2026-09-23T06:20:49Zhttps://orbi.uliege.be/oai/requestoai:orbi.ulg.ac.be:2268/2133842026-09-01T13:32:17Zcom_f00col_f03class_f02
doctoral thesis
http://purl.org/coar/resource_type/c_db06
info:eu-repo/semantics/doctoralThesis
restricted access
http://purl.org/coar/access_right/c_16ec
info:eu-repo/semantics/restrictedAccess
Role of the dorsomedial and ventrolateral medulla in the regulation of pain sensitivity in the endotoxemic organism
Koulchitsky, Stanislav
Gourine, Valery
Kulchitsky, Vladimir
2000-05-30
https://orbi.uliege.be/handle/2268/213384
info:hdl:2268/213384
ru
vagus nerve
nociception
thermoregulation
electron microscopy
brainstem
Life sciences
Anatomy (cytology, histology, embryology...) & physiology
Sciences du vivant
Anatomie (cytologie, histologie, embryologie...) & physiologie
This study compared the physiological and morphological effects of vagus nerve transection to the chemical destruction of its central projections.
Subdiaphragmatic vagotomy disturbed nociception and body temperature regulation during endotoxemia. Micro-injections of glutamate or vanilloid receptor agonists in toxic concentrations into the nucleus tractus solitarii (NTS) and the caudal ventrolateral medulla (CVLM) lead to the similar effect. Both types of intervention – vagotomy, and central microinjections – were followed by structural alterations in NTS and CVLM, which was visualized by the electron microscopy.
The results suggest involvement of NTS and CVLM neurons in the regulation of nociceptive threshold during the acute phase reaction to endotoxins.
Institute of Physiology of the National Academy of Sciences of Belarus