Article (Scientific journals)
Focalized external radiotherapy for resected solitary brain metastasis: does the dogma stand?
Coucke, Philippe; Zouhair, Abderrahim; Ozsahin, Mahmut et al.
1998In Radiotherapy and Oncology, 47 (1), p. 99-101
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Keywords :
Focalized external irradiation; Resected solitary brain metastasis; Dogma
Abstract :
[en] To investigate whether whole brain irradiation might be replaced by focalized irradiation after resection of a single brain metastasis in patients where extracranial tumor control is deemed to be obtained. Patients and methods: Twelve patients were introduced in a phase I/II prospective study of conformal postoperative external irradiation after resection of a solitary brain metastasis. The radiation treatment consisted of 50.4 Gy (1.8 Gy per fraction, five fractions per week). The planning target volume consisted of the tumor bed and a 2 cm safety margin. All treatments were optimized with head immobilization, dedicated tomodensitometry and computer assisted three-dimensional treatment planning. Results: The median survival was 7.2 months (range 2.4–50.4 months). Eleven of the 12 patients died. Eight of the 12 patients presented intracranial recurrence and seven died as a consequence of intracranial tumor progression. Conclusions: Focalized external irradiation cannot serve as a reasonable alternative to whole brain radiotherapy (WBRT) even for patients with apparently one single resected brain metastasis. The dogma of ‘one metastasis=multiple metastases' seems to be confirmed.
Disciplines :
Oncology
Hematology
Author, co-author :
Coucke, Philippe  ;  Centre Hospitalier Universitaire Vaudois > Radiation Oncology
Zouhair, Abderrahim;  Centre Hospitalier Universitaire Vaudois > Radiation Oncology
Ozsahin, Mahmut;  Centre Hospitalier Universitaire Vaudois > Radiation Oncology
De Tribolet, Nicoles;  Centre Hospitalier Universitaire Vaudois > Neurosurgery
Mirimanoff, René;  Centre Hospitalier Universitaire Vaudois > Radiation Oncology
Language :
English
Title :
Focalized external radiotherapy for resected solitary brain metastasis: does the dogma stand?
Publication date :
1998
Journal title :
Radiotherapy and Oncology
ISSN :
0167-8140
eISSN :
1879-0887
Publisher :
Elsevier Scientific, Limerick, Ireland
Volume :
47
Issue :
1
Pages :
99-101
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 18 February 2010

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