2026-09-25T21:12:09Zhttps://orbi.uliege.be/oai/requestoai:orbi.ulg.ac.be:2268/1752182026-09-01T13:29:20Zcom_f00col_f03class_g01
doctoral thesis
http://purl.org/coar/resource_type/c_db06
info:eu-repo/semantics/doctoralThesis
open access
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info:eu-repo/semantics/openAccess
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Engineering of poly(2-oxazoline)s for a potential use in biomedical applications
Legros, Camille
2014-10-31
235
https://orbi.uliege.be/handle/2268/175218
info:hdl:2268/175218
https://orbi.uliege.be/bitstream/2268/175218/1/THESE%20-%20VF.pdf
en
polyoxazolines
nanogel
hydrogel
responsiveness
crystallization
LCST
aldehyde
protein repellent
cytotoxicity
Physical, chemical, mathematical & earth Sciences
Chemistry
Physique, chimie, mathématiques & sciences de la terre
Chimie
This PhD work is based on the design of poly(2-oxazoline) (POx)
hydrogels and nanogels, by chemical or physical cross-linking, aimed to be used for
biomedical applications. Nanogels were first prepared in dilute media and in inverse
emulsion based on a statistical copolymer made of 2-ethyl-2-oxazoline and ethylene
imine units. These stimuli-responsive nanogels were swelling in acidic media and
were cleaved in reductive environment. They proved to be non-cytotoxic and act as
protein repellent. Second, a reactive platform based on a statistical POx polymer
bearing aldehyde functionalities was engineered, enabling the synthesis of graft and
cross-linked POx. Last, a block copolymer made of 2-methyl- and 2-isopropyl-2-
oxazoline units, proved to self-assemble into micelles when heated above its LCST,
for a short period of time (< 1h30). When annealed for a longer time (> 1h30),
crystallization-driven self-assembly led to the formation of different morphologies
(fiber rods and cross-linked micelles).
ULiège - Université de Liège