Key role of estrogen receptor β in the organization of brain and behavior of the Japanese quail

[en] Estrogens play a key role in the sexual differentiation of the brain and behavior. While early estrogen actions exert masculinizing effects on the brain of male rodents, a diametrically opposite effect is observed in birds where estrogens demasculinize the brain of females. Yet, the two vertebrate classes express similar sex differences in the brain and behavior. Although ERα is thought to play a major role in these processes in rodents, the role of ERβ is still controversial. In birds, the identity of the estrogen receptor(s) underlying the demasculinization of the female brain remains unclear. The aim of the present study was thus to determine in Japanese quail the effects of specific agonists of ERα (propylpyrazole triol, PPT) and ERβ (diarylpropionitrile, DPN) administered at the beginning of the sensitive period (embryonic day 7, E7) on the sexual differentiation of male sexual behavior and on the density of vasotocin-immunoreactive (VT-ir) fibers, a known marker of the organizational action of estrogens on the quail brain. We demonstrate that estradiol benzoate and the ERβ agonist (DPN) demasculinize male sexual behavior and decrease the density of VT-ir fibers in the medial preoptic nucleus and the bed nucleus of the stria terminalis, while PPT has no effect on these measures. These results clearly indicate that ERβ, but not ERα, is involved in the estrogen-induced sexual differentiation of brain and sexual behavior in quail. © 2020 Elsevier Inc.

Disciplines :

Neurosciences & comportement

Auteur, co-auteur :

Court, Lucas ; Université de Liège - ULiège > Neurosciences-Neuroendocrinology

Vandries, Laura ; Université de Liège - ULiège > Neurosciences-Neuroendocrinology

Balthazart, Jacques ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques

Cornil, Charlotte ; Université de Liège - ULiège > Neurosciences-Neuroendocrinology

Langue du document :

Anglais

Titre :

Key role of estrogen receptor β in the organization of brain and behavior of the Japanese quail

Date de publication/diffusion :

2020

Titre du périodique :

Hormones and Behavior

ISSN :

0018-506X

eISSN :

1095-6867

Maison d'édition :

Academic Press Inc.

Volume/Tome :

125

Pagination :

104827

Peer reviewed :

Peer reviewed vérifié par ORBi

Intitulé du projet de recherche :

NIMH Grant R01 MH50388

Organisme subsidiant :

NIMH - National Institute of Mental Health [US-MD]

Disponible sur ORBi :

depuis le 16 octobre 2020

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Nombre de vues

100 (dont 13 ULiège)

Nombre de téléchargements

3 (dont 3 ULiège)

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