Article (Scientific journals)
Interactions of sugar-based bolaamphiphiles with biomimetic systems of plasma membranes
Nasir, Mehmet Nail; Crowet, Jean-Marc; Lins, Laurence et al.
2016In Biochimie, 130, p. 23-32
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Keywords :
glycolipid; membrane interaction; cholesterol influence; Langmuir monolayer; isothermal titration calorimetry; IR spectroscopy; in silico analysis
Abstract :
[en] Glycolipids constitute a class of molecules with various biological activities. Among them, sugar-based bolaamphiphiles characterized by their biocompatibility, biodegradability and lower toxicity, became interesting for the development of efficient and low cost lipid-based drug delivery systems. Their activity seems to be closely related to their interactions with the lipid components of the plasma membrane of target cells. Despite many works devoted to the chemical synthesis and characterization of sugar-based bolaamphiphiles, their interactions with plasma membrane have not been completely elucidated. In this work, two sugar-based bolaamphiphiles differing only at the level of their sugar residues were chemically synthetized. Their interactions with membranes have been investigated using model membranes containing or not sterol and with in silico approaches. Our findings indicate that the nature of sugar residues has no significant influence for their membrane interacting properties, while the presence of sterol attenuates the interactions of both bolaamphiphiles with the membrane systems. The understanding of this distinct behavior of bolaamphiphiles towards sterol-containing membrane systems could be useful for their applications as drug delivery systems.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Nasir, Mehmet Nail ;  Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Chimie générale et organique
Crowet, Jean-Marc ;  Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biophysique moléc. aux interfaces
Lins, Laurence  ;  Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biophysique moléc. aux interfaces
Obounou Akong, Firmin 
Haudrechy, Arnaud
Bouquillon, Sandrine
Deleu, Magali  ;  Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Biophysique moléc. aux interfaces
Language :
English
Title :
Interactions of sugar-based bolaamphiphiles with biomimetic systems of plasma membranes
Publication date :
2016
Journal title :
Biochimie
ISSN :
0300-9084
eISSN :
1638-6183
Publisher :
Elsevier, Paris, France
Volume :
130
Pages :
23-32
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
ARC-FIELD (13/17-10), FNRS PDR NEAMEMB (T.1003.14)
Available on ORBi :
since 13 April 2016

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