Article (Scientific journals)
A Non-Cofactor Role of Thiamine Derivatives in Excitable Cells?
Bettendorff, Lucien
1996In Archives of Physiology and Biochemistry, 104 (6), p. 745-751
Peer Reviewed verified by ORBi
 

Files


Full Text
Bettendorff1996.pdf
Publisher postprint (995.52 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
thiamine
Abstract :
[en] Thiamine diphosphate (TDP) is an important cofactor of pyruvate (PDH) and alpha-ketoglutarate (KGDH) dehydrogenases and transketolase. Thiamine deficiency leads to reversible and irreversible brain lesions due to impaired oxidative metabolism. A specific non-cofactor role for thiamine has also been proposed in excitable cells and thiamine triphosphate (TTP) might be involved in the regulation of ion channels. Thiamine is taken up by neuroblastoma cells through a high affinity transporter. Inside the cells, it is rapidly phosphorylated to TDP. This high turnover TDP pool is the precursor for TTP. Most of the TDP however has a low turnover and is associated with PDH and KGDH in mitochondria. In excised inside-out patches from neuroblastoma cells, TTP, at a concentration of 1 microM, activates chloride channels of large unitary conductance, the so-called maxi-Cl- channels. These channels are inhibited by oxythiamine from the outide. In addition to the role of TTP in the regulation of chloride channels, thiamine itself, or a presently unknown analog, may have trophic effects on neuronal cells.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Bettendorff, Lucien  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique
Language :
English
Title :
A Non-Cofactor Role of Thiamine Derivatives in Excitable Cells?
Publication date :
1996
Journal title :
Archives of Physiology and Biochemistry
ISSN :
1381-3455
eISSN :
1744-4160
Publisher :
Taylor & Francis
Volume :
104
Issue :
6
Pages :
745-751
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 January 2009

Statistics


Number of views
29 (0 by ULiège)
Number of downloads
0 (0 by ULiège)

Scopus citations®
 
15
Scopus citations®
without self-citations
14
OpenCitations
 
14

Bibliography


Similar publications



Contact ORBi