Article (Scientific journals)
Neuroimaging of narcolepsy
Dang Vu, Thien Thanh; Desseilles, Martin; Schwartz, Sophie et al.
2009In CNS and Neurological Disorders Drug Targets, 8 (4), p. 254-263
Peer Reviewed verified by ORBi
 

Files


Full Text
DangVu_CNSNDDT_2009.pdf
Publisher postprint (639.29 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
Benzhydryl Compounds/therapeutic use; Brain/drug effects/physiopathology/radionuclide imaging; Brain Mapping/methods; Central Nervous System Stimulants/therapeutic use; Diagnostic Imaging; Humans; Magnetic Resonance Imaging; Models, Neurological; Narcolepsy/drug therapy/physiopathology/radionuclide imaging; Positron-Emission Tomography; Tomography, Emission-Computed, Single-Photon
Abstract :
[en] Neuroimaging techniques have refined the characterization of neural structures involved in the regulation of normal sleep-wake cycle in healthy humans. Yet brain imaging studies in patients with sleep disorders still remain scarce. In narcoleptic patients, structural and functional brain imaging studies have suggested the involvement of the hypothalamus in the pathophysiology of narcolepsy, plausibly consistent with an impairment of the hypocretin-orexin system. Some recent studies have further suggested that cataplexy, a key feature of the narcoleptic syndrome, might result from a dysfunction of the hypothalamus and its interactions with limbic structures. Other neuroimaging studies have focused on the assessment of neurotransmission and the effects of pharmacological treatment in narcoleptic patients. However, the neural correlates of some main symptoms of narcolepsy, such as sleep attacks, hypnagogic/hypnopompic hallucinations and sleep paralysis, are still unknown. In addition, the description of brain activity patterns during sleep in narcoleptic patients needs further investigation. Neuroimaging has proven to be a valuable tool for the study of sleep regulation and sleep disorders; its future developments will undoubtedly improve our understanding of the neural mechanisms underlying narcolepsy with cataplexy.
Disciplines :
Neurology
Author, co-author :
Dang Vu, Thien Thanh ;  Université de Liège - ULiège > Département des sciences cliniques > Neurologie
Desseilles, Martin ;  Université de Liège - ULiège > Département des sciences cliniques > Psychiatrie et psychologie médicale
Schwartz, Sophie
Maquet, Pierre  ;  Université de Liège - ULiège > Centre de recherches du cyclotron - Département des sciences cliniques
Language :
English
Title :
Neuroimaging of narcolepsy
Publication date :
2009
Journal title :
CNS and Neurological Disorders Drug Targets
ISSN :
1871-5273
eISSN :
1996-3181
Publisher :
Bentham Science Publishers Ltd., Amsterdam, Netherlands
Volume :
8
Issue :
4
Pages :
254-263
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 29 December 2010

Statistics


Number of views
33 (1 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
14
Scopus citations®
without self-citations
9
OpenCitations
 
16

Bibliography


Similar publications



Contact ORBi