Cognitive compensatory processes of older, clinically fit patients with hematologic malignancies undergoing chemotherapy: A longitudinal cohort study

Libert, Y.; Borghgraef, C.; Beguin, Yves; Delvaux, N.; DEVOS, Martine; Doyen, C.; Dubruille, S.; Etienne, Anne-Marie; Liénard, A.; Merckaert, I.; Reynaert, C.; Slachmuylder, J.-L.; Straetmans, N.; Van Den Neste, E.; Bron, D.; Razavi, D.

doi:10.1002/pon.4424

Article (Périodiques scientifiques)

Cognitive compensatory processes of older, clinically fit patients with hematologic malignancies undergoing chemotherapy: A longitudinal cohort study

Libert, Y.; Borghgraef, C.; Beguin, Yves et al.

2017 • In Psycho-oncology, 26 (12), p. 2086-2093

Peer reviewed vérifié par ORBi

Permalien
https://hdl.handle.net/2268/220479

DOI
10.1002/pon.4424

PubMed
28316129

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Mots-clés :

Article; FCSR IR test; Hospital Anxiety and Depression Scale

Résumé :

[en] Objective: Despite the well-known negative impacts of cancer and anticancer therapies on cognitive performance, little is known about the cognitive compensatory processes of older patients with cancer. This study was designed to investigate the cognitive compensatory processes of older, clinically fit patients with hematologic malignancies undergoing chemotherapy. Methods: We assessed 89 consecutive patients (age ≥ 65 y) without severe cognitive impairment and 89 age-, sex-, and education level-matched healthy controls. Cognitive compensatory processes were investigated by (1) comparing cognitive performance of patients and healthy controls in novel (first exposure to cognitive tasks) and non-novel (second exposure to the same cognitive tasks) contexts, and (2) assessing psychological factors that may facilitate or inhibit cognitive performance, such as motivation, psychological distress, and perceived cognitive performance. We assessed cognitive performance with the Trail-Making, Digit Span and FCSR-IR tests, psychological distress with the Hospital Anxiety and Depression Scale, and perceived cognitive performance with the FACT-Cog questionnaire. Results: In novel and non-novel contexts, average cognitive performances of healthy controls were higher than those of patients and were associated with motivation. Cognitive performance of patients was not associated with investigated psychological factors in the novel context but was associated with motivation and psychological distress in the non-novel context. Conclusions: Older, clinically fit patients with hematologic malignancies undergoing chemotherapy demonstrated lower cognitive compensatory processes compared to healthy controls. Reducing distress and increasing motivation may improve cognitive compensatory processes of patients in non-novel contexts. Copyright © 2017 John Wiley & Sons, Ltd.

Disciplines :

Hématologie

Auteur, co-auteur :

Libert, Y.; Université Libre de Bruxelles, Brussels, Belgium

Borghgraef, C.; Université Libre de Bruxelles, Brussels, Belgium

Beguin, Yves ; Université de Liège - ULiège > GIGA-R : Hématologie

Delvaux, N.; Université Libre de Bruxelles, Brussels, Belgium

DEVOS, Martine ; Centre Hospitalier Universitaire de Liège - CHU > Centre d'oncologie

Doyen, C.; Université Catholique de Louvain, Yvoir, Belgium

Dubruille, S.; Université Libre de Bruxelles, Brussels, Belgium

Etienne, Anne-Marie ; Université de Liège - ULiège > Département de Psychologie > Psychologie de la santé

Liénard, A.; Université Libre de Bruxelles - ULB

Merckaert, I.; Université Libre de Bruxelles, Brussels, Belgium

Plus d'auteurs (6 en +)

Langue du document :

Anglais

Titre :

Cognitive compensatory processes of older, clinically fit patients with hematologic malignancies undergoing chemotherapy: A longitudinal cohort study

Date de publication/diffusion :

2017

Titre du périodique :

Psycho-oncology

ISSN :

1057-9249

eISSN :

1099-1611

Maison d'édition :

John Wiley and Sons Ltd

Volume/Tome :

Fascicule/Saison :

Pagination :

2086-2093

Peer reviewed :

Peer reviewed vérifié par ORBi

Disponible sur ORBi :

depuis le 18 février 2018

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127 (dont 2 ULiège)

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237 (dont 2 ULiège)

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Bibliographie

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