 is induced by autophagy in human synovial fibroblasts and by p62/SQSTM1 overexpression in HEK293 cells. Biochemical Journal, 478 (16), 3145-3155. doi:10.1042/BCJ20210174

CHARLIER, E.* , DEROYER, C.* , NEUVILLE, S., Plener, Z., MALAISE, O., Ciregia, F., Gillet, P., Reuter, G., Salvé, M., Withofs, N., Hustinx, R., de Seny, D.* , & Malaise, M.*. (2020). Toward diagnostic relevance of the α(V)β(5), α(V)β(3), and α(V)β(6) integrins in OA: expression within human cartilage and spinal osteophytes. Bone Research, 8, 35. doi:10.1038/s41413-020-00110-4

Ciregia, F., Baiwir, D., COBRAIVILLE, G., DEWAEL, T., Mazzucchelli, G., Badot, V., Di Romana, S., Sidiras, P., Sokolova, T., Durez, P., Malaise, M., & de Seny, D. (2020). Glycosylation deficiency of lipopolysaccharide-binding protein and corticosteroid-binding globulin associated with activity and response to treatment for rheumatoid arthritis. Journal of Translational Medicine, 18 (1). doi:10.1186/s12967-019-02188-9

de Seny, D., Bianchi, E., Baiwir, D., COBRAIVILLE, G., Collin, C., Deliège, M., Kaiser, M.-J., Mazzucchelli, G., Hauzeur, J.-P., Delvenne, P., & Malaise, M. (2020). Proteins involved in the endoplasmic reticulum stress are modulated in synovitis of osteoarthritis, chronic pyrophosphate arthropathy and rheumatoid arthritis, and correlate with the histological inflammatory score. Scientific Reports, 10 (1). doi:10.1038/s41598-020-70803-7

Nys, G., COBRAIVILLE, G., Servais, A.-C., Malaise, M., DE SENY, D., & Fillet, M. (2019). Targeted proteomics reveals serum amyloid A variants and alarmins S100A8-S100A9 as key plasma biomarkers of rheumatoid arthritis. Talanta. doi:10.1016/j.talanta.2019.06.044

DEROYER, C., CHARLIER, E., NEUVILLE, S., MALAISE, O., GILLET, P., KURTH, W., Chariot, A., MALAISE, M., & DE SENY, D. (2019). CEMIP (KIAA1199) induces a fibrosis-like process in osteoarthritic chondrocytes. Cell Death and Disease. doi:10.1038/s41419-019-1377-8

BONHOMME, O., ANDRE, B., GESTER, F., DE SENY, D., MOERMANS, C., Struman, I., Louis, R., MALAISE, M., & GUIOT, J. (2019). Biomarkers in systemic sclerosis-associated interstitial lung disease: review of the literature. Rheumatology. doi:10.1093/rheumatology/kez230

Fosse, P., KAISER, M.-J., Namur, G., DE SENY, D., Malaise, M., & Hustinx, R. (2018). (18)F- FDG PET/CT joint assessment of early therapeutic response in rheumatoid arthritis patients treated with rituximab. European Journal of Hybrid Imaging, 2 (1), 6. doi:10.1186/s41824-017-0022-y

RELIC, B., CHARLIER, A., DEROYER, C., MALAISE, O., Crine, Y., NEUVILLE, S., GILLET, P., DE SENY, D., & Malaise, M. (2018). Serum starvation raises turnover of phosphorylated p62/SQSTM1 (Serine 349), reveals expression of proteasome and N-glycanase1 interactive protein RAD23B and sensitizes human synovial fibroblasts to BAY 11-7085-induced cell death. Oncotarget, 9 (88), 35830-35843. doi:10.18632/oncotarget.26295

Amorim, C., Andris, F., Arckens, L., Arnould, T., Aron, S., Bakker, J., Balligand, M., Balthazart, J., Baron, F., Beck, B., Beguin, Y., Behets, C., Bellefroid, E., Bertrand, L., Bettendorff, L., Bindels, L., Blankert, B., Blanpain, C., Bondue, A., ... Wittamer, V. (2017). L’expérimentation animale reste indispensable (OPINION). La Libre Belgique.

Ourradi, K., Xu, Y., DE SENY, D., Kirwan, J., Blom, A., & Sharif, M. (2017). Development and validation of novel biomarker assays for osteoarthritis. PLoS ONE, 12 (7), 0181334. doi:10.1371/journal.pone.0181334

CHARLIER, E., RELIC, B., Deroyer, C., MALAISE, O., NEUVILLE, S., Collée, J., MALAISE, M., & DE SENY, D. (2016). Insights on Molecular Mechanisms of Chondrocytes Death in Osteoarthritis. International Journal of Molecular Sciences. doi:10.3390/ijms17122146

DE SENY, D., COBRAIVILLE, G., Leprince, P., Fillet, M., Collin, C., Mathieu, M., HAUZEUR, J.-P., Gangji, V., & Malaise, M. (2016). Biomarkers of inflammation and innate immunity in atrophic nonunion fracture. Journal of Translational Medicine. doi:10.1186/s12967-016-1019-1

RELIC, B., CHARLIER, E., Deroyer, C., MALAISE, O., NEUVILLE, S., Desoroux A, Gillet, P., DE SENY, D., & Malaise, M. (26 April 2016). BAY 11-7085 induces glucocorticoid receptor activation and autophagy that collaborate with apoptosis to induce human synovial fibroblast cell death. Oncotarget, 7 (17), 23370-82. doi:10.18632/oncotarget.8042

MALAISE, O., RELIC, B., Charlier, E., Zeddou, M., NEUVILLE, S., Deroyer, C., Gillet, P., Louis, E., Malaise, M., & DE SENY, D. (2016). Glucocorticoid-induced leucine zipper (GILZ) is involved in glucocorticoid-induced and mineralocorticoid-induced leptin production by osteoarthritis synovial fibroblasts. Arthritis Research and Therapy, 18 (1), 219. doi:10.1186/s13075-016-1119-6

DE SENY, D., COBRAIVILLE, G., CHARLIER, E., NEUVILLE, S., LUTTERI, L., LE GOFF, C., MALAISE, D., MALAISE, O., CHAPELLE, J.-P., RELIC, B., & MALAISE, M. (2015). Apolipoprotein-A1 as a damage-associated molecular patterns protein in osteoarthritis: ex vivo and in vitro pro-inflammatory properties. PLoS ONE. doi:10.1371/journal.pone.0122904

DE SENY, D., COBRAIVILLE, G., CHARLIER, E., NEUVILLE, S., Esser, N., MALAISE, D., MALAISE, O., Calvo, F., RELIC, B., & MALAISE, M. (2013). Acute-phase serum amyloid a in osteoarthritis: regulatory mechanism and proinflammatory properties. PLoS ONE. doi:10.1371/journal.pone.0066769

Zeddou, M., RELIC, B., MALAISE, O., CHARLIER, E., Desouroux, A., BEGUIN, Y., DE SENY, D., & Malaise, M. (2012). Differential signalling through ALK-1 and ALK-5 regulates leptin expression in Mesenchymal Stem Cells. Stem Cells and Development, 21 (11), 1948-54. doi:10.1089/scd.2011.0321

DE SENY, D., Sharif, M., Fillet, M., COBRAIVILLE, G., Meuwis, M.-A., Marée, R., HAUZEUR, J.-P., Wehenkel, L., Louis, E., Merville, M.-P., Kirwan, J., Ribbens, C., & Malaise, M. (2011). Discovery and biochemical characterisation of four novel biomarkers for osteoarthritis. Annals of the Rheumatic Diseases, 70 (6), 1144-52. doi:10.1136/ard.2010.135541

De Bock, M., De Seny, D., Meuwis, M.-A., Chapelle, J.-P., Louis, E., Malaise, M., Merville, M.-P., & Fillet, M. (2009). Challenges for Biomarker Discovery in Body Fluids Using SELDI-TOF-MS. Journal of Biomedicine and Biotechnology. doi:10.1155/2010/906082

De Seny, D., Ribbens, C., Cobraiville, G., Meuwis, M.-A., Marée, R., Geurts, P., Wehenkel, L., Louis, E., Merville, M.-P., Fillet, M., & Malaise, M. (2009). Protéomique par SELDI-TOF-MS des maladies inflammatoires articulaires: identification des protéines S100 comme protéines d'intérêt. Revue Médicale de Liège, 64 (Spec No), 29-35.

Quesada Calvo, F.* , Fillet, M.* , De Seny, D., Meuwis, M.-A., Marée, R., Crahay, C., Paulissen, G., Rocks, N., Guéders, M., Wehenkel, L., Merville, M.-P., Louis, R., Foidart, J.-M., Noël, A., & Cataldo, D. (2009). Biomarker discovery in asthma-related inflammation and remodeling. Proteomics, 9 (8), 2163-2170. doi:10.1002/pmic.200800643

Relic, B., Zeddou, M., Desoroux, A., Beguin, Y., De Seny, D., & Malaise, M. (2009). Genistein induces adipogenesis but inhibits leptin induction in human synovial fibroblasts. Laboratory Investigation, 89 (7), 811-822. doi:10.1038/labinvest.2009.41

Meuwis, M.-A.* , Fillet, M.* , Lutteri, L., Marée, R., Geurts, P., De Seny, D., Malaise, M., Chapelle, J.-P., Wehenkel, L., Belaiche, J., Merville, M.-P.* , & Louis, E.*. (2008). Proteomics for prediction and characterization of response to infliximab in Crohn's disease: a pilot study. Clinical Biochemistry, 41 (12), 960-7. doi:10.1016/j.clinbiochem.2008.04.021

De Seny, D.* , Fillet, M.* , Meuwis, M.-A., Geurts, P., Lutteri, L., Ribbens, C., Bours, V., Wehenkel, L., Piette, J., Malaise, M., & Merville, M.-P. (2005). Discovery of new rheumatoid arthritis biomarkers using the surface-enhanced laser desorption/ionization time-of-flight mass spectrometry ProteinChip approach. Arthritis and Rheumatism, 52 (12), 3801-12. doi:10.1002/art.21607

Geurts, P., Fillet, M., De Seny, D., Meuwis, M.-A., Malaise, M., Merville, M.-P., & Wehenkel, L. (2005). Proteomic mass spectra classification using decision tree based ensemble methods. Bioinformatics, 21 (14), 3138-45. doi:10.1093/bioinformatics/bti494

Prosperi, C., De Seny, D., Llabres, G., Galleni, M., & Lamotte-Brasseur, J. (December 2002). Active-site mutants of class B beta-lactamases: substrate binding and mechanistic study. Cellular and Molecular Life Sciences, 59 (12), 2136-2143. doi:10.1007/s000180200013

De Seny, D., Prosperi, C., Bebrone, C., Rossolini, G. M., Page, M. I., Noel, P., Frère, J.-M., & Galleni, M. (01 May 2002). Mutational analysis of the two zinc-binding sites of the Bacillus cereus 569/H/9 metallo-beta-lactamase. Biochemical Journal, 363 (Pt 3), 687-696. doi:10.1042/bj3630687

De Seny, D., Heinz, U., Wommer, S., Kiefer, M., Meyer-Klaucke, W., Galleni, M., Frère, J.-M., Bauer, R., & Adolph, H. W. (30 November 2001). Metal Ion Binding and Coordination Geometry for Wild Type and Mutants of Metallo-Beta -Lactamase from Bacillus Cereus 569/H/9 (Bcii): A Combined Thermodynamic, Kinetic, and Spectroscopic Approach. Journal of Biological Chemistry, 276 (48), 45065-78. doi:10.1074/jbc.M106447200

Prosperi, C., Llabres, G., De Seny, D., Soto, R. P., Valladares, M. H., Laraki, N., Frère, J.-M., & Galleni, M. (25 January 1999). Interaction between Class B Beta-Lactamases and Suicide Substrates of Active-Site Serine Beta-Lactamases. FEBS Letters, 443 (2), 109-11. doi:10.1016/S0014-5793(98)01689-5

Paul-Soto, R., Bauer, R., Frère, J.-M., Galleni, M., Meyer-Klaucke, W., Nolting, H., Rossolini, G. M., DE SENY, D., Hernandez-Valladares, M., Zeppezauer, M., & Adolph, H. W. (1999). Mono- and binuclear Zn2+-beta-lactamase. Role of the conserved cysteine in the catalytic mechanism. Journal of Biological Chemistry, 274 (19), 13242-9. doi:10.1074/jbc.274.19.13242