Reference : Perinatal growth hormone (GH) physiology : effect of GH-releasing factor on maternal ...
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
Perinatal growth hormone (GH) physiology : effect of GH-releasing factor on maternal and fetal secretion of pituitary and placental GH.
De Zegher, F. [ > > ]
Vanderschueren-Lodeweyckx, M. [ > > ]
Spitz, B. [ > > ]
Faijerson, Y. [ > > ]
Blomberg, F. [ > > ]
Beckers, Albert mailto [Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie >]
Hennen, Georges [Université de Liège - ULiège > > Endocrinologie clinique >]
Frankenne, Francis [Université de Liège - ULiège > Département des sciences cliniques > > >]
Journal of Clinical Endocrinology and Metabolism
Endocrine Society
Yes (verified by ORBi)
Chevy Chase
[en] Cesarean Section ; Female ; Fetal Blood/analysis ; Growth Hormone/blood/secretion ; Growth Hormone-Releasing Hormone/analogs & derivatives/pharmacology ; Humans ; Peptide Fragments/pharmacology ; Pituitary Gland, Anterior/drug effects/secretion ; Placenta/drug effects/secretion ; Placenta Previa/physiopathology ; Pregnancy ; Sermorelin
[en] To study regulation of the secretion of human pituitary GH (hGH) and placental GH (hPGH) in the pregnant woman and human fetus, the GH-releasing factor Sermorelin [GRF-(l–29)-NH2] was administered to pregnant women at term (n = 5), just before elective cesarean section; saline was administered in control studies (n = 5). The effects of GRF-(1–29)-NH2 administration on maternal and fetal serum concentrations of hGH and GRF-(l–29)-NH2 and maternal serum levels of hPGH were evaluated at birth. The mean time span between injection and birth was 20 min (range, 15–25 min). Cord serum hGH concentrations were similar in infants of GRF-(1–29)-NH2-injected mothers and control infants. GRF-(l–29)-NH2 elicited a consistent but small rise in maternal hGH serum concentrations (P = 0.08), whereas hPGH concentrations remained unaltered. Finally, GRF-(l–29)-NH2 concentrations were undetectable in cord serum, but readily detectable in concomitantly obtained maternal serum.

In conclusion, these data suggest that hGH secretion in the pregnant woman at term is suppressed at the pituitary level, that GRF does not affect hPGH secretion, and that fetal hGH secretion is independent of circulating maternal GRF, probably because of lack of transplacental GRF passage.
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